Lycopene inhibits NF-KB-Mediated IL-8 expression and changes redox and PPARγ signalling in cigarette smoke-stimulated macrophages

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Simone, Rossella E ^a   Russo, Marco ^b   Catalano, Assunta ^a   Monego, Giovanni ^c   Froehlich, Kati ^b   Boehm, Volker ^b   Palozza, Paola ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CIGARETTE SMOKE; DNA; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LYCOPENE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; ANTIOXIDANT; CAROTENOID;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STIMULATION; CELL STRAIN THP 1; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MACROPHAGE; MALE; NONHUMAN; OXIDATION REDUCTION STATE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENETICS; LUNG ALVEOLUS MACROPHAGE; METABOLISM; OXIDATION REDUCTION REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING; WESTERN BLOTTING; WISTAR RAT;

LYCOPERSICON ESCULENTUM; RATTUS;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CAROTENOIDS; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; INTERLEUKIN-8; MACROPHAGES, ALVEOLAR; MALE; NF-KAPPA B; OXIDATION-REDUCTION; PPAR GAMMA; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMOKING;

EID: 79956282901     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019652     Document Type: Article

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