Acyclic retinoid inhibits angiogenesis by suppressing the MAPK pathway

Laboratory Investigation

Volumn 90, Issue 1, 2010, Pages 52-60

  Komi, Yusuke ^a,b   Sogabe, Yukihisa ^a   Ishibashi, Naoto ^c   Sato, Yasufumi ^d   Moriwaki, Hisataka ^e   Shimokado, Kentaro ^b   Kojima, Soichi ^a  

^a Chemical Biology Department   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c Tokyo Research Laboratory   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e GIFU UNIVERSITY   (Japan)

Author keywords

ACR; HCC; MAPK pathway; Phosphorylation; Tumor angiogenesis; VEGF receptor

Indexed keywords

3,7,11,15 TETRAMETHYLHEXAECA 2,4,6,10,14 PENTANOIC ACID; ANGIOGENESIS INHIBITOR; ANGIOPOIETIN 1; MITOGEN ACTIVATED PROTEIN KINASE; RETINOIC ACID; RETINOID DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CELL MIGRATION; CHICKEN; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION; TUMOR XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; CARCINOMA, HEPATOCELLULAR; CATTLE; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; TRANSPLANTATION, HETEROLOGOUS; TRETINOIN; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 73349126408     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.110     Document Type: Article

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