Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation

Free Radical Biology and Medicine

Volumn 40, Issue 12, 2006, Pages 2175-2182

  Kume, Shinji ^a   Haneda, Masakazu ^b   Kanasaki, Keizo ^a   Sugimoto, Toshiro ^a   Araki, Shin ichi ^a   Isono, Motohide ^a   Isshiki, Keiji ^a   Uzu, Takashi ^a   Kashiwagi, Atsunori ^a   Koya, Daisuke ^a,c  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Free radical; Mesangial cell; Oxidative stress; p53; Renal diseases; Silent information regulator 2; SIRT1

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; SILENT INFORMATION REGULATOR PROTEIN 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; DEACETYLATION; ENZYME RELEASE; EVALUATION; GLOMERULONEPHRITIS; INHIBITION KINETICS; KIDNEY DISEASE; MAMMAL; MESANGIUM CELL; MORPHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; UPREGULATION;

ACETYLATION; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELL SURVIVAL; HUMANS; HYDROGEN PEROXIDE; MESANGIAL CELLS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDATIVE STRESS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; RNA INTERFERENCE; SIRTUINS; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

MAMMALIA; MURINAE;

EID: 33745166337     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2006.02.014     Document Type: Article

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