Plasma levels of vitamin E and carotenoids are decreased in patients with nonalcoholic steatohepatitis (NASH)

European Journal of Medical Research

Volumn 16, Issue 2, 2011, Pages 76-78

  Erhardt, Andreas ^a   Stahl, W ^a   Sies, H ^a   Lirussi, F ^b   Donner, A ^c   Haussinger D ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF PADOVA   (Italy)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Antioxidants; NASH; Vitamin A; Vitamin E

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA CAROTENE; ALPHA TOCOPHEROL; ASPARTATE AMINOTRANSFERASE; BETA CAROTENE; BETA CRYPTOXANTHIN; CAROTENOID; GAMMA TOCOPHEROL; LYCOPENE; XANTHOPHYLL; ZEAXANTHIN; FERRITIN; MULTIVITAMIN; REACTIVE OXYGEN METABOLITE; RETINOL; TRANSFERRIN;

ADULT; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; PATHOGENESIS; VITAMIN BLOOD LEVEL; BLOOD SAMPLING; BODY MASS; FATTY ACID OXIDATION; HUMAN TISSUE; INSULIN RESISTANCE; LIVER BIOPSY; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PEROXISOME; VITAMIN SUPPLEMENTATION;

EID: 79952784603     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: 10.1186/2047-783x-16-2-76     Document Type: Article

References (12)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002 Apr 18;346(16):1221-31.
2. Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 2003 Nov;98(11):2485-90. (Pubitemid 37448761)
3. Dufour JF, Oneta CM, Gonvers JJ, Bihl F, Cerny A, Cereda JM, et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2006 Dec; 4(12):1537-43. (Pubitemid 44880031)
4. von Herbay A, de Groot H, Hegi U, Stremmel W, Strohmeyer G, Sies H. Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease. J Hepatol. 1994 Jan;20(1):41-6. (Pubitemid 24043084)
5. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol. 1999 Sep;94(9):2467-74. (Pubitemid 29420675)
6. Aust O, Sies H, Stahl W, Polidori MC. Analysis of lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids. J Chromatography. 2001 Nov 30; 936(1-2):83-93. (Pubitemid 33044623)
7. Lavine JE. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr. 2000 Jun; 136(6):734-8. (Pubitemid 30415645)
8. Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology. 2003 Aug;38(2):413-9. (Pubitemid 36919862)
9. Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Alimentary Pharmacology & Therapeutics. 2001 Oct;15(10):1667-72. (Pubitemid 32912411)
10. Sies H, Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. The American Journal of Clinical Nutrition. 1995 Dec;62(6 Suppl):1315S-21S.
11. Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010 May 6;362(18):1675-85.
12. Rao AV, Rao LG. Carotenoids and human health. Pharmacol Res. 2007 Mar;55(3):207-16. (Pubitemid 46518154)