Expansion of the clavulanic acid gene cluster: Identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus

Journal of Bacteriology

Volumn 182, Issue 14, 2000, Pages 4087-4095

  Li, Rongfeng ^a   Khaleeli, Nusrat ^a   Townsend, Craig A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLAVULANIC ACID; CYTOCHROME P450; HYDROGENASE;

ARTICLE; DNA FLANKING REGION; DRUG SYNTHESIS; GENE CLUSTER; GENE FUNCTION; GENE LOCATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STREPTOMYCES CLAVULIGERUS;

AMINO ACID SEQUENCE; BASE SEQUENCE; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CLAVULANIC ACID; CYTOCHROME P-450 ENZYME SYSTEM; FERREDOXINS; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, INSERTIONAL; OPEN READING FRAMES; RESTRICTION MAPPING; SEQUENCE ANALYSIS, DNA; STREPTOMYCES;

PROKARYOTA; STREPTOMYCES CLAVULIGERUS;

EID: 0033933826     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.14.4087-4095.2000     Document Type: Article

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