Metabolic engineering

Advances in Biochemical Engineering/Biotechnology

Volumn 100, Issue , 2005, Pages 1-17

  Raab, R Michael ^a   Tyo, Keith ^a   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Bioinformatics; Metabolic engineering; Systems biology

Indexed keywords

RECOMBINANT PROTEIN;

BIOSYNTHESIS; BIOTECHNOLOGY; ENERGY METABOLISM; FORECASTING; METHODOLOGY; PHYSIOLOGY; PROTEIN ENGINEERING; REVIEW;

BIOTECHNOLOGY; ENERGY METABOLISM; FORECASTING; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 32944481561     PISSN: 07246145     EISSN: None     Source Type: Book Series    
DOI: 10.1007/b136411     Document Type: Review

References (43)

1. Stephanopoulos G (1999) Metabolic fluxes and metabolic engineering. Metab Eng 1:1-11
2. Stephanopoulos G, Vallino JJ (1991) Network rigidity and metabolic engineering in metabolite overproduction. Science 252:1675-1681
3. Bailey JE (1991) Toward a Science of Metabolic Engineering. Science 252:1668-1675
4. Sudesh K, Taguchi K, Doi Y (2002) Effect of increased PHA synthase activity on polyhydroxyalkanoates biosynthesis in Synechocystis sp PCC 6803. Int J Bio Macromol 30
5. Niederberger P, Prasad R, Miozzari G, Kacser H (1992) A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast. Biochem J 287:473-479
6. Farmer WR, Liao JC (2000) Improving lycopene production in Escherichia coli by engineering metabolic control. Nat Biotechnol 18:533-537
7. Lu JL, Liao TC (1997) Metabolic engineering and control analysis for production of aromatics: Role of transaldolase. Biotechnol Bioeng 53:132-138
8. Ostergaard S, Olsson L, Johnston M, Nielsen J (2000) Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network. Nat Biotechnol 18:1283-1286
9. Aiba S, Matsuoka M (1979) Identification of metabolic model: Citrate production from glucose by Candida lipolytica. Biotechnol Bioeng 21:1373-1386
10. Stafford D, Yanagimachi K, Stephanopoulos G (2001) Metabolic engineering of indene bioconversion in Rhodococcus sp. Adv Biochem Eng Biotechnol 73:85-101
11. Ohta K, Beall DS, Mejia JP, Shanmugam KT, Ingram LO (1991) Metabolic Engineering of Klebsiella-Oxytoca M5a1 for Ethanol-Production from Xylose, Glucose. Appl Env Microbiol 57:2810-2815
12. van Maris AJA, Konings WN, van Dijken JP, Pronk JT (2004) Microbial export of lactic and 3-hydroxypropanoic acid: implications for industrial fermentation processes. Metab Eng 6:245-255
13. Koffas MAG, Jung GY, Aon JC, Stephanopoulos G (2002) Effect of pyruvate carboxylase overexpression on the physiology of Corynebacterium glutamicum. Appl Env Microbiol 68:5422-5428
14. Koffas MAG, Jung GY, Stephanopoulos G (2003) Engineering metabolism and product formation in Corynebacterium glutamicum by coordinated gene overexpression. Metab Eng 5:32-41
15. Tong IT, Liao HH, Cameron DC (1991) 1,3-Propanediol production by Escherichia-coli expressing genes from the klebsiella-pneumoniae-dha regulon. Appl Env Microbiol 57:3541-3546
16. Vives J, Juanola S, Cairo JJ, Godia F (2003) Metabolic engineering of apoptosis in cultured animal cells: implications for the biotechnology industry. Metab Eng 5:124-132
17. Cameron DC, Altaras NE, Hoffman ML, Shaw AJ (1998) Metabolic engineering of propanediol pathways. Biotechnol Progr 14:116-125
18. Danner H, Braun R (1999) Biotechnology for the production of commodity chemicals from biomass. Chem Soc Rev 28:395-405
19. Buckland BC et al. (1999) Microbial conversion of indene to indandiol: a key intermediate in the synthesis of CRIXIVAN. Metab Eng 1:63-74
20. Stafford DE et al. (2002) Optimizing bioconversion pathways through systems analysis and metabolic engineering. Proc Natl Acad Sci USA 99:1801-1806
21. Hood EE, Woodard SL, Horn ME (2002) Monoclonal antibody manufacturing in transgenic plants - myths and realities. Curr Opin Biotechnol 13:630-635
22. Larrick J, Yu L, Naftzger C, Jaiswal S, Wyco K (2002) In: Hood E, Howard J (eds.) Plants as factories for protein production. Kluwer Academic, Boston. pp. 79-101
23. Morrow KJ (2002) Economics of antibody production - Various options available for large-scale bioprocessing. Genet Eng News 22:1-39
24. Nikolov Z, Hammes D (2002) In: Hood E, Howard J (eds) Plants as factories for protein production. Kluwer Academic, Boston. pp. 159-174
25. Thiel KA (2004) Biomanufacturing, from bust to boom...to bubble? Nat Biotechnol 22:1365-1372
26. Stephanopoulos G (2000) Bioinformatics, metabolic engineering. Metabol Eng 2:157-158
27. Lavoisier AL, DeLaplace PS (1994) Memoir on heat. Obes Res 2:189-203
28. Wang F, Raab RM, Washabaugh MW, Buckland BC (2000) Gene therapy, metabolic engineering. Metab Eng 2:126-139
29. Keasling JD (1999) Gene-expression tools for the metabolic engineering of bacteria. Trends Biotechnol 17:452-460
30. Goryshin IY, Jendrisak J, Hoffman LM, Meis R, Reznikoff WS (2000) Insertional transposon mutagenesis by electroporation of released Tn5 transposition complexes. Nat Biotechnol 18:97-100
31. Tobin MB, Gustafsson C, Huisman GW (2000) Directed evolution: the 'rational' basis for 'irrational' design. Curr Opin Struc Biol 10:421-427
32. Park SM, Klapa MI, Sinskey AJ, Stephanopoulos G (1999) Metabolite and isotopomer balancing in the analysis of metabolic cycles: II. Applications. Biotechnol Bioeng 62:392-401
33. Klapa MI, Park SM, Sinskey AJ, Stephanopoulos G (1999) Metabolite and isotopomer balancing in the analysis of metabolic cycles: I. Theory. Biotechnol Bioeng 62:375-391
34. Klapa MI, Aon JC, Stephanopoulos G (2003) Systematic quantification of complex metabolic flux networks using stable isotopes and mass spectrometry. Eur J Biochem 270:3525-3542
35. Price ND, Papin JA, Schilling CH, Palsson BO (2003) Genome-scale microbial in silico models: the constraints-based approach. Trends Biotechnol 21:162-169
36. Edwards JS, Ibarra RU, Palsson BO (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 19:125-130
37. Fell D (1997) Understanding the control of metabolism. Portland, Brookfield, VT
38. Stephanopoulos G, Aristidou AA, Nielsen J (1998) Metabolic engineering: principles, methodologies. Academic, San Diego
39. Nielsen J (2003) It is all about metabolic fluxes. J Bacteriol 185:7031-7035
40. Gill RT, Wildt S, Yang YT, Ziesman S, Stephanopoulos G (2002) Genome wide screening for trait conferring genes using DNA micro-arrays. P Natl Acad Sci USA 99:7033
41. Raab RM, Stephanopoulos G(2004) Dynamics of gene silencing by RNA interference. Biotechnol Bioeng 88:121-132
42. Ashrafi K et al. (2003) Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421:268-272
43. Chan C, Hwang D, Stephanopoulos GN, Yarmush ML, Stephanopoulos G (2003) Application of multivariate analysis to optimize function of cultured hepatocytes. Biotechnol Progr 19:580-598