-
1
-
-
85027927719
-
Enterotypes of the human gut microbiome
-
Arumugam M, et al. Enterotypes of the human gut microbiome. Nature. 2011;473(7346):174-180.
-
(2011)
Nature
, vol.473
, Issue.7346
, pp. 174-180
-
-
Arumugam, M.1
-
2
-
-
46249085739
-
Evolution of mammals and their gut microbes
-
Ley RE, et al. Evolution of mammals and their gut microbes. Science. 2008;320(5883):1647-1651.
-
(2008)
Science
, vol.320
, Issue.5883
, pp. 1647-1651
-
-
Ley, R.E.1
-
3
-
-
76249120134
-
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
-
Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med. 2010;16(2):228-231.
-
(2010)
Nat Med.
, vol.16
, Issue.2
, pp. 228-231
-
-
Clarke, T.B.1
Davis, K.M.2
Lysenko, E.S.3
Zhou, A.Y.4
Yu, Y.5
Weiser, J.N.6
-
4
-
-
77950353786
-
Homeostasis and inflammation in the intestine
-
Garrett WS, Gordon JI, Glimcher LH. Homeostasis and inflammation in the intestine. Cell. 2010;140(6):859-870.
-
(2010)
Cell
, vol.140
, Issue.6
, pp. 859-870
-
-
Garrett, W.S.1
Gordon, J.I.2
Glimcher, L.H.3
-
5
-
-
0030119726
-
Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice
-
Kandori H, Hirayama K, Takeda M, Doi K. Histochemical, lectin-histochemical and morphometrical characteristics of intestinal goblet cells of germfree and conventional mice. Exp Anim. 1996;45(2):155-160.
-
(1996)
Exp Anim.
, vol.45
, Issue.2
, pp. 155-160
-
-
Kandori, H.1
Hirayama, K.2
Takeda, M.3
Doi, K.4
-
6
-
-
33750818632
-
Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling
-
Pabst O, et al. Adaptation of solitary intestinal lymphoid tissue in response to microbiota and chemokine receptor CCR7 signaling. J Immunol. 2006;177(10):6824-6832.
-
(2006)
J Immunol.
, vol.177
, Issue.10
, pp. 6824-6832
-
-
Pabst, O.1
-
7
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331(6015):337-341.
-
(2011)
Science
, vol.331
, Issue.6015
, pp. 337-341
-
-
Atarashi, K.1
-
8
-
-
77955383804
-
An innately dangerous balancing act: Intestinal homeostasis, inflammation, and colitis-associated cancer
-
Asquith M, Powrie F. An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J Exp Med. 2010;207(8):1573-1577.
-
(2010)
J Exp Med.
, vol.207
, Issue.8
, pp. 1573-1577
-
-
Asquith, M.1
Powrie, F.2
-
9
-
-
33750932588
-
Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease
-
Scanlan PD, Shanahan F, O'Mahony C, Marchesi JR. Culture-independent analyses of temporal variation of the dominant fecal microbiota and targeted bacterial subgroups in Crohn's disease. J Clin Microbiol. 2006;44(11):3980-3988.
-
(2006)
J Clin Microbiol.
, vol.44
, Issue.11
, pp. 3980-3988
-
-
Scanlan, P.D.1
Shanahan, F.2
O'Mahony, C.3
Marchesi, J.R.4
-
10
-
-
30944466824
-
Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
-
Manichanh C, et al. Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut. 2006;55(2):205-211.
-
(2006)
Gut.
, vol.55
, Issue.2
, pp. 205-211
-
-
Manichanh, C.1
-
11
-
-
79953748870
-
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives
-
Joossens M, et al. Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives. Gut. 2011;60(5):631-637.
-
(2011)
Gut.
, vol.60
, Issue.5
, pp. 631-637
-
-
Joossens, M.1
-
13
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411(6837):599-603.
-
(2001)
Nature
, vol.411
, Issue.6837
, pp. 599-603
-
-
Hugot, J.P.1
-
14
-
-
0035897904
-
Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
-
Hampe J, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet. 2001;357(9272):1925- 1928.
-
(2001)
Lancet
, vol.357
, Issue.9272
, pp. 1925-1928
-
-
Hampe, J.1
-
15
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411(6837):603-606.
-
(2001)
Nature
, vol.411
, Issue.6837
, pp. 603-606
-
-
Ogura, Y.1
-
16
-
-
38849163741
-
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
-
Watanabe T, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest. 2008;118(2):545-559.
-
(2008)
J Clin Invest.
, vol.118
, Issue.2
, pp. 545-559
-
-
Watanabe, T.1
-
17
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi KS, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005;307(5710):731-734.
-
(2005)
Science
, vol.307
, Issue.5710
, pp. 731-734
-
-
Kobayashi, K.S.1
-
18
-
-
79960131814
-
Identification of an innate T helper type 17 response to intestinal bacterial pathogens
-
Geddes K, et al. Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med. 2011;17(7):837-844.
-
(2011)
Nat Med.
, vol.17
, Issue.7
, pp. 837-844
-
-
Geddes, K.1
-
19
-
-
39149094587
-
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
-
Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity. 2008;28(2):246-257.
-
(2008)
Immunity
, vol.28
, Issue.2
, pp. 246-257
-
-
Kim, Y.G.1
Park, J.H.2
Shaw, M.H.3
Franchi, L.4
Inohara, N.5
Nunez, G.6
-
20
-
-
0041827164
-
Nods, Nalps and Naip: Intracellular regulators of bacterial-induced inflammation
-
Chamaillard M, Girardin SE, Viala J, Philpott DJ. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol. 2003;5(9):581-592.
-
(2003)
Cell Microbiol.
, vol.5
, Issue.9
, pp. 581-592
-
-
Chamaillard, M.1
Girardin, S.E.2
Viala, J.3
Philpott, D.J.4
-
21
-
-
70349468054
-
Nod2 is required for the regulation of commensal microbiota in the intestine
-
Petnicki-Ocwieja T, et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci U S A. 2009;106(37):15813-15818.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.37
, pp. 15813-15818
-
-
Petnicki-Ocwieja, T.1
-
22
-
-
80052580369
-
Nod2 is essential for temporal development of intestinal microbial communities
-
Rehman A, et al. Nod2 is essential for temporal development of intestinal microbial communities. Gut. 2011;60(10):1354-1362.
-
(2011)
Gut.
, vol.60
, Issue.10
, pp. 1354-1362
-
-
Rehman, A.1
-
23
-
-
84857798453
-
Altered gut microbiota composition in immune-impaired Nod2 (-/-) mice
-
Mondot S, et al. Altered gut microbiota composition in immune-impaired Nod2 (-/-) mice. Gut. 2012;61(4):634-635.
-
(2012)
Gut.
, vol.61
, Issue.4
, pp. 634-635
-
-
Mondot, S.1
-
24
-
-
78650099360
-
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
-
Frank DN, et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis. 2011;17(1):179-184.
-
(2011)
Inflamm Bowel Dis.
, vol.17
, Issue.1
, pp. 179-184
-
-
Frank, D.N.1
-
25
-
-
34548764423
-
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
-
Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol. 2007;8(10):1086-1094.
-
(2007)
Nat Immunol.
, vol.8
, Issue.10
, pp. 1086-1094
-
-
Denning, T.L.1
Wang, Y.C.2
Patel, S.R.3
Williams, I.R.4
Pulendran, B.5
-
26
-
-
34848889673
-
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
-
Garrett WS, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131(1):33-45.
-
(2007)
Cell
, vol.131
, Issue.1
, pp. 33-45
-
-
Garrett, W.S.1
-
27
-
-
33845658661
-
Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice
-
Lieu HT, et al. Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology. 2006;44(6):1452-1464.
-
(2006)
Hepatology
, vol.44
, Issue.6
, pp. 1452-1464
-
-
Lieu, H.T.1
-
28
-
-
67650474246
-
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
-
Pickert G, et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009;206(7):1465-1472.
-
(2009)
J Exp Med.
, vol.206
, Issue.7
, pp. 1465-1472
-
-
Pickert, G.1
-
29
-
-
67650330166
-
Carcinogenesis in IBD: Potential targets for the prevention of colorectal cancer
-
Feagins LA, Souza RF, Spechler SJ. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat Rev Gastroenterol Hepatol. 2009;6(5):297-305.
-
(2009)
Nat Rev Gastroenterol Hepatol.
, vol.6
, Issue.5
, pp. 297-305
-
-
Feagins, L.A.1
Souza, R.F.2
Spechler, S.J.3
-
30
-
-
33745033287
-
Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection
-
Rosenstiel P, et al. Influence of polymorphisms in the NOD1/CARD4 and NOD2/CARD15 genes on the clinical outcome of Helicobacter pylori infection. Cell Microbiol. 2006;8(7):1188-1198.
-
(2006)
Cell Microbiol.
, vol.8
, Issue.7
, pp. 1188-1198
-
-
Rosenstiel, P.1
-
31
-
-
70749146442
-
Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer
-
Mockelmann N, et al. Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC Gastroenterol. 2009;9:79.
-
(2009)
BMC Gastroenterol.
, vol.9
, pp. 79
-
-
Mockelmann, N.1
-
32
-
-
34548162712
-
An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression
-
Neufert C, Becker C, Neurath MF. An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression. Nat Protoc. 2007;2(8):1998-2004.
-
(2007)
Nat Protoc.
, vol.2
, Issue.8
, pp. 1998-2004
-
-
Neufert, C.1
Becker, C.2
Neurath, M.F.3
-
33
-
-
58649101347
-
Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath J, et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell. 2009;15(2):91-102.
-
(2009)
Cancer Cell
, vol.15
, Issue.2
, pp. 91-102
-
-
Bollrath, J.1
-
34
-
-
58649108302
-
IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, et al. IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009;15(2):103-113.
-
(2009)
Cancer Cell
, vol.15
, Issue.2
, pp. 103-113
-
-
Grivennikov, S.1
-
35
-
-
0034193039
-
IL-6 is required for the development of Th1 cell-mediated murine colitis
-
Yamamoto M, Yoshizaki K, Kishimoto T, Ito H. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol. 2000;164(9):4878- 4882.
-
(2000)
J Immunol.
, vol.164
, Issue.9
, pp. 4878-4882
-
-
Yamamoto, M.1
Yoshizaki, K.2
Kishimoto, T.3
Ito, H.4
-
36
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav E, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145(5):745-757.
-
(2011)
Cell
, vol.145
, Issue.5
, pp. 745-757
-
-
Elinav, E.1
-
37
-
-
84864270714
-
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
-
Hashimoto T, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 2012;487(7408):477-481.
-
(2012)
Nature
, vol.487
, Issue.7408
, pp. 477-481
-
-
Hashimoto, T.1
-
38
-
-
33845995125
-
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
-
Zeissig S, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut. 2007;56(1):61-72.
-
(2007)
Gut.
, vol.56
, Issue.1
, pp. 61-72
-
-
Zeissig, S.1
-
39
-
-
38649115342
-
Microbial influences in inflammatory bowel diseases
-
Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008;134(2):577-594.
-
(2008)
Gastroenterology
, vol.134
, Issue.2
, pp. 577-594
-
-
Sartor, R.B.1
-
40
-
-
15544369658
-
Host-bacterial mutualism in the human intestine
-
Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science. 2005;307(5717):1915-1920.
-
(2005)
Science
, vol.307
, Issue.5717
, pp. 1915-1920
-
-
Backhed, F.1
Ley, R.E.2
Sonnenburg, J.L.3
Peterson, D.A.4
Gordon, J.I.5
-
41
-
-
79956078164
-
Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease
-
Bloom SM, et al. Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. Cell Host Microbe. 2011;9(5):390-403.
-
(2011)
Cell Host Microbe.
, vol.9
, Issue.5
, pp. 390-403
-
-
Bloom, S.M.1
-
42
-
-
77950290164
-
Remote control of intestinal tumorigenesis by innate immunity
-
Secher T, Gaillot O, Ryffel B, Chamaillard M. Remote control of intestinal tumorigenesis by innate immunity. Cancer Res. 2010;70(5):1749-1752.
-
(2010)
Cancer Res.
, vol.70
, Issue.5
, pp. 1749-1752
-
-
Secher, T.1
Gaillot, O.2
Ryffel, B.3
Chamaillard, M.4
-
43
-
-
84860216630
-
Microbial exposure during early life has persistent effects on natural killer T cell function
-
Olszak T, et al. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012;336(6080):489-493.
-
(2012)
Science
, vol.336
, Issue.6080
, pp. 489-493
-
-
Olszak, T.1
-
44
-
-
12144287610
-
The NOD2 3020insC mutation and the risk of colorectal cancer
-
Kurzawski G, et al. The NOD2 3020insC mutation and the risk of colorectal cancer. Cancer Res. 2004;64(5):1604-1606.
-
(2004)
Cancer Res.
, vol.64
, Issue.5
, pp. 1604-1606
-
-
Kurzawski, G.1
-
45
-
-
14044261247
-
Association between mutations in the C ARD15/NOD2 gene and colorectal cancer in a Greek population
-
Papaconstantinou I, et al. Association between mutations in the C ARD15/NOD2 gene and colorectal cancer in a Greek population. Int J Cancer. 2005;114(3):433-435.
-
(2005)
Int J Cancer
, vol.114
, Issue.3
, pp. 433-435
-
-
Papaconstantinou, I.1
-
46
-
-
33645074918
-
Caspase recruitment domain-containing protein 15 mutations in patients with colorectal cancer
-
Roberts RL, Gearry RB, Allington MD, Morrin HR, Robinson BA, Frizelle FA. Caspase recruitment domain-containing protein 15 mutations in patients with colorectal cancer. Cancer Res. 2006;66(5):2532-2535.
-
(2006)
Cancer Res.
, vol.66
, Issue.5
, pp. 2532-2535
-
-
Roberts, R.L.1
Gearry, R.B.2
Allington, M.D.3
Morrin, H.R.4
Robinson, B.A.5
Frizelle, F.A.6
-
47
-
-
1842586664
-
Mucosal cytokine production during remission after resection for Crohn's disease and its relationship to future relapse
-
Yamamoto T, Umegae S, Kitagawa T, Matsumoto K. Mucosal cytokine production during remission after resection for Crohn's disease and its relationship to future relapse. Aliment Pharmacol Ther. 2004;19(6):671-678.
-
(2004)
Aliment Pharmacol Ther.
, vol.19
, Issue.6
, pp. 671-678
-
-
Yamamoto, T.1
Umegae, S.2
Kitagawa, T.3
Matsumoto, K.4
-
48
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in crohn disease and experimental colitis in vivo
-
Atreya R, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. 2000;6(5):583-588.
-
(2000)
Nat Med.
, vol.6
, Issue.5
, pp. 583-588
-
-
Atreya, R.1
-
49
-
-
80052358980
-
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
-
Jones SA, Scheller J, Rose-John S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 2011;121(9):3375-3383.
-
(2011)
J Clin Invest.
, vol.121
, Issue.9
, pp. 3375-3383
-
-
Jones, S.A.1
Scheller, J.2
Rose-John, S.3
-
50
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga T, et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989;58(3):573-581.
-
(1989)
Cell
, vol.58
, Issue.3
, pp. 573-581
-
-
Taga, T.1
-
51
-
-
79959369355
-
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
-
Normand S, et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011;108(23):9601-9606.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.23
, pp. 9601-9606
-
-
Normand, S.1
-
52
-
-
0033028596
-
Systematic determination of genetic network architecture
-
Tavazoie S, Hughes JD, Campbell MJ, Cho RJ, Church GM. Systematic determination of genetic network architecture. Nat Genet. 1999;22(3):281-285.
-
(1999)
Nat Genet.
, vol.22
, Issue.3
, pp. 281-285
-
-
Tavazoie, S.1
Hughes, J.D.2
Campbell, M.J.3
Cho, R.J.4
Church, G.M.5
-
53
-
-
38449084962
-
Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue
-
Weigmann B, Tubbe I, Seidel D, Nicolaev A, Becker C, Neurath MF. Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue. Nat Protoc. 2007;2(10):2307-2311.
-
(2007)
Nat Protoc.
, vol.2
, Issue.10
, pp. 2307-2311
-
-
Weigmann, B.1
Tubbe, I.2
Seidel, D.3
Nicolaev, A.4
Becker, C.5
Neurath, M.F.6
|