-
1
-
-
37249009271
-
Motif module map reveals enforcement of aging by continual NF-jB activity
-
Adler AS, Sinha S, Kawahara T, Zhang JY, Segal E, Chang HY (2007) Motif module map reveals enforcement of aging by continual NF-jB activity. Genes Dev. 21, 3244-3257.
-
(2007)
Genes Dev
, vol.21
, pp. 3244-3257
-
-
Adler, A.S.1
Sinha, S.2
Kawahara, T.3
Zhang, J.Y.4
Segal, E.5
Chang, H.Y.6
-
2
-
-
34249669270
-
Sirt1 regulates aging and resistance to oxidative stress in the heart
-
Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J (2009) Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ. Res. 100, 1512-1521.
-
(2009)
Circ. Res.
, vol.100
, pp. 1512-1521
-
-
Alcendor, R.R.1
Gao, S.2
Zhai, P.3
Zablocki, D.4
Holle, E.5
Yu, X.6
Tian, B.7
Wagner, T.8
Vatner, S.F.9
Sadoshima, J.10
-
3
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 11, 191-198.
-
(2005)
Nat. Med.
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
4
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks AS, Kon N, Knight C, Matsumoto M, Gutierrez-Juarez R, Rossetti L, Gu W, Accili D (2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8, 333-341.
-
(2008)
Cell Metab
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
Knight, C.3
Matsumoto, M.4
Gutierrez-Juarez, R.5
Rossetti, L.6
Gu, W.7
Accili, D.8
-
5
-
-
48349110303
-
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
-
Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA (2008) A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 3, e2264.
-
(2008)
PLoS ONE
, vol.3
-
-
Barger, J.L.1
Kayo, T.2
Vann, J.M.3
Arias, E.B.4
Wang, J.5
Hacker, T.A.6
Wang, Y.7
Raederstorff, D.8
Morrow, J.D.9
Leeuwenburgh, C.10
Allison, D.B.11
Saupe, K.W.12
Cartee, G.D.13
Weindruch, R.14
Prolla, T.A.15
-
6
-
-
33751072349
-
Resveratrol improves survival and health of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves survival and health of mice on a high-calorie diet. Nature 444, 337-342.
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
de Cabo, R.26
Sinclair, D.A.27
more..
-
7
-
-
45549098657
-
SIRT1 regulates energy metabolism and response to caloric restriction in mice
-
Boily G, Seifert EL, Bevilacqua L, He XH, Sabourin G, Estey C, Moffat C, Crawford S, Saliba S, Jardine K, Xuan J, Evans M, Harper ME, McBurney MW (2008) SIRT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE 3, e1759.
-
(2008)
PLoS ONE
, vol.3
-
-
Boily, G.1
Seifert, E.L.2
Bevilacqua, L.3
He, X.H.4
Sabourin, G.5
Estey, C.6
Moffat, C.7
Crawford, S.8
Saliba, S.9
Jardine, K.10
Xuan, J.11
Evans, M.12
Harper, M.E.13
McBurney, M.W.14
-
8
-
-
68949113934
-
SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
-
Boily G, He XH, Pearce B, Jardine K, McBurney MW (2009) SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol. Oncogene 28, 2882-2893.
-
(2009)
Oncogene
, vol.28
, pp. 2882-2893
-
-
Boily, G.1
He, X.H.2
Pearce, B.3
Jardine, K.4
McBurney, M.W.5
-
9
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L, Cohen D, Robinson A, Motta MC, van Veen E, Czopik A, Steele AD, Crowe H, Marmor S, Luo J, Gu W, Guarente L (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6, 759-767.
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
Motta, M.C.4
van Veen, E.5
Czopik, A.6
Steele, A.D.7
Crowe, H.8
Marmor, S.9
Luo, J.10
Gu, W.11
Guarente, L.12
-
10
-
-
5444262078
-
IKKb-NFjB activation causes severe muscle wasting in mice
-
Cai D, Frantz JD, Tawa Jr NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE (2004) IKKb-NFjB activation causes severe muscle wasting in mice. Cell 119, 285-298.
-
(2004)
Cell
, vol.119
, pp. 285-298
-
-
Cai, D.1
Frantz, J.D.2
Tawa N.E., Jr.3
Melendez, P.A.4
Oh, B.C.5
Lidov, H.G.6
Hasselgren, P.O.7
Frontera, W.R.8
Lee, J.9
Glass, D.J.10
Shoelson, S.E.11
-
11
-
-
28844469898
-
Increase in activity during calorie restriction requires SIRT1
-
Chen D, Steele AD, Lindquist S, Guarente L (2005a) Increase in activity during calorie restriction requires SIRT1. Science 310, 1641.
-
(2005)
Science
, vol.310
, pp. 1641
-
-
Chen, D.1
Steele, A.D.2
Lindquist, S.3
Guarente, L.4
-
12
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB (2005b) Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123, 437-448.
-
(2005)
Cell
, vol.123
, pp. 437-448
-
-
Chen, W.Y.1
Wang, D.H.2
Yen, R.C.3
Luo, J.4
Gu, W.5
Baylin, S.B.6
-
13
-
-
72849130743
-
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
-
Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente L (2009) Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. Genes Dev. 23, 2812-2817.
-
(2009)
Genes Dev
, vol.23
, pp. 2812-2817
-
-
Cohen, D.E.1
Supinski, A.M.2
Bonkowski, M.S.3
Donmez, G.4
Guarente, L.5
-
14
-
-
67650439330
-
Caloric restriction delays disease onset and mortality in rhesus monkeys
-
Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325, 201-204.
-
(2009)
Science
, vol.325
, pp. 201-204
-
-
Colman, R.J.1
Anderson, R.M.2
Johnson, S.C.3
Kastman, E.K.4
Kosmatka, K.J.5
Beasley, T.M.6
Allison, D.B.7
Cruzen, C.8
Simmons, H.A.9
Kemnitz, J.W.10
Weindruch, R.11
-
15
-
-
34249846128
-
Resveratrol stimulates AMP kinase activity in neurons
-
Dasgupta B, Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. PNAS 104, 7217-7222.
-
(2007)
PNAS
, vol.104
, pp. 7217-7222
-
-
Dasgupta, B.1
Milbrandt, J.2
-
16
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 8, 347-358.
-
(2008)
Cell Metab
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
Milne, J.C.6
Lambert, P.D.7
Mataki, C.8
Elliott, P.J.9
Auwerx, J.10
-
17
-
-
44849096876
-
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
-
Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA (2008) The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 3, e2020.
-
(2008)
PLoS ONE
, vol.3
-
-
Firestein, R.1
Blander, G.2
Michan, S.3
Oberdoerffer, P.4
Ogino, S.5
Campbell, J.6
Bhimavarapu, A.7
Luikenhuis, S.8
de Cabo, R.9
Fuchs, C.10
Hahn, W.C.11
Guarente, L.P.12
Sinclair, D.A.13
-
18
-
-
33845868198
-
Sirtuins as potential targets for metabolic syndrome
-
Guarente L (2006) Sirtuins as potential targets for metabolic syndrome. Nature 444, 868-874.
-
(2006)
Nature
, vol.444
, pp. 868-874
-
-
Guarente, L.1
-
19
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.L.10
Scherer, B.11
Sinclair, D.A.12
-
20
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
21
-
-
67650563916
-
SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer
-
Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J (2009) SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer. J. Biol. Chem. 284, 18210-18217.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18210-18217
-
-
Kabra, N.1
Li, Z.2
Chen, L.3
Li, B.4
Zhang, X.5
Wang, C.6
Yeatman, T.7
Coppola, D.8
Chen, J.9
-
22
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 2570-2580.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
23
-
-
58149090925
-
SIRT6 links histone H3 lysine 9 deacetylation to NF-jB-dependent gene expression and organismal life span
-
Kawahara T, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui K, Boxer LD, Chang HY, Chua KF (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-jB-dependent gene expression and organismal life span. Cell 136, 62-74.
-
(2009)
Cell
, vol.136
, pp. 62-74
-
-
Kawahara, T.1
Michishita, E.2
Adler, A.S.3
Damian, M.4
Berber, E.5
Lin, M.6
McCord, R.A.7
Ongaigui, K.8
Boxer, L.D.9
Chang, H.Y.10
Chua, K.F.11
-
24
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD (2009) FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 10, 392-404.
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
Tsang, S.7
Wu, S.Y.8
Chiang, C.M.9
Veenstra, T.D.10
-
25
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim JE, Chen J, Lou Z (2008) DBC1 is a negative regulator of SIRT1. Nature 451, 583-587.
-
(2008)
Nature
, vol.451
, pp. 583-587
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
26
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122.
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
Geny, B.11
Laakso, M.12
Puigserver, P.13
Auwerx, J.14
-
27
-
-
63249112836
-
Overexpression of SIRT1 protects pancreatic b-cells against cytokine toxicity by suppressing the nuclear factor-jB signaling pathway
-
Lee JH, Song MY, Song EK, Kim EK, Moon WS, Han MK, Park JW, Kwon KB, Park BH (2009) Overexpression of SIRT1 protects pancreatic b-cells against cytokine toxicity by suppressing the nuclear factor-jB signaling pathway. Diabetes 58, 344-351.
-
(2009)
Diabetes
, vol.58
, pp. 344-351
-
-
Lee, J.H.1
Song, M.Y.2
Song, E.K.3
Kim, E.K.4
Moon, W.S.5
Han, M.K.6
Park, J.W.7
Kwon, K.B.8
Park, B.H.9
-
28
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente M (2007) SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol. Cell 28, 91-106.
-
(2007)
Mol. Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, M.6
-
29
-
-
45549096918
-
SIRT1 inhibition reduces IGF-1/IRS-2/Ras/ERK1/2 signaling and protects neurons
-
Li Y, Xu W, McBurney MW, Longo VD (2008) SIRT1 inhibition reduces IGF-1/IRS-2/Ras/ERK1/2 signaling and protects neurons. Cell Metab. 8, 38-48.
-
(2008)
Cell Metab
, vol.8
, pp. 38-48
-
-
Li, Y.1
Xu, W.2
McBurney, M.W.3
Longo, V.D.4
-
30
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Kaikobad I (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. PNAS 104, 14855-14860.
-
(2007)
PNAS
, vol.104
, pp. 14855-14860
-
-
Mattagajasingh, I.1
Kim, C.S.2
Naqvi, A.3
Yamamori, T.4
Hoffman, T.A.5
Jung, S.B.6
DeRicco, J.7
Kasuno, K.8
Kaikobad, I.9
-
31
-
-
65249087389
-
SIRT5 deacetylates carbamoyl phosphate synthatase 1 and regulates the urea cycle
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L (2009) SIRT5 deacetylates carbamoyl phosphate synthatase 1 and regulates the urea cycle. Cell 137, 560-570.
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
32
-
-
56749156405
-
SIRT1 redistribution on chromatin promotes genomic stability and alters gene expression during aging
-
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA (2008) SIRT1 redistribution on chromatin promotes genomic stability and alters gene expression during aging. Cell 135, 907-918.
-
(2008)
Cell
, vol.135
, pp. 907-918
-
-
Oberdoerffer, P.1
Michan, S.2
McVay, M.3
Mostoslavsky, R.4
Vann, J.5
Park, S.K.6
Hartlerode, A.7
Stegmuller, J.8
Hafner, A.9
Loerch, P.10
Wright, S.M.11
Mills, K.D.12
Bonni, A.13
Yankner, B.A.14
Scully, R.15
Prolla, T.A.16
Alt, F.W.17
Sinclair, D.A.18
-
33
-
-
47749128879
-
-
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH (2008) Sirt1 protects against high-fat diet induced metabolic damage. PNAS 105, 9793-9798.
-
(2008)
PNAS
, vol.105
, pp. 9793-9798
-
-
-
34
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B, Helfand SL (2004) Sir2 mediates longevity in the fly through a pathway related to calorie restriction. PNAS 101, 15998-16003.
-
(2004)
PNAS
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
35
-
-
40949123149
-
Activation of innate immunity system during aging: NF-jB signaling is the molecular culprit of inflamm-aging
-
Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T (2007) Activation of innate immunity system during aging: NF-jB signaling is the molecular culprit of inflamm-aging. Ageing Res. Rev. 7, 83-105.
-
(2007)
Ageing Res. Rev.
, vol.7
, pp. 83-105
-
-
Salminen, A.1
Huuskonen, J.2
Ojala, J.3
Kauppinen, A.4
Kaarniranta, K.5
Suuronen, T.6
-
36
-
-
51649112590
-
Sirt1-null mice develop an autoimmune-like condition
-
Sequeira J, Boily G, Bazinet S, Saliba S, He X, Jardine K, Kennedy C, Staines W, Rousseaux C, Mueller R, McBurney MW (2008) Sirt1-null mice develop an autoimmune-like condition. Exp. Cell Res. 314, 3069-3074.
-
(2008)
Exp. Cell Res.
, vol.314
, pp. 3069-3074
-
-
Sequeira, J.1
Boily, G.2
Bazinet, S.3
Saliba, S.4
He, X.5
Jardine, K.6
Kennedy, C.7
Staines, W.8
Rousseaux, C.9
Mueller, R.10
McBurney, M.W.11
-
37
-
-
63549094179
-
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
-
Smith JL, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O (2009) Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Syst Biol 3, 31-45.
-
(2009)
BMC Syst Biol
, vol.3
, pp. 31-45
-
-
Smith, J.L.1
Kenney, R.D.2
Gagne, D.J.3
Frushour, B.P.4
Ladd, W.5
Galonek, H.L.6
Israelian, K.7
Song, J.8
Razvadauskaite, G.9
Lynch, A.V.10
Carney, D.P.11
Johnson, R.J.12
Lavu, S.13
Iffland, A.14
Elliott, P.J.15
Lambert, P.D.16
Elliston, K.O.17
Jirousek, M.R.18
Milne, J.C.19
Boss, O.20
more..
-
38
-
-
23744485726
-
Caspasedependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
-
Sundararajan R, Chen G, Mukherjee C, White E (2005) Caspasedependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene 24, 4908-4920.
-
(2005)
Oncogene
, vol.24
, pp. 4908-4920
-
-
Sundararajan, R.1
Chen, G.2
Mukherjee, C.3
White, E.4
-
39
-
-
70349208608
-
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
-
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP (2009) Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J. Clin. Invest. 119, 2758-2771.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2758-2771
-
-
Sundaresan, N.R.1
Gupta, M.2
Kim, G.3
Rajamohan, S.B.4
Isbatan, A.5
Gupta, M.P.6
-
40
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA, Guarente L (2001) Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
41
-
-
41449083867
-
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
-
Vakhrusheva O, Smolka C, Gajawada P, Kostin S, Boettger T, Kubin T, Braun T, Bober E (2009) Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710.
-
(2009)
Circ. Res.
, vol.102
, pp. 703-710
-
-
Vakhrusheva, O.1
Smolka, C.2
Gajawada, P.3
Kostin, S.4
Boettger, T.5
Kubin, T.6
Braun, T.7
Bober, E.8
-
42
-
-
59649117804
-
Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuindependent manner
-
Van Gool F, Gallí M, Gueydan C, Kruys V, Prevot PP, Bedalov A, Mostoslavsky R, Alt FW, De SmedtT, Leo O (2009) Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuindependent manner. Nat. Med. 15, 206-210.
-
(2009)
Nat. Med.
, vol.15
, pp. 206-210
-
-
Van Gool, F.1
Gallí, M.2
Gueydan, C.3
Kruys, V.4
Prevot, P.P.5
Bedalov, A.6
Mostoslavsky, R.7
Alt, F.W.8
De Smedt, T.9
Leo, O.10
-
43
-
-
53149144656
-
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
-
Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Lahusen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX (2008a) Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol. Cell 32, 11-20.
-
(2008)
Mol. Cell
, vol.32
, pp. 11-20
-
-
Wang, R.H.1
Zheng, Y.2
Kim, H.S.3
Xu, X.4
Cao, L.5
Lahusen, T.6
Lee, M.H.7
Xiao, C.8
Vassilopoulos, A.9
Chen, W.10
Gardner, K.11
Man, Y.G.12
Hung, M.C.13
Finkel, T.14
Deng, C.X.15
-
44
-
-
53149137486
-
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
-
Wang RH, Sengupta K, Li C, Kim HS, Cao L, Xiao C, Kim S, Xu X, Zheng Y, Chilton B, Jia R, Zheng ZM, Appella E, Wang XW, Ried T, Deng CX (2008b) Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14, 312-323.
-
(2008)
Cancer Cell
, vol.14
, pp. 312-323
-
-
Wang, R.H.1
Sengupta, K.2
Li, C.3
Kim, H.S.4
Cao, L.5
Xiao, C.6
Kim, S.7
Xu, X.8
Zheng, Y.9
Chilton, B.10
Jia, R.11
Zheng, Z.M.12
Appella, E.13
Wang, X.W.14
Ried, T.15
Deng, C.X.16
-
46
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay aging in metazoans
-
Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay aging in metazoans. Nature 430, 686-689.
-
(2004)
Nature
, vol.430
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
Howitz, K.4
Helfand, S.L.5
Tatar, M.6
Sinclair, D.7
-
47
-
-
3242719545
-
Modulation of NF-jB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW (2004) Modulation of NF-jB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380.
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
Keller, M.D.4
Jones, D.R.5
Frye, R.A.6
Mayo, M.W.7
-
48
-
-
65349096174
-
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
-
Yuan J, Minter-Dykhouse K, Lou Z (2009) A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J. Cell Biol. 185, 203-211.
-
(2009)
J. Cell Biol.
, vol.185
, pp. 203-211
-
-
Yuan, J.1
Minter-Dykhouse, K.2
Lou, Z.3
-
50
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W (2008) Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451, 587-591.
-
(2008)
Nature
, vol.451
, pp. 587-591
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
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