Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria

Science

Volumn 303, Issue 5664, 2004, Pages 1662-1665

  Macpherson, Andrew J ^a   Uhr, Therese ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; IMMUNOLOGY;

MACROPHAGES; PATHOGENIC BACTERIA;

CELLS;

IMMUNOGLOBULIN A;

BACTERIUM; BIOLOGY;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BACTERIUM CULTURE; COMMENSALISM; CONTROLLED STUDY; DENDRITIC CELL; ENTEROBACTER CLOACAE; FLUORESCENCE ACTIVATED CELL SORTING; HOST RESISTANCE; IMMUNE SYSTEM; INTESTINE MUCOSA; MACROPHAGE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SPLEEN;

ANIMALS; ANTIGEN PRESENTATION; B-LYMPHOCYTES; BACTERIA; DENDRITIC CELLS; ENTEROBACTER CLOACAE; GERM-FREE LIFE; IMMUNITY, MUCOSAL; IMMUNITY, NATURAL; IMMUNOGLOBULIN A; INTESTINAL MUCOSA; INTESTINES; LEUKOCYTES; LYMPH NODES; MACROPHAGES; MESENTERY; MICE; MICE, INBRED C57BL; PEYER'S PATCHES; PHAGOCYTOSIS; SALMONELLA TYPHIMURIUM; SPECIFIC PATHOGEN-FREE ORGANISMS; SPLEEN;

ANIMALIA; BACTERIA (MICROORGANISMS); ENTEROBACTER; ENTEROBACTER CLOACAE; SALMONELLA TYPHIMURIUM; VERTEBRATA;

EID: 1542618118     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1091334     Document Type: Article

References (17)

1. A. J. Macpherson, L. Hunziker, K. McCoy, A. Lamarre, Microbes Infect. 3, 1021 (2001).
2. L. V. Hooper et al., Science 291, 881 (2001).
3. R. D. Berg, Trends Microbiol. 4, 430 (1996).
4. S. Fagarasan et al., Science 298, 1424 (2002).
5. Methods are available as supporting material on Science Online.
6. A. J. Macpherson, unpublished data
7. C. L. Wells, M. A. Maddaus, R. L. Simmons, Rev. Infect. Dis. 10, 958 (1988).
8. M. Nagl et al., Clin. Diagn. Lab. Immunol. 9, 1165 (2002).
9. P. Sansonetti, Semin. Immunol. 13, 381 (2001).
10. R. Forster et al., Cell 99, 23 (1999).
11. L. E. Post, A. E. Arfsten, G. R. Davis, M. Nomura, J. Biol. Chem. 255, 4653 (1980).
12. F.-P. Huang et al., J. Exp. Med. 191, 435 (2000).
13. M. Rescigno et al., Nature Immunol. 2, 361 (2001).
14. M. R. Neutra, E. Pringault, J. P. Kraehenbuhl, Annu. Rev. Immunol. 14, 275 (1996).
15. H. Hamada et al., J. Immunol. 168, 57 (2002).
16. A. J. Macpherson et al., Science 288, 2222 (2000).
17. We thank E. Niederer, L. Marmaril, B. Stecher, B. Odermatt, and R. Förster for help and materials and R. Zinkernagel, H. Hengartner, C. Mueller, N. Harris, H. Uhlig, A. Mowat, G. Macpherson, T. Junt, and M. van den Broek for comments. The work was financed through the Swiss Nationalfonds (31-50900.97, 31-50884.97, 31000A0-100421/1) and Kanton Zürich.