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This article reviews discoveries related to the linker regions that allow certain polypeptides of Type I processive PKSs to interact only with others to form a protein channel for substrates and puts these interactions into the context of other well-known protein-protein interfaces
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Tsuji S.Y., Wu N., Khosla C. Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins. Biochemistry. 40:2001;2317-2325. This article reviews discoveries related to the linker regions that allow certain polypeptides of Type I processive PKSs to interact only with others to form a protein channel for substrates and puts these interactions into the context of other well-known protein-protein interfaces.
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This provocative set of experiments suggests that PKSs containing a second TE-type protein have evolved a mechanism for editing misprimed ACP domains and thereby maintain high macrolide production levels
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Insights about the biosynthesis of the avermectin deoxysugar l-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans
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Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway
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