Microbial isoprenoid production: An example of green chemistry through metabolic engineering

Advances in Biochemical Engineering/Biotechnology

Volumn 100, Issue , 2005, Pages 19-51

  Maury, Jérôme ^a   Asadollahi, Mohammad A ^a   Møller, Kasper ^a   Clark, Anthony ^b   Nielsen, Jens ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b Analysis and Perception Department   (Switzerland)

Author keywords

Cell factories; Green chemistry; Isoprenoids; Metabolic engineering

Indexed keywords

RECOMBINANT PROTEIN; TERPENE;

BIOREACTOR; BIOTECHNOLOGY; CULTURE TECHNIQUE; ENVIRONMENTAL PROTECTION; GENETICS; METABOLISM; METHODOLOGY; MICROBIOLOGY; PROTEIN ENGINEERING; REVIEW; SACCHAROMYCES CEREVISIAE;

BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CONSERVATION OF NATURAL RESOURCES; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; TERPENES;

EID: 32944474480     PISSN: 07246145     EISSN: None     Source Type: Book Series    
DOI: 10.1007/b136410     Document Type: Review

References (202)

1. Nielsen J (2001) Appl Microbiol Biot 55:263
2. Ostergaard S, Olsson L, Nielsen J (2001) Biotechnol Bioeng 73:412
3. Thykaer J, Nielsen J (2003) Metab Eng 5:56
4. Stephanopoulos G, Gill RT (2001) Adv Biochem Eng Biotechnol 73:1
5. Burkart MD (2003) Org Biomol Chem 1:1
6. Grabley S, Thiericke R (1999) Adv Biochem Eng Biotechnol 64:101
7. EuropaBio (2003) White biotechnology: Gateway to a more sustainable future. EuropaBio, Lyon. Available at http://www.mckinsey.com/clientservice/ chemicals/pdf/BioVision_Booklet_final.pdf
8. Robin J, Jakobsen M, Beyer M, Noorman H, Nielsen J (2001) Appl Microbiol Biotechnol 57:357
9. Sacchettini JC, Poulter CD (1997) Science 277:1788
10. McCaskill D, Croteau R (1997) Adv Biochem Eng Biotechnol 55:107
11. Wallach O (1887) Justus Liebigs Ann Chem 239:1
12. Ruzicka L (1953) Experientia 9:357
13. Katsuki H, Bloch K (1967) J Biol Chem 242:222
14. Lynen F (1967) Pure Appl Chem 14:137
15. Rohmer M, Knani M, Simonin P, Sutter B, Sahm H (1993) Biochem J 295:517
16. Rohmer M (1999) Nat Prod Rep 16:565
17. Broers STJ (1994) PhD thesis, Eidgenössische Technische Hochschule Zürich
18. Schwarz MK (1994) PhD thesis, Eidgenössische Technische Hochschule Zürich
19. Bach TJ, Boronat A, Campos N, Ferrer A, Vollack K-U (1999) Crit Rev Biochem Mol Biol 34:107
20. Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau R (1995) J Biol Chem 270:8686
21. Mukaiyama T, Shiina I, Iwadare H, Saitoh M, Nishimura T, Ohkawa N, Sakoh H, Nishimura K, Tani Y-I, Hasegawa M, Yamada K, Saitoh K (1999) Chem Eur J 5:121
22. Danishefsky SJ, Masters JJ, Young WB, Link JT, Snyder LB, Magee TV, Jung DK, Isaacs RCA, Bornmann WG, Alaimo CA, Coburn CA, Di Grandi MJ (1996) J Am Chem Soc 118:2843
23. Miyaoka H, Honda D, Mitome H, Yamada Y (2002) Tetrahedron Lett 43:7773
24. Sandmann G, Albrecht M, Schnurr G, Knörzer O, Böger P (1999) Trends Biotechnol 17:233
25. Daum G, Lees ND, Bard M, Dickson R (1998) Yeast 14:1471
26. Veen M, Lang C (2004) Appl Microbiol Biot 63:635
27. Lees ND, Bard M, Kirsch DR (1999) Crit Rev Biochem Mol Biol 34:33
28. Kurihara T, Ueda M, Kamasawa N, Osumi M, Tanaka A (1992) J Biochem (Tokyo) 112:845
29. Trocha PJ, Sprinson DB (1976) Arch Biochem Biophys 174:45
30. Servouse M, Karst F (1986) Biochem J 240:541
31. Dimster-Denk D, Rine J (1996) Mol Cell Biol 16:3981
32. Dixon G, Scanlon D, Cooper S, Broad P (1997) J Steroid Biochem Mol Biol 62:165
33. Dimster-Denk D, Rine J, Phillips J, Scherer S, Cundiff P, DeBord K, Gilliland D, Hickman S, Jarvis A, Tong L, Ashby M (1999) J Lipid Res 40:850
34. Campobasso N, Patel M, Wilding IE, Kallender H, Rosenberg M, Gwynn MN (2004) J Biol Chem 279:44883
35. Basson ME, Thorsness M, Rine J (1986) Proc Natl Acad Sci USA 83:5563
36. Dorsey JK, Porter JW (1968) J Biol Chem 243:4667
37. Anderson MS, Muehlbacher M, Street IP, Proffitt J, Poulter CD (1989) J Biol Chem 264:19169
38. Barkley SJ, Cornish RM, Poulter CD (2004) J Bacteriol 186:1811
39. Kaneda K, Kuzuyama T, Takagi M, Seto H (2001) Proc Natl Acad Sci 98:932
40. Bergès T, Guyonnet D, Karst F (1997) J Bacteriol 179:4664
41. Eberhardt NL, Rilling HC (1975) J Biol Chem 250:863
42. Reed BC, Rilling HC (1975) Biochemistry 14:50
43. Barnard GF, Langton B, Popjak G (1978) Biochem Biophys Res Commun 85:1097
44. Yeh LS, Rilling HC (1977) Arch Biochem Biophys 183:718
45. Barnard GF, Popjak G (1981) Biochim Biophys Acta 661:87
46. Modis Y, Wierenga RK (1999) Structure Fold Des 7:1279
47. Modis Y, Wierenga RK (2000) J Mol Biol 297:1171
48. Kursula P, Ojala J, Lambeir AM, Wierenga RK (2002) Biochemistry 41:15543
49. Kanayama N, Himeda Y, Atomi H, Ueda M, Tanaka A (1997) J Biochem (Tokyo) 122:616
50. Kurihara T, Ueda M, Tanaka A (1989) J Biochem (Tokyo) 106:474
51. Kim SA, Copeland L (1997) Appl Environ Microbiol 63:3432
52. Theisen MJ, Misra I, Saadat D, Campobasso N, Miziorko HM, Harrison DH (2004) Proc Natl Acad Sci USA 101:16442
53. Middleton B (1972) Biochem J 126:35
54. Cabano J, Buesa C, Hegardt FG, Marrero PF (1997) Insect Biochem Mol Biol 27:499
55. Middleton B, Tubbs PK (1975) Methods Enzymol 35:173
56. Istvan ES, Deisenhofer J (2001) Science 292:1160
57. Durr IF, Rudney H (1960) J Biol Chem 235:2572
58. Yang D, Shipman LW, Roessner CA, Scott AI, Sacchettini JC (2002) J Biol Chem 277:9462
59. Gray JC, Kekwick RG (1972) Biochim Biophys Acta 279:290
60. Tchen TT (1958) J Biol Chem 233:1100
61. Porter JW (1985) Methods Enzymol 110:71
62. Romanowski MJ, Bonanno JB, Burley SK (2002) Proteins 47:568
63. Bloch K, Chaykin S, Phillips AH, De Waard A (1959) J Biol Chem 234:2595
64. Bonanno JB, Edo C, Eswar N, Pieper U, Romanowski MJ, Ilyin V, Gerchman SE, Kycia H, Studier FW, Sali A, Burley SK (2001) Proc Natl Acad Sci USA 98:12896
65. Durbecq V, Sainz G, Oudjama Y, Clantin B, Bompard-Gilles C, Tricot C, Caillet J, Stalon V, Droogmans L, Villeret V (2001) EMBO J 20:1530
66. Wouters J, Oudjama Y, Ghosh S, Stalon V, Droogmans L, Oldfield E (2003) J Am Chem Soc 125:3198
67. Steinbacher S, Kaiser J, Eisenreich W, Huber R, Bacher A, Rohdich F (2003) J Biol Chem 278:18401
68. Reardpon JE, Abeles RH (1985) J Am Chem Soc 107:4078
69. Agranoff BW, Eggerer H, Henning U, Lynen F (1960) J Biol Chem 235:326
70. Street IP, Poulter CD (1990) Biochemistry 29:7531
71. Rilling HC (1985) Methods Enzymol 110:145
72. Bartlett DL, King CH, Poulter CD (1985) Methods Enzymol 110:171
73. Goldstein JL, Brown MS (1990) Nature 343:425
74. Hampton R, Dimster-Denk D, Rine J (1996) Trends Biochem Sci 21:140
75. Hampton RY (1998) Curr Opin Lipidol 9:93
76. Thorsness M, Schafer W, D'Ari L, Rine J (1989) Mol Cell Biol 9:5702
77. Dimster-Denk D, Thorsness MK, Rine J (1994) Mol Biol Cell 5:655
78. Hampton RY, Rine J (1994) J Cell Biol 125:299
79. Nakanishi M, Goldstein JL, Brown MS (1988) J Biol Chem 263:8929
80. Shearer AG, Hampton RY (2004) J Biol Chem 279:188
81. Hampton RY, Bhakta H (1997) Proc Natl Acad Sci USA 94:12944
82. Gardner RG, Hampton RY (1999) J Biol Chem 274:31671
83. Gardner RG, Shan H, Matsuda SP, Hampton RY (2001) J Biol Chem 276:8681
84. Casey WM, Keesler GA, Parks LW (1992) J Bacteriol 174:7283
85. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW (2001) Appl Environ Microbiol 67:2982
86. Grabińska K, Palamarczyk G (2002) FEMS Yeast Res 2:259
87. Haug JS, Goldner CM, Yazlovitskaya EM, Voziyan PA, Melnykovych G (1994) Biochim Biophys Acta 1223:133
88. Melnykovych G, Haug JS, Goldner CM (1992) Biochem Biophys Res Commun 186:543
89. Machida K, Tanaka T, Fujita K, Taniguchi M (1998) J Bacteriol 180:4460
90. Brown MS, Goldstein JL (1980) J Lipid Res 21:505
91. Szkopińska A, Świeżewska E, Karst F (2000) Biochem Biophys Res Commun 267:473
92. Grabowska D, Karst F, Szkopińska A (1998) FEBS Lett 434:406
93. Karst F, Plochocka D, Meyer S, Szkopińska A (2004) Cell Biol Int 28:193
94. Gillman EC, Slusher LB, Martin NC, Hopper AK (1991) Mol Cell Biol 11:2382
95. Kamińska J, Grabińska K, Kwapisz M, Sikora J, Smagowicz WJ, Palamarczyk G, Żoła̧dek T, Boguta M (2002) FEMS Yeast Res 2:31
96. Zhou D, White RH (1991) Biochem J 273:627
97. Cane DE, Rossi T, Pachlatko JP (1979) Tetrahedron Lett 20:3639
98. Cane DE, Rossi T, Tillman AM, Pachlatko JP (1981) J Am Chem Soc 103:1838
99. Flesch G, Rohmer M (1988) Eur J Biochem 175:405
100. Sprenger GA, Schörken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H (1997) Proc Natl Acad Sci USA 94:12857
101. Lois L-M, Campos N, Putra SR, Danielsen K, Rohmer M, Boronat A (1998) Proc Natl Acad Sci USA 95:2105
102. Lange BM, Wildung MR, McCaskill D, Croteau R (1998) Proc Natl Acad Sci USA 95:2100
103. Wilding EI, Brown JR, Bryant AP, Chalker AF, Holmes DJ, Ingraham KA, Iordanescu S, So CY, Rosenberg M, Gwynn MN (2000) J Bacteriol 182:4319
104. Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW, Lehnbeuter KR, Stauffacher CV, Gwynn MN, Rodwell VW (2002) J Bacteriol 184:2116
105. Bochar DA, Stauffacher CV, Rodwell VW (1999) Mol Genet Metab 66:122
106. Doolittle WF, Logsdon JM (1998) Curr Biol 8:209
107. Takagi M, Kuzuyama T, Takahashi S, Seto H (2000) J Bacteriol 182:4153
108. Hamano Y, Dairi T, Yamamoto M, Kawasaki T, Kaneda K, Kuzuyama T, Itoh N, Seto H (2001) Biosci Biotechnol Biochem 65:1627
109. Hamano Y, Dairi T, Yamamoto M, Kuzuyama T, Itoh N, Seto H (2002) Biosci Biotechnol Biochem 66:808
110. Kawasaki T, Kuzuyama T, Furihata K, Itoh N, Seto H, Dairi T (2003) J Antibiot (Tokyo) 56:957
111. Begley M, Gahan CG, Kollas AK, Hintz M, Hill C, Jomaa H, Eberl M (2004) FEBS Lett 561:99
112. Rodríguez-Concepción M, Boronat A (2002) Plant Physiol 130:1079
113. Eisenreich W, Bacher A, Arigoni D, Rohdich F (2004) Cell Mol Life Sci 61:1401
114. Eubanks LM, Poulter CD (2003) Biochemistry 42:1140
115. Takahashi S, Kuzuyama T, Watanabe H, Seto H (1998) Proc Natl Acad Sci USA 95:9879
116. Kuzuyama T, Takahashi S, Takagi M, Seto H (2000) J Biol Chem 275:19928
117. Hoeffler J-F, Tritsch D, Grosdemange-Billiard C, Rohmer M (2002) Eur J Biochem 269:4446
118. Proteau PJ (2004) Bioorg Chem 32:483
119. Kuzuyama T (2002) Biosci Biotechnol Biochem 66:1619
120. Campos N, Rodríguez-Concepción M, Sauret-Güeto S, Gallego F, Lois L-M, Boronat A (2001) Biochem J 353:59
121. Rohdich F, Wungsintaweekul J, Fellermeier M, Sagner S, Herz S, Kis K, Eisenreich W, Bacher A, Zenk MH (1999) Proc Natl Acad Sci USA 96:11758
122. Kuzuyama T, Takagi M, Kaneda K, Dairi T, Seto H (2000) Tetrahedron Lett 41:703
123. Hunter WN, Bond CS, Gabrielsen M, Kemp LE (2003) Biochem Soc Trans 31:537
124. Lüttgen H, Rohdich F, Herz S, Wungsintaweekul J, Hecht S, Schuhr CA, Fellermeier M, Sagner S, Zenk MH, Bacher A, Eisenreich W (2000) Proc Natl Acad Sci USA 97:1062
125. Kuzuyama T, Takagi M, Kaneda K, Dairi T, Seto H (2000) Tetrahedron Lett 41:2925
126. Miallau L, Alphey MS, Kemp LE, Leonard GA, McSweeney SM, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN (2003) Proc Natl Acad Sci USA 100:9173
127. Takagi M, Kuzuyama T, Kaneda K, Dairi T, Seto H (2000) Tetrahedron Lett 41:3395
128. Herz S, Wungsintaweekul J, Schuhr CA, Hecht S, Lüttgen H, Sagner S, Fellermeier M, Eisenreich W, Zenk MH, Bacher A, Rohdich F (2000) Proc Natl Acad Sci USA 97:2486
129. Freiberg C, Wieland B, Spaltmann F, Ehlert K, Brotz H, Labischinski H (2001) J Mol Microbiol Biotechnol 3:483
130. Campbell TL, Brown ED (2002) J Bacteriol 184:5609
131. Gabrielsen M, Bond CS, Hallyburton I, Hecht S, Bacher A, Eisenreich W, Rohdich F, Hunter WN (2004) J Biol Chem
132. Rodríguez-Concepción M, Campos N, Maria LL, Maldonado C, Hoeffler J-F, Grosdemange-Billiard C, Rohmer M, Boronat A (2000) FEBS Lett 473:328
133. Giner J-L, Jaun B, Arigoni D (1998) J Chem Soc Chem Commun 1857
134. Charon L, Hoeffler J-F, Pale-Grosdemange C, Lois L-M, Campos N, Boronat A, Rohmer M (2000) Biochem J 346:737
135. Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H (2001) FEBS Lett 509:317
136. Altincicek B, Kollas AK, Sanderbrand S, Wiesner J, Hintz M, Beck E, Jomaa H (2001) J Bacteriol 183:2411
137. Altincicek B, Kollas A, Eberl M, Wiesner J, Sanderbrand S, Hintz M, Beck E, Jomaa H (2001) FEBS Lett 499:37
138. Hecht S, Eisenreich W, Adam P, Amslinger S, Kis K, Bacher A, Arigoni D, Rohdich F (2001) Proc Natl Acad Sci USA 98:14837
139. Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F (2002) J Mol Biol 316:79
140. Campos N, Rodríguez-Concepción M, Seemann M, Rohmer M, Boronat A (2001) FEBS Lett 488:170
141. Seemann M, Bui BT, Wolff M, Tritsch D, Campos N, Boronat A, Marquet A, Rohmer M (2002) Angew Chem Int Edit 41:4337
142. Altincicek B, Duin EC, Reichenberg A, Hedderich R, Kollas AK, Hintz M, Wagner S, Wiesner J, Beck E, Jomaa H (2002) FEBS Lett 532:437
143. Eberl M, Hintz M, Reichenberg A, Kollas AK, Wiesner J, Jomaa H (2003) FEBS Lett 544:4
144. Wolff M, Seemann M, Tse Sum BB, Frapart Y, Tritsch D, Garcia EA, Rodríguez-Concepción M, Boronat A, Marquet A, Rohmer M (2003) FEBS Lett 541:115
145. Brandt W, Dessoy MA, Fulhorst M, Gao W, Zenk MH, Wessjohann LA (2004) Chem Biochem 5:311
146. Hahn FM, Hurlburt AP, Poulter CD (1999) J Bacteriol 181:4499
147. Cunningham FX, Lafond TP, Gantt E (2000) J Bacteriol 182:5841
148. Kajiwara S, Fraser PD, Kondo K, Misawa N (1997) Biochem J 324:421
149. Wang C-W, Oh M-K, Liao JC (1999) Biotechnol Bioeng 62:235
150. Hoeffler J-F, Hemmerlin A, Grosdemange-Billiard C, Bach TJ, Rohmer M (2002) Biochem J 366:573
151. Kuzuyama T, Takagi M, Takahashi S, Seto H (2000) J Bacteriol 182:891
152. Yajima S, Nonaka T, Kuzuyama T, Seto H, Ohsawa K (2002) J Biochem (Tokyo) 131:313
153. Reuter K, Sanderbrand S, Jomaa H, Wiesner J, Steinbrecher I, Beck E, Hintz M, Klebe G, Stubbs MT (2002) J Biol Chem 277:5378
154. Grolle S, Bringer-Meyer S, Sahm H (2000) FEMS Microbiol Lett 191:131
155. Koppisch AT, Fox DT, Blagg BS, Poulter CD (2002) Biochemistry 41:236
156. Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP (2001) Nat Struct Biol 8:641
157. Kemp LE, Bond CS, Hunter WN (2001) Acta Crystallogr D Biol Crystallogr 57:1189
158. Rohdich F, Wungsintaweekul J, Lüttgen H, Fischer M, Eisenreich W, Schuhr CA, Fellermeier M, Schramek N, Zenk MH, Bacher A (2000) Proc Natl Acad Sci USA 97:8251
159. Richard SB, Ferrer JL, Bowman ME, Lillo AM, Tetzlaff CN, Cane DE, Noel JP (2002) J Biol Chem 277:8667
160. Kishida H, Wada T, Unzai S, Kuzuyama T, Takagi M, Terada T, Shirouzu M, Yokoyama S, Tame JR, Park SY (2003) Acta Crystallogr D Biol Crystallogr 59:23
161. Rohdich F, Zepeck F, Adam P, Hecht S, Kaiser J, Laupitz R, Grawert T, Amslinger S, Eisenreich W, Bacher A, Arigoni D (2003) Proc Natl Acad Sci USA 100:1586
162. Kollas AK, Duin EC, Eberl M, Altincicek B, Hintz M, Reichenberg A, Henschker D, Henne A, Steinbrecher I, Ostrovsky DN, Hedderich R, Beck E, Jomaa H, Wiesner J (2002) FEBS Lett 532:432
163. Marshall JH, Wilmoth GJ (1981) J Bacteriol 147:900
164. Johnson EA, Schroeder WA (1996) Adv Biochem Eng Biotechnol 53:119
165. Misawa N, Nakagawa M, Kobayashi K, Yamano S, Izawa Y, Nakamura K, Harashima K (1990) J Bacteriol 172:6704
166. Lee PC, Schmidt-Dannert C (2002) Appl Microbiol Biot 60:1
167. Schmidt-Dannert C (2000) Curr Opin Biotechnol 11:255
168. Arthington-Skaggs BA, Crowell DN, Yang H, Sturley SL, Bard M (1996) FEBS Lett 392:161
169. Yamano S, Ishii T, Nakagawa M, Ikenaga H, Misawa N (1994) Biosci Biotechnol Biochem 58:1112
170. Miura Y, Kondo K, Shimada H, Saito T, Nakamura K, Misawa N (1998) Biotechnol Bioeng 58:306
171. Miura Y, Kondo K, Saito T, Shimada H, Fraser PD, Misawa N (1998) Appl Environ Microbiol 64:1226
172. Shimada H, Kondo K, Fraser PD, Miura Y, Saito T, Misawa N (1998) Appl Environ Microbiol 64:2676
173. Huang Q, Roessner CA, Croteau R, Scott AI (2001) Bioorg Med Chem 9:2237
174. Reiling KK, Yoshikuni Y, Martin VJJ, Newman J, Bohlmann J, Keasling JD (2004) Biotechnol Bioeng 87:200
175. Martin VJJ, Yoshikuni Y, Keasling JD (2001) Biotechnol Bioeng 75:497
176. Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Nat Biotechnol 21:796
177. Wang C-W, Oh M-K, Liao JC (2000) Biotechnol Prog 16:922
178. Matthews PD, Wurtzel ET (2000) Appl Microbiol Biot 53:396
179. Harker M, Bramley PM (1999) FEBS Lett 448:115
180. Kim S-W, Keasling JD (2001) Biotechnol Bioeng 72:408
181. Albrecht M, Misawa N, Sandmann G (1999) Biotechnol Lett 21:791
182. Kingston DGI (2001) Chem Commun 1:867
183. Sandmann G (2001) Trends Plant Sci 6:14
184. Ruther A, Misawa N, Böger P, Sandmann G (1997) Appl Microbiol Biot 48:162
185. Farmer WR, Liao JC (2001) Biotechnol Prog 17:57
186. Wang G-Y, Keasling JD (2002) Metab Eng 4:193
187. Jackson BE, Hart-Wells EA, Matsuda SPT (2003) Org Lett 5:1629
188. Tapiero H, Townsend DM, Tew KD (2004) Biomed Pharmacother 58:100
189. Nishino H (1998) Mutat Res 402:159
190. Johnson EJ (2002) Nutr Clin Care 5:56
191. Cooper DA, Eldridge AL, Peters JC (1999) Nutr Rev 57:201
192. Albrecht M, Takaichi S, Misawa N, Schnurr G, Böger P, Sandmann G (1997) J Biotechnol 58:177
193. Albrecht M, Takaichi S, Steiger S, Wang Z-Y, Sandmann G (2000) Nat Biotechnol 18:843
194. Yokoyama A, Shizuri Y, Misawa N (1998) Tetrahedron Lett 39:3709
195. Steiger S, Takaichi S, Sandmann G (2002) J Biotechnol 97:51
196. Schmidt-Dannert C, Umeno D, Arnold FH (2000) Nat Biotechnol 18:750
197. Carter OA, Peters RJ, Croteau R (2003) Phytochem 64:425
198. Misawa N, Yamano S, Ikenaga H (1991) Appl Environ Microbiol 57:1847
199. Edwards JS, Palsson BØ (2000) Proc Natl Acad Sci USA 97:5528
200. Reed JL, Vo TD, Schilling CH, Palsson BØ (2003) Genome Biol 4:54
201. Förster J, Famili I, Fu P, Palsson BØ, Nielsen J (2003) Genome Res 13:244
202. Patil KR, Åkesson M, Nielsen J (2004) Curr Opin Biotechnol 15:64