메뉴 건너뛰기




Volumn 33, Issue , 2013, Pages 231-248

Omega-3 fatty acids, hepatic lipid metabolism, and nonalcoholic fatty liver disease

Author keywords

Hepatic lipid metabolism; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Omega 3 fatty acids; Treatment

Indexed keywords

APOLIPOPROTEIN; ARACHIDONIC ACID; CORN OIL; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; INTERLEUKIN 1BETA; LINOLENIC ACID; LIVER X RECEPTOR ALPHA; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA; SAFFLOWER OIL; SPHINGOMYELIN PHOSPHODIESTERASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SUNFLOWER OIL; TUMOR NECROSIS FACTOR ALPHA; VERY LOW DENSITY LIPOPROTEIN;

EID: 84880683621     PISSN: 01999885     EISSN: 15454312     Source Type: Book Series    
DOI: 10.1146/annurev-nutr-071812-161230     Document Type: Article
Times cited : (253)

References (90)
  • 1
    • 84987566733 scopus 로고
    • The nomenclature of lipids
    • -1977. The nomenclature of lipids. Eur. J. Biochem. 79:11-21
    • (1977) Eur. J. Biochem. , vol.79 , pp. 11-21
  • 3
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
    • Argo CK, Northup PG, Al-Osaimi AM, Caldwell SH. 2009. Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J. Hepatol. 51:371-79
    • (2009) J. Hepatol. , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3    Caldwell, S.H.4
  • 4
    • 84861417701 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A new and important cardiovascular risk factor?
    • Bhatia LS, CurzenNP, Calder PC, Byrne CD. 2012. Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur. Heart J. 33:1190-200
    • (2012) Eur. Heart J. , vol.33 , pp. 1190-1200
    • Bhatia, L.S.1    Curzennp Calder, P.C.2    Byrne, C.D.3
  • 5
    • 79955455705 scopus 로고    scopus 로고
    • Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    • Blasbalg TL, Hibbeln J.R., Ramsden CE, Majchrzak SF, Rawlings RR. 2011. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am. J. Clin. Nutr. 93:950-62
    • (2011) Am. J. Clin. Nutr. , vol.93 , pp. 950-962
    • Blasbalg, T.L.1    Hibbeln, J.R.2    Ramsden, C.E.3    Majchrzak, S.F.4    Rawlings, R.R.5
  • 6
    • 77956234760 scopus 로고    scopus 로고
    • Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet
    • Boini KM, Zhang C, Xia M, Poklis JL, Li PL. 2010. Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet. J. Pharmacol. Exp. Ther. 334:839-46
    • (2010) J. Pharmacol. Exp. Ther. , vol.334 , pp. 839-846
    • Boini, K.M.1    Zhang, C.2    Xia, M.3    Poklis, J.L.4    Li, P.L.5
  • 7
    • 30844437681 scopus 로고    scopus 로고
    • Docosahexaenoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk-and 26S proteasome-dependent pathways
    • Botolin D, WangY, Christian B, Jump DB. 2006. Docosahexaenoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk-and 26S proteasome-dependent pathways. J. Lipid Res. 47:181-92
    • (2006) J. Lipid Res. , vol.47 , pp. 181-192
    • Botolin, D.1    Wang, Y.2    Christian, B.3    Jump, D.B.4
  • 8
    • 30944455145 scopus 로고    scopus 로고
    • Insulin resistance: A metabolic pathway to chronic liver disease
    • Bugianesi E, McCullough AJ, Marchesini G. 2005. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42:987-1000
    • (2005) Hepatology , vol.42 , pp. 987-1000
    • Bugianesi, E.1    McCullough, A.J.2    Marchesini, G.3
  • 10
    • 84861211655 scopus 로고    scopus 로고
    • Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity
    • Cai L, Wang Z, Ji A, Meyer JM, van der Westhuyzen DR. 2012. Scavenger receptor CD36 expression contributes to adipose tissue inflammation and cell death in diet-induced obesity. PLoS ONE 7: e36785
    • (2012) PLoS ONE , vol.7
    • Cai, L.1    Wang, Z.2    Ji, A.3    Meyer, J.M.4    Van Der Westhuyzen, D.R.5
  • 11
    • 79952022410 scopus 로고    scopus 로고
    • Omega-3 fatty acids and inflammatory processes
    • Calder PC. 2010. Omega-3 fatty acids and inflammatory processes. Nutrients 2:355-74
    • (2010) Nutrients , vol.2 , pp. 355-374
    • Calder, P.C.1
  • 12
    • 78649759130 scopus 로고    scopus 로고
    • Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010
    • Calder PC, Dangour AD, Diekman C, Eilander A, Koletzko B, et al. 2010. Essential fats for future health. Proceedings of the 9th Unilever Nutrition Symposium, 26-27 May 2010. Eur. J. Clin. Nutr. 64(Suppl. 4):S1-13
    • (2010) Eur. J. Clin. Nutr. , vol.64 , Issue.SUPPL. 4
    • Calder, P.C.1    Dangour, A.D.2    Diekman, C.3    Eilander, A.4    Koletzko, B.5
  • 13
    • 73949087595 scopus 로고    scopus 로고
    • Understanding omega-3 polyunsaturated fatty acids
    • Calder PC, Yaqoob P. 2009. Understanding omega-3 polyunsaturated fatty acids. Postgrad. Med. 121:148-57
    • (2009) Postgrad. Med. , vol.121 , pp. 148-157
    • Calder, P.C.1    Yaqoob, P.2
  • 14
    • 33646882162 scopus 로고    scopus 로고
    • Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: A pilot study
    • Capanni M, Calella F, Biagini MR, Genise S, Raimondi L, et al. 2006. Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment. Pharmacol. Ther. 23:1143-51
    • (2006) Aliment. Pharmacol. Ther. , vol.23 , pp. 1143-1151
    • Capanni, M.1    Calella, F.2    Biagini, M.R.3    Genise, S.4    Raimondi, L.5
  • 15
    • 80051815847 scopus 로고    scopus 로고
    • Different fatty acids inhibit apoB100 secretion by different pathways: Unique roles for ER stress, ceramide, and autophagy
    • Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, et al. 2011. Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy. J. Lipid Res. 52:1636-51
    • (2011) J. Lipid Res. , vol.52 , pp. 1636-1651
    • Caviglia, J.M.1    Gayet, C.2    Ota, T.3    Hernandez-Ono, A.4    Conlon, D.M.5
  • 16
    • 0037307248 scopus 로고    scopus 로고
    • Randomized controlled trial of the effect of n-3 fatty acid supplementation on themetabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity
    • Chan DC, Watts GF, Mori TA, Barrett PH, Redgrave TG, Beilin LJ. 2003. Randomized controlled trial of the effect of n-3 fatty acid supplementation on themetabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity. Am. J. Clin. Nutr. 77:300-7
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 300-307
    • Chan, D.C.1    Watts, G.F.2    Mori, T.A.3    Barrett, P.H.4    Redgrave, T.G.5    Beilin, L.J.6
  • 18
    • 3843061127 scopus 로고    scopus 로고
    • Central role for liver X receptor in insulinmediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    • Chen G, Liang G, Ou J, Goldstein JL, Brown MS. 2004. Central role for liver X receptor in insulinmediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl. Acad. Sci. USA 101:11245-50
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 11245-11250
    • Chen, G.1    Liang, G.2    Ou, J.3    Goldstein, J.L.4    Brown, M.S.5
  • 19
    • 70349430938 scopus 로고    scopus 로고
    • Bile acids: Regulation of synthesis
    • Chiang JY. 2009. Bile acids: regulation of synthesis. J. Lipid Res. 50:1955-66
    • (2009) J. Lipid Res. , vol.50 , pp. 1955-1966
    • Chiang, J.Y.1
  • 20
    • 84867940403 scopus 로고    scopus 로고
    • New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: Modulation by endogenous omega-3 fatty acid-derived lipid mediators
    • Claria J, Gonzalez-Periz A, Lopez-Vicario C, Rius B, Titos E. 2011. New insights into the role of macrophages in adipose tissue inflammation and fatty liver disease: modulation by endogenous omega-3 fatty acid-derived lipid mediators. Front. Immunol. 2:49
    • (2011) Front. Immunol. , vol.2 , pp. 49
    • Claria, J.1    Gonzalez-Periz, A.2    Lopez-Vicario, C.3    Rius, B.4    Titos, E.5
  • 21
    • 79959786449 scopus 로고    scopus 로고
    • Disorders of bile acid synthesis
    • Clayton PT. 2011. Disorders of bile acid synthesis. J. Inherit. Metab. Dis. 34:593-604
    • (2011) J. Inherit. Metab. Dis. , vol.34 , pp. 593-604
    • Clayton, P.T.1
  • 22
    • 14544275997 scopus 로고    scopus 로고
    • Origins and evolution of the Western diet: Health implications for the 21st century
    • Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, et al. 2005. Origins and evolution of the Western diet: health implications for the 21st century. Am. J. Clin. Nutr. 81:341-54
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 341-354
    • Cordain, L.1    Eaton, S.B.2    Sebastian, A.3    Mann, N.4    Lindeberg, S.5
  • 23
    • 17144431854 scopus 로고    scopus 로고
    • Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line
    • D?Alessio A, Al-Lamki RS, Bradley J.R., Pober JS. 2005. Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line. Am. J. Pathol. 166:1273-82
    • (2005) Am. J. Pathol. , vol.166 , pp. 1273-1282
    • Dalessio, A.1    Al-Lamki, R.S.2    Bradley, J.R.3    Pober, J.S.4
  • 24
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. 2005. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115:1343-51
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 25
    • 70349300663 scopus 로고    scopus 로고
    • Fats and fatty acid requirements for adults
    • Elmadfa I, Kornsteiner M. 2009. Fats and fatty acid requirements for adults. Ann. Nutr. Metab. 55:56-75
    • (2009) Ann. Nutr. Metab. , vol.55 , pp. 56-75
    • Elmadfa, I.1    Kornsteiner, M.2
  • 26
    • 77956040410 scopus 로고    scopus 로고
    • Saturatedand n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: Reversal and improvement of glucose tolerance by lipid metabolism inhibitors
    • Frangioudakis G, Garrard J, Raddatz K, Nadler JL, Mitchell TW, Schmitz-Peiffer C. 2010. Saturatedand n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. Endocrinology 151:4187-96
    • (2010) Endocrinology , vol.151 , pp. 4187-4196
    • Frangioudakis, G.1    Garrard, J.2    Raddatz, K.3    Nadler, J.L.4    Mitchell, T.W.5    Schmitz-Peiffer, C.6
  • 27
    • 0019305684 scopus 로고
    • Sphingomyelin suppresses the binding and utilization of low density lipoproteins by skin fibroblasts
    • Gatt S, Bierman EL. 1980. Sphingomyelin suppresses the binding and utilization of low density lipoproteins by skin fibroblasts. J. Biol. Chem. 255:3371-76
    • (1980) J. Biol. Chem. , vol.255 , pp. 3371-3376
    • Gatt, S.1    Bierman, E.L.2
  • 28
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • Haus JM, Kashyap SR, Kasumov T, Zhang R, Kelly KR, et al. 2009. Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 58: 337-43
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5
  • 29
    • 0023912168 scopus 로고
    • George O. Burr and the discovery of essential fatty acids
    • Holman RT. 1988. George O. Burr and the discovery of essential fatty acids. J. Nutr. 118:535-40
    • (1988) J. Nutr. , vol.118 , pp. 535-540
    • Holman, R.T.1
  • 30
    • 0031888889 scopus 로고    scopus 로고
    • The slow discovery of the importance of ω3 essential fatty acids in human health
    • Holman RT. 1998. The slow discovery of the importance of ω3 essential fatty acids in human health. J. Nutr. 128:427-33S
    • (1998) J. Nutr. , vol.128
    • Holman, R.T.1
  • 31
    • 79960299110 scopus 로고    scopus 로고
    • Probiotics as an emerging therapeutic strategy to treat NAFLD: Focus on molecular and biochemical mechanisms
    • Iacono A, Raso GM, Canani RB, Calignano A, Meli R. 2011. Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms. J. Nutr. Biochem. 22: 699-711
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 699-711
    • Iacono, A.1    Raso, G.M.2    Canani, R.B.3    Calignano, A.4    Meli, R.5
  • 32
    • 84872271480 scopus 로고    scopus 로고
    • Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease
    • Ikegami T, Hyogo H, Honda A, Miyazaki T, Tokushige K, et al. 2012. Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease. J. Gastroenterol. 47:1257-66
    • (2012) J. Gastroenterol. , vol.47 , pp. 1257-1266
    • Ikegami, T.1    Hyogo, H.2    Honda, A.3    Miyazaki, T.4    Tokushige, K.5
  • 33
    • 8144229872 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription
    • Ishii S, Iizuka K, Miller BC, Uyeda K. 2004. Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc. Natl. Acad. Sci. USA 101:15597-602
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 15597-15602
    • Ishii, S.1    Iizuka, K.2    Miller, B.C.3    Uyeda, K.4
  • 35
    • 0038561165 scopus 로고    scopus 로고
    • Xylulose 5-phosphate mediates glucoseinduced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
    • Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. 2003. Xylulose 5-phosphate mediates glucoseinduced lipogenesis by xylulose 5-phosphate- activated protein phosphatase in rat liver. Proc. Natl. Acad. Sci. USA 100:5107-12
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 5107-5112
    • Kabashima, T.1    Kawaguchi, T.2    Wadzinski, B.E.3    Uyeda, K.4
  • 36
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany NY, Mangelsdorf DJ. 2006. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68:159-91
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 37
    • 84863404227 scopus 로고    scopus 로고
    • Dietary fish oil regulates gene expression of cholesterol and bile acid transporters in mice
    • Kamisako T, Tanaka Y, Ikeda T, Yamamoto K, Ogawa H. 2012. Dietary fish oil regulates gene expression of cholesterol and bile acid transporters in mice. Hepatol. Res. 42:321-26
    • (2012) Hepatol. Res. , vol.42 , pp. 321-326
    • Kamisako, T.1    Tanaka, Y.2    Ikeda, T.3    Yamamoto, K.4    Ogawa, H.5
  • 38
    • 78650700860 scopus 로고    scopus 로고
    • Docosapentaenoic acid (22:5n-3): A review of its biological effects
    • Kaur G, Cameron-Smith D, Garg M, Sinclair AJ. 2011. Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog. Lipid Res. 50:28-34
    • (2011) Prog. Lipid Res. , vol.50 , pp. 28-34
    • Kaur, G.1    Cameron-Smith, D.2    Garg, M.3    Sinclair, A.J.4
  • 39
    • 84867892916 scopus 로고    scopus 로고
    • Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease
    • Kim EH, Bae JS, Hahm KB, Cha JY. 2012. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1mice ameliorate high-fat diet-induced non-alcoholic fatty liver disease. Biochem. Pharmacol. 84:1359-65
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 1359-1365
    • Kim, E.H.1    Bae, J.S.2    Hahm, K.B.3    Cha, J.Y.4
  • 40
    • 0037324442 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: New recommendations from the American Heart Association
    • Kris-Etherton PM, Harris WS, Appel LJ. 2003. Omega-3 fatty acids and cardiovascular disease: new recommendations from the American Heart Association. Arterioscler. Thromb. Vasc. Biol. 23:151-52
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 151-152
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 42
    • 84864390922 scopus 로고    scopus 로고
    • The epidemiology, pathogenesis and histopathology of fatty liver disease
    • Levene AP, Goldin RD. 2012. The epidemiology, pathogenesis and histopathology of fatty liver disease. Histopathology 61:141-52
    • (2012) Histopathology , vol.61 , pp. 141-152
    • Levene, A.P.1    Goldin, R.D.2
  • 43
    • 77952105540 scopus 로고    scopus 로고
    • Resolvins and protectins: Natural pharmacophores for resolution biology
    • Levy BD. 2010. Resolvins and protectins: natural pharmacophores for resolution biology. Prostaglandins Leukot. Essent. Fatty Acids 82:327-32
    • (2010) Prostaglandins Leukot. Essent. Fatty Acids , vol.82 , pp. 327-332
    • Levy, B.D.1
  • 44
    • 79952218554 scopus 로고    scopus 로고
    • Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis
    • Li T, Matozel M, Boehme S, Kong B, Nilsson LM, et al. 2011. Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology 53:996-1006
    • (2011) Hepatology , vol.53 , pp. 996-1006
    • Li, T.1    Matozel, M.2    Boehme, S.3    Kong, B.4    Nilsson, L.M.5
  • 45
    • 0028784298 scopus 로고
    • Compartmentalized production of ceramide at the cell surface
    • Liu P, Anderson RG. 1995. Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270:27179-85
    • (1995) J. Biol. Chem. , vol.270 , pp. 27179-27185
    • Liu, P.1    Anderson, R.G.2
  • 46
    • 70349408730 scopus 로고    scopus 로고
    • Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes
    • Lorente-Cebrian S, Bustos M, Marti A, Martinez JA, Moreno-Aliaga MJ. 2009. Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes. Clin. Sci. (Lond.) 117:243-49
    • (2009) Clin. Sci. (Lond. , vol.117 , pp. 243-249
    • Lorente-Cebrian, S.1    Bustos, M.2    Marti, A.3    Martinez, J.A.4    Moreno-Aliaga, M.J.5
  • 47
    • 6944240423 scopus 로고    scopus 로고
    • N-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon
    • MaDW, Seo J, Davidson LA, Callaway ES, Fan YY, et al. 2004. n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon. FASEB J. 18:1040-42
    • (2004) FASEB J. , vol.18 , pp. 1040-1042
    • Ma, D.W.1    Seo, J.2    Davidson, L.A.3    Callaway, E.S.4    Fan, Y.Y.5
  • 48
    • 80052319523 scopus 로고    scopus 로고
    • Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPARα/-activity in microvascular endothelial cells
    • Madonna R, Salerni S, Schiavone D, Glatz JF, Geng YJ, De Caterina R. 2011. Omega-3 fatty acids attenuate constitutive and insulin-induced CD36 expression through a suppression of PPARα/-activity in microvascular endothelial cells. Thromb. Haemost. 106:500-10
    • (2011) Thromb. Haemost. , vol.106 , pp. 500-510
    • Madonna, R.1    Salerni, S.2    Schiavone, D.3    Glatz, J.F.4    Geng, Y.J.5    De Caterina, R.6
  • 49
    • 78851471191 scopus 로고    scopus 로고
    • Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by 1H-magnetic resonance spectroscopy in a rat model
    • Marsman HA, HegerM, Kloek JJ, Nienhuis SL, van Werven J.R., et al. 2011. Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by 1H-magnetic resonance spectroscopy in a rat model. J. Gastroenterol. Hepatol. 26:356-63
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 356-363
    • Marsman, H.A.1    Heger, M.2    Kloek, J.J.3    Nienhuis, S.L.4    Van Werven, J.R.5
  • 50
    • 0029031099 scopus 로고
    • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion
    • Merrill AH Jr, Lingrell S, Wang E, Nikolova-Karakashian M, Vales TR, Vance DE. 1995. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. J. Biol. Chem. 270:13834-41
    • (1995) J. Biol. Chem. , vol.270 , pp. 13834-13841
    • Merrill Jr., A.H.1    Lingrell, S.2    Wang, E.3    Nikolova-Karakashian, M.4    Vales, T.R.5    Vance, D.E.6
  • 51
    • 80053350340 scopus 로고    scopus 로고
    • Are we consuming enough long chain omega-3 polyunsaturated fatty acids for optimal health?
    • Meyer BJ. 2011. Are we consuming enough long chain omega-3 polyunsaturated fatty acids for optimal health? Prostaglandins Leukot. Essent. Fatty Acids 85:275-80
    • (2011) Prostaglandins Leukot. Essent. Fatty Acids , vol.85 , pp. 275-280
    • Meyer, B.J.1
  • 53
    • 84864516631 scopus 로고    scopus 로고
    • Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults
    • Mirmiran P, Hosseinpour-Niazi S, Naderi Z, Bahadoran Z, SadeghiM, Azizi F. 2012. Association between interaction and ratio of ω-3 and ω-6 polyunsaturated fatty acid and the metabolic syndrome in adults. Nutrition 28:856-63
    • (2012) Nutrition , vol.28 , pp. 856-863
    • Mirmiran, P.1    Hosseinpour-Niazi, S.2    Naderi, Z.3    Bahadoran, Z.4    Sadeghi, M.5    Azizi, F.6
  • 55
    • 77956519382 scopus 로고    scopus 로고
    • Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis
    • Moles A, Tarrats N, Morales A, DominguezM, Bataller R, et al. 2010. Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am. J. Pathol. 177:1214-24
    • (2010) Am. J. Pathol. , vol.177 , pp. 1214-1224
    • Moles, A.1    Tarrats, N.2    Morales, A.3    Dominguez, M.4    Bataller, R.5
  • 56
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD
    • Musso G, Gambino R, CassaderM. 2009. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog. Lipid Res. 48:1-26
    • (2009) Prog. Lipid Res. , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 57
    • 34047166373 scopus 로고    scopus 로고
    • N-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-α-dependent manner
    • Neschen S, Morino K, Dong J, Wang-Fischer Y, Cline GW, et al. 2007. n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-α-dependent manner. Diabetes 56:1034-41
    • (2007) Diabetes , vol.56 , pp. 1034-1041
    • Neschen, S.1    Morino, K.2    Dong, J.3    Wang-Fischer, Y.4    Cline, G.W.5
  • 59
    • 19944433566 scopus 로고    scopus 로고
    • Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin-resistant" T-455C APOC3 gene polymorphism in heart disease patients: Example of gene-diet interaction
    • Olivieri O, Martinelli N, Sandri M, Bassi A, Guarini P, et al. 2005. Apolipoprotein C-III, n-3 polyunsaturated fatty acids, and "insulin- resistant" T-455C APOC3 gene polymorphism in heart disease patients: example of gene-diet interaction. Clin. Chem. 51:360-67
    • (2005) Clin. Chem. , vol.51 , pp. 360-367
    • Olivieri, O.1    Martinelli, N.2    Sandri, M.3    Bassi, A.4    Guarini, P.5
  • 60
    • 77953272067 scopus 로고    scopus 로고
    • Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid
    • Opreanu M, Lydic TA, Reid GE, McSorley KM, Esselman WJ, Busik JV. 2010. Inhibition of cytokine signaling in human retinal endothelial cells through downregulation of sphingomyelinases by docosahexaenoic acid. Invest. Ophthalmol. Vis. Sci. 51:3253-63
    • (2010) Invest. Ophthalmol. Vis. Sci. , vol.51 , pp. 3253-3263
    • Opreanu, M.1    Lydic, T.A.2    Reid, G.E.3    McSorley, K.M.4    Esselman, W.J.5    Busik, J.V.6
  • 61
    • 58149253146 scopus 로고    scopus 로고
    • Hepatic steatosis in n-3 fatty acid depleted mice: Focus on metabolic alterations related to tissue fatty acid composition
    • Pachikian BD, Neyrinck AM, Cani PD, Portois L, Deldicque L, et al. 2008. Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition. BMC Physiol. 8:21
    • (2008) BMC Physiol. , vol.8 , pp. 21
    • Pachikian, B.D.1    Neyrinck, A.M.2    Cani, P.D.3    Portois, L.4    Deldicque, L.5
  • 63
    • 44449090993 scopus 로고    scopus 로고
    • Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control
    • Pan M, Maitin V, Parathath S, Andreo U, Lin SX, et al. 2008. Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc. Natl. Acad. Sci. USA 105:5862-67
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 5862-5867
    • Pan, M.1    Maitin, V.2    Parathath, S.3    Andreo, U.4    Lin, S.X.5
  • 65
    • 84875261030 scopus 로고    scopus 로고
    • Oxysterol generation and liverXreceptor-dependent reverse cholesterol transport: Not all roads lead to Rome
    • Pannu PS, Allahverdian S, Francis GA. 2013. Oxysterol generation and liverXreceptor-dependent reverse cholesterol transport: Not all roads lead to Rome. Mol. Cell. Endocrinol. 368:99-107
    • (2013) Mol. Cell. Endocrinol. , vol.368 , pp. 99-107
    • Pannu, P.S.1    Allahverdian, S.2    Francis, G.A.3
  • 66
    • 0032570977 scopus 로고    scopus 로고
    • Medium chain fatty acid metabolism and energy expenditure: Obesity treatment implications
    • Papamandjaris AA, MacDougall DE, Jones PJ. 1998. Medium chain fatty acid metabolism and energy expenditure: obesity treatment implications. Life Sci. 62:1203-15
    • (1998) Life Sci. , vol.62 , pp. 1203-1215
    • Papamandjaris, A.A.1    MacDougall, D.E.2    Jones, P.J.3
  • 67
    • 84858703583 scopus 로고    scopus 로고
    • Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
    • Parker HM, Johnson NA, Burdon CA, Cohn JS, O?Connor HT, George J. 2012. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J. Hepatol. 56: 944-51
    • (2012) J. Hepatol. , vol.56 , pp. 944-951
    • Parker, H.M.1    Johnson, N.A.2    Burdon, C.A.3    Cohn, J.S.4    Oconnor, H.T.5    George, J.6
  • 70
    • 79952274147 scopus 로고    scopus 로고
    • Fish consumption and socio-economic factors among residents of Arkhangelsk city and the rural Nenets autonomous area
    • Petrenya N, Dobrodeeva L, Brustad M, Bichkaeva F, Menshikova E, et al. 2011. Fish consumption and socio-economic factors among residents of Arkhangelsk city and the rural Nenets autonomous area. Int. J. Circumpolar Health 70:46-58
    • (2011) Int. J. Circumpolar Health , vol.70 , pp. 46-58
    • Petrenya, N.1    Dobrodeeva, L.2    Brustad, M.3    Bichkaeva, F.4    Menshikova, E.5
  • 71
    • 67649422686 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-redefining platelet response to fish oils
    • Phang M, Garg ML, Sinclair AJ. 2009. Inhibition of platelet aggregation by omega-3 polyunsaturated fatty acids is gender specific-redefining platelet response to fish oils. Prostaglandins Leukot. Essent. Fatty Acids 81:35-40
    • (2009) Prostaglandins Leukot. Essent. Fatty Acids , vol.81 , pp. 35-40
    • Phang, M.1    Garg, M.L.2    Sinclair, A.J.3
  • 72
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • Postic C, Girard J. 2008. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J. Clin. Invest. 118:829-38
    • (2008) J. Clin. Invest. , vol.118 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 73
    • 78651249542 scopus 로고    scopus 로고
    • The role of adipose tissue in mediating the beneficial effects of dietary fish oil
    • Puglisi MJ, Hasty AH, Saraswathi V. 2011. The role of adipose tissue in mediating the beneficial effects of dietary fish oil. J. Nutr. Biochem. 22:101-8
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 101-108
    • Puglisi, M.J.1    Hasty, A.H.2    Saraswathi, V.3
  • 74
    • 39749122734 scopus 로고    scopus 로고
    • The opposing effects of n-3 and n-6 fatty acids
    • Schmitz G, Ecker J. 2008. The opposing effects of n-3 and n-6 fatty acids. Prog. Lipid Res. 47:147-55
    • (2008) Prog. Lipid Res. , vol.47 , pp. 147-155
    • Schmitz, G.1    Ecker, J.2
  • 75
    • 79451476075 scopus 로고    scopus 로고
    • The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease
    • Shapiro H, Tehilla M, Attal-Singer J, Bruck R, Luzzatti R, Singer P. 2011. The therapeutic potential of long-chain omega-3 fatty acids in nonalcoholic fatty liver disease. Clin. Nutr. 30:6-19
    • (2011) Clin. Nutr. , vol.30 , pp. 6-19
    • Shapiro, H.1    Tehilla, M.2    Attal-Singer, J.3    Bruck, R.4    Luzzatti, R.5    Singer, P.6
  • 77
    • 46449123205 scopus 로고    scopus 로고
    • The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases
    • Simopoulos AP. 2008. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood ) 233:674-88
    • (2008) Exp. Biol. Med. (Maywood , vol.233 , pp. 674-688
    • Simopoulos, A.P.1
  • 78
    • 77956460533 scopus 로고    scopus 로고
    • Triglycerides and gallstone formation
    • Smelt AH. 2010. Triglycerides and gallstone formation. Clin. Chim. Acta 411:1625-31
    • (2010) Clin. Chim. Acta , vol.411 , pp. 1625-1631
    • Smelt, A.H.1
  • 79
    • 70349269872 scopus 로고    scopus 로고
    • Review of fat and fatty acid requirements and criteria for developing dietary guidelines
    • Smit LA, Mozaffarian D, Willett W. 2009. Review of fat and fatty acid requirements and criteria for developing dietary guidelines. Ann. Nutr. Metab. 55:44-55
    • (2009) Ann. Nutr. Metab. , vol.55 , pp. 44-55
    • Smit, L.A.1    Mozaffarian, D.2    Willett, W.3
  • 80
    • 38749115791 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease
    • Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, et al. 2008. Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Dig. Liver Dis. 40:194-99
    • (2008) Dig. Liver Dis. , vol.40 , pp. 194-199
    • Spadaro, L.1    Magliocco, O.2    Spampinato, D.3    Piro, S.4    Oliveri, C.5
  • 81
    • 84862075971 scopus 로고    scopus 로고
    • Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes
    • Sung KC, Jeong WS, Wild SH, Byrne CD. 2012. Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes. Diabetes Care 35:717-22
    • (2012) Diabetes Care , vol.35 , pp. 717-722
    • Sung, K.C.1    Jeong, W.S.2    Wild, S.H.3    Byrne, C.D.4
  • 82
    • 77951218102 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit
    • Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, et al. 2010. Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit. J. Biol. Chem. 285:11681-91
    • (2010) J. Biol. Chem. , vol.285 , pp. 11681-11691
    • Takeuchi, Y.1    Yahagi, N.2    Izumida, Y.3    Nishi, M.4    Kubota, M.5
  • 84
    • 0037098291 scopus 로고    scopus 로고
    • Carbohydrate responsive element-binding protein (ChREBP): A key regulator of glucose metabolism and fat storage
    • Uyeda K, Yamashita H, Kawaguchi T. 2002. Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage. Biochem. Pharmacol. 63:2075-80
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 2075-2080
    • Uyeda, K.1    Yamashita, H.2    Kawaguchi, T.3
  • 85
    • 33750139770 scopus 로고    scopus 로고
    • Innovative dietary sources of n-3 fatty acids
    • Whelan J, Rust C. 2006. Innovative dietary sources of n-3 fatty acids. Annu. Rev. Nutr. 26:75-103
    • (2006) Annu. Rev. Nutr. , vol.26 , pp. 75-103
    • Whelan, J.1    Rust, C.2
  • 86
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. 2003. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J. Clin. Invest. 112:1821-30
    • (2003) J. Clin. Invest. , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5
  • 87
    • 33745856925 scopus 로고    scopus 로고
    • Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-α agonist
    • Xu J, Christian B, Jump DB. 2006. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-α agonist. J. Biol. Chem. 281:18351-62
    • (2006) J. Biol. Chem. , vol.281 , pp. 18351-18362
    • Xu, J.1    Christian, B.2    Jump, D.B.3
  • 88
    • 3943108870 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets
    • Zhao A, Yu J, Lew JL, Huang L, Wright SD, Cui J. 2004. Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. DNA Cell Biol. 23:519-26
    • (2004) DNA Cell Biol. , vol.23 , pp. 519-526
    • Zhao, A.1    Yu, J.2    Lew, J.L.3    Huang, L.4    Wright, S.D.5    Cui, J.6
  • 89
    • 63449137594 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
    • Zhu FS, Liu S, Chen XM, Huang ZG, Zhang DW. 2008. Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J. Gastroenterol. 14:6395-400
    • (2008) World J. Gastroenterol. , vol.14 , pp. 6395-6400
    • Zhu, F.S.1    Liu, S.2    Chen, X.M.3    Huang, Z.G.4    Zhang, D.W.5
  • 90
    • 82955188750 scopus 로고    scopus 로고
    • N-3 PUFA supplementation triggers PPAR-αactivation and PPAR-α/NF-κB interaction: Anti-inflammatory implications in liver ischemiareperfusion injury
    • Zuniga J, Cancino M, Medina F, Varela P, Vargas R, et al. 2011. n-3 PUFA supplementation triggers PPAR-αactivation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemiareperfusion injury. PLoS ONE 6:e28502
    • (2011) PLoS ONE , vol.6
    • Zuniga, J.1    Cancino, M.2    Medina, F.3    Varela, P.4    Vargas, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.