Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Eaves Pyles, Tonyia ^a   Bu, Heng Fu ^b   Tan, Xiao di ^b   Cong, Yingzi ^a   Patel, Jignesh ^a   Davey, Robert A ^a   Strasser, Jane E ^c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; FLUORESCEIN; INTERLEUKIN 8; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 5; BIOLOGICAL MARKER; SMALL INTERFERING RNA;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BACTERIAL VIRULENCE; BASOLATERAL MEMBRANE; CELL LINE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENDOSOME; ESCHERICHIA COLI; ESCHERICHIA COLI K 12; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; INNATE IMMUNITY; INTERNALIZATION; INTESTINE EPITHELIUM CELL; LYSOSOME; MONOLAYER CULTURE; NEUTROPHIL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; SALMONELLA; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; ANIMAL; CELL MOTION; CELL POLARITY; CYTOLOGY; DRUG EFFECT; ENDOCYTOSIS; IMMUNOLOGY; INFLAMMATION; INTESTINE CELL; INTRACELLULAR SPACE; LYMPHOCYTE; METABOLISM; PATHOLOGY; RAT; SALMONELLA TYPHIMURIUM; SECRETION;

ESCHERICHIA COLI; SALMONELLA;

ANIMALS; BIOLOGICAL MARKERS; CELL MOVEMENT; CELL POLARITY; ENDOCYTOSIS; ENDOSOMES; ENTEROCYTES; FLAGELLIN; HUMANS; INFLAMMATION; INTERLEUKIN-8; INTRACELLULAR SPACE; LYMPHOCYTES; LYSOSOMES; RATS; RNA, SMALL INTERFERING; SALMONELLA TYPHIMURIUM; TOLL-LIKE RECEPTOR 5;

EID: 80052839279     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024869     Document Type: Article

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