-
1
-
-
0033961732
-
Therole of natural products in a modern drug discovery program
-
Strohl, W.R. (2000) Therole of natural products in a modern drug discovery program. DrugDiscovery Today, 5,39-41.
-
(2000)
DrugDiscovery Today
, vol.5
, pp. 39-41
-
-
Strohl, W.R.1
-
2
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman, D.J. and Cragg, G.M. (2007) Natural products as sources of new drugs over the last 25 years. Journal of Natural Products, 70,461-477.
-
(2007)
Journal of Natural Products
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
3
-
-
84892306677
-
Natural Products, Drug Discovery and Therapeutic Medicine
-
The Humana Press, Totowa, NJ.
-
Zhang, L. and Demain, A.L. (2005) Natural Products, Drug Discovery and Therapeutic Medicine, The Humana Press, Totowa, NJ.
-
(2005)
-
-
Zhang, L.1
Demain, A.L.2
-
5
-
-
33845631601
-
Microbial metabolomics: past, present and future methodologies
-
Mashego, M.R., Rumbold, K., De Mey, M. et al. (2006) Microbial metabolomics: past, present and future methodologies. Biotechnology Letters, 29,1-16.
-
(2006)
Biotechnology Letters
, vol.29
, pp. 1-16
-
-
Mashego, M.R.1
Rumbold, K.2
De Mey, M.3
-
6
-
-
0346328227
-
Metabolic engineering for drug discovery and development
-
Khosla, C. and Keasling, J.D. (2003) Metabolic engineering for drug discovery and development. Nature Reviews Drug Discovery, 2,1019-1025.
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, pp. 1019-1025
-
-
Khosla, C.1
Keasling, J.D.2
-
7
-
-
0032600888
-
Metabolic fluxes and metabolic engineering
-
Stephanopoulos, G. (1999) Metabolic fluxes and metabolic engineering. Metabolic Engineering, 1,1-11.
-
(1999)
Metabolic Engineering
, vol.1
, pp. 1-11
-
-
Stephanopoulos, G.1
-
8
-
-
32944481561
-
Metabolic engineering
-
Raab, R.M., Tyo, K. and Stephanopoulos, G. (2005) Metabolic engineering. Advances in Biochemical Engineering/Biotechnology, 100,1-17.
-
(2005)
Advances in Biochemical Engineering/Biotechnology
, vol.100
, pp. 1-17
-
-
Raab, R.M.1
Tyo, K.2
Stephanopoulos, G.3
-
9
-
-
20544457864
-
Metabolic engineering in the-omics era: elucidating and modulating regulatory networks
-
Vemuri, G.N. and Aristidou, A.A. (2005) Metabolic engineering in the-omics era: elucidating and modulating regulatory networks. Microbiology and Molecular Biology Reviews, 69,197-216.
-
(2005)
Microbiology and Molecular Biology Reviews
, vol.69
, pp. 197-216
-
-
Vemuri, G.N.1
Aristidou, A.A.2
-
10
-
-
41549090467
-
Metabolic flux analysis in biotechnology processes
-
Iwatani, S., Yamada, Y. and Usuda, Y. (2008) Metabolic flux analysis in biotechnology processes. Biotechnology Letters, 30,791-799.
-
(2008)
Biotechnology Letters
, vol.30
, pp. 791-799
-
-
Iwatani, S.1
Yamada, Y.2
Usuda, Y.3
-
11
-
-
38349151554
-
Metabolic flux analysis and metabolic engineering of microorganisms
-
Kim, H.U., Kim, T.Y. and Lee, S.Y. (2008) Metabolic flux analysis and metabolic engineering of microorganisms. Molecular Biosystems, 4,113-120.
-
(2008)
Molecular Biosystems
, vol.4
, pp. 113-120
-
-
Kim, H.U.1
Kim, T.Y.2
Lee, S.Y.3
-
12
-
-
33845638400
-
Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum
-
Kleijn, R.J., Liu, F., Winden, W.A.v. et al. (2007) Cytosolic NADPH metabolism in penicillin-G producing and non-producing chemostat cultures of Penicillium chrysogenum. Metabolic Engineering, 9,112-123.
-
(2007)
Metabolic Engineering
, vol.9
, pp. 112-123
-
-
Kleijn, R.J.1
Liu, F.2
Winden, W.A.V.3
-
13
-
-
3242726864
-
Impact of 'ome' analyses on inverse metabolic engineering
-
Bro, C. and Nielsen, J. (2004) Impact of 'ome' analyses on inverse metabolic engineering. Metabolic Engineering, 6,204-211.
-
(2004)
Metabolic Engineering
, vol.6
, pp. 204-211
-
-
Bro, C.1
Nielsen, J.2
-
14
-
-
0037026501
-
Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes
-
Bailey, J.E., Sburlati, A., Hatzimanikatis, V. et al. (2002) Inverse metabolic engineering: a strategy for directed genetic engineering of useful phenotypes. Biotechnology and Bioengineering, 79,568-579.
-
(2002)
Biotechnology and Bioengineering
, vol.79
, pp. 568-579
-
-
Bailey, J.E.1
Sburlati, A.2
Hatzimanikatis, V.3
-
15
-
-
37549016345
-
Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog
-
Jaluria, P., Betenbaugh, M., Konstantopoulos, K. and Shiloach, J. (2007) Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog. BMC Biotechnology, 7,71.
-
(2007)
BMC Biotechnology
, vol.7
, pp. 71
-
-
Jaluria, P.1
Betenbaugh, M.2
Konstantopoulos, K.3
Shiloach, J.4
-
16
-
-
34249327283
-
Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells
-
Jaluria, P., Betenbaugh, M., Konstantopoulos, K. et al. (2006) Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells. Metabolic Engineering, 9,241-251.
-
(2006)
Metabolic Engineering
, vol.9
, pp. 241-251
-
-
Jaluria, P.1
Betenbaugh, M.2
Konstantopoulos, K.3
-
17
-
-
0037316031
-
Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains
-
Askenazi, M., Driggers, E.M., Holtzman, D.A. et al. (2003) Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains. Nature Biotechnology, 21,150-156.
-
(2003)
Nature Biotechnology
, vol.21
, pp. 150-156
-
-
Askenazi, M.1
Driggers, E.M.2
Holtzman, D.A.3
-
18
-
-
0031127256
-
Proteome analysis: from protein characterization to biological function
-
Pennington, S.R., Wilkins, M.R., Hochstrasser, D.F. and Dunn, M.J. (1999) Proteome analysis: from protein characterization to biological function. Trends in Cell Biology, 7,168-173.
-
(1999)
Trends in Cell Biology
, vol.7
, pp. 168-173
-
-
Pennington, S.R.1
Wilkins, M.R.2
Hochstrasser, D.F.3
Dunn, M.J.4
-
19
-
-
27644446855
-
Global physiological understanding and metabolic engineering of microorganisms based on omics studies
-
Park, S.J., Lee, S.Y., Cho, J. et al. (2005) Global physiological understanding and metabolic engineering of microorganisms based on omics studies. Applied Microbiology and Biotechnology, 68,567-579.
-
(2005)
Applied Microbiology and Biotechnology
, vol.68
, pp. 567-579
-
-
Park, S.J.1
Lee, S.Y.2
Cho, J.3
-
20
-
-
34250783088
-
Integrative analysis oftranscriptomic and proteomic data: challenges. Solutions and Applications
-
Nie, L., Wu, G., Culley, D.E. et al. (2007) Integrative analysis oftranscriptomic and proteomic data: challenges. Solutions and Applications. Critical Reviews in Biotechnology, 27,63-75.
-
(2007)
Critical Reviews in Biotechnology
, vol.27
, pp. 63-75
-
-
Nie, L.1
Wu, G.2
Culley, D.E.3
-
21
-
-
0142072824
-
Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling
-
Han, M.-J., Jeong, K.J., Yoo, J.-S. and Lee, S.Y. (2003) Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling. Applied and Environmental Microbiology, 69,5772-5781.
-
(2003)
Applied and Environmental Microbiology
, vol.69
, pp. 5772-5781
-
-
Han, M.-J.1
Jeong, K.J.2
Yoo, J.-S.3
Lee, S.Y.4
-
22
-
-
35848947417
-
Leptin in reproduction
-
Blüher, S. and Mantzoros, C.S. (2007) Leptin in reproduction. Current Opinion in Endocrinology, Diabetes and Obesity, 14,458-464.
-
(2007)
Current Opinion in Endocrinology, Diabetes and Obesity
, vol.14
, pp. 458-464
-
-
Blüher, S.1
Mantzoros, C.S.2
-
23
-
-
15044362439
-
Glucagon-like peptide 1 and its derivatives in the treatment of diabetes
-
Nauck, M.A. and Meier, J.J. (2005) Glucagon-like peptide 1 and its derivatives in the treatment of diabetes. Regulatory Peptides, 128,135-148.
-
(2005)
Regulatory Peptides
, vol.128
, pp. 135-148
-
-
Nauck, M.A.1
Meier, J.J.2
-
24
-
-
0035723503
-
Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes
-
Gutniak, M.K., Svartberg, J., Hellstrom, P.M. et al. (2001) Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes. Journal of Internal Medicine, 250,81-87.
-
(2001)
Journal of Internal Medicine
, vol.250
, pp. 81-87
-
-
Gutniak, M.K.1
Svartberg, J.2
Hellstrom, P.M.3
-
25
-
-
34047176968
-
Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1
-
Lee, D.-H., Kim, S.-G., Park, Y.-C. et al. (2007) Proteome analysis of recombinant Escherichia coli producing human glucagon-like peptide-1. Analytical Tools for Proteomics, 849,323-330.
-
(2007)
Analytical Tools for Proteomics
, vol.849
, pp. 323-330
-
-
Lee, D.-H.1
Kim, S.-G.2
Park, Y.-C.3
-
26
-
-
33845631601
-
Microbial metabolomics: past, present and future methodologies
-
Mashego, M.R., Rumbold, K., Mey, M.D. et al. (2006) Microbial metabolomics: past, present and future methodologies. Biotechnology Letters, 29,1-16.
-
(2006)
Biotechnology Letters
, vol.29
, pp. 1-16
-
-
Mashego, M.R.1
Rumbold, K.2
Mey, M.D.3
-
27
-
-
34548025085
-
Metabolomics: current state and evolving methodologies and tools
-
Oldiges, M., Lütz, S., Pflug, S. et al. (2007) Metabolomics: current state and evolving methodologies and tools. Applied Microbiology and Biotechnology, 76,495-511.
-
(2007)
Applied Microbiology and Biotechnology
, vol.76
, pp. 495-511
-
-
Oldiges, M.1
Lütz, S.2
Pflug, S.3
-
28
-
-
10044287191
-
Stimulation, monitoring, and analysis of pathway dynamics by metabolic profiling in the aromatic amino acid pathway
-
Oldiges, M., Kunze, M., Degenring, D. et al. (2004) Stimulation, monitoring, and analysis of pathway dynamics by metabolic profiling in the aromatic amino acid pathway. Biotechnology Progress, 20,1623-1633.
-
(2004)
Biotechnology Progress
, vol.20
, pp. 1623-1633
-
-
Oldiges, M.1
Kunze, M.2
Degenring, D.3
-
29
-
-
0345701916
-
Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures
-
Ketchum, R.E.B., Rithner, C.D., Qiu, D. et al. (2003) Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Plant Metabolomics, 62,901-909.
-
(2003)
Plant Metabolomics
, vol.62
, pp. 901-909
-
-
Ketchum, R.E.B.1
Rithner, C.D.2
Qiu, D.3
-
31
-
-
0026766423
-
Isolation and molecular characterization of a novel broad-host-range plasmid from Bordetella bronchiseptica with sequence similarities to plasmids from Gram-positive organisms
-
Antoine, R. and Locht, C. (1992) Isolation and molecular characterization of a novel broad-host-range plasmid from Bordetella bronchiseptica with sequence similarities to plasmids from Gram-positive organisms. Molecular Microbiology, 6,1785-1799.
-
(1992)
Molecular Microbiology
, vol.6
, pp. 1785-1799
-
-
Antoine, R.1
Locht, C.2
-
32
-
-
0036258027
-
Identification of novel sulfur-containing bacterial polyesters: biosynthesis of poly(3-hydroxy-S-propyl-ω-thioalkanoates) containing thioether linkages in the side chains
-
Ewering, C., Lutke-Eversloh, T., Luftmann, H. and Steinbuchel, A. (2002) Identification of novel sulfur-containing bacterial polyesters: biosynthesis of poly(3-hydroxy-S-propyl-ω-thioalkanoates) containing thioether linkages in the side chains. Microbiology (Reading, England), 148,1397-1406.
-
(2002)
Microbiology (Reading, England)
, vol.148
, pp. 1397-1406
-
-
Ewering, C.1
Lutke-Eversloh, T.2
Luftmann, H.3
Steinbuchel, A.4
-
33
-
-
0036729771
-
Biotransformation of eugenol to ferulic acid by a recombinant strain of Ralstonia eutropha H16
-
Overhage, J., Steinbuchel, A. and Priefert, H. (2002) Biotransformation of eugenol to ferulic acid by a recombinant strain of Ralstonia eutropha H16. Applied and Environmental Microbiology, 68,4315-4321.
-
(2002)
Applied and Environmental Microbiology
, vol.68
, pp. 4315-4321
-
-
Overhage, J.1
Steinbuchel, A.2
Priefert, H.3
-
34
-
-
13844254903
-
Directed evolution of copy number of abroad host range plasmid for metabolic engineering
-
Tao, L., Jackson, R.E. and Cheng, Q. (2005) Directed evolution of copy number of abroad host range plasmid for metabolic engineering. Evolutionary Engineering, 7,10-17.
-
(2005)
Evolutionary Engineering
, vol.7
, pp. 10-17
-
-
Tao, L.1
Jackson, R.E.2
Cheng, Q.3
-
35
-
-
0030579206
-
Probing the limits of expression levels by varying promoter strength and plasmid copy number in Saccharomyces cerevisiae
-
Nacken, V., Achstetter, T. and Degryse, E. (1996) Probing the limits of expression levels by varying promoter strength and plasmid copy number in Saccharomyces cerevisiae. Gene, 175,253-260.
-
(1996)
Gene
, vol.175
, pp. 253-260
-
-
Nacken, V.1
Achstetter, T.2
Degryse, E.3
-
36
-
-
0029990844
-
Cloning of heterologous genes specifying detrimental proteins on pUC-derived plasmids in Escherichia coli
-
Müller, J., Dijl, J.V., Venema, G. and Bron, S. (1996) Cloning of heterologous genes specifying detrimental proteins on pUC-derived plasmids in Escherichia coli. Molecular Genetics and Genomics, 252,207-211.
-
(1996)
Molecular Genetics and Genomics
, vol.252
, pp. 207-211
-
-
Müller, J.1
Dijl, J.V.2
Venema, G.3
Bron, S.4
-
37
-
-
0034496492
-
Low-copyplasmidscanperformaswellasorbetterthanhigh-copy plasmids for metabolic engineering of bacteria
-
Jones, K.L., Kim, S.-W. and Keasling, J.D. (2000) Low-copyplasmidscanperformaswellasorbetterthanhigh-copy plasmids for metabolic engineering of bacteria. Metabolic Engineering, 2,328-338.
-
(2000)
Metabolic Engineering
, vol.2
, pp. 328-338
-
-
Jones, K.L.1
Kim, S.-W.2
Keasling, J.D.3
-
38
-
-
0035723632
-
Continuous-culture studies on the stability and expression of recombinant streptokinase in Escherichia coli
-
Yazdani, S. and Mukherjee, K. (2004) Continuous-culture studies on the stability and expression of recombinant streptokinase in Escherichia coli. Bioprocess and Biosystems Engineering, 24,341-346.
-
(2004)
Bioprocess and Biosystems Engineering
, vol.24
, pp. 341-346
-
-
Yazdani, S.1
Mukherjee, K.2
-
39
-
-
0030932409
-
A method for construction of E. coli strains with multiple DNA insertions in the chromosome
-
Peredelchuk, M.Y. and Bennett, G.N. (1997) A method for construction of E. coli strains with multiple DNA insertions in the chromosome. Gene, 187,231-238.
-
(1997)
Gene
, vol.187
, pp. 231-238
-
-
Peredelchuk, M.Y.1
Bennett, G.N.2
-
40
-
-
0033983166
-
Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda In Ch, a simple Escherichia coli plasmid-chromosome shuttle system
-
Boyd, D., Weiss, D.S., Chen, J.C. and Beckwith, J. (2000) Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda In Ch, a simple Escherichia coli plasmid-chromosome shuttle system. Journal of Bacteriology, 182,842-847.
-
(2000)
Journal of Bacteriology
, vol.182
, pp. 842-847
-
-
Boyd, D.1
Weiss, D.S.2
Chen, J.C.3
Beckwith, J.4
-
41
-
-
0034705144
-
An efficient recombination system for chromosome engineering in Escherichia coli
-
Yu, D., Ellis, H.M., Lee, E.C. et al. (2000) An efficient recombination system for chromosome engineering in Escherichia coli. Proceedings of the National Academy of Sciences, 97,5978-5983.
-
(2000)
Proceedings of the National Academy of Sciences
, vol.97
, pp. 5978-5983
-
-
Yu, D.1
Ellis, H.M.2
Lee, E.C.3
-
42
-
-
37349092706
-
6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli
-
Wang, Y. and Pfeifer, B.A. (2007) 6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. Metabolic Engineering, 10,33-38.
-
(2007)
Metabolic Engineering
, vol.10
, pp. 33-38
-
-
Wang, Y.1
Pfeifer, B.A.2
-
43
-
-
0032885106
-
Gene-expressiontoolsforthe metabolic engineering of bacteria
-
Keasling, J.D. (1999) Gene-expressiontoolsforthe metabolic engineering of bacteria. Trends in Biotechnology, 17,452-460.
-
(1999)
Trends in Biotechnology
, vol.17
, pp. 452-460
-
-
Keasling, J.D.1
-
44
-
-
29544444196
-
Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli
-
Yuan, L.Z., Rouviere, P.E., LaRossa, R.A. and Suh, W. (2006) Chromosomal promoter replacement of the isoprenoid pathway for enhancing carotenoid production in E. coli. Metabolic Engineering, 8,79-90.
-
(2006)
Metabolic Engineering
, vol.8
, pp. 79-90
-
-
Yuan, L.Z.1
Rouviere, P.E.2
LaRossa, R.A.3
Suh, W.4
-
45
-
-
0035916370
-
Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
-
Kim, S.-W. and Keasling, J.D. (2001) Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production. Biotechnology and Bioengineering, 72,408-415.
-
(2001)
Biotechnology and Bioengineering
, vol.72
, pp. 408-415
-
-
Kim, S.-W.1
Keasling, J.D.2
-
46
-
-
0036663602
-
Amplification of HMG-CoA reductase production enhances carotenoid accumulation in Neurospora crassa
-
Wang, G.-Y. and Keasling, J.D. (2002) Amplification of HMG-CoA reductase production enhances carotenoid accumulation in Neurospora crassa. Metabolic Engineering, 4,193-201.
-
(2002)
Metabolic Engineering
, vol.4
, pp. 193-201
-
-
Wang, G.-Y.1
Keasling, J.D.2
-
47
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
Martin, V.J.J., Pitera, D.J., Withers, S.T. et al. (2003) Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nature Biotechnology, 21,796-802.
-
(2003)
Nature Biotechnology
, vol.21
, pp. 796-802
-
-
Martin, V.J.J.1
Pitera, D.J.2
Withers, S.T.3
-
48
-
-
0035230281
-
Process development and metabolic engineering for the overproduction of natural and unnatural polyketides in Metabolic Engineering
-
(ed. l. Nielsen), Springer, Berlin
-
McDaniel, R., Licari, P. and Khosla, C. (2001) Process development and metabolic engineering for the overproduction of natural and unnatural polyketides in Metabolic Engineering, vol. 73 (ed. l. Nielsen), Springer, Berlin, pp. 31-52.
-
(2001)
, vol.73
, pp. 31-52
-
-
McDaniel, R.1
Licari, P.2
Khosla, C.3
-
49
-
-
0031905709
-
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
-
Kealey, J.T., Liu, L., Santi, D.V. et al. (1998) Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proceedings of the National Academy of Sciences of the United States of America, 95,505-509.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 505-509
-
-
Kealey, J.T.1
Liu, L.2
Santi, D.V.3
-
50
-
-
0030249160
-
Generation of polyketide libraries via combinatorial biosynthesis
-
Khosla, C.Z.R. (1996) Generation of polyketide libraries via combinatorial biosynthesis. Trends in Biotechnology, 14,335-341.
-
(1996)
Trends in Biotechnology
, vol.14
, pp. 335-341
-
-
Khosla, C.Z.R.1
-
51
-
-
4544297816
-
Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum
-
Reeves, A.R., Cernota, W.H., Brikun, I.A. et al. (2004) Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum. Metabolic Engineering, 6,300-312.
-
(2004)
Metabolic Engineering
, vol.6
, pp. 300-312
-
-
Reeves, A.R.1
Cernota, W.H.2
Brikun, I.A.3
-
52
-
-
33745036968
-
Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora ery-thraea
-
Reeves, A.R., Brikun, I.A., Cernota, W.H. et al. (2006) Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora ery-thraea. Journal of Industrial Microbiology and Biotechnology, 33,600-609.
-
(2006)
Journal of Industrial Microbiology and Biotechnology
, vol.33
, pp. 600-609
-
-
Reeves, A.R.1
Brikun, I.A.2
Cernota, W.H.3
-
53
-
-
34147183821
-
Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
-
Oliynyk, M., Samborskyy, M., Lester, J.B. et al. (2007) Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nature Biotechnology, 25,447-453.
-
(2007)
Nature Biotechnology
, vol.25
, pp. 447-453
-
-
Oliynyk, M.1
Samborskyy, M.2
Lester, J.B.3
-
54
-
-
33645057433
-
Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae
-
Mutka, S.C., Bondi, S.M., Carney, J.R. et al. (2006) Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae. FEMS Yeast Research, 6,40-47.
-
(2006)
FEMS Yeast Research
, vol.6
, pp. 40-47
-
-
Mutka, S.C.1
Bondi, S.M.2
Carney, J.R.3
-
55
-
-
0026415106
-
Modular organization of genes required for complex polyketide biosynthesis
-
Donadio, S., Staver, M.J., McAlpine, J.B. et al. (1991) Modular organization of genes required for complex polyketide biosynthesis. Science, 252,675-679.
-
(1991)
Science
, vol.252
, pp. 675-679
-
-
Donadio, S.1
Staver, M.J.2
McAlpine, J.B.3
-
56
-
-
0032082974
-
The role of metabolic engineering in the production of secondary metabolites
-
Nielsen, J. (1998) The role of metabolic engineering in the production of secondary metabolites. Current Opinion in Microbiology, 1,330-336.
-
(1998)
Current Opinion in Microbiology
, vol.1
, pp. 330-336
-
-
Nielsen, J.1
-
57
-
-
0036897816
-
Nonnatural substrates for polyketide synthases and their associated modifying enzymes
-
Pohl, N.L. (2002) Nonnatural substrates for polyketide synthases and their associated modifying enzymes. Current Opinion in Chemical Biology, 6,773-778.
-
(2002)
Current Opinion in Chemical Biology
, vol.6
, pp. 773-778
-
-
Pohl, N.L.1
-
58
-
-
0035793858
-
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
-
Pfeifer, B.A., Admiraal, S.J., Gramajo, H. et al. (2001) Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science, 291,1790-1792.
-
(2001)
Science
, vol.291
, pp. 1790-1792
-
-
Pfeifer, B.A.1
Admiraal, S.J.2
Gramajo, H.3
-
59
-
-
0036306047
-
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B
-
Pfeifer, B., Hu, Z., Licari, P. and Khosla, C. (2002) Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Applied and Environmental Microbiology, 68,3287-3292.
-
(2002)
Applied and Environmental Microbiology
, vol.68
, pp. 3287-3292
-
-
Pfeifer, B.1
Hu, Z.2
Licari, P.3
Khosla, C.4
-
60
-
-
1942455740
-
Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli
-
Lau, J., Tran, C., Licari, P. and Galazzo, J. (2004) Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. Journal ofBiotechnology, 110,95-103.
-
(2004)
Journal ofBiotechnology
, vol.110
, pp. 95-103
-
-
Lau, J.1
Tran, C.2
Licari, P.3
Galazzo, J.4
-
61
-
-
0042100690
-
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
-
Murli, S., Kennedy, J., Dayem, L.C. et al. (2003) Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. Journal of Industrial Microbiology and Biotechnology, 30 500-509.
-
(2003)
Journal of Industrial Microbiology and Biotechnology
, vol.30
, pp. 500-509
-
-
Murli, S.1
Kennedy, J.2
Dayem, L.C.3
-
62
-
-
0036526451
-
Carbon flux distribution in antibiotic-producing chemostat cultures of Streptomyces lividans
-
Avignone Rossa, C., White, J., Kuiper, A. et al. (2002) Carbon flux distribution in antibiotic-producing chemostat cultures of Streptomyces lividans. Metabolic engineering, 4,138-150.
-
(2002)
Metabolic engineering
, vol.4
, pp. 138-150
-
-
Avignone Rossa, C.1
White, J.2
Kuiper, A.3
-
63
-
-
0026784840
-
Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2)
-
Takano, E., Gramajo, H.C., Strauch, E. et al. (1992) Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2). Molecular Microbiology, 6,2797-2804.
-
(1992)
Molecular Microbiology
, vol.6
, pp. 2797-2804
-
-
Takano, E.1
Gramajo, H.C.2
Strauch, E.3
-
64
-
-
0036795791
-
Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans
-
Butler, M.J., Bruheim, P., Jovetic, S. et al. (2002) Engineering of primary carbon metabolism for improved antibiotic production in Streptomyces lividans. Applied and Environmental Microbiology, 68,4731-4739.
-
(2002)
Applied and Environmental Microbiology
, vol.68
, pp. 4731-4739
-
-
Butler, M.J.1
Bruheim, P.2
Jovetic, S.3
-
66
-
-
0036008847
-
Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae
-
Yoon, Y.J., Beck, B.J., Kim, B.S. et al. (2002) Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology, 9,203-214.
-
(2002)
Chemistry & Biology
, vol.9
, pp. 203-214
-
-
Yoon, Y.J.1
Beck, B.J.2
Kim, B.S.3
-
67
-
-
0032082090
-
Combinatorial biosynthesis for new drug discovery
-
Hutchinson, C.R. (1998) Combinatorial biosynthesis for new drug discovery. Current Opinion in Microbiology, 1,319-329.
-
(1998)
Current Opinion in Microbiology
, vol.1
, pp. 319-329
-
-
Hutchinson, C.R.1
-
68
-
-
27144509740
-
Combinatorialpolyketidebiosynthesisbydenovodesignand rearrangement of modular polyketide synthase genes
-
Menzella, H.G., Reid, R., Carney, J.R. et al. (2005)Combinatorialpolyketidebiosynthesisbydenovodesignand rearrangement of modular polyketide synthase genes. Nature Biotechnology, 23,1171-1176.
-
(2005)
Nature Biotechnology
, vol.23
, pp. 1171-1176
-
-
Menzella, H.G.1
Reid, R.2
Carney, J.R.3
-
69
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen, J.R., Hutchinson, C.R., Cane, D.E. and Khosla, C. (1997) Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science, 277,367-369.
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
70
-
-
33845621530
-
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase
-
Ward, S.L., Desai, R.P., Hu, Z. et al. (2007) Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. Journal ofIndustrial Microbiology and Biotechnology, 34,9-15.
-
(2007)
Journal ofIndustrial Microbiology and Biotechnology
, vol.34
, pp. 9-15
-
-
Ward, S.L.1
Desai, R.P.2
Hu, Z.3
-
71
-
-
0037500087
-
Metabolic engineering of β-lactam production
-
Thykaer, J. and Nielsen, J. (2003) Metabolic engineering of β-lactam production. Metabolic Engineering, 5,56-69.
-
(2003)
Metabolic Engineering
, vol.5
, pp. 56-69
-
-
Thykaer, J.1
Nielsen, J.2
-
72
-
-
0032082974
-
The role of metabolic engineering in the production of secondary metabolites
-
Nielsen, J. (1998) The role of metabolic engineering in the production of secondary metabolites. Current Opinion in Microbiology, 1,330-336.
-
(1998)
Current Opinion in Microbiology
, vol.1
, pp. 330-336
-
-
Nielsen, J.1
-
73
-
-
0028420272
-
Resistance of antibiotics mediated by target alterations
-
Spratt, B.G. (1994) Resistance of antibiotics mediated by target alterations. Science, 264,388-393.
-
(1994)
Science
, vol.264
, pp. 388-393
-
-
Spratt, B.G.1
-
74
-
-
0017727925
-
Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus
-
Reading, C. and Cole, M. (1977) Clavulanic acid: a beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 11,852-857.
-
(1977)
Antimicrobial Agents and Chemotherapy
, vol.11
, pp. 852-857
-
-
Reading, C.1
Cole, M.2
-
75
-
-
33745699440
-
Involvement of nitrogen-containing compounds in β-lactam biosynthesis and its control
-
Demain, A.L. and Vaishnav, P. (2006) Involvement of nitrogen-containing compounds in β-lactam biosynthesis and its control. Critical Reviews in Biotechnology, 26,67-82.
-
(2006)
Critical Reviews in Biotechnology
, vol.26
, pp. 67-82
-
-
Demain, A.L.1
Vaishnav, P.2
-
76
-
-
0038236925
-
Industrial production of β-lactam antibiotics
-
Elander, R.P. (2003) Industrial production of β-lactam antibiotics. AppliedMicrobiology & Biotechnology, 61,385-392.
-
(2003)
AppliedMicrobiology & Biotechnology
, vol.61
, pp. 385-392
-
-
Elander, R.P.1
-
77
-
-
1442300124
-
Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in streptomyces clavuligenis
-
Tahlan, K., Park, H.U., Wong, A., Beatty, P.H. and Jensen, S.E. (2004) Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in streptomyces clavuligenis. 48,930-939.
-
(2004)
, vol.48
, pp. 930-939
-
-
Tahlan, K.1
Park, H.U.2
Wong, A.3
Beatty, P.H.4
Jensen, S.E.5
-
78
-
-
33646041617
-
Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis
-
Bushell, M.E., Kirk, S., Zhao, H.-J. and Avignone-Rossa, C.A. (2006) Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis. Enzyme and Microbial Technology, 39,149-157.
-
(2006)
Enzyme and Microbial Technology
, vol.39
, pp. 149-157
-
-
Bushell, M.E.1
Kirk, S.2
Zhao, H.-J.3
Avignone-Rossa, C.A.4
-
79
-
-
0030700274
-
Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus
-
Ives, P.R. and Bushell, M.E. (1997) Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus. Microbiology (Reading, England), 143,3573-3579.
-
(1997)
Microbiology (Reading, England)
, vol.143
, pp. 3573-3579
-
-
Ives, P.R.1
Bushell, M.E.2
-
80
-
-
33646082272
-
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus
-
Li, R. and Townsend, C.A. (2006) Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabolic Engineering, 8,240-252.
-
(2006)
Metabolic Engineering
, vol.8
, pp. 240-252
-
-
Li, R.1
Townsend, C.A.2
-
81
-
-
0028048859
-
Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis
-
Aidoo, K.A., Wong, A., Alexander, D.C. et al. (1994) Cloning, sequencing and disruption of a gene from Streptomyces clavuligerus involved in clavulanic acid biosynthesis. Gene, 147,41-46.
-
(1994)
Gene
, vol.147
, pp. 41-46
-
-
Aidoo, K.A.1
Wong, A.2
Alexander, D.C.3
-
82
-
-
0034004958
-
Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus
-
Jensen, S.E., Elder, K.J., Aidoo, K.A. and Paradkar, A.S., (2000) Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 44,720-726.
-
(2000)
Antimicrobial Agents and Chemotherapy
, vol.44
, pp. 720-726
-
-
Jensen, S.E.1
Elder, K.J.2
Aidoo, K.A.3
Paradkar, A.S.4
-
83
-
-
0033933826
-
Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus
-
Li, R., Khaleeli, N. and Townsend, C.A. (2000) Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. The Journal of Bacteriology, 182,4087-4095.
-
(2000)
The Journal of Bacteriology
, vol.182
, pp. 4087-4095
-
-
Li, R.1
Khaleeli, N.2
Townsend, C.A.3
-
84
-
-
0347361709
-
Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus
-
Jensen, S.E., Paradkar, A.S., Mosher, R.H. et al. (2004) Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus. Antimicrobial Agents and Chemotherapy, 48,192-202.
-
(2004)
Antimicrobial Agents and Chemotherapy
, vol.48
, pp. 192-202
-
-
Jensen, S.E.1
Paradkar, A.S.2
Mosher, R.H.3
-
85
-
-
0030954966
-
Aregulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds
-
Perez-Llarena, F.J., Liras, P., Rodriguez-Garcia, A. and Martin, J.F. (1997)Aregulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. The Journal of Bacteriology, 179,2053-2059.
-
(1997)
The Journal of Bacteriology
, vol.179
, pp. 2053-2059
-
-
Perez-Llarena, F.J.1
Liras, P.2
Rodriguez-Garcia, A.3
Martin, J.F.4
-
86
-
-
35348922983
-
Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585
-
Hung, T.V., Malla, S., Park, B.C. et al. (2007) Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. Journal of Microbiology and Biotechnology, 17,1538-1545.
-
(2007)
Journal of Microbiology and Biotechnology
, vol.17
, pp. 1538-1545
-
-
Hung, T.V.1
Malla, S.2
Park, B.C.3
-
87
-
-
84889285474
-
Terpenoids as Therapeutic Drugs and Pharmaceutical
-
(eds L. Zhang and A.L. Demain), The Humana Press, Totowa, NJ.
-
Wang, G., Tang, W. and Bidigare, R.R. (2005) Terpenoids as Therapeutic Drugs and Pharmaceutical (eds L. Zhang and A.L. Demain), The Humana Press, Totowa, NJ.
-
(2005)
-
-
Wang, G.1
Tang, W.2
Bidigare, R.R.3
-
88
-
-
33751120932
-
Production of isoprenoid pharmaceuticals by engineered microbes
-
Chang, M.C.Y. and Keasling, J.D. (2006) Production of isoprenoid pharmaceuticals by engineered microbes. Nature Chemical Biology, 2,674-681.
-
(2006)
Nature Chemical Biology
, vol.2
, pp. 674-681
-
-
Chang, M.C.Y.1
Keasling, J.D.2
-
89
-
-
34250750268
-
Production and engineering ofter penoids inplant cell culture
-
Roberts, S.C. (2007) Production and engineering ofter penoids inplant cell culture. Nature Chemical Biology, 3,387-395.
-
(2007)
Nature Chemical Biology
, vol.3
, pp. 387-395
-
-
Roberts, S.C.1
-
90
-
-
0029922877
-
Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis
-
Rohmer, M., Seemann, M., Horbach, S. et al. (1996) Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis. Journal of the American Chemical Society, 118,2564-2566.
-
(1996)
Journal of the American Chemical Society
, vol.118
, pp. 2564-2566
-
-
Rohmer, M.1
Seemann, M.2
Horbach, S.3
-
91
-
-
0034700150
-
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes
-
Lange, B.M., Rujan, T., Martin, W. and Croteau, R. (2000) Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes. Proceedings of the National Academy of Sciences of the United States of America, 97,13172-13177.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 13172-13177
-
-
Lange, B.M.1
Rujan, T.2
Martin, W.3
Croteau, R.4
-
92
-
-
0032478189
-
Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis
-
Lois, L.M., Campos, N., Putra, S.R. et al. (1998) Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 95,2105-2110.
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, pp. 2105-2110
-
-
Lois, L.M.1
Campos, N.2
Putra, S.R.3
-
93
-
-
0037452578
-
The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein
-
Rohdich, F., Zepeck, F., Adam, P. et al. (2003) The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein. Proceedings of the National Academy of Sciences of the United States of America, 100,1586-1591.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 1586-1591
-
-
Rohdich, F.1
Zepeck, F.2
Adam, P.3
-
94
-
-
0034685844
-
Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli
-
Rodríguez-Concepción, M., Campos, N., Lois, L.M. et al. (2000) Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli. FEBS Letters, 473,328-332.
-
(2000)
FEBS Letters
, vol.473
, pp. 328-332
-
-
Rodríguez-Concepción, M.1
Campos, N.2
Lois, L.M.3
-
95
-
-
0032693034
-
Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocy-tidyl-2-C-methylerythritol
-
Rohdich, F., Wungsintaweekul, J., Fellermeier, M. et al. (1999) Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocy-tidyl-2-C-methylerythritol. Proceedings of the National Academy of Sciences of the United States of America, 96,11758-11763.
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, pp. 11758-11763
-
-
Rohdich, F.1
Wungsintaweekul, J.2
Fellermeier, M.3
-
96
-
-
0033964943
-
Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
-
Luttgen, H., Rohdich, F., Herz, S. et al. (2000) Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Proceedings of the National Academy of Sciences of the United States of America, 97,1062-1067.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 1062-1067
-
-
Luttgen, H.1
Rohdich, F.2
Herz, S.3
-
97
-
-
0034646297
-
Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate
-
Herz, S., Wungsintaweekul, J., Schuhr, C.A. et al. (2000) Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate. Proceedings of the National Academy of Sciences of the United States of America, 97,2486-2490.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 2486-2490
-
-
Herz, S.1
Wungsintaweekul, J.2
Schuhr, C.A.3
-
98
-
-
32944474480
-
Microbial isoprenoid production: an example of green chemistry through metabolic engineering
-
Maury, J., Asadollahi, M.A., Møller, K. et al. (2005) Microbial isoprenoid production: an example of green chemistry through metabolic engineering. Advances in Biochemical Engineering/Biotechnology, 100,19-51.
-
(2005)
Advances in Biochemical Engineering/Biotechnology
, vol.100
, pp. 19-51
-
-
Maury, J.1
Asadollahi, M.A.2
Møller, K.3
-
100
-
-
33847309176
-
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli
-
Pitera, D.J., Paddon, C.J., Newman, J.D. and Keasling, J.D. (2007) Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metabolic Engineering, 9,193-207.
-
(2007)
Metabolic Engineering
, vol.9
, pp. 193-207
-
-
Pitera, D.J.1
Paddon, C.J.2
Newman, J.D.3
Keasling, J.D.4
-
101
-
-
15044338866
-
The global distribution of clinical episodes of Plasmodium falciparum malaria
-
Snow, R.W., Guerra, C.A., Noor, A.M. et al. (2005) The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature, 434,214-217.
-
(2005)
Nature
, vol.434
, pp. 214-217
-
-
Snow, R.W.1
Guerra, C.A.2
Noor, A.M.3
-
102
-
-
0034664686
-
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L
-
Mercke, P., Bengtsson, M., Bouwmeester, H.J. et al. (2000) Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L. Archives of Biochemistry and Biophysics, 381,173-180.
-
(2000)
Archives of Biochemistry and Biophysics
, vol.381
, pp. 173-180
-
-
Mercke, P.1
Bengtsson, M.2
Bouwmeester, H.J.3
-
103
-
-
0039812510
-
Heme-containing oxygenases
-
Sono, M., Roach, M.P., Coulter, E.D. and Dawson, J.H. (1996) Heme-containing oxygenases. Chemical Reviews, 96,2841-2888.
-
(1996)
Chemical Reviews
, vol.96
, pp. 2841-2888
-
-
Sono, M.1
Roach, M.P.2
Coulter, E.D.3
Dawson, J.H.4
-
105
-
-
34247182988
-
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s
-
Chang, M.C.Y., Eachus, R.A., Trieu, W. et al. (2007) Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nature Chemical Biology, 3,274-277.
-
(2007)
Nature Chemical Biology
, vol.3
, pp. 274-277
-
-
Chang, M.C.Y.1
Eachus, R.A.2
Trieu, W.3
-
106
-
-
36649037393
-
Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli
-
Leonard, E. and Koffas, M.A. (2007) Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Applied and Environmental Microbiology, 73,7246-7251.
-
(2007)
Applied and Environmental Microbiology
, vol.73
, pp. 7246-7251
-
-
Leonard, E.1
Koffas, M.A.2
-
107
-
-
33645870422
-
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
-
Ro, D.-K., Paradise, E.M., Ouellet, M. et al. (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature, 440,940-943.
-
(2006)
Nature
, vol.440
, pp. 940-943
-
-
Ro, D.-K.1
Paradise, E.M.2
Ouellet, M.3
-
108
-
-
36249014291
-
An update on microbial carotenoid production: application of recent metabolic engineering tools
-
Das, A., Yoon, S.-H., Lee, S.-H. et al. (2007) An update on microbial carotenoid production: application of recent metabolic engineering tools. Applied Microbiology and Biotechnology, 77,505-512.
-
(2007)
Applied Microbiology and Biotechnology
, vol.77
, pp. 505-512
-
-
Das, A.1
Yoon, S.-H.2
Lee, S.-H.3
-
109
-
-
0037073482
-
Antioxidants in photosynthesis and human nutrition
-
Demmig-Adams, B. and Adams, W.W. III (2002) Antioxidants in photosynthesis and human nutrition. Science, 298,2149-2153.
-
(2002)
Science
, vol.298
, pp. 2149-2153
-
-
Demmig-Adams, B.1
Adams III, W.W.2
-
110
-
-
35548954677
-
Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene
-
Klein-Marcuschamera, D., Ajikumara, P.K. and Stephanopoulos, G. (2007) Engineering microbial cell factories for biosynthesis of isoprenoid molecules: beyond lycopene. Trends in Biotechnology, 25,417-424.
-
(2007)
Trends in Biotechnology
, vol.25
, pp. 417-424
-
-
Klein-Marcuschamera, D.1
Ajikumara, P.K.2
Stephanopoulos, G.3
-
111
-
-
33747787434
-
Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering
-
Nimsa, E., Duboisb, C.P., Robertsa, S.C. and Walker, E.L. (2006) Expression profiling of genes involved in paclitaxel biosynthesis for targeted metabolic engineering. Metabolic Engineering, 8,385-394.
-
(2006)
Metabolic Engineering
, vol.8
, pp. 385-394
-
-
Nimsa, E.1
Duboisb, C.P.2
Robertsa, S.C.3
Walker, E.L.4
-
113
-
-
0015211527
-
Plantantitumoragents. VI. Isolationand structureofTaxol, a novel antileukemic and antitumor agent from Taxus brevifolia
-
Wani, M.C.,Taylor, H.L.,Wall,M.E. et al. (1971) Plantantitumoragents. VI. Isolationand structureofTaxol, a novel antileukemic and antitumor agent from Taxus brevifolia. Journal of theAmerican Chemical Society, 93,2325-2327.
-
(1971)
Journal of theAmerican Chemical Society
, vol.93
, pp. 2325-2327
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
-
114
-
-
0034712232
-
The oxetane ring in taxol
-
Wang, M., Cornett, B., Nettles, J. et al. (2000) The oxetane ring in taxol. The Journal of Organic Chemistry, 65,1059-1068.
-
(2000)
The Journal of Organic Chemistry
, vol.65
, pp. 1059-1068
-
-
Wang, M.1
Cornett, B.2
Nettles, J.3
-
115
-
-
0028964563
-
Cyclization of geranylgeranyl diphosphate to taxa-4 (5),11(12)-diene is the committed step of Taxol biosynthesis in Pacific yew
-
Koepp, A.E., Hezari, M., Zajicek, J. et al. (1995) Cyclization of geranylgeranyl diphosphate to taxa-4 (5),11(12)-diene is the committed step of Taxol biosynthesis in Pacific yew. Journal of Biological Chemistry, 270,8686-8690.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 8686-8690
-
-
Koepp, A.E.1
Hezari, M.2
Zajicek, J.3
-
116
-
-
0030003383
-
Studies onthe biosynthesis ofTaxol: the taxane carbon skeleton is not of mevalonoid origin
-
Eisenreich, W., Menhard, B., Hylands, P.J. et al. (1996) Studies onthe biosynthesis ofTaxol: the taxane carbon skeleton is not of mevalonoid origin. Proceedings of the NationalAcademy of Sciences ofthe United States of America, 93,6431-6436.
-
(1996)
Proceedings of the NationalAcademy of Sciences ofthe United States of America
, vol.93
, pp. 6431-6436
-
-
Eisenreich, W.1
Menhard, B.2
Hylands, P.J.3
-
117
-
-
0030801551
-
Taxol biosynthesis: an update
-
Hezari, M. and Croteau, R. (1997) Taxol biosynthesis: an update. Planta Medica, 63,291-295.
-
(1997)
Planta Medica
, vol.63
, pp. 291-295
-
-
Hezari, M.1
Croteau, R.2
-
118
-
-
2642518854
-
Cytochrome P450 taxadiene 5α-hydroxy-lase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of Taxol biosynthesis
-
Jennewein, S., Long, R.M., Williams, R.M. and Croteau, R. (2004) Cytochrome P450 taxadiene 5α-hydroxy-lase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of Taxol biosynthesis. Chemistry & Biology, 11,379-387.
-
(2004)
Chemistry & Biology
, vol.11
, pp. 379-387
-
-
Jennewein, S.1
Long, R.M.2
Williams, R.M.3
Croteau, R.4
-
119
-
-
0034652139
-
Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
-
Walker, K., Schoendorf, A. and Croteau, R. (2000) Molecular cloning of a taxa-4(20),11(12)-dien-5α-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Archives of Biochemistry and Biophysics, 374,371-380.
-
(2000)
Archives of Biochemistry and Biophysics
, vol.374
, pp. 371-380
-
-
Walker, K.1
Schoendorf, A.2
Croteau, R.3
-
120
-
-
0034610386
-
Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2a-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli
-
Walker, K. and Croteau, R. (2000) Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2a-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 97,13591-13596.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 13591-13596
-
-
Walker, K.1
Croteau, R.2
-
121
-
-
0034681193
-
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli
-
Walker, K. and Croteau, R. (2000) Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America, 97,583-587.
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, pp. 583-587
-
-
Walker, K.1
Croteau, R.2
-
122
-
-
0036789932
-
Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis
-
Walker, K., Fujisaki, S., Long, R. and Croteau, R. (2002) Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain-CoA acyltransferase that functions in Taxol biosynthesis. Proceedings ofthe National Academy ofSciences ofthe United States of America, 99,12715-12720.
-
(2002)
Proceedings ofthe National Academy ofSciences ofthe United States of America
, vol.99
, pp. 12715-12720
-
-
Walker, K.1
Fujisaki, S.2
Long, R.3
Croteau, R.4
-
123
-
-
33846142212
-
Taxanes: perspectives for biotechnological production
-
Frense, D. (2007) Taxanes: perspectives for biotechnological production. Applied Microbiology and Biotechnology, 73,1233-1240.
-
(2007)
Applied Microbiology and Biotechnology
, vol.73
, pp. 1233-1240
-
-
Frense, D.1
-
124
-
-
0029737648
-
Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
-
Yukimune, Y., Tabata, H., Higashi, Y. and Hara, Y. (1996) Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nature Biotechnology, 14,1129-1132.
-
(1996)
Nature Biotechnology
, vol.14
, pp. 1129-1132
-
-
Yukimune, Y.1
Tabata, H.2
Higashi, Y.3
Hara, Y.4
-
125
-
-
0035002665
-
Enhancement of Taxol production and excretion in Taxus chinensis cell culture by fungal elicitation and medium renewal
-
Wang, C., Wu, J. and Mei, X. (2001) Enhancement of Taxol production and excretion in Taxus chinensis cell culture by fungal elicitation and medium renewal. Applied Microbiology and Biotechnology, 55,404-410.
-
(2001)
Applied Microbiology and Biotechnology
, vol.55
, pp. 404-410
-
-
Wang, C.1
Wu, J.2
Mei, X.3
-
126
-
-
33846142212
-
Taxanes: perspectives for biotechnological production
-
Qian, Z., Zhao, Z., Xu, Y. et al. (2006) Taxanes: perspectives for biotechnological production. Applied Microbiology and Biotechnology, 73,1233-1240.
-
(2006)
Applied Microbiology and Biotechnology
, vol.73
, pp. 1233-1240
-
-
Qian, Z.1
Zhao, Z.2
Xu, Y.3
-
127
-
-
34548431347
-
Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures
-
Ketchum, R.E.B., Wherland, L. and Croteau, R.B. (2007) Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures. Plant Cell Reports, 26,1025-1033.
-
(2007)
Plant Cell Reports
, vol.26
, pp. 1025-1033
-
-
Ketchum, R.E.B.1
Wherland, L.2
Croteau, R.B.3
-
128
-
-
6444235290
-
Metabolic engineering ofisoprenoidbiosynthesisin Arabidopsis for the production of taxadiene, the first committed precursor of Taxol
-
Besumbes, Ó., Sauret-Güeto, S., Phillips, M.A. et al. (2004) Metabolic engineering ofisoprenoidbiosynthesisin Arabidopsis for the production of taxadiene, the first committed precursor of Taxol. Biotechnology and Bioengineering, 88,168-175.
-
(2004)
Biotechnology and Bioengineering
, vol.88
, pp. 168-175
-
-
Besumbes, Ó.1
Sauret-Güeto, S.2
Phillips, M.A.3
-
129
-
-
33846058003
-
Redirection of carotenoid metabolism for the efficient production oftaxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit
-
Kovacs, K., Zhang, L., Linforth, R.S.T. et al. (2007) Redirection of carotenoid metabolism for the efficient production oftaxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit. Transgenic Research, 16,121-126.
-
(2007)
Transgenic Research
, vol.16
, pp. 121-126
-
-
Kovacs, K.1
Zhang, L.2
Linforth, R.S.T.3
-
130
-
-
0036252577
-
Production of paclitaxel and baccatin III in a 20-L airlift bioreactor by a cell suspension of Taxus wallichiana
-
Navia-Osorio, A., Garden, H., Cusido, R.M. et al. (2002) Production of paclitaxel and baccatin III in a 20-L airlift bioreactor by a cell suspension of Taxus wallichiana. Planta Medica, 68,336-340.
-
(2002)
Planta Medica
, vol.68
, pp. 336-340
-
-
Navia-Osorio, A.1
Garden, H.2
Cusido, R.M.3
-
131
-
-
0034838359
-
Engineering Escherichia coli forthe synthesis of taxadiene, a key intermediate in the biosynthesis of Taxol
-
Huang, Q., Roessner, C.A., Croteau, R. and Scott, A.I. (2001) Engineering Escherichia coli forthe synthesis of taxadiene, a key intermediate in the biosynthesis of Taxol. Bioorganic & Medicinal Chemistry, 9,2237-2242.
-
(2001)
Bioorganic & Medicinal Chemistry
, vol.9
, pp. 2237-2242
-
-
Huang, Q.1
Roessner, C.A.2
Croteau, R.3
Scott, A.I.4
-
132
-
-
33645573250
-
Genetic engineering of taxol biosynthetic genes in Saccharo-myces cerevisiae
-
Dejong, J.M., Liu, Y., Bollon, A.P. et al. (2006) Genetic engineering of taxol biosynthetic genes in Saccharo-myces cerevisiae. Biotechnology and Bioengineering, 93,212-224.
-
(2006)
Biotechnology and Bioengineering
, vol.93
, pp. 212-224
-
-
Dejong, J.M.1
Liu, Y.2
Bollon, A.P.3
|