Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling

Gastroenterology

Volumn 139, Issue 4, 2010, Pages 1277-1288

  Gibson, Deanna L ^a,b   Montero, Marinieve ^a   Ropeleski, Mark J ^c   Bergstrom, Kirk S B ^a   Ma, Caixia ^a   Ghosh, Sanjoy ^a,b   Merkens, Helen ^a   Huang, Jingtian ^a   Mnsson, Lisa E ^a   Sham, Ho Pan ^a   McNagny, Kelly M ^a   Vallance, Bruce A ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

Enteric Bacteria; IBD; Inflammatory Bowel Diseases; Intestinal Homeostasis

Indexed keywords

INTERLEUKIN 11; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; STAT3 PROTEIN, MOUSE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TYPE; COLITIS; CRYOPROTECTION; DISEASE PREDISPOSITION; HEMATOPOIETIC CELL; INNATE IMMUNITY; INTESTINE EPITHELIUM; INTESTINE INJURY; INTESTINE MUCOSA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; DEFICIENCY; IMMUNOLOGY; INFLAMMATORY BOWEL DISEASES; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; COLITIS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-11; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 77957364734     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.06.057     Document Type: Article

References (34)

1. S. Rakoff-Nahoum, J. Paglino, and F. Eslami-Varzaneh Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis Cell 118 2004 229 241
2. R. Ungaro, M. Fukata, and D. Hsu A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis Am J Physiol Gastrointest Liver Physiol 296 2009 G1167 G1179
3. S.L. Brown, T.E. Riehl, and M.R. Walker Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury J Clin Invest 117 2007 258 269
4. E. Cario, G. Gerken, and D.K. Podolsky Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function Gastroenterology 132 2007 1359 1374
5. A. Nenci, C. Becker, and A. Wullaert Epithelial NEMO links innate immunity to chronic intestinal inflammation Nature 446 2007 557 561
6. K.S. Bergstrom, J.A. Guttman, and M. Rumi Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen Infect Immun 76 2008 796 811
7. L. Eckmann Animal models of inflammatory bowel disease: lessons from enteric infections Ann N Y Acad Sci 1072 2006 28 38
8. H. Ishigame, S. Kakuta, and T. Nagai Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses Immunity 30 2009 108 119
9. S.A. Luperchio, and D.B. Schauer Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia Microbes Infect 3 2001 333 340
10. C. Ma, M.E. Wickham, and J.A. Guttman Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map) Cell Microbiol 8 2006 1669 1686
11. D.L. Gibson, C. Ma, and K.S. Bergstrom MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis Cell Microbiol 10 2008 618 631
12. D.L. Gibson, C. Ma, and C.M. Rosenberger Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis Cell Microbiol 10 2008 388 403
13. M.A. Khan, C. Ma, and L.A. Knodler Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice Infect Immun 74 2006 2522 2536
14. B.A. Vallance, W. Deng, and K. Jacobson Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium Infect Immun 71 2003 3443 3453
15. G. Pickert, C. Neufert, and M. Leppkes STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing J Exp Med 206 2009 1465 1472
16. H. Jiang, P.H. Patel, and A. Kohlmaier Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut Cell 137 2009 1343 1355
17. R.J. Wang, R.Y. Peng, and Y.B. Gao Jak/STAT signaling pathway of IL-11 in the protection of intestinal epithelial cells from neutron radiation [in Chinese] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25 2009 27 30
18. M. Vijay-Kumar, C.J. Sanders, and R.T. Taylor Deletion of TLR5 results in spontaneous colitis in mice J Clin Invest 117 2007 3909 3921
19. L. Su, L. Shen, and D.R. Clayburgh Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis Gastroenterology 136 2009 551 563
20. G.A. Grassl, Y. Valdez, and K.S. Bergstrom Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis Gastroenterology 134 2008 768 780
21. B. Hoang, A. Trinh, and L. Birnbaumer Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts Am J Physiol Gastrointest Liver Physiol 292 2007 G1511 G1519
22. M. Boerma, J. Wang, and A.F. Burnett Local administration of interleukin-11 ameliorates intestinal radiation injury in rats Cancer Res 67 2007 9501 9506
23. M.J. Ropeleski, J. Tang, and M.M. Walsh-Reitz Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress Gastroenterology 124 2003 1358 1368
24. K.R. Herrlinger, T. Witthoeft, and A. Raedler Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease Am J Gastroenterol 101 2006 793 797
25. B.E. Sands, B.D. Winston, and B. Salzberg Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease Aliment Pharmacol Ther 16 2002 399 406
26. K. Sugimoto Role of STAT3 in inflammatory bowel disease World J Gastroenterol 14 2008 5110 5114
27. K. Takeda, K. Noguchi, and W. Shi Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality Proc Natl Acad Sci U S A 94 1997 3801 3804
28. T. Alonzi, I.P. Newton, and P.J. Bryce Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis Cytokine 26 2004 45 56
29. S. Kiessling, G. Muller-Newen, and S.N. Leeb Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells J Biol Chem 279 2004 10304 10315
30. R.L. Peterson, L. Wang, and L. Albert Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease Lab Invest 78 1998 1503 1512
31. B.E. Sands, S. Bank, and C.A. Sninsky Preliminary evaluation of safety and activity of recombinant human interleukin 11 in patients with active Crohn's disease Gastroenterology 117 1999 58 64
32. J. Cosnes, and P. Seksik Inflammatory bowel diseases: from sulfasalazine to biologics [in French] Gastroenterol Clin Biol 33 2009 692 701
33. K. Mitsuyama, S. Matsumoto, and J. Masuda Therapeutic strategies for targeting the IL-6/STAT3 cytokine signaling pathway in inflammatory bowel disease Anticancer Res 27 2007 3749 3756
34. J. Bollrath, T.J. Phesse, and V.A. von Burstin gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis Cancer Cell 15 2009 91 102