Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Biochemical and Biophysical Research Communications

Volumn 425, Issue 2, 2012, Pages 121-126

  Jiang, Yugang ^a   Wang, Mian ^a   Huang, Kai ^a   Zhang, Zhihui ^a   Shao, Nan ^a   Zhang, Yuanqi ^a   Wang, Wenjian ^a   Wang, Shenming ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Interleukin 1 ; Macrophage; NLRP3 inflammasome; Oxidized low density lipoprotein

Indexed keywords

CATHEPSIN B; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; OXIDIZED LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; HUMAN; HUMAN CELL; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ATHEROSCLEROSIS; CARRIER PROTEINS; CASPASE 1; CATHEPSIN B; CELLS, CULTURED; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPROTEINS, LDL; MACROPHAGES; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES;

EID: 84865348839     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.011     Document Type: Article

References (25)

1. Liu S.X., Hou F.F., Guo Z.J., Nagai R., Zhang W.R., Liu Z.Q., Zhou Z.M., Zhou M., Xie D., Wang G.B., Zhang X. Advanced oxidation protein products accelerate atherosclerosis through promoting oxidative stress and inflammation. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1156-1162.
2. Ruan X.Z., Moorhead J.F., Tao J.L., Ma K.L., Wheeler D.C., Powis S.H., Varghese Z. Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines. Arterioscler. Thromb. Vasc. Biol. 2006, 26:1150-1155.
3. Yang P.Y., Rui Y.C., Yang P.Y., Yu Y.L. Proteomic analysis of foam cells. Methods Mol. Biol. 2007, 357:297-305.
4. Church L.D., Cook G.P., McDermott M.F. Primer: inflammasomes and interleukin 1beta in inflammatory disorders. Nat. Clin. Pract. Rheumatol. 2008, 4:34-42.
5. Dinarello C.A. Anti-inflammatory agents: present and future. Cell 2010, 140:935-950.
6. Rader D.J. IL-1 and atherosclerosis: a murine twist to an evolving human story. J. Clin. Invest. 2012, 122:27-30.
7. Galea J., Armstrong J., Gadsdon P., Holden H., Francis S.E., Holt C.M. Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. Arterioscler. Thromb. Vasc. Biol. 1996, 16:1000-1006.
8. Kirii H., Niwa T., Yamada Y., Wada H., Saito K., Iwakura Y., Asano M., Moriwaki H., Seishima M. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2003, 23:656-660.
9. Martinon F., Petrilli V., Mayor A., Tardivel A., Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006, 440:237-241.
10. Martinon F., Burns K., Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 2002, 10:417-426.
11. Tschopp J., Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?. Nat. Rev. Immunol. 2010, 10:210-215.
12. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
13. Kanneganti T.D., Lamkanfi M., Kim Y.G., Chen G., Park J.H., Franchi L., Vandenabeele P., Nunez G. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 2007, 26:433-443.
14. Hornung V., Bauernfeind F., Halle A., Samstad E.O., Kono H., Rock K.L., Fitzgerald K.A., Latz E. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008, 9:847-856.
15. Li W., Yuan X.M., Olsson A.G., Brunk U.T. Uptake of oxidized LDL by macrophages results in partial lysosomal enzyme inactivation and relocation. Arterioscler. Thromb. Vasc. Biol. 1998, 18:177-184.
16. Sharif O., Bolshakov V.N., Raines S., Newham P., Perkins N.D. Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol. 2007, 8:1.
17. Dostert C., Petrilli V., Van Bruggen R., Steele C., Mossman B.T., Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008, 320:674-677.
18. Cassel S.L., Eisenbarth S.C., Iyer S.S., Sadler J.J., Colegio O.R., Tephly L.A., Carter A.B., Rothman P.B., Flavell R.A., Sutterwala F.S. The Nalp3 inflammasome is essential for the development of silicosis. Proc. Natl. Acad. Sci. USA 2008, 105:9035-9040.
19. Yuan X.M., Li W., Olsson A.G., Brunk U.T. The toxicity to macrophages of oxidized low-density lipoprotein is mediated through lysosomal damage. Atherosclerosis 1997, 133:153-161.
20. Stewart C.R., Stuart L.M., Wilkinson K., van Gils J.M., Deng J., Halle A., Rayner K.J., Boyer L., Zhong R., Frazier W.A., Lacy-Hulbert A., El K.J., Golenbock D.T., Moore K.J. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 2010, 11:155-161.
21. Bauernfeind F.G., Horvath G., Stutz A., Alnemri E.S., MacDonald K., Speert D., Fernandes-Alnemri T., Wu J., Monks B.G., Fitzgerald K.A., Hornung V., Latz E. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 2009, 183:787-791.
22. Segovia J., Sabbah A., Mgbemena V., Tsai S.Y., Chang T.H., Berton M.T., Morris I.R., Allen I.C., Ting J.P., Bose S. TLR2/MyD88/NF-kappaB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One 2012, 7:e29695.
23. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 2001, 1:135-145.
24. Halle A., Hornung V., Petzold G.C., Stewart C.R., Monks B.G., Reinheckel T., Fitzgerald K.A., Latz E., Moore K.J., Golenbock D.T. The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 2008, 9:857-865.
25. Terada K., Yamada J., Hayashi Y., Wu Z., Uchiyama Y., Peters C., Nakanishi H. Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia. Glia 2010, 58:114-124.