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Volumn 1, Issue 1, 1999, Pages 1-11

Metabolic Fluxes and Metabolic Engineering

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; GENETIC ENGINEERING; HUMAN; METABOLISM; REVIEW;

EID: 0032600888     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1006/mben.1998.0101     Document Type: Article
Times cited : (455)

References (85)
  • 1
    • 0018393802 scopus 로고
    • Identification of metabolic model: Citrate production from glucose byCandida lipolytica
    • Aiba S., Matsuoka M. Identification of metabolic model: Citrate production from glucose byCandida lipolytica. Biotechnol. Bioeng. 21:1979;1373-1386.
    • (1979) Biotechnol. Bioeng. , vol.21 , pp. 1373-1386
    • Aiba, S.1    Matsuoka, M.2
  • 2
    • 0028485307 scopus 로고
    • Modification of the central metabolic pathways ofEscherichia coliBacillus subtilis
    • Aristidou A. A., Bennett G. N., San K.-Y. Modification of the central metabolic pathways ofEscherichia coliBacillus subtilis. Biotechnol. Bioeng. 44:1994;944-951.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 944-951
    • Aristidou, A.A.1    Bennett, G.N.2    San, K.-Y.3
  • 3
    • 0025895183 scopus 로고
    • Towards a science of metabolic engineering
    • Bailey J. E. Towards a science of metabolic engineering. Science. 252:1991;1668-1674.
    • (1991) Science , vol.252 , pp. 1668-1674
    • Bailey, J.E.1
  • 4
    • 0025726498 scopus 로고
    • Studies on the utilization of lactose byCorynebacterium glutamicumEscherichia coli
    • Brabetz W., Liebl W., Schleifer K.-H. Studies on the utilization of lactose byCorynebacterium glutamicumEscherichia coli. Arch. Microbiol. 155:1991;607.
    • (1991) Arch. Microbiol. , vol.155 , pp. 607
    • Brabetz, W.1    Liebl, W.2    Schleifer, K.-H.3
  • 5
    • 0025238865 scopus 로고
    • A 'top-down' approach to the determination of control coefficients by metabolic control theory
    • Brown G. C., Hafner R. P., Brand M. D. A 'top-down' approach to the determination of control coefficients by metabolic control theory. Eur. J. Biochem. 188:1990;321-325.
    • (1990) Eur. J. Biochem. , vol.188 , pp. 321-325
    • Brown, G.C.1    Hafner, R.P.2    Brand, M.D.3
  • 12
    • 0032521590 scopus 로고    scopus 로고
    • Effect of reversible reactions on isotope label redistribution. Analysis of the pentose phosphate pathway
    • Follstad B. D., Stephanopoulos G. Effect of reversible reactions on isotope label redistribution. Analysis of the pentose phosphate pathway. Eur. J. Biochem. 1998.
    • (1998) Eur. J. Biochem.
    • Follstad, B.D.1    Stephanopoulos, G.2
  • 13
    • 0030141280 scopus 로고    scopus 로고
    • Analysis and design of metabolic reaction networks via mixed-integer linear optimization
    • Hatzimanikatis V., Floudas C., Bailey J. E. Analysis and design of metabolic reaction networks via mixed-integer linear optimization. AIChE Journal. 1996;1277-1292.
    • (1996) AIChE Journal , pp. 1277-1292
    • Hatzimanikatis, V.1    Floudas, C.2    Bailey, J.E.3
  • 14
    • 0015989446 scopus 로고
    • A linear steady-state treatment of enzymatic chains. General properties, control and effector strength
    • Heinrich R., Rapoport T. A. A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur. J. Biochem. 42:1974;39-95.
    • (1974) Eur. J. Biochem. , vol.42 , pp. 39-95
    • Heinrich, R.1    Rapoport, T.A.2
  • 15
    • 0026588574 scopus 로고
    • Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producingCorynebacterium glutamicum
    • Ikeda M., Katsumata R. Metabolic engineering to produce tyrosine or phenylalanine in a tryptophan-producingCorynebacterium glutamicum. Appl. Environ. Microbiol. 58:1992;781-785.
    • (1992) Appl. Environ. Microbiol. , vol.58 , pp. 781-785
    • Ikeda, M.1    Katsumata, R.2
  • 21
    • 0019867207 scopus 로고
    • Plasmid-assisted molecular breeding: New technique for enhanced biodegradation of persistent toxic chemicals
    • Kellogg S. T., Chatterjee D. K., Chakrabarty A. M. Plasmid-assisted molecular breeding: new technique for enhanced biodegradation of persistent toxic chemicals. Science. 214:1981;1133-1135.
    • (1981) Science , vol.214 , pp. 1133-1135
    • Kellogg, S.T.1    Chatterjee, D.K.2    Chakrabarty, A.M.3
  • 22
    • 0023874286 scopus 로고
    • Heterologous Expression of a Bacterial Hemoglobin Improves the Growth Properties of RecombinantEscherichia coli
    • Khosla C., Bailey J. E. Heterologous Expression of a Bacterial Hemoglobin Improves the Growth Properties of RecombinantEscherichia coli. Nature. 331:1988;633-635.
    • (1988) Nature , vol.331 , pp. 633-635
    • Khosla, C.1    Bailey, J.E.2
  • 25
    • 0028422740 scopus 로고
    • Photosynthetic water splitting: In situ photoprecipitation of metallocatalysts for photoevolution of hydrogen and oxygen
    • Lee J. W., Tevault C. V., Blankinship S. L., Collins R. T., Greenbaum E. Photosynthetic water splitting: In situ photoprecipitation of metallocatalysts for photoevolution of hydrogen and oxygen. Energy Fuels : ACS J. 8:1994;770-773.
    • (1994) Energy Fuels : ACS J. , vol.8 , pp. 770-773
    • Lee, J.W.1    Tevault, C.V.2    Blankinship, S.L.3    Collins, R.T.4    Greenbaum, E.5
  • 26
    • 0028434213 scopus 로고
    • Metabolic engineering ofPseudomonas putidap
    • Lee J.-Y., Roh J.-R., Kim H.-S. Metabolic engineering ofPseudomonas putidap. Biotechnol. Bioeng. 43:1994;1146-1152.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 1146-1152
    • Lee, J.-Y.1    Roh, J.-R.2    Kim, H.-S.3
  • 27
    • 0027601708 scopus 로고
    • Advances in metabolic control analysis
    • Liao J. C., Delgado J. Advances in metabolic control analysis. Biotechnol. Progr. 9:1993;221-233.
    • (1993) Biotechnol. Progr. , vol.9 , pp. 221-233
    • Liao, J.C.1    Delgado, J.2
  • 28
    • 0039802827 scopus 로고
    • Impact of Biotechnology on the Chemical Industry
    • MacQuitty J. J. Impact of Biotechnology on the Chemical Industry. ACS Sympos. Ser. 362:1988;11-29.
    • (1988) ACS Sympos. Ser. , vol.362 , pp. 11-29
    • MacQuitty, J.J.1
  • 29
    • 0028484019 scopus 로고
    • Examination of primary metabolic pathways in a murine hybridoma with carbon-13 NMR spectroscopy
    • Mancuso A., Sharfstein S. T., Tucker S. N., Clark D. S., Blanch H. W. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 NMR spectroscopy. Biotechnol. Bioeng. 44:1994;563-585.
    • (1994) Biotechnol. Bioeng. , vol.44 , pp. 563-585
    • Mancuso, A.1    Sharfstein, S.T.2    Tucker, S.N.3    Clark, D.S.4    Blanch, H.W.5
  • 34
    • 0028577728 scopus 로고
    • Targeting of the polyhydroxybutyrate biosynthetic pathway to the plastids ofArabidopsis thaliana
    • Nawrath C., Poirier Y., Somerville C. Targeting of the polyhydroxybutyrate biosynthetic pathway to the plastids ofArabidopsis thaliana. Proc. Nat'l. Acad. Sci. USA. 91:1994;12760.
    • (1994) Proc. Nat'l. Acad. Sci. USA , vol.91 , pp. 12760
    • Nawrath, C.1    Poirier, Y.2    Somerville, C.3
  • 35
    • 0026004726 scopus 로고
    • Cellular engineering
    • Nerem R. M. Cellular engineering. Ann. Biomed. Eng. 19:1991;529-545.
    • (1991) Ann. Biomed. Eng. , vol.19 , pp. 529-545
    • Nerem, R.M.1
  • 36
    • 0031015551 scopus 로고    scopus 로고
    • Flux distributions in anaerobic, glucose-limited continuous cultures ofS. cerevisiae
    • Nissen T. L., Schulze U., Nielsen J., Villadsen J. Flux distributions in anaerobic, glucose-limited continuous cultures ofS. cerevisiae. Microbiology. 143:1997;203-218.
    • (1997) Microbiology , vol.143 , pp. 203-218
    • Nissen, T.L.1    Schulze, U.2    Nielsen, J.3    Villadsen, J.4
  • 41
    • 0039210755 scopus 로고
    • Equations and calculations for fermenations of butyric acid bacteria
    • Papoutsakis E. T. Equations and calculations for fermenations of butyric acid bacteria. Biotechnol. Bioeng. 26:1984;1741-1187.
    • (1984) Biotechnol. Bioeng. , vol.26 , pp. 1741-1187
    • Papoutsakis, E.T.1
  • 42
    • 0343196707 scopus 로고    scopus 로고
    • Metabolic and physiological studies ofCorynebacterium glutamicum
    • Park S. M., Sinskey A. J., Stephanopoulos G. Metabolic and physiological studies ofCorynebacterium glutamicum. Biotechnol. Bioeng. 55:1997a;864-879.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 864-879
    • Park, S.M.1    Sinskey, A.J.2    Stephanopoulos, G.3
  • 46
    • 0343035686 scopus 로고    scopus 로고
    • Stoichiometric model ofEscherichia coli
    • Pramanik J., Keasling J. D. Stoichiometric model ofEscherichia coli. Biotechnol. Bioeng. 50:1997;398-421.
    • (1997) Biotechnol. Bioeng. , vol.50 , pp. 398-421
    • Pramanik, J.1    Keasling, J.D.2
  • 48
    • 0014649230 scopus 로고
    • Biochemical Systems Analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions
    • Savageau M. A. Biochemical Systems Analysis. I. Some mathematical properties of the rate law for the component enzymatic reactions. J. Theor. Biol. 25:1969a;365-369.
    • (1969) J. Theor. Biol. , vol.25 , pp. 365-369
    • Savageau, M.A.1
  • 49
    • 0014658880 scopus 로고
    • Biochemical Systems Analysis. II. The steady-state solutions for an n-pool system using a power-law approximation
    • Savageau M. A. Biochemical Systems Analysis. II. The steady-state solutions for an n-pool system using a power-law approximation. J. Theor. Biol. 25:1969b;370-376.
    • (1969) J. Theor. Biol. , vol.25 , pp. 370-376
    • Savageau, M.A.1
  • 50
    • 0014733809 scopus 로고
    • Biochemical Systems Analysis. III. Dynamic solutions using a power-law approximation
    • Savageau M. A. Biochemical Systems Analysis. III. Dynamic solutions using a power-law approximation. J. Theor. Biol. 26:1970;215-226.
    • (1970) J. Theor. Biol. , vol.26 , pp. 215-226
    • Savageau, M.A.1
  • 51
    • 45949117248 scopus 로고
    • Biochemical systems theory and metabolic control theory: 1. Fundamental similarities and differences
    • Savageau M. A., Voit E. O., Invine D. H. Biochemical systems theory and metabolic control theory: 1. Fundamental similarities and differences. Math. Biosci. 86:1987a;127-145.
    • (1987) Math. Biosci. , vol.86 , pp. 127-145
    • Savageau, M.A.1    Voit, E.O.2    Invine, D.H.3
  • 52
    • 45949116170 scopus 로고
    • Biochemical systems theory and metabolic control theory: 2. The role of summation and connectivity relationships
    • Savageau M. A., Voit E. O., Invine D. H. Biochemical systems theory and metabolic control theory: 2. The role of summation and connectivity relationships. Math. Biosci. 86:1987b;147-169.
    • (1987) Math. Biosci. , vol.86 , pp. 147-169
    • Savageau, M.A.1    Voit, E.O.2    Invine, D.H.3
  • 53
    • 0027604285 scopus 로고
    • Determining metabolic sensitivity coefficients directly from experimental data
    • Schlosser P. M., Holcomb T., Bailey J. E. Determining metabolic sensitivity coefficients directly from experimental data. Biotechnol. Bioeng. 41:1993;1027-1038.
    • (1993) Biotechnol. Bioeng. , vol.41 , pp. 1027-1038
    • Schlosser, P.M.1    Holcomb, T.2    Bailey, J.E.3
  • 54
    • 0343471424 scopus 로고    scopus 로고
    • Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices
    • Schmidt K., Carlsen M., Nielsen J., Villadsen J. Modeling isotopomer distributions in biochemical networks using isotopomer mapping matrices. Biotechnol. Bioeng. 55:1997;831-840.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 831-840
    • Schmidt, K.1    Carlsen, M.2    Nielsen, J.3    Villadsen, J.4
  • 55
    • 0024248526 scopus 로고
    • Cloning of theAlcaligenes eutrophusEscherichia coli
    • Schubert P., Steinbüchel A., Schlegel H. G. Cloning of theAlcaligenes eutrophusEscherichia coli. J. Bacteriol. 170:1988;5837-5847.
    • (1988) J. Bacteriol. , vol.170 , pp. 5837-5847
    • Schubert, P.1    Steinbüchel, A.2    Schlegel, H.G.3
  • 58
    • 0032485899 scopus 로고    scopus 로고
    • Experimental determination of group flux control coefficients in metabolic networks
    • Simpson T. W., Shimizu H., Stephanopoulos G. Experimental determination of group flux control coefficients in metabolic networks. Biotechnol. Bioeng. 1998.
    • (1998) Biotechnol. Bioeng.
    • Simpson, T.W.1    Shimizu, H.2    Stephanopoulos, G.3
  • 59
    • 0023690652 scopus 로고
    • Cloning and expression inEscherichia coliAlcaligenes eutrophus
    • Slater S. C., Voige W. H., Dennis D. E. Cloning and expression inEscherichia coliAlcaligenes eutrophus. J. Bacteriol. 170:1988;4431-4436.
    • (1988) J. Bacteriol. , vol.170 , pp. 4431-4436
    • Slater, S.C.1    Voige, W.H.2    Dennis, D.E.3
  • 61
    • 0025866296 scopus 로고
    • Network rigidity and metabolic engineering in metabolite overproduction
    • Stephanopoulos G., Vallino J. J. Network rigidity and metabolic engineering in metabolite overproduction. Science. 252:1991;1675-1681.
    • (1991) Science , vol.252 , pp. 1675-1681
    • Stephanopoulos, G.1    Vallino, J.J.2
  • 63
    • 0031214696 scopus 로고    scopus 로고
    • Flux amplification in complex metabolic networks
    • Stephanopoulos G., Simpson T. W. Flux amplification in complex metabolic networks. Chem. Eng. Sci. 52:1997;2607-2627.
    • (1997) Chem. Eng. Sci. , vol.52 , pp. 2607-2627
    • Stephanopoulos, G.1    Simpson, T.W.2
  • 64
    • 0030561421 scopus 로고    scopus 로고
    • Detecting and dissecting metabolic fluxes using biosynthetic fractional 13C labeling and two-dimensional NMR spectroscopy
    • Szyperski T., Bailey J. E., Wuthrich K. Detecting and dissecting metabolic fluxes using biosynthetic fractional 13C labeling and two-dimensional NMR spectroscopy. Trends Biotechnol. 14:1996;453-459.
    • (1996) Trends Biotechnol. , vol.14 , pp. 453-459
    • Szyperski, T.1    Bailey, J.E.2    Wuthrich, K.3
  • 65
    • 0031554630 scopus 로고    scopus 로고
    • An online physiological-state recognition system for the lysine fermentation process based on a metabolic reaction model
    • Takiguchi N., Shimizu H., Shioya S. An online physiological-state recognition system for the lysine fermentation process based on a metabolic reaction model. Biotechnol. Bioeng. 55:1997;170-181.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 170-181
    • Takiguchi, N.1    Shimizu, H.2    Shioya, S.3
  • 66
    • 0023784732 scopus 로고
    • Prospects for laboratory engineering of bacteria to degrade pollutants
    • Timmis K. N., Rojo F., Ramos J. L. Prospects for laboratory engineering of bacteria to degrade pollutants. Basic Life Sci. 45:1988;61-79.
    • (1988) Basic Life Sci. , vol.45 , pp. 61-79
    • Timmis, K.N.1    Rojo, F.2    Ramos, J.L.3
  • 67
    • 0025786724 scopus 로고
    • 1,3-propanediol production byEscherichia coliKlebsiella pneumonia dha
    • Tong I.-T., Liao H. H., Cameron D. C. 1,3-propanediol production byEscherichia coliKlebsiella pneumonia dha. Appl. Environ. Microbiol. 57:1991;3541-3546.
    • (1991) Appl. Environ. Microbiol. , vol.57 , pp. 3541-3546
    • Tong, I.-T.1    Liao, H.H.2    Cameron, D.C.3
  • 69
    • 0023521881 scopus 로고
    • Intelligent Sensors in Biotechnology: Applications for the Monitoring of Fermentations and Cellular Metabolism
    • Vallino J. J., Stephanopoulos G. Intelligent Sensors in Biotechnology: Applications for the Monitoring of Fermentations and Cellular Metabolism. Ann. NY Acad. Sci. 506:1987;413-430.
    • (1987) Ann. NY Acad. Sci. , vol.506 , pp. 413-430
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 70
    • 0028086742 scopus 로고
    • Carbon flux distributions at the glucose 6-phosphate branch point inCorynebacterium glutamicum
    • Vallino J. J., Stephanopoulos G. Carbon flux distributions at the glucose 6-phosphate branch point inCorynebacterium glutamicum. Biotechnol. Progr. 10:1994a;327-334.
    • (1994) Biotechnol. Progr. , vol.10 , pp. 327-334
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 71
    • 0028011306 scopus 로고
    • Carbon flux distributions at the pyruvate branch point inCorynebacterium glutamicum
    • Vallino J. J., Stephanopoulos G. Carbon flux distributions at the pyruvate branch point inCorynebacterium glutamicum. Biotechnol. Progr. 10:1994b;320-326.
    • (1994) Biotechnol. Progr. , vol.10 , pp. 320-326
    • Vallino, J.J.1    Stephanopoulos, G.2
  • 72
    • 0028764687 scopus 로고
    • Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates
    • van der Heijden R. T. J. M., Heijnen J. J., Hellinga C., Romein B., Luyben K. Ch. A. M. Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol. Bioeng. 43:1994a;3-10.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 3-10
    • Van Der Heijden, R.T.J.M.1    Heijnen, J.J.2    Hellinga, C.3    Romein, B.4    Luyben K. Ch., A.M.5
  • 73
    • 0028764649 scopus 로고
    • Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross measurement errors
    • van der Heijden R. T. J. M., Heijnen J. J., Hellinga C., Romein B., Luyben K. Ch. A. M. Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross measurement errors. Biotechnol. Bioeng. 43:1994b;11-20.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 11-20
    • Van Der Heijden, R.T.J.M.1    Heijnen, J.J.2    Hellinga, C.3    Romein, B.4    Luyben K. Ch., A.M.5
  • 75
    • 0027909387 scopus 로고
    • Biochemical production capabilities ofEscherichia coli
    • Varma A., Boesch B. W., Palsson B. O. Biochemical production capabilities ofEscherichia coli. Biotechnol. Bioeng. 42:1993b;59-73.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 59-73
    • Varma, A.1    Boesch, B.W.2    Palsson, B.O.3
  • 76
    • 0020812944 scopus 로고
    • Application of macroscopic balances to the identification of gross measurement errors
    • Wang N. S., Stephanopoulos G. Application of macroscopic balances to the identification of gross measurement errors. Biotechnol. Bioeng. 25:1983;2177-2208.
    • (1983) Biotechnol. Bioeng. , vol.25 , pp. 2177-2208
    • Wang, N.S.1    Stephanopoulos, G.2
  • 77
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks: I. modeling and simulation of carbon isotope labeling experiments
    • Wiechert W., de Graaf A. A. Bidirectional reaction steps in metabolic networks: I. modeling and simulation of carbon isotope labeling experiments. Biotechnol. Bioeng. 55:1997;101-117.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 101-117
    • Wiechert, W.1    De Graaf, A.A.2
  • 78
    • 0031554628 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks: II. flux estimation and statistical analysis
    • Wiechert W., Siefke C., de Graaf A. A., Marx A. Bidirectional reaction steps in metabolic networks: II. flux estimation and statistical analysis. Biotechnol. Bioeng. 55:1997;118-135.
    • (1997) Biotechnol. Bioeng. , vol.55 , pp. 118-135
    • Wiechert, W.1    Siefke, C.2    De Graaf, A.A.3    Marx, A.4
  • 79
  • 80
    • 0030914227 scopus 로고    scopus 로고
    • Metabolic Engineering and Human Disease
    • Yarmush M. L., Berthiaume F. Metabolic Engineering and Human Disease. Nature Biotechnol. 15:1997;525-528.
    • (1997) Nature Biotechnol. , vol.15 , pp. 525-528
    • Yarmush, M.L.1    Berthiaume, F.2
  • 81
    • 0028953195 scopus 로고
    • Metabolic engineering of a pentose metabolism pathway in ethanologenicZymomonas mobilis
    • Zhang M., Eddy C., Deandra K., Finkelstein M., Picataggio S. Metabolic engineering of a pentose metabolism pathway in ethanologenicZymomonas mobilis. Science. 267:1995;240-243.
    • (1995) Science , vol.267 , pp. 240-243
    • Zhang, M.1    Eddy, C.2    Deandra, K.3    Finkelstein, M.4    Picataggio, S.5
  • 82
    • 0028036096 scopus 로고
    • Modeling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices
    • Zupke C., Stephanopoulos G. Modeling of isotope distributions and intracellular fluxes in metabolic networks using atom mapping matrices. Biotechnol. Progr. 10:1994;489-498.
    • (1994) Biotechnol. Progr. , vol.10 , pp. 489-498
    • Zupke, C.1    Stephanopoulos, G.2
  • 83
    • 0029239589 scopus 로고
    • Intracellular flux analysis in hybridomas using mass balances and in vitro C13 NMR
    • Zupke C., Stephanopoulos G. Intracellular flux analysis in hybridomas using mass balances and in vitro C13 NMR. Biotechnol. Bioeng. 45:1995;292-303.
    • (1995) Biotechnol. Bioeng. , vol.45 , pp. 292-303
    • Zupke, C.1    Stephanopoulos, G.2
  • 84
    • 0028790261 scopus 로고
    • Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas
    • Zupke C., Sinskey A. J., Stephanopoulos G. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl. Microbiol. Biotechnol. 44:1995;27-36.
    • (1995) Appl. Microbiol. Biotechnol. , vol.44 , pp. 27-36
    • Zupke, C.1    Sinskey, A.J.2    Stephanopoulos, G.3
  • 85
    • 0031149582 scopus 로고    scopus 로고
    • Numerical isotopomer analysis: Estimation of metabolic activity
    • Zupke C., Tompkins R., Yarmush M. Numerical isotopomer analysis: estimation of metabolic activity. Anal. Biochem. 247:1997;287-293.
    • (1997) Anal. Biochem. , vol.247 , pp. 287-293
    • Zupke, C.1    Tompkins, R.2    Yarmush, M.3


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