Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells

Nature Immunology

Volumn 6, Issue 5, 2005, Pages 507-514

  Rimoldi, Monica ^a   Chieppa, Marcello ^b,f   Salucci, Valentina ^a   Avogadri, Francesca ^a   Sonzogni, Angelica ^a   Sampietro, Gianluca M ^c   Nespoli, Angelo ^d   Viale, Giuseppe ^a,e   Allavena, Paola ^b   Rescigno, Maria ^a  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d SAN GERARDO HOSPITAL   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; INTERLEUKIN 7; CYTOKINE; THYMIC STROMAL LYMPHOPOIETIN;

ARTICLE; CELL DIFFERENTIATION; CELL POLARITY; CONTROLLED STUDY; DENDRITIC CELL; EPITHELIUM CELL; HELPER CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNE SYSTEM; NORMAL HUMAN; POLARIZATION; PRIORITY JOURNAL; PROTEIN SECRETION; CELL CULTURE; COLON; CYTOLOGY; GENE EXPRESSION REGULATION; HOMEOSTASIS; IMMUNOLOGY; INTESTINE; METABOLISM; SECRETION; TH1 CELL; TH2 CELL;

CELL DIFFERENTIATION; CELLS, CULTURED; COLON; CYTOKINES; DENDRITIC CELLS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; INTERLEUKIN-12; INTESTINES; TH1 CELLS; TH2 CELLS;

EID: 18244387204     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1192     Document Type: Article

References (42)

1. Nagler-Anderson, C. Man the barrier! Strategic defences in the intestinal mucosa. Nat. Rev. Immunol. 1, 59-67 (2001).
2. Neutra, M.R., Mantis, N.J. & Kraehenbuhl, J.P. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat. Immunol. 2, 1004-1009 (2001).
3. Rescigno, M. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2, 361-367 (2001).
4. Niess, J.H. et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307, 254-258 (2005).
5. Rescigno, M. Dendritic cells and the complexity of microbial infection. Trends Microbiol. 10, 425-461 (2002).
6. Iwasaki, A. & Medzhitov, R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5, 987-995 (2004).
7. Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
8. Bilsborough, J. & Viney, J.L. Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 127, 300-309 (2004).
9. Alpan, O., Rudomen, G. & Matzinger, P. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J. Immunol. 166, 4843-4852 (2001).
10. Akbari, O., DeKruyff, R.H. & Umetsu, D.T. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2, 725-731 (2001).
11. Iwasaki, A. & Kelsall, B.L. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3α, MIP-3β, and secondary lymphoid organ chemokine. J. Exp. Med. 191, 1381-1394 (2000).
12. +, and double-negative Peyer's patch dendritic cells. J. Immunol. 166, 4884-4890 (2001).
13. + Peyer's patch dendritic cells secrete IL-6 and induce IgA secretion from naive B cells. J. Immunol. 171, 3684-3690 (2003).
14. Zhang, M. et al. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5, 1124-1133 (2004).
15. McWilliam, A.S. et al. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J. Exp. Med. 184, 2429-2432 (1996).
16. Trinchieri, G., Pflanz, S. & Kastelein, R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 19, 641-644 (2003).
17. Reche, P.A. et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J. Immunol. 167, 336-343 (2001).
18. Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3, 673-680 (2002).
19. Soumelis, V. & Liu, Y.J. Human thymic stromal lymphopoietin: a novel epithelial cell-derived cytokine and a potential key player in the induction of allergic inflammation. Springer Semin. Immunopathol. 25, 325-333 (2004).
20. Gilliet, M. et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J. Exp. Med. 197, 1059-1063 (2003).
21. + T cell homeostatic expansion. Nat. Immunol. 5, 426-434 (2004).
22. Rimoldi, M., Chieppa, M., Vulcano, M., Allavena, P. & Rescigno, M. Intestinal epithelial cells control DC function. Ann. NY Acad. Sci. 1029, 66-74 (2004).
23. Bouma, G. & Strober, W. The immunological and genetic basis of inflammatory bowel disease. Nat. Rev. Immunol. 3, 521-533 (2003).
24. Mowat, A.M. Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 3, 331-341 (2003).
25. Anjuere, F. et al. Transcutaneous immunization with cholera toxin B subunit adjuvant suppresses IgE antibody responses via selective induction of Th1 immune responses. J. Immunol. 170, 1586-1592 (2003).
26. Macpherson, A.J. et al. A primitive Tcell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222-2226 (2000).
27. Macpherson, A.J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
28. Jang, M.H. et al. Intestinal villous M cells: an antigen entry site in the mucosal epithelium. Proc. Natl. Acad. Sci. USA 101, 6110-6115 (2004).
29. Mastroeni, P. & Menager, N. Development of acquired immunity to Salmonella. J. Med. Microbiol. 52, 453-459 (2003).
30. + TCR-αβ cells and IFN-γ in bacterial clearance independent of intracellular location. J. Immunol. 156, 3321-3326 (1996).
31. George, A. Generation of gamma interferon responses in murine Peyer's patches following oral immunization. Infect. Immun. 64, 4606-4611 (1996).
32. Liesenfeld, O., Kosek, J.C. & Suzuki, Y. Gamma interferon induces Fas-dependent apoptosis of Peyer's patch T cells in mice following peroral infection with Toxoplasma gondii. Infect. Immun. 65, 4682-4689 (1997).
33. Vossenkamper, A. et al. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur. J. Immunol. 34, 3197-3207 (2004).
34. Sierra, F. et al. Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc. Natl. Acad. Sci. USA 98, 13722-13727 (2001).
35. Vanbervliet, B. et al. Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur. J. Immunol. 32, 231-242 (2002).
36. Dieu-Nosjean, M.C. et al. Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J. Exp. Med. 192, 705-718 (2000).
37. Eckmann, L. & Kagnoff, M.F. Cytokines in host defense against Salmonella. Microbes Infect. 3, 1191-1200 (2001).
38. Neish, A.S. et al. Prokaryotic regulation of epithelial responses by inhibition of IkappaB-alpha ubiquitination. Science 289, 1560-1563 (2000).
39. Kelly, D. et al. Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA. Nat. Immunol. 5, 104-112 (2004).
40. Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
41. Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/ macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179, 1109-1118 (1994).
42. Whither RNAi? Nat. Cell Biol. 5, 489-490 (2003).