메뉴 건너뛰기




Volumn 25, Issue 5, 2013, Pages 323-333

An epithelial armamentarium to sense the microbiota

Author keywords

Intestinal epithelial cells; Microbiota; Nod like receptors; Pattern recognition receptors; Toll like receptors

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CHEMOKINE RECEPTOR CCR9; INTERLEUKIN 10; INTERLEUKIN 6; KERATINOCYTE GROWTH FACTOR; PATTERN RECOGNITION RECEPTOR; SECRETORY IMMUNOGLOBULIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; UVOMORULIN;

EID: 84888866750     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2013.09.007     Document Type: Review
Times cited : (15)

References (196)
  • 1
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • Mowat A.M., Viney J.L. The anatomical basis of intestinal immunity. Immunological Reviews 1997, 156:145-166.
    • (1997) Immunological Reviews , vol.156 , pp. 145-166
    • Mowat, A.M.1    Viney, J.L.2
  • 2
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • O'Hara A.M., Shanahan F. The gut flora as a forgotten organ. EMBO Reports 2006, 7:688-693.
    • (2006) EMBO Reports , vol.7 , pp. 688-693
    • O'Hara, A.M.1    Shanahan, F.2
  • 3
    • 77958170401 scopus 로고    scopus 로고
    • Intestinal goblet cells and mucins in health and disease: recent insights and progress
    • Kim Y.S., Ho S.B. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Current Gastroenterology Reports 2010, 12:319-330.
    • (2010) Current Gastroenterology Reports , vol.12 , pp. 319-330
    • Kim, Y.S.1    Ho, S.B.2
  • 4
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole J.R., Wheeler L.W., McDonald K.G., Wang B., Konjufca V., Knoop K.A., et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 2012, 483:345-349.
    • (2012) Nature , vol.483 , pp. 345-349
    • McDole, J.R.1    Wheeler, L.W.2    McDonald, K.G.3    Wang, B.4    Konjufca, V.5    Knoop, K.A.6
  • 5
    • 84873672050 scopus 로고    scopus 로고
    • Paneth cells: maestros of the small intestinal crypts
    • Clevers H.C., Bevins C.L. Paneth cells: maestros of the small intestinal crypts. Annual Review of Physiology 2013, 75:289-311.
    • (2013) Annual Review of Physiology , vol.75 , pp. 289-311
    • Clevers, H.C.1    Bevins, C.L.2
  • 7
    • 35548974423 scopus 로고    scopus 로고
    • Identification of stem cells in small intestine and colon by marker gene Lgr5
    • Barker N., van Es J.H., Kuipers J., Kujala P., van den Born M., Cozijnsen M., et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007, 449:1003-1007.
    • (2007) Nature , vol.449 , pp. 1003-1007
    • Barker, N.1    van Es, J.H.2    Kuipers, J.3    Kujala, P.4    van den Born, M.5    Cozijnsen, M.6
  • 8
    • 0016325705 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian Theory of the origin of the four epithelial cell types
    • Cheng H., Leblond C.P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian Theory of the origin of the four epithelial cell types. American Journal of Anatomy 1974, 141:537-561.
    • (1974) American Journal of Anatomy , vol.141 , pp. 537-561
    • Cheng, H.1    Leblond, C.P.2
  • 9
    • 84871635651 scopus 로고    scopus 로고
    • Nod-like receptors in intestinal host defense: controlling pathogens, the microbiota, or both?
    • Robertson S.J., Girardin S.E. Nod-like receptors in intestinal host defense: controlling pathogens, the microbiota, or both?. Current Opinion in Gastroenterology 2012, 29:15-22.
    • (2012) Current Opinion in Gastroenterology , vol.29 , pp. 15-22
    • Robertson, S.J.1    Girardin, S.E.2
  • 10
    • 33745463739 scopus 로고    scopus 로고
    • A comprehensive map of the toll-like receptor signaling network
    • Oda K., Kitano H. A comprehensive map of the toll-like receptor signaling network. Molecular Systems Biology 2006, 2.
    • (2006) Molecular Systems Biology , vol.2
    • Oda, K.1    Kitano, H.2
  • 11
    • 1842583729 scopus 로고    scopus 로고
    • Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    • Otte J.-M., Cario E., Podolsky D.K. Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 2004, 126:1054-1070.
    • (2004) Gastroenterology , vol.126 , pp. 1054-1070
    • Otte, J.-M.1    Cario, E.2    Podolsky, D.K.3
  • 12
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infection and Immunity 2000, 68:7010-7017.
    • (2000) Infection and Immunity , vol.68 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 13
    • 0038781673 scopus 로고    scopus 로고
    • Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex
    • Suzuki M., Hisamatsu T., Podolsky D.K. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infection and Immunity 2003, 71:3503-3511.
    • (2003) Infection and Immunity , vol.71 , pp. 3503-3511
    • Suzuki, M.1    Hisamatsu, T.2    Podolsky, D.K.3
  • 14
    • 0037036469 scopus 로고    scopus 로고
    • TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
    • Abreu M.T., Arnold E.T., Thomas L.S., Gonsky R., Zhou Y., Hu B., et al. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. Journal of Biological Chemistry 2002, 277:2043-2047.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 2043-2047
    • Abreu, M.T.1    Arnold, E.T.2    Thomas, L.S.3    Gonsky, R.4    Zhou, Y.5    Hu, B.6
  • 15
    • 34248397191 scopus 로고    scopus 로고
    • Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA
    • Ewaschuk J.B., Backer J.L., Churchill T.A., Obermeier F., Krause D.O., Madsen K.L. Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA. Infection and Immunity 2007, 75:2572-2579.
    • (2007) Infection and Immunity , vol.75 , pp. 2572-2579
    • Ewaschuk, J.B.1    Backer, J.L.2    Churchill, T.A.3    Obermeier, F.4    Krause, D.O.5    Madsen, K.L.6
  • 16
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004, 118:229-241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 17
    • 80054122238 scopus 로고    scopus 로고
    • The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine
    • Vaishnava S., Yamamoto M., Severson K.M., Ruhn K.A., Yu X., Koren O., et al. The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (New York, NY) 2011, 334:255-258.
    • (2011) Science (New York, NY) , vol.334 , pp. 255-258
    • Vaishnava, S.1    Yamamoto, M.2    Severson, K.M.3    Ruhn, K.A.4    Yu, X.5    Koren, O.6
  • 18
    • 84864886608 scopus 로고    scopus 로고
    • Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides
    • Frantz A.L., Rogier E.W., Weber C.R., Shen L., Cohen D.A., Fenton L.A., et al. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunology 2012, 5:501-512.
    • (2012) Mucosal Immunology , vol.5 , pp. 501-512
    • Frantz, A.L.1    Rogier, E.W.2    Weber, C.R.3    Shen, L.4    Cohen, D.A.5    Fenton, L.A.6
  • 19
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001, 411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6
  • 20
    • 77954314592 scopus 로고    scopus 로고
    • Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation
    • Gong J., Xu J., Zhu W., Gao X., Li N., Li J. Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation. Clinical Immunology (Orlando, FL) 2010, 136:245-256.
    • (2010) Clinical Immunology (Orlando, FL) , vol.136 , pp. 245-256
    • Gong, J.1    Xu, J.2    Zhu, W.3    Gao, X.4    Li, N.5    Li, J.6
  • 21
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot J.P., Chamaillard M., Zouali H., Lesage S., Cézard J.P., Belaiche J., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cézard, J.P.5    Belaiche, J.6
  • 22
    • 0042858341 scopus 로고    scopus 로고
    • Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells
    • Hisamatsu T., Suzuki M., Podolsky D.K. Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells. Journal of Biological Chemistry 2003, 278:3296-3298.
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 3296-3298
    • Hisamatsu, T.1    Suzuki, M.2    Podolsky, D.K.3
  • 24
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci A., Becker C., Wullaert A., Gareus R., van Loo G., Danese S., et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 2007, 446:557-561.
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1    Becker, C.2    Wullaert, A.3    Gareus, R.4    van Loo, G.5    Danese, S.6
  • 25
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C., Troy A.E., Taylor B.C., Berman-Booty L.D., Guild K.J., Du Y., et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007, 446:552-556.
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3    Berman-Booty, L.D.4    Guild, K.J.5    Du, Y.6
  • 28
    • 84876861178 scopus 로고    scopus 로고
    • Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense
    • Hu G., Gong A.-Y., Roth A.L., Huang B.Q., Ward H.D., Zhu G., et al. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. PLoS Pathogens 2013, 9:e1003-e1261.
    • (2013) PLoS Pathogens , vol.9
    • Hu, G.1    Gong, A.-Y.2    Roth, A.L.3    Huang, B.Q.4    Ward, H.D.5    Zhu, G.6
  • 31
    • 33748271299 scopus 로고    scopus 로고
    • Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    • Fukata M., Chen A., Klepper A., Krishnareddy S., Vamadevan A.S., Thomas L.S., et al. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology 2006, 131:862-877.
    • (2006) Gastroenterology , vol.131 , pp. 862-877
    • Fukata, M.1    Chen, A.2    Klepper, A.3    Krishnareddy, S.4    Vamadevan, A.S.5    Thomas, L.S.6
  • 35
    • 77954559878 scopus 로고    scopus 로고
    • The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
    • Hernandez Y., Sotolongo J., Breglio K., Conduah D., Chen A., Xu R., et al. The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterology 2010, 10:82.
    • (2010) BMC Gastroenterology , vol.10 , pp. 82
    • Hernandez, Y.1    Sotolongo, J.2    Breglio, K.3    Conduah, D.4    Chen, A.5    Xu, R.6
  • 36
    • 36549082403 scopus 로고    scopus 로고
    • Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    • Fukata M., Chen A., Vamadevan A.S., Cohen J., Breglio K., Krishnareddy S., et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 2007, 133:1869-1881.
    • (2007) Gastroenterology , vol.133 , pp. 1869-1881
    • Fukata, M.1    Chen, A.2    Vamadevan, A.S.3    Cohen, J.4    Breglio, K.5    Krishnareddy, S.6
  • 37
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • Fukata M., Shang L., Santaolalla R., Sotolongo J., Pastorini C., España C., et al. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflammatory Bowel Diseases 2011, 17:1464-1473.
    • (2011) Inflammatory Bowel Diseases , vol.17 , pp. 1464-1473
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5    España, C.6
  • 38
    • 33646374141 scopus 로고    scopus 로고
    • Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
    • Khan M.A., Ma C., Knodler L.A., Valdez Y., Rosenberger C.M., Deng W., et al. Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice. Infection and Immunity 2006, 74:2522-2536.
    • (2006) Infection and Immunity , vol.74 , pp. 2522-2536
    • Khan, M.A.1    Ma, C.2    Knodler, L.A.3    Valdez, Y.4    Rosenberger, C.M.5    Deng, W.6
  • 40
    • 84865464872 scopus 로고    scopus 로고
    • Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice
    • 708-18.e1-5
    • Sodhi C.P., Neal M.D., Siggers R., Sho S., Ma C., Branca M.F., et al. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology 2012, 143. 708-18.e1-5.
    • (2012) Gastroenterology , vol.143
    • Sodhi, C.P.1    Neal, M.D.2    Siggers, R.3    Sho, S.4    Ma, C.5    Branca, M.F.6
  • 41
    • 84875469082 scopus 로고    scopus 로고
    • A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis
    • Neal M.D., Sodhi C.P., Dyer M., Craig B.T., Good M., Jia H., et al. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis. Journal of Immunology (Baltimore, Md.: 1950) 2013, 190:3451-3551.
    • (2013) Journal of Immunology (Baltimore, Md.: 1950) , vol.190 , pp. 3451-3551
    • Neal, M.D.1    Sodhi, C.P.2    Dyer, M.3    Craig, B.T.4    Good, M.5    Jia, H.6
  • 45
    • 22744453319 scopus 로고    scopus 로고
    • Toll-like receptors-2 -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria
    • Microbiology & Gut Biology Group, Tayside Tissue & Tumour Bank
    • Furrie E., Macfarlane S., Thomson G., Macfarlane G.T. Toll-like receptors-2 -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 2005, 115:565-574. Microbiology & Gut Biology Group, Tayside Tissue & Tumour Bank.
    • (2005) Immunology , vol.115 , pp. 565-574
    • Furrie, E.1    Macfarlane, S.2    Thomson, G.3    Macfarlane, G.T.4
  • 48
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • Podolsky D.K., Gerken G., Eyking A., Cario E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 2009, 137:209-220.
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 49
    • 77958610178 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
    • Lowe E.L., Crother T.R., Rabizadeh S., Hu B., Wang H., Chen S., et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS ONE 2010, 5:e13027.
    • (2010) PLoS ONE , vol.5
    • Lowe, E.L.1    Crother, T.R.2    Rabizadeh, S.3    Hu, B.4    Wang, H.5    Chen, S.6
  • 51
    • 38049174332 scopus 로고    scopus 로고
    • Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis
    • Gibson D.L., Ma C., Rosenberger C.M., Bergstrom K.S.B., Valdez Y., Huang J.T., et al. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cellular Microbiology 2007, 10:388-403.
    • (2007) Cellular Microbiology , vol.10 , pp. 388-403
    • Gibson, D.L.1    Ma, C.2    Rosenberger, C.M.3    Bergstrom, K.S.B.4    Valdez, Y.5    Huang, J.T.6
  • 52
    • 77957364734 scopus 로고    scopus 로고
    • Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling
    • Gibson D.L., Montero M., Ropeleski M.J., Bergstrom K.S.B., Ma C., Ghosh S., et al. Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling. Gastroenterology 2010, 139:1277-1288.
    • (2010) Gastroenterology , vol.139 , pp. 1277-1288
    • Gibson, D.L.1    Montero, M.2    Ropeleski, M.J.3    Bergstrom, K.S.B.4    Ma, C.5    Ghosh, S.6
  • 53
    • 33748493563 scopus 로고    scopus 로고
    • Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis
    • Watanabe T., Kitani A., Murray P.J., Wakatsuki Y., Fuss I.J., Strober W. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 2006, 25:473-485.
    • (2006) Immunity , vol.25 , pp. 473-485
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Wakatsuki, Y.4    Fuss, I.J.5    Strober, W.6
  • 54
    • 3242692641 scopus 로고    scopus 로고
    • Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    • Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 2004, 127:224-238.
    • (2004) Gastroenterology , vol.127 , pp. 224-238
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 55
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132:1359-1374.
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 56
    • 69249109191 scopus 로고    scopus 로고
    • TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    • Ey B., Eyking A., Gerken G., Podolsky D.K., Cario E. TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. Journal of Biological Chemistry 2009, 284:22332-22343.
    • (2009) Journal of Biological Chemistry , vol.284 , pp. 22332-22343
    • Ey, B.1    Eyking, A.2    Gerken, G.3    Podolsky, D.K.4    Cario, E.5
  • 57
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001, 410:1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3    Hawn, T.R.4    Yi, E.C.5    Goodlett, D.R.6
  • 58
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz A.T., Navas T.A., Lyons S., Godowski P.J., Madara J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Journal of Immunology (Baltimore, Md.: 1950) 2001, 167:1882-1885.
    • (2001) Journal of Immunology (Baltimore, Md.: 1950) , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 59
    • 5644248031 scopus 로고    scopus 로고
    • In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    • Bambou J.-C., Giraud A., Ménard S., Begue B., Rakotobe S., Heyman M., et al. In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain. Journal of Biological Chemistry 2004, 279:42984-42992.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 42984-42992
    • Bambou, J.-C.1    Giraud, A.2    Ménard, S.3    Begue, B.4    Rakotobe, S.5    Heyman, M.6
  • 60
    • 4844224383 scopus 로고    scopus 로고
    • Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells
    • Tallant T., Deb A., Kar N., Lupica J., de Veer M.J., DiDonato J.A. Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiology 2004, 4:33.
    • (2004) BMC Microbiology , vol.4 , pp. 33
    • Tallant, T.1    Deb, A.2    Kar, N.3    Lupica, J.4    de Veer, M.J.5    DiDonato, J.A.6
  • 61
    • 33745868678 scopus 로고    scopus 로고
    • Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
    • Rhee S.H., Kim H., Moyer M.P., Pothoulakis C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. Journal of Biological Chemistry 2006, 281:18560-18568.
    • (2006) Journal of Biological Chemistry , vol.281 , pp. 18560-18568
    • Rhee, S.H.1    Kim, H.2    Moyer, M.P.3    Pothoulakis, C.4
  • 62
  • 63
    • 80052839279 scopus 로고    scopus 로고
    • Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism
    • Eaves-Pyles T., Bu H.-F., Tan X.-D., Cong Y., Patel J., Davey R.A., et al. Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism. PLoS ONE 2011, 6:e24869.
    • (2011) PLoS ONE , vol.6
    • Eaves-Pyles, T.1    Bu, H.-F.2    Tan, X.-D.3    Cong, Y.4    Patel, J.5    Davey, R.A.6
  • 66
    • 0037238970 scopus 로고    scopus 로고
    • Intestinal epithelial toll-like receptors: to protect. And serve?
    • Gewirtz A.T. Intestinal epithelial toll-like receptors: to protect. And serve?. Current Pharmaceutical Design 2003, 9:1-5.
    • (2003) Current Pharmaceutical Design , vol.9 , pp. 1-5
    • Gewirtz, A.T.1
  • 68
    • 84876098777 scopus 로고    scopus 로고
    • A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin
    • Sheridan J., Mack D.R., Amre D.K., Israel D.M., Cherkasov A., Li H., et al. A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. PLoS ONE 2013, 8:e61326.
    • (2013) PLoS ONE , vol.8
    • Sheridan, J.1    Mack, D.R.2    Amre, D.K.3    Israel, D.M.4    Cherkasov, A.5    Li, H.6
  • 69
    • 83555166070 scopus 로고    scopus 로고
    • Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice
    • Hardenberg G., Yao Y., Piccirillo C.A., Levings M.K., Steiner T.S. Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflammatory Bowel Diseases 2012, 18:85-93.
    • (2012) Inflammatory Bowel Diseases , vol.18 , pp. 85-93
    • Hardenberg, G.1    Yao, Y.2    Piccirillo, C.A.3    Levings, M.K.4    Steiner, T.S.5
  • 70
  • 71
    • 0032768352 scopus 로고    scopus 로고
    • Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease
    • Boudeau J., Glasser A.L., Masseret E., Joly B., Darfeuille-Michaud A. Invasive ability of an Escherichia coli strain isolated from the ileal mucosa of a patient with Crohn's disease. Infection and Immunity 1999, 67:4499-4509.
    • (1999) Infection and Immunity , vol.67 , pp. 4499-4509
    • Boudeau, J.1    Glasser, A.L.2    Masseret, E.3    Joly, B.4    Darfeuille-Michaud, A.5
  • 76
    • 78649545020 scopus 로고    scopus 로고
    • TLR5 activation induces secretory interleukin-1 receptor antagonist (sIL-1Ra) and reduces inflammasome-associated tissue damage
    • Carvalho F.A., Aitken J.D., Gewirtz A.T., Vijay-Kumar M. TLR5 activation induces secretory interleukin-1 receptor antagonist (sIL-1Ra) and reduces inflammasome-associated tissue damage. Mucosal Immunology 2010, 4:102-111.
    • (2010) Mucosal Immunology , vol.4 , pp. 102-111
    • Carvalho, F.A.1    Aitken, J.D.2    Gewirtz, A.T.3    Vijay-Kumar, M.4
  • 77
    • 0034469910 scopus 로고    scopus 로고
    • Physiologic role of interleukin-1 receptor antagonist
    • Arend W.P., Gabay C. Physiologic role of interleukin-1 receptor antagonist. Arthritis Research 2000, 2:245-248.
    • (2000) Arthritis Research , vol.2 , pp. 245-248
    • Arend, W.P.1    Gabay, C.2
  • 78
    • 84857049212 scopus 로고    scopus 로고
    • Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
    • Carvalho F.A., Nalbantoglu I., Ortega-Fernandez S., Aitken J.D., Su Y., Koren O., et al. Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 2012, 61:373-384.
    • (2012) Gut , vol.61 , pp. 373-384
    • Carvalho, F.A.1    Nalbantoglu, I.2    Ortega-Fernandez, S.3    Aitken, J.D.4    Su, Y.5    Koren, O.6
  • 80
    • 52549099416 scopus 로고    scopus 로고
    • Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin
    • Lightfield K.L., Persson J., Brubaker S.W., Witte C.E., Moltke von J., Dunipace E.A., et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunology 2008, 9:1171-1178.
    • (2008) Nature Immunology , vol.9 , pp. 1171-1178
    • Lightfield, K.L.1    Persson, J.2    Brubaker, S.W.3    Witte, C.E.4    Moltke von, J.5    Dunipace, E.A.6
  • 81
    • 33749576792 scopus 로고    scopus 로고
    • Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
    • Fink S.L., Cookson B.T. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cellular Microbiology 2006, 8:1812-1825.
    • (2006) Cellular Microbiology , vol.8 , pp. 1812-1825
    • Fink, S.L.1    Cookson, B.T.2
  • 83
    • 84859911615 scopus 로고    scopus 로고
    • NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense
    • Franchi L., Kamada N., Nakamura Y., Burberry A., Kuffa P., Suzuki S., et al. NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nature Immunology 2012, 13:449-456.
    • (2012) Nature Immunology , vol.13 , pp. 449-456
    • Franchi, L.1    Kamada, N.2    Nakamura, Y.3    Burberry, A.4    Kuffa, P.5    Suzuki, S.6
  • 88
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee J., Mo J.-H., Katakura K., Alkalay I., Rucker A.N., Liu Y.-T., et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nature Cell Biology 2006, 8:1327-1336.
    • (2006) Nature Cell Biology , vol.8 , pp. 1327-1336
    • Lee, J.1    Mo, J.-H.2    Katakura, K.3    Alkalay, I.4    Rucker, A.N.5    Liu, Y.-T.6
  • 89
    • 77149150067 scopus 로고    scopus 로고
    • Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells
    • Ghadimi D., Vrese M.de, Heller K.J., Schrezenmeir J. Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells. Inflammatory Bowel Diseases 2010, 16:410-427.
    • (2010) Inflammatory Bowel Diseases , vol.16 , pp. 410-427
    • Ghadimi, D.1    Vrese, M.2    Heller, K.J.3    Schrezenmeir, J.4
  • 90
    • 79952184248 scopus 로고    scopus 로고
    • Ligation of intestinal epithelial cells drives a Th1-polarized regulatory or inflammatory type effector response in vitro
    • de Kivit S., van Hoffen E., Korthagen N., Garssen J., Willemsen L.E.M., Apical T.L.R. ligation of intestinal epithelial cells drives a Th1-polarized regulatory or inflammatory type effector response in vitro. Immunobiology 2011, 216:518-527.
    • (2011) Immunobiology , vol.216 , pp. 518-527
    • de Kivit, S.1    van Hoffen, E.2    Korthagen, N.3    Garssen, J.4    Willemsen, L.E.M.5    Apical, T.L.R.6
  • 92
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D., Katakura K., Karmeli F., Hayashi T., Reinus C., Rudensky B., et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004, 126:520-528.
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3    Hayashi, T.4    Reinus, C.5    Rudensky, B.6
  • 96
    • 84866058423 scopus 로고    scopus 로고
    • TLR9 is important for protection against intestinal damage and for intestinal repair
    • Rose W.A., Sakamoto K., Leifer C.A. TLR9 is important for protection against intestinal damage and for intestinal repair. Scientific Reports 2012, 2:574.
    • (2012) Scientific Reports , vol.2 , pp. 574
    • Rose, W.A.1    Sakamoto, K.2    Leifer, C.A.3
  • 101
    • 0036828844 scopus 로고    scopus 로고
    • Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation
    • Gutierrez O., Pipaon C., Inohara N., Fontalba A., Ogura Y., Prosper F., et al. Induction of Nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation. Journal of Biological Chemistry 2002, 277:41701-41705.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 41701-41705
    • Gutierrez, O.1    Pipaon, C.2    Inohara, N.3    Fontalba, A.4    Ogura, Y.5    Prosper, F.6
  • 102
    • 0037379915 scopus 로고    scopus 로고
    • TNF-α and IFN-β regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • Rosenstiel P., Fantini M., Bräutigam K., Kühbacher T., Waetzig G.H., Seegert D., et al. TNF-α and IFN-β regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 2003, 124:1001-1009.
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Bräutigam, K.3    Kühbacher, T.4    Waetzig, G.H.5    Seegert, D.6
  • 103
    • 31944437924 scopus 로고    scopus 로고
    • Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
    • Masumoto J., Yang K., Varambally S., Hasegawa M., Tomlins S.A., Qiu S., et al. Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. Journal of Experimental Medicine 2006, 203:203-213.
    • (2006) Journal of Experimental Medicine , vol.203 , pp. 203-213
    • Masumoto, J.1    Yang, K.2    Varambally, S.3    Hasegawa, M.4    Tomlins, S.A.5    Qiu, S.6
  • 104
    • 84868277964 scopus 로고    scopus 로고
    • Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide
    • Huang F.-C. Regulation of Salmonella flagellin-induced interleukin-8 in intestinal epithelial cells by muramyl dipeptide. Cellular Immunology 2012, 278:1-9.
    • (2012) Cellular Immunology , vol.278 , pp. 1-9
    • Huang, F.-C.1
  • 105
    • 1342344961 scopus 로고    scopus 로고
    • Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors
    • Kim J.G., Lee S.J., Kagnoff M.F. Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infection and Immunity 2004, 72:1487-1495.
    • (2004) Infection and Immunity , vol.72 , pp. 1487-1495
    • Kim, J.G.1    Lee, S.J.2    Kagnoff, M.F.3
  • 106
    • 33749266363 scopus 로고    scopus 로고
    • Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop
    • Begue B., Dumant C., Bambou J.C., Beaulieu J.F., Chamaillard M., Hugot J.P., et al. Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop. Journal of Cellular Physiology 2006, 209:241-252.
    • (2006) Journal of Cellular Physiology , vol.209 , pp. 241-252
    • Begue, B.1    Dumant, C.2    Bambou, J.C.3    Beaulieu, J.F.4    Chamaillard, M.5    Hugot, J.P.6
  • 107
    • 17944380130 scopus 로고    scopus 로고
    • CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri
    • Girardin S.E., Tournebize R., Mavris M., Page A.L., Li X., Stark G.R., et al. CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Reports 2001, 2:736-742.
    • (2001) EMBO Reports , vol.2 , pp. 736-742
    • Girardin, S.E.1    Tournebize, R.2    Mavris, M.3    Page, A.L.4    Li, X.5    Stark, G.R.6
  • 108
    • 9244245293 scopus 로고    scopus 로고
    • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    • Viala J., Chaput C., Boneca I.G., Cardona A., Girardin S.E., Moran A.P., et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nature Immunology 2004, 5:1166-1174.
    • (2004) Nature Immunology , vol.5 , pp. 1166-1174
    • Viala, J.1    Chaput, C.2    Boneca, I.G.3    Cardona, A.4    Girardin, S.E.5    Moran, A.P.6
  • 109
    • 79955048935 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen
    • Hasegawa M., Yamazaki T., Kamada N., Tawaratsumida K., Kim Y.-G., Núñez G., et al. Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. Journal of Immunology (Baltimore, Md.: 1950) 2011, 186:4872-4880.
    • (2011) Journal of Immunology (Baltimore, Md.: 1950) , vol.186 , pp. 4872-4880
    • Hasegawa, M.1    Yamazaki, T.2    Kamada, N.3    Tawaratsumida, K.4    Kim, Y.-G.5    Núñez, G.6
  • 110
    • 34548425221 scopus 로고    scopus 로고
    • A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni
    • Zilbauer M., Dorrell N., Elmi A., Lindley K.J., Schüller S., Jones H.E., et al. A major role for intestinal epithelial nucleotide oligomerization domain 1 (NOD1) in eliciting host bactericidal immune responses to Campylobacter jejuni. Cellular Microbiology 2007, 9:2404-2416.
    • (2007) Cellular Microbiology , vol.9 , pp. 2404-2416
    • Zilbauer, M.1    Dorrell, N.2    Elmi, A.3    Lindley, K.J.4    Schüller, S.5    Jones, H.E.6
  • 111
    • 84873651671 scopus 로고    scopus 로고
    • Vibrio cholerae O395 outer membrane vesicles modulate intestinal epithelial cells in a NOD1 protein-dependent manner and induce dendritic cell-mediated Th2/Th17 cell responses
    • Chatterjee D., Chaudhuri K. Vibrio cholerae O395 outer membrane vesicles modulate intestinal epithelial cells in a NOD1 protein-dependent manner and induce dendritic cell-mediated Th2/Th17 cell responses. Journal of Biological Chemistry 2013, 288:4299-4309.
    • (2013) Journal of Biological Chemistry , vol.288 , pp. 4299-4309
    • Chatterjee, D.1    Chaudhuri, K.2
  • 113
    • 10744222688 scopus 로고    scopus 로고
    • Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis
    • Ogura Y., Lala S., Xin W., Smith E., Dowds T.A., Chen F.F., et al. Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 2003, 52:1591-1597.
    • (2003) Gut , vol.52 , pp. 1591-1597
    • Ogura, Y.1    Lala, S.2    Xin, W.3    Smith, E.4    Dowds, T.A.5    Chen, F.F.6
  • 115
    • 80052580369 scopus 로고    scopus 로고
    • Nod2 is essential for temporal development of intestinal microbial communities
    • Rehman A., Sina C., Gavrilova O., Häsler R., Ott S., Baines J.F., et al. Nod2 is essential for temporal development of intestinal microbial communities. Gut 2011, 60:1354-1362.
    • (2011) Gut , vol.60 , pp. 1354-1362
    • Rehman, A.1    Sina, C.2    Gavrilova, O.3    Häsler, R.4    Ott, S.5    Baines, J.F.6
  • 116
  • 119
    • 84877292277 scopus 로고    scopus 로고
    • Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis
    • Robertson S.J., Zhou J.Y., Geddes K., Rubino S.J., Cho J.H., Girardin S.E., et al. Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis. Gut Microbes 2013, 4:222-231.
    • (2013) Gut Microbes , vol.4 , pp. 222-231
    • Robertson, S.J.1    Zhou, J.Y.2    Geddes, K.3    Rubino, S.J.4    Cho, J.H.5    Girardin, S.E.6
  • 124
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav E., Strowig T., Kau A.L., Henao-Mejia J., Thaiss C.A., Booth C.J., et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3    Henao-Mejia, J.4    Thaiss, C.A.5    Booth, C.J.6
  • 125
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
    • Henao-Mejia J., Elinav E., Jin C., Hao L., Mehal W.Z., Strowig T., et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012, 482:179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3    Hao, L.4    Mehal, W.Z.5    Strowig, T.6
  • 126
    • 84876713274 scopus 로고    scopus 로고
    • Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice
    • Sun Y., Zhang M., Chen C.C., Gillilland M., Sun X., Zaatari El M., et al. Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology 2013, 144:1478-1487.
    • (2013) Gastroenterology , vol.144 , pp. 1478-1487
    • Sun, Y.1    Zhang, M.2    Chen, C.C.3    Gillilland, M.4    Sun, X.5    Zaatari El, M.6
  • 127
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu M.T., Vora P., Faure E., Thomas L.S., Arnold E.T., Arditi M. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. Journal of Immunology (Baltimore, Md.: 1950) 2001, 167:1609-1616.
    • (2001) Journal of Immunology (Baltimore, Md.: 1950) , vol.167 , pp. 1609-1616
    • Abreu, M.T.1    Vora, P.2    Faure, E.3    Thomas, L.S.4    Arnold, E.T.5    Arditi, M.6
  • 128
    • 77952381089 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis
    • Vamadevan A.S., Fukata M., Arnold E.T., Thomas L.S., Hsu D., Abreu M.T. Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis. Innate Immunity 2010, 16:93-103.
    • (2010) Innate Immunity , vol.16 , pp. 93-103
    • Vamadevan, A.S.1    Fukata, M.2    Arnold, E.T.3    Thomas, L.S.4    Hsu, D.5    Abreu, M.T.6
  • 130
    • 39149129371 scopus 로고    scopus 로고
    • MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells
    • Lenoir C., Sapin C., Broquet A.H., Jouniaux A.-M., Bardin S., Gasnereau I., et al. MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells. Life Sciences 2008, 82:519-528.
    • (2008) Life Sciences , vol.82 , pp. 519-528
    • Lenoir, C.1    Sapin, C.2    Broquet, A.H.3    Jouniaux, A.-M.4    Bardin, S.5    Gasnereau, I.6
  • 131
    • 78650150386 scopus 로고    scopus 로고
    • Sera from patients with Crohn's disease break bacterial lipopolysaccharide tolerance of human intestinal epithelial cells via MD-2 activity
    • Seksik P., Sokol H., Grondin V., Adrie C., Duboc H., Pigneur B., et al. Sera from patients with Crohn's disease break bacterial lipopolysaccharide tolerance of human intestinal epithelial cells via MD-2 activity. Innate Immunity 2010, 16:381-390.
    • (2010) Innate Immunity , vol.16 , pp. 381-390
    • Seksik, P.1    Sokol, H.2    Grondin, V.3    Adrie, C.4    Duboc, H.5    Pigneur, B.6
  • 134
    • 0037307854 scopus 로고    scopus 로고
    • Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut
    • Melmed G., Thomas L.S., Lee N., Tesfay S.Y., Lukasek K., Michelsen K.S., et al. Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. Journal of Immunology (Baltimore, Md.: 1950) 2003, 170:1406-1415.
    • (2003) Journal of Immunology (Baltimore, Md.: 1950) , vol.170 , pp. 1406-1415
    • Melmed, G.1    Thomas, L.S.2    Lee, N.3    Tesfay, S.Y.4    Lukasek, K.5    Michelsen, K.S.6
  • 135
    • 21644477461 scopus 로고    scopus 로고
    • SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
    • Qin J., Qian Y., Yao J., Grace C., Li X. SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms. Journal of Biological Chemistry 2005, 280:25233-25241.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 25233-25241
    • Qin, J.1    Qian, Y.2    Yao, J.3    Grace, C.4    Li, X.5
  • 136
    • 78649287637 scopus 로고    scopus 로고
    • Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation
    • Kadota C., Ishihara S., Aziz M.M., Rumi M.A., Oshima N., Mishima Y., et al. Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation. Clinical and Experimental Immunology 2010, 162:348-361.
    • (2010) Clinical and Experimental Immunology , vol.162 , pp. 348-361
    • Kadota, C.1    Ishihara, S.2    Aziz, M.M.3    Rumi, M.A.4    Oshima, N.5    Mishima, Y.6
  • 137
    • 34247175428 scopus 로고    scopus 로고
    • The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
    • Xiao H., Gulen M.F., Qin J., Yao J., Bulek K., Kish D., et al. The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis. Immunity 2007, 26:461-475.
    • (2007) Immunity , vol.26 , pp. 461-475
    • Xiao, H.1    Gulen, M.F.2    Qin, J.3    Yao, J.4    Bulek, K.5    Kish, D.6
  • 138
    • 33645843063 scopus 로고    scopus 로고
    • Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells
    • Lotz M. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. Journal of Experimental Medicine 2006, 203:973-984.
    • (2006) Journal of Experimental Medicine , vol.203 , pp. 973-984
    • Lotz, M.1
  • 139
    • 84860324915 scopus 로고    scopus 로고
    • Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium
    • Afrazi A., Sodhi C.P., Good M., Jia H., Siggers R., Yazji I., et al. Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. Journal of Immunology (Baltimore, Md.: 1950) 2012, 188:4543-4557.
    • (2012) Journal of Immunology (Baltimore, Md.: 1950) , vol.188 , pp. 4543-4557
    • Afrazi, A.1    Sodhi, C.P.2    Good, M.3    Jia, H.4    Siggers, R.5    Yazji, I.6
  • 140
    • 77955909527 scopus 로고    scopus 로고
    • NF-kappaB-mediated expression of MAPK phosphatase-1 is an early step in desensitization to TLR ligands in enterocytes
    • Wang J., Ford H.R., Grishin A.V. NF-kappaB-mediated expression of MAPK phosphatase-1 is an early step in desensitization to TLR ligands in enterocytes. Mucosal Immunology 2010, 3:523-534.
    • (2010) Mucosal Immunology , vol.3 , pp. 523-534
    • Wang, J.1    Ford, H.R.2    Grishin, A.V.3
  • 142
    • 77958105934 scopus 로고    scopus 로고
    • MiR-146a mediates protective innate immune tolerance in the neonate intestine
    • Chassin C., Kocur M., Pott J., Duerr C.U., Gütle D., Lotz M., et al. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host and Microbe 2010, 8:358-368.
    • (2010) Cell Host and Microbe , vol.8 , pp. 358-368
    • Chassin, C.1    Kocur, M.2    Pott, J.3    Duerr, C.U.4    Gütle, D.5    Lotz, M.6
  • 143
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • Artis D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nature Reviews Immunology 2008, 8:411-420.
    • (2008) Nature Reviews Immunology , vol.8 , pp. 411-420
    • Artis, D.1
  • 144
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno M., Urbano M., Valzasina B., Francolini M., Rotta G., Bonasio R., et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunology 2001, 2:361-367.
    • (2001) Nature Immunology , vol.2 , pp. 361-367
    • Rescigno, M.1    Urbano, M.2    Valzasina, B.3    Francolini, M.4    Rotta, G.5    Bonasio, R.6
  • 145
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess J.H., Brand S., Gu X., Landsman L., Jung S., McCormick B.A., et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science (New York, NY) 2005, 307:254-258.
    • (2005) Science (New York, NY) , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3    Landsman, L.4    Jung, S.5    McCormick, B.A.6
  • 147
    • 82155183271 scopus 로고    scopus 로고
    • In vivo structure/function and expression analysis of the CX3C chemokine fractalkine
    • Kim K.W., Vallon-Eberhard A., Zigmond E., Farache J., Shezen E., Shakhar G., et al. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood 2011, 118:e156-e167.
    • (2011) Blood , vol.118
    • Kim, K.W.1    Vallon-Eberhard, A.2    Zigmond, E.3    Farache, J.4    Shezen, E.5    Shakhar, G.6
  • 148
    • 84856815290 scopus 로고    scopus 로고
    • Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    • Rivollier A., He J., Kole A., Valatas V., Kelsall B.L. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. Journal of Experimental Medicine 2012, 209:139-155.
    • (2012) Journal of Experimental Medicine , vol.209 , pp. 139-155
    • Rivollier, A.1    He, J.2    Kole, A.3    Valatas, V.4    Kelsall, B.L.5
  • 149
    • 77952794397 scopus 로고    scopus 로고
    • Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
    • Varol C., Zigmond E., Jung S. Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nature Reviews Immunology 2010, 10:415-426.
    • (2010) Nature Reviews Immunology , vol.10 , pp. 415-426
    • Varol, C.1    Zigmond, E.2    Jung, S.3
  • 151
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol C., Vallon-Eberhard A., Elinav E., Aychek T., Shapira Y., Luche H., et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 2009, 31:502-512.
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1    Vallon-Eberhard, A.2    Elinav, E.3    Aychek, T.4    Shapira, Y.5    Luche, H.6
  • 152
    • 73949107838 scopus 로고    scopus 로고
    • Intestinal CD103+ but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    • Schulz O., Jaensson E., Persson E.K., Liu X., Worbs T., Agace W.W., et al. Intestinal CD103+ but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. Journal of Experimental Medicine 2009, 206:3101-3114.
    • (2009) Journal of Experimental Medicine , vol.206 , pp. 3101-3114
    • Schulz, O.1    Jaensson, E.2    Persson, E.K.3    Liu, X.4    Worbs, T.5    Agace, W.W.6
  • 153
    • 77949911050 scopus 로고    scopus 로고
    • Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    • Niess J.H., Adler G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. Journal of Immunology (Baltimore, Md.: 1950) 2010, 184:2026-2037.
    • (2010) Journal of Immunology (Baltimore, Md.: 1950) , vol.184 , pp. 2026-2037
    • Niess, J.H.1    Adler, G.2
  • 154
    • 79951790272 scopus 로고    scopus 로고
    • CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions
    • Weber B., Saurer L., Schenk M., Dickgreber N., Mueller C. CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. European Journal of Immunology 2011, 41:773-779.
    • (2011) European Journal of Immunology , vol.41 , pp. 773-779
    • Weber, B.1    Saurer, L.2    Schenk, M.3    Dickgreber, N.4    Mueller, C.5
  • 155
    • 79951772860 scopus 로고    scopus 로고
    • Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    • Hadis U., Wahl B., Schulz O., Hardtke-Wolenski M., Schippers A., Wagner N., et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 2011, 34:237-246.
    • (2011) Immunity , vol.34 , pp. 237-246
    • Hadis, U.1    Wahl, B.2    Schulz, O.3    Hardtke-Wolenski, M.4    Schippers, A.5    Wagner, N.6
  • 156
    • 84874688283 scopus 로고    scopus 로고
    • Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells
    • Diehl G.E., Longman R.S., Zhang J.X., Breart B., Galan C., Cuesta A., et al. Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 2013, 494:116-120.
    • (2013) Nature , vol.494 , pp. 116-120
    • Diehl, G.E.1    Longman, R.S.2    Zhang, J.X.3    Breart, B.4    Galan, C.5    Cuesta, A.6
  • 157
    • 84870900504 scopus 로고    scopus 로고
    • Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    • Zigmond E., Varol C., Farache J., Elmaliah E., Satpathy A.T., Friedlander G., et al. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 2012, 37:1076-1090.
    • (2012) Immunity , vol.37 , pp. 1076-1090
    • Zigmond, E.1    Varol, C.2    Farache, J.3    Elmaliah, E.4    Satpathy, A.T.5    Friedlander, G.6
  • 158
    • 69549084637 scopus 로고    scopus 로고
    • A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells
    • Fortin G., Raymond M., Van V.Q., Rubio M., Gautier P., Sarfati M., et al. A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells. Journal of Experimental Medicine 2009, 206:1995-2011.
    • (2009) Journal of Experimental Medicine , vol.206 , pp. 1995-2011
    • Fortin, G.1    Raymond, M.2    Van, V.Q.3    Rubio, M.4    Gautier, P.5    Sarfati, M.6
  • 160
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. Journal of Experimental Medicine 2007, 204:1757-1764.
    • (2007) Journal of Experimental Medicine , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6
  • 161
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid. Journal of Experimental Medicine 2007, 204:1775-1785.
    • (2007) Journal of Experimental Medicine , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 163
    • 33645054315 scopus 로고    scopus 로고
    • Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    • Worbs T., Bode U., Yan S., Hoffmann M.W., Hintzen G., Bernhardt G., et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. Journal of Experimental Medicine 2006, 203:519-527.
    • (2006) Journal of Experimental Medicine , vol.203 , pp. 519-527
    • Worbs, T.1    Bode, U.2    Yan, S.3    Hoffmann, M.W.4    Hintzen, G.5    Bernhardt, G.6
  • 165
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • Kinnebrew M.A., Buffie C.G., Diehl G.E., Zenewicz L.A., Leiner I., Hohl T.M., et al. Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 2012, 36:276-287.
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1    Buffie, C.G.2    Diehl, G.E.3    Zenewicz, L.A.4    Leiner, I.5    Hohl, T.M.6
  • 166
    • 27144526644 scopus 로고    scopus 로고
    • Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different
    • Rimoldi M., Chieppa M., Larghi P., Vulcano M., Allavena P., Rescigno M. Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different. Blood 2005, 106:2818-2826.
    • (2005) Blood , vol.106 , pp. 2818-2826
    • Rimoldi, M.1    Chieppa, M.2    Larghi, P.3    Vulcano, M.4    Allavena, P.5    Rescigno, M.6
  • 167
    • 77951897845 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus
    • Hanabuchi S., Ito T., Park W.R., Watanabe N., Shaw J.L., Roman E., et al. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. Journal of Immunology (Baltimore, Md.: 1950) 2010, 184:2999-3007.
    • (2010) Journal of Immunology (Baltimore, Md.: 1950) , vol.184 , pp. 2999-3007
    • Hanabuchi, S.1    Ito, T.2    Park, W.R.3    Watanabe, N.4    Shaw, J.L.5    Roman, E.6
  • 168
    • 67649243735 scopus 로고    scopus 로고
    • Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
    • Iliev I.D., Mileti E., Matteoli G., Chieppa M., Rescigno M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal Immunology 2009, 2:340-350.
    • (2009) Mucosal Immunology , vol.2 , pp. 340-350
    • Iliev, I.D.1    Mileti, E.2    Matteoli, G.3    Chieppa, M.4    Rescigno, M.5
  • 169
    • 80051904734 scopus 로고    scopus 로고
    • Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation
    • Reardon C., Lechmann M., Brustle A., Gareau M.G., Shuman N., Philpott D., et al. Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity 2011, 35:223-235.
    • (2011) Immunity , vol.35 , pp. 223-235
    • Reardon, C.1    Lechmann, M.2    Brustle, A.3    Gareau, M.G.4    Shuman, N.5    Philpott, D.6
  • 170
    • 18244387204 scopus 로고    scopus 로고
    • Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    • Rimoldi M., Chieppa M., Salucci V., Avogadri F., Sonzogni A., Sampietro G.M., et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nature Immunology 2005, 6:507-514.
    • (2005) Nature Immunology , vol.6 , pp. 507-514
    • Rimoldi, M.1    Chieppa, M.2    Salucci, V.3    Avogadri, F.4    Sonzogni, A.5    Sampietro, G.M.6
  • 171
  • 172
    • 79959664629 scopus 로고    scopus 로고
    • The light and dark sides of intestinal intraepithelial lymphocytes
    • Cheroutre H., Lambolez F., Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes. Nature Reviews Immunology 2011, 11:445-456.
    • (2011) Nature Reviews Immunology , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 174
    • 0029131501 scopus 로고
    • Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium
    • Lundqvist C., Baranov V., Hammarstrom S., Athlin L., Hammarstrom M.L. Intra-epithelial lymphocytes. Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. International Immunology 1995, 7:1473-1487.
    • (1995) International Immunology , vol.7 , pp. 1473-1487
    • Lundqvist, C.1    Baranov, V.2    Hammarstrom, S.3    Athlin, L.4    Hammarstrom, M.L.5
  • 175
    • 0034741125 scopus 로고    scopus 로고
    • Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE)
    • Shires J., Theodoridis E., Hayday A.C. Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 2001, 15:419-434.
    • (2001) Immunity , vol.15 , pp. 419-434
    • Shires, J.1    Theodoridis, E.2    Hayday, A.C.3
  • 176
  • 177
    • 0037020246 scopus 로고    scopus 로고
    • A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes
    • Mysorekar I.U., Lorenz R.G., Gordon J.I. A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes. Journal of Biological Chemistry 2002, 277:37811-37819.
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 37811-37819
    • Mysorekar, I.U.1    Lorenz, R.G.2    Gordon, J.I.3
  • 178
    • 0028675005 scopus 로고
    • Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis
    • Puddington L., Olson S., Lefrancois L. Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis. Immunity 1994, 1:733-739.
    • (1994) Immunity , vol.1 , pp. 733-739
    • Puddington, L.1    Olson, S.2    Lefrancois, L.3
  • 179
    • 1842731811 scopus 로고    scopus 로고
    • Acquired and natural memory T cells join forces at the mucosal front line
    • Cheroutre H., Madakamutil L. Acquired and natural memory T cells join forces at the mucosal front line. Nature Reviews Immunology 2004, 4:290-300.
    • (2004) Nature Reviews Immunology , vol.4 , pp. 290-300
    • Cheroutre, H.1    Madakamutil, L.2
  • 180
    • 0033986966 scopus 로고    scopus 로고
    • The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
    • Wurbel M.A., Philippe J.M., Nguyen C., Victorero G., Freeman T., Wooding P., et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. European Journal of Immunology 2000, 30:262-271.
    • (2000) European Journal of Immunology , vol.30 , pp. 262-271
    • Wurbel, M.A.1    Philippe, J.M.2    Nguyen, C.3    Victorero, G.4    Freeman, T.5    Wooding, P.6
  • 181
    • 0033231492 scopus 로고    scopus 로고
    • Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
    • Zabel B.A., Agace W.W., Campbell J.J., Heath H.M., Parent D., Roberts A.I., et al. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. Journal of Experimental Medicine 1999, 190:1241-1256.
    • (1999) Journal of Experimental Medicine , vol.190 , pp. 1241-1256
    • Zabel, B.A.1    Agace, W.W.2    Campbell, J.J.3    Heath, H.M.4    Parent, D.5    Roberts, A.I.6
  • 182
    • 0027944111 scopus 로고
    • Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin
    • Cepek K.L., Shaw S.K., Parker C.M., Russell G.J., Morrow J.S., Rimm D.L., et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature 1994, 372:190-193.
    • (1994) Nature , vol.372 , pp. 190-193
    • Cepek, K.L.1    Shaw, S.K.2    Parker, C.M.3    Russell, G.J.4    Morrow, J.S.5    Rimm, D.L.6
  • 183
    • 0025039030 scopus 로고
    • A new surface antigen on intraepithelial lymphocytes in the intestine
    • Kilshaw P.J., Murant S.J. A new surface antigen on intraepithelial lymphocytes in the intestine. European Journal of Immunology 1990, 20:2201-2207.
    • (1990) European Journal of Immunology , vol.20 , pp. 2201-2207
    • Kilshaw, P.J.1    Murant, S.J.2
  • 186
    • 2442685319 scopus 로고    scopus 로고
    • DNA fragmentation and detachment of enterocytes induced by anti-CD3 mAb-activated intraepithelial lymphocytes
    • Yaguchi K., Kayaba S., Soga H., Yamagishi M., Tamura A., Kasahara S., et al. DNA fragmentation and detachment of enterocytes induced by anti-CD3 mAb-activated intraepithelial lymphocytes. Cell and Tissue Research 2004, 315:71-84.
    • (2004) Cell and Tissue Research , vol.315 , pp. 71-84
    • Yaguchi, K.1    Kayaba, S.2    Soga, H.3    Yamagishi, M.4    Tamura, A.5    Kasahara, S.6
  • 188
    • 84870252354 scopus 로고    scopus 로고
    • New concepts in the generation and functions of IgA
    • Pabst O. New concepts in the generation and functions of IgA. Nature Reviews Immunology 2012, 12:821-832.
    • (2012) Nature Reviews Immunology , vol.12 , pp. 821-832
    • Pabst, O.1
  • 189
    • 0018092512 scopus 로고
    • Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin
    • Moreau M.C., Ducluzeau R., Guy-Grand D., Muller M.C. Increase in the population of duodenal immunoglobulin A plasmocytes in axenic mice associated with different living or dead bacterial strains of intestinal origin. Infection and Immunity 1978, 21:532-539.
    • (1978) Infection and Immunity , vol.21 , pp. 532-539
    • Moreau, M.C.1    Ducluzeau, R.2    Guy-Grand, D.3    Muller, M.C.4
  • 190
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D., Brézillon C., Bérard M., Werts C., Varona R., Boneca I.G., et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 2008, 456:507-510.
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1    Brézillon, C.2    Bérard, M.3    Werts, C.4    Varona, R.5    Boneca, I.G.6
  • 191
    • 48749091530 scopus 로고    scopus 로고
    • Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    • Tsuji M., Suzuki K., Kitamura H., Maruya M., Kinoshita K., Ivanov I.I., et al. Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut. Immunity 2008, 29:261-271.
    • (2008) Immunity , vol.29 , pp. 261-271
    • Tsuji, M.1    Suzuki, K.2    Kitamura, H.3    Maruya, M.4    Kinoshita, K.5    Ivanov, I.I.6
  • 192
    • 48549103766 scopus 로고    scopus 로고
    • Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
    • Shang L., Fukata M., Thirunarayanan N., Martin A.P., Arnaboldi P., Maussang D., et al. Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology 2008, 135:529-538.e1.
    • (2008) Gastroenterology , vol.135
    • Shang, L.1    Fukata, M.2    Thirunarayanan, N.3    Martin, A.P.4    Arnaboldi, P.5    Maussang, D.6
  • 193
    • 0344507499 scopus 로고    scopus 로고
    • Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells
    • Goodrich M.E., McGee D.W. Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells. Immunology Letters 1999, 67:11-14.
    • (1999) Immunology Letters , vol.67 , pp. 11-14
    • Goodrich, M.E.1    McGee, D.W.2
  • 194
    • 34250205694 scopus 로고    scopus 로고
    • Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    • He B., Xu W., Santini P.A., Polydorides A.D., Chiu A., Estrella J., et al. Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 2007, 26:812-826.
    • (2007) Immunity , vol.26 , pp. 812-826
    • He, B.1    Xu, W.2    Santini, P.A.3    Polydorides, A.D.4    Chiu, A.5    Estrella, J.6
  • 195
    • 79952812916 scopus 로고    scopus 로고
    • Disparate effects of bacteria and Toll-like receptor-dependant bacterial ligand stimulation on immunoglobulin A transcytosis
    • Diebel L.N., Liberati D.M. Disparate effects of bacteria and Toll-like receptor-dependant bacterial ligand stimulation on immunoglobulin A transcytosis. Journal of Trauma 2011, 70:691-700.
    • (2011) Journal of Trauma , vol.70 , pp. 691-700
    • Diebel, L.N.1    Liberati, D.M.2
  • 196
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science (New York, NY) 2004, 303:1662-1665.
    • (2004) Science (New York, NY) , vol.303 , pp. 1662-1665
    • Macpherson, A.J.1    Uhr, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.