Integrating transcriptional and metabolite profiles to direct the engineering of lovastatin-producing fungal strains

Nature Biotechnology

Volumn 21, Issue 2, 2003, Pages 150-156

  Askenazi, Manor ^a   Driggers, Edward M ^a   Holtzman, Douglas A ^a   Norman, Thea C ^a   Iverson, Sara ^a   Zimmer, Daniel P ^a   Boers, Mary Ellen ^a   Blomquist, Paul R ^a   Martinez, Eduardo J ^a   Monreal, Alex W ^a   Feibelman, Toby P ^a   Mayorga, Maria E ^a   Maxon, Mary E ^b   Sykes, Kristie ^a   Tobin, Jenny Vittum ^a   Cordero, Etchell ^a   Salama, Sofie R ^c   Trueheart, Joshua ^a   Royer, John C ^a   Madden, Kevin T ^a  

^a Microbia PE Inc   (United States)

^b Cytokinetics Inc   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGI; GENES; GENETIC ENGINEERING; METABOLITES;

FUNGAL STRAINS;

BIOTECHNOLOGY;

DNA FRAGMENT; MEVINOLIN;

ARTICLE; ASPERGILLUS TERREUS; CARBON METABOLISM; CHROMOSOME STRUCTURE; FATTY ACID METABOLISM; FERMENTATION TECHNIQUE; FUNGAL STRAIN; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION; SPOROGENESIS;

ASPERGILLUS; BENZOFURANS; ENERGY METABOLISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENETIC ENGINEERING; LOVASTATIN; PRINCIPAL COMPONENT ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SPECIES SPECIFICITY; STATISTICS; TRANSCRIPTION, GENETIC;

ASPERGILLUS; ASPERGILLUS TERREUS; FUNGI;

EID: 0037316031     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt781     Document Type: Article

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