Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 844-849

  Inokuchi, Sayaka ^a   Aoyama, Tomonori ^a   Miura, Kouichi ^a   Österreicher, Christoph H ^a   Kodama, Yuzo ^a   Miyai, Katsumi ^b   Akira, Shizuo ^c   Brenner, David A ^a   Seki, Ekihiro ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; JNK; Liver cancer; NF kB; TNF

Indexed keywords

ALPHA FETOPROTEIN; CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; HEPATITIS; INFLAMMATORY INFILTRATE; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL DAMAGE; LIVER FIBROSIS; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; CELL DIVISION; FEMALE; GENE DELETION; HEPATOCYTES; INFLAMMATION; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; LIVER REGENERATION; MALE; MICE; SEX CHARACTERISTICS;

MUS;

EID: 76249087046     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909781107     Document Type: Article

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