A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 296, Issue 6, 2009, Pages

  Ungaro, Ryan ^b   Fukata, Masayuki ^a   Hsu, David ^b   Hernandez, Yasmin ^b   Breglio, Keith ^b   Chen, Anli ^b   Xu, Ruliang ^b   Sotolongo, John ^a   Espana, Cecillia ^a   Zaias, Julia ^a   Elson, Greg ^c   Mayer, Lloyd ^b   Kosco Vilbois, Marie ^c   Abreu, Maria T ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NOVIMMUNE SA   (Switzerland)

Author keywords

Antigen presenting cells; Inflammatory bowel disease; Innate immunity

Indexed keywords

AMPHIREGULIN; CD45RB ANTIGEN; CYCLOOXYGENASE 2; DEXTRAN SULFATE; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROSTAGLANDIN E2; PROTEIN MD 2; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 ANTAGONIST ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL ISOLATION; COLITIS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN-PRESENTING CELLS; BACTERIAL TRANSLOCATION; CELL MOVEMENT; CELL PROLIFERATION; CHEMOKINES; COLITIS; CYCLOOXYGENASE 2; CYTOKINES; DEXTRAN SULFATE; DINOPROSTONE; EPITHELIAL CELLS; FEMALE; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; LYMPH NODES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REGENERATION; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

EID: 67049095880     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90496.2008     Document Type: Article

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