Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli

Journal of Biotechnology

Volumn 110, Issue 1, 2004, Pages 95-103

  Lau, Janice ^a   Tran, Carnie ^a   Licari, Peter ^a   Galazzo, Jorge ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

6 Deoxyerythronolide B; Escherichia coli; Fed batch bioprocess; Polyketide production

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; CELL CULTURE; DENSITY (SPECIFIC GRAVITY); ESCHERICHIA COLI; GENES;

BIOPROCESS; ERYTHROMYCIN;

BIOTECHNOLOGY;

6 DEOXYERYTHRONOLIDE B SYNTHASE; AMMONIA; ANTIBIOTIC AGENT; BACTERIAL ENZYME; ERYTHROMYCIN; ERYTHRONOLIDE B; MACROCYCLIC COMPOUND; POLYKETIDE; PROPIONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOREACTOR; BIOSYNTHESIS; CELL DENSITY; CULTURE MEDIUM; ESCHERICHIA COLI; FED BATCH REACTOR; FERMENTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROPOLYSPORA;

AMMONIA; BIOREACTORS; BIOTECHNOLOGY; CELL COUNT; CULTURE MEDIA; ERYTHROMYCIN; ESCHERICHIA COLI; FERMENTATION; PROPIONIC ACIDS; STREPTOMYCES COELICOLOR; TIME FACTORS;

ESCHERICHIA COLI; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHRAEA;

EID: 1942455740     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2004.02.001     Document Type: Article

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