Coffee and Type 2 Diabetes Risk

Coffee: Emerging Health Effects and Disease Prevention

Volumn , Issue , 2012, Pages 141-179

  Matusheski, Nathan V ^a   Bidel, Siamak ^b,c   Tuomilehto, Jaakko ^c,d  

^a Kraft Foods Inc   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Caffeinated coffee; Coffee and type 2 diabetes; Coffee consumption; Coffee preparation; Glucose tolerance; Lifestyle related factors

Indexed keywords

EID: 84886032711     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781119949893.ch8     Document Type: Chapter

References (183)

1. Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention. www.cdc.gov/diabetes/ pubs/pdf/ndfs_2007.pdf (accessed May 16, 2011)
2. Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E., Williamson, D. F. Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence. Popul. Health Metr. 2010, 8, 29.
3. United Health Group. The United States of Diabetes: Challenges and opportunities in the decade ahead. United Health Group, November 2010. www.unitedhealthgroup.com (accessed May 16, 2011)
4. Shaw, J. E., Sicree, R. A., Zimmet, P. Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res. Clin. Pract. 2010, 87, 4-14.
5. DeFronzo, R. A. From the Triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes. 2009, 58, 773-795.
6. World Health Organization: Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. Geneva, World Health Organization 2006.
7. Voight, B. F., et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 2010, 42, 579-589.
8. Farin, H. M., Abbasi, F., Reaven, G. M. Body mass index and waist circumference both contribute to differences in insulin-mediated glucose disposal in nondiabetic adults. Am. J. Clin. Nutr. 2006, 83, 47-51.
9. Mozaffarian, D., Kamineni, A., Carnethon, M., Djoussé, L., Mukamal, K. J., Siscovick, D. Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study. Arch. Intern. Med. 2009, 169, 798-807.
10. Hu, G., Lindstrom, J., Valle, T. T., Eriksson, J. G., Jousilahti, P., Silventoinen, K., Qiao, Q., Tuomilehto, J. Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation. Arch. Intern. Med. 2004, 164, 892-896.
11. Tuomilehto, J., et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N. Engl. J. Med. 2001, 344, 1343-1350.
12. Knowler, W. C., Fowler, S. E., Hamman, R. F., Christophi, C. A., Hoffman, H. J., Brenneman, A. T., Brown-Friday, J. O., Goldberg, R., Venditti, E., Nathan, D. M. 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 2009, 374, 1677-1686.
13. Tuomilehto, J. Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes. Diabetes Care. 2009, 32 (Suppl 2), S189-S193.
14. Salas-Salvadó, J., et al. Reduction in the incidence of type 2 diabetes with the Mediterranean diet: results of the PREDIMED-Reus nutrition intervention randomized trial. Diabetes Care. 2011, 34, 14-19.
15. de Munter, J. S. L., Hu, F. B., Spiegelman, D., Franz, M., van Dam, R. M. Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med. 2007, 4, e261.
16. Priebe, M. G., van Binsbergen, J. J., de Vos, R., Vonk, R. J. Whole grain foods for the prevention of type 2 diabetes mellitus. Cochrane Database Syst. Rev. 2008, 1, CD006061.
17. Liu, S., Serdula, M., Janket, S. J., Cook, N. R., Sesso, H. D.,Willett, W. C., Manson, J. E., Buring, J. E. A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women. Diabetes Care. 2004, 27, 2993-2996.
18. Villegas, R., Shu, X. O., Gao, Y. T., Yang, G., Elasy, T., Li, H., Zheng, W. Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women. J. Nutr. 2008, 138, 574-580.
19. Baliunas, D. O., Taylor, B. J., Irving, H., Roerecke, M., Patra, J., Mohapatra, S., Rehm, J. Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 2009, 32, 2123-2132.
20. Thomas, D., Elliott, E. J. Low glycaemic index, or low glycaemic load, diets for diabetes mellitus. Cochrane Database Syst. Rev. 2009, i, CD006296.
21. van Dam, R. M., Feskens, E. J. M. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2002, 360, 1477-1478.
22. Saremi, A., Tulloch-Reid, M., Knowler,W. C. Coffee consumption and the incidence of type 2 diabetes. Diabetes Care. 2003, 26, 2211-2212.
23. Reunanen, A., Heliövaara, M., Aho, K. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2003, 361, 702-703.
24. Carlsson, S., Hammar, N., Grill, V., Kaprio, J. Coffee consumption and risk of type 2 diabetes in Finnish twins. Int. J. Epidemiol. 2004, 33, 616-617.
25. Rosengren, A., Dotevall, A.,Wilhelmsen, L., Thelle, D., Johansson, S. Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study. J. Intern. Med. 2004, 255, 89-95.
26. Salazar-Martinez, E., Willett, W. C., Ascherio, A., Manson, J. E., Leitzmann, M. F., Stampfer, M. J., Hu, F. B. Coffee consumption and risk for type 2 diabetes mellitus. Ann. Intern. Med. 2004, 140, 1-8.
27. Tuomilehto, J., Hu, G., Bidel, S., Lindstrom, J., Jousilahti, P. Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA. 2004, 291, 1213-1219.
28. van Dam, R. M., Dekker, J. M., Nijpels, G., Stehouwer, C. D., Bouter, L. M., Heine, R. J. Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study. Diabetologia. 2004, 47, 2152-2159.
29. Greenberg, J. A., Axen, K. V., Schnoll, R., Boozer, C. N. Coffee, tea and diabetes: the role of weight loss and caffeine. Int. J. Obes. 2005, 29, 1121-1129.
30. Iso, H., Date, C., Wakai, K., Fukui, M., Tamakoshi, A. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann. Intern. Med. 2006, 144, 554-562.
31. Paynter, N. P., Yeh, H. C., Voutilainen, S., Schmidt, M. I., Heiss, G., Folsom, A. R., Brancati, F. L., Kao, W. H. L. Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study. Am. J. Epidemiol. 2006, 164, 1075-1084.
32. Pereira, M. A., Parker, E. D., Folsom, A. R. Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausalwomen. Arch. Intern. Med. 2006, 166, 1311-1316.
33. van Dam, R. M.,Willett,W. C., Manson, J. E., Hu, F. B. Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women. Diabetes Care. 2006, 29, 398-403.
34. Smith, B., Wingard, D. L., Smith, T. C., Kritz-Silverstein, D., Barrett-Connor, E. Does coffee consumption reduce the risk of type 2 diabetes in individuals with impaired glucose? Diabetes Care. 2006, 29, 2385-2390.
35. Hu, G., Jousilahti, P., Peltonen, M., Bidel, S., Tuomilehto, J. Joint association of coffee consumption and other factors to the risk of type 2 diabetes: a prospective study in Finland. Int. J. Obes. 2006, 30, 1742-1749.
36. Adeney, K. L., Williams, M. A., Schiff, M. A., Qiu, C., Sorensen, T. K. Coffee consumption and the risk of gestational diabetes mellitus. Acta Obstet. Gynecol. Scand. 2007, 86, 161-166.
37. Bidel, S., Silventoinen, K., Hu, G., Lee, D.H., Kaprio, J., Tuomilehto, J. Coffee consumption, serum γ-glutamyltransferase and risk of type II diabetes. Eur. J. Clin. Nutr. 2007, 62, 178-185.
38. Hamer, M., Witte, D. R., Mosdøl, A., Marmot, M. G., Brunner, E. J. Prospective study of coffee and tea consumption in relation to risk of type 2 diabetes mellitus among men and women: the Whitehall II study. Brit. J. Nutr. 2008, 100, 1046-1053.
39. Odegaard, A. O., Pereira, M. A., Koh, W. P., Arakawa, K., Lee, H. P., Yu, M. C. Coffee, tea, and incident type 2 diabetes: the Singapore Chinese Health Study. Am. J. Clin. Nutr. 2008, 88, 979-985.
40. Fuhrman, B. J., Smit, E., Crespo, C. J., Garcia-Palmieri, M. R. Coffee intake and risk of incident diabetes in Puerto Rican men: results from the Puerto Rico Heart Health Program. Public Health Nutr. 2009, 12, 842-848.
41. Kato, M., Noda, M., Inoue, M., Kadowaki, T., Tsugane, S. Psychological factors, coffee and risk of diabetes mellitus among middle-aged Japanese: a population-based prospective study in the JPHC study cohort. Endocr. J. 2009, 56, 459-468.
42. van Dieren, S., Uiterwaal, C. S., van der Schouw, Y. T., van der A, D. L., Boer, J. M., Spijkerman, A., Grobbee, D. E., Beulens, J. W. Coffee and tea consumption and risk of type 2 diabetes. Diabetologia. 2009, 52, 2561-2569.
43. Zhang,Y., Lee, E. T., Cowan, L. D., Fabsitz, R. R.,Howard, B.V. Coffee consumption and the incidence of type 2 diabetes in men and women with normal glucose tolerance: the Strong Heart Study. Nutr. Metab. Cardiov. Dis. 2010, 21, 418-423.
44. Oba, S., Nagata, C., Nakamura, K., Fujii, K., Kawachi, T., Takatsuka, N., Shimizu, H. Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women. Brit. J. Nutr. 2010, 103, 453-459.
45. Sartorelli, D. S., Fagherazzi, G., Balkau, B., Touillaud, M. S., Boutron-Ruault, M. C., de Lauzon-Guillain, B., Clavel-Chapelon, F. Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. Am. J. Clin. Nutr. 2010, 91, 1002-1012.
46. Boggs, D. A., Rosenberg, L., Ruiz-Narvaez, E. A., Palmer, J. R. Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women. Am. J. Clin. Nutr. 2010, 92, 960-966.
47. Isogawa, A., Noda, M., Takahashi, Y., Kadowaki, T., Tsugane, S. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2003, 361, 703-704.
48. Agardh, E. E., Carlsson, S., Ahlbom, A., Efendic, S., Grill, V., Hammar, N., Hilding, A., Östenson, C. G. Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women. J. Intern. Med. 2004, 255, 645-652.
49. Agardh, E. E., Ahlbom, A., Andersson, T., Ostenson, C. G. The magnitude of bias in a cross-sectional study on lifestyle factors in relation to type 2 diabetes. Scand. J. Public Health. 2006, 34, 665-668.
50. Yamaji, T., Mizoue, T., Tabata, S., Ogawa, S., Yamaguchi, K., Shimizu, E., Mineshita, M., Kono, S. Coffee consumption and glucose tolerance status in middle-aged Japanese men. Diabetologia. 2004, 47, 2145-2151.
51. Soriguer, F., Rojo-Martínez, G., de Antonio, I. E. Coffee consumption and type 2 diabetes mellitus. Ann. Intern. Med. 2004, 141, 321-323.
52. Faerch, K., Lau, C., Tetens, I., Pedersen, O. B., Jorgensen, T., Borch-Johnsen, K., Glumer, C. A statistical approach based on substitution of macronutrients provides additional information to models analyzing single dietary factors in relation to type 2 diabetes in Danish adults: the Inter99 study. J. Nutr. 2005, 135, 1177-1182.
53. Panagiotakos, D. B., et al. Long-term, moderate coffee consumption is associated with lower prevalence of diabetes mellitus among elderly non-tea drinkers from the Mediterranean Islands (MEDIS Study). Rev. Diabet. Stud. 2007, 4, 105-111.
54. Lin,W. Y., Xaiver Pi-Sunyer, F., Chen, C. C., Davidson, L. E., Liu, C. S., Li, T. C.,Wu, M. F., Li, C. I., Chen, W., Lin, C. C. Coffee consumption is inversely associated with type 2 diabetes in Chinese. Eur. J. Clin. Invest. 2011, 41, 659-666.
55. van Dam, R. M., Hu, F. B. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA. 2005, 294, 97-104.
56. Huxley, R., Lee, C. M. Y., Barzi, F., Timmermeister, L., Czernichow, S., Perkovic, V., Grobbee, D. E., Batty, D.,Woodward, M. Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis. Arch. Int. Med. 2009, 169, 2053-2063.
57. van Dusseldorp, M., Katan, M. B., van Vliet, T., Demacker, P. N., Stalenhoef, A. F. Cholesterol-raising factor from boiled coffee does not pass a paper filter. Arterioscler. Thromb. 1991, 11, 586-593.
58. Urgert, R., de Groot, C. P. Consumption of unfiltered coffee brews in elderly Europeans. SENECA investigators. Eur. J. Clin. Nutr. 1996, 50 (Suppl 2), S101-S104.
59. van Dam, R. M., Feskens, E. J. M. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2003, 361, 703.
60. Goto, A., Song, Y., Chen, B. H., Manson, J. E., Buring, J. E., Liu, S. Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. Diabetes. 2011, 60, 269-275.
61. van Dam, R. M., Feskins, E. J. M., Kromhout, D. Coffee consumption in relation to hyperinsulinemia and glucose intolerance in elderly men. Ann. Nutr. Metab. 2003, 47, 627-628.
62. Bidel, S., Hu, G., Sundvall, J., Kaprio, J., Tuomilehto, J. Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels - a cross-sectional analysis. Horm. Metab. Res. 2006, 38, 38-43.
63. Hiltunen, L. A. Are there associations between coffee consumption and glucose tolerance in elderly subjects? Eur. J. Clin. Nutr. 2006, 60, 1222-1225.
64. Arnlov, J., Vessby, B., Riserus, U. Coffee consumption and insulin sensitivity. JAMA. 2004, 291, 1199-1201.
65. Wu, T.,Willett,W. C., Hankinson, S. E., Giovannucci, E. Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women. Diabetes Care. 2005, 28, 1390-1396.
66. Loopstra-Masters, R. C., Liese, A. D., Haffner, S. M., Wagenknecht, L. E., Hanley, A. J. Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function. Diabetologia. 2011, 54, 320-328.
67. Kempf, K., et al. Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am. J. Clin. Nutr. 2010, 91, 950-957.
68. Fredholm, B. B., ed. Methylxanthines, 1st edition, Heidelberg: Springer-Verlag; 2010.
69. Cheraskin, E., Ringsdorf, W. M., Setyaadmadja, A. T., Barrett, R. A. Effect of caffeine versus placebo supplementation on blood-glucose concentration. Lancet. 1967, 1, 1299-1300.
70. Robinson, L. E., Savani, S., Battram, D. S., McLaren, D. H., Sathasivam, P., Graham, T. E. Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J. Nutr. 2004, 134, 2528-2533.
71. Robinson, L. E., Spafford, C., Graham, T. E., Smith, G. N. Acute caffeine ingestion and glucose tolerance in women with or without gestational diabetes mellitus. J. Obstet. Gynaecol. Can. 2009, 31, 304-312.
72. Graham, T. E., Sathasivam, P., Rowland, M., Marko, N., Greer, F., Battram, D. Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can. J. Physiol. Pharmacol. 2001, 79, 559-565.
73. Keijzers, G. B., De Galan, B. E., Tack, C. J., Smits, P. Caffeine can decrease insulin sensitivity in humans. Diabetes Care. 2002, 25, 364-369.
74. Thong, F. S. L., Derave, W., Kiens, B., Graham, T. E., Ursø, B., Wojtaszewski, J. F. P., Hansen, B. F., Richter, E. A. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes. 2002, 51, 583-590.
75. Petrie, H. J., Chown, S. E., Belfie, L. M., Duncan, A. M., McLaren, D. H., Conquer, J. A., Graham, T. E. Caffeine ingestion increases the insulin response to an oral-glucose-tolerance test in obese men before and after weight loss. Am. J. Clin. Nutr. 2004, 80, 22-28.
76. Prokop, L. The influencing of adrenaline activity by caffeine. Med. Klin. 1964, 59, 2016-2020.
77. Deibert, D. C., DeFronzo, R. A. Epinephrine-induced insulin resistance in man. J. Clin. Invest. 1980, 65, 717-721.
78. Thong, F. S. L., Graham, T. E. Caffeine-induced impairment of glucose tolerance is abolished by beta-adrenergic receptor blockade in humans. J. Appl. Physiol. 2002, 92, 2347-2352.
79. Battram, D. S., Bugaresti, J., Gusba, J., Graham, T. E. Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia. J. Appl. Physiol. 2007, 102, 374-381.
80. Dekker, M. J., Gusba, J. E., Robinson, L. E., Graham, T. E. Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeineconsuming males. Brit. J. Nutr. 2007, 98, 556-562.
81. Jankelson, O. M., Beaser, S. B., Howard, F. M., Mayer, J. Effect of coffee on glucose tolerance and circulating insulin in men with maturity-onset diabetes. Lancet. 1967, 1, 527-529.
82. Feinberg, L. J., Sandberg, H., De Castro, O., Bellet, S. Effects of coffee ingestion on oral glucose tolerance curves in normal human subjects. Metabolism. 1968, 17, 916-922.
83. Goldman, J. A., Ovadia, J. The effect of coffee on glucose tolerance in normal and prediabetic pregnant women. Obstet. Gynecol. 1969, 33, 214-218.
84. Wachman, A., Hattner, R. S., George, B., Bernstein, D. S. Effects of decaffeinated and nondecaffeinated coffee ingestion on blood glucose and plasma radioimmunoreactive insulin responses to rapid intravenous infusion of glucose in normal man. Metabolism. 1970, 19, 539-546.
85. Pizziol, A., Tikhonoff, V., Paleari, C. D., Russo, E., Mazza, A., Ginocchio, G., Onesto, C., Pavan, L., Casiglia, E., Pessina, A. C. Effects of caffeine on glucose tolerance: a placebo-controlled study. Eur. J. Clin. Nutr. 1998, 52, 846-849.
86. Johnston, K. L., Clifford, M. N., Morgan, L. M. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am. J. Clin. Nutr. 2003, 78, 728-733.
87. Battram, D. S., Arthur, R., Weekes, A., Graham, T. E. The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men. J. Nutr. 2006, 136, 1276-1280.
88. Lane, J. D., Hwang, A. L., Feinglos, M. N., Surwit, R. S. Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffee. Endocr. Pract. 2007, 13, 239-243.
89. Thom, E. The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J. Int. Med. Res. 2007, 35, 900-908.
90. Louie, J. C. Y., Atkinson, F., Petocz, P., Brand-Miller, J. C. Delayed effects of coffee, tea and sucrose on postprandial glycemia in lean, young, healthy adults. Asia Pac. J. Nutr. 2008, 17, 657-662.
91. Moisey, L. L., Kacker, S., Bickerton, A. C., Robinson, L. E., Graham, T. E. Caffeinated coffee consumption impairs blood glucose homeostasis in response to high and low glycemic index meals in healthy men. Am. J. Clin. Nutr. 2008, 87, 1254-1261.
92. Matusheski, N. V.,Wolever, T.M. S., Black, R. M. Effect of decaffeinated coffee on the serum glucose and insulin responses elicited by oral glucose. FASEB J. 2009, 23, LB452.
93. van Dijk, A. E., Olthof, M. R., Meeuse, J. C., Seebus, E., Heine, R. J., van Dam, R. M. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. Diabetes Care. 2009, 32, 1023-1025.
94. Greenberg, J. A., Owen, D. R., Geliebter, A. Decaffeinated coffee and glucose metabolism in young men. Diabetes Care. 2010, 33, 278-280.
95. Moisey, L. L., Robinson, L. E., Graham, T. E. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Brit. J. Nutr. 2010, 103, 833-841.
96. Beaudoin, M. S., Robinson, L. E., Graham, T. E. An oral lipid challenge and acute intake of caffeinated coffee additively decrease glucose tolerance in healthy men. J. Nutr. 2011, 141, 574-581.
97. Graham, T. E., Hibbert, E., Sathasivam, P. Metabolic and exercise endurance effects of coffee and caffeine ingestion. J. Appl. Physiol. 1998, 85, 883-889.
98. Olthof, M. R., van Dijk, A. E., Deacon, C. F.,Heine, R. J., vanDam, R. M. Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on incretin hormones. Nutr. Metab. 2011, 8, 10.
99. Naismith, D. J., Akinyanju, P. A., Szanto, S., Yudkin. J. The effect in volunteers of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting. Nutr. Metab. 1970, 12, 144-151.
100. van Dam, R. M., Pasman, W. J., Verhoef, P. Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers. Diabetes Care. 2004, 27, 2990-2992.
101. Graham, T. E., Battram, D. S., Dela, F., El-Sohemy, A., Thong, F. S. L. Does caffeine alter muscle carbohydrate and fat metabolism during exercise? Appl. Physiol. Nutr. Metab. 2008, 33, 1311-1318.
102. Hamada, T., Kotani, K., Higashi, A., Ikeda, J., Tagaki, E., Igarashi, A., Matsubara, C., Yoshida, T., Sakane, N. Lack of association of the Trp64Arg polymorphism of beta3-adrenergic receptor gene with energy expenditure in response to caffeine among young healthy women. Tohoku J. Exp. Med. 2008, 214, 365-370.
103. International Coffee Organization. Exports by exporting countries to all destinations. International Coffee Organization, London, England. April 2010. http://www.ico.org/prices/m1.htm (accessed June 14, 2011).
104. Farah, A., Donangelo, C. M. Phenolic compounds in coffee. Braz. J. Plant Physiol. 2006, 18, 23-36.
105. Schrader, K., Kiehne, A., Engelhardt, U. H., Maier, H. G. Determination of chlorogenic acids with lactones in roasted coffee. J. Sci. Food Agric. 1996, 71, 392-398.
106. McCarty, M. F. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. Med. Hypotheses. 2005, 64, 848-853.
107. Oka, K. Pharmacological bases of coffee nutrients for diabetes prevention. Yakugaku Zasshi. 2007, 127, 1825-1836.
108. Tunnicliffe, J. M., Shearer, J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl. Physiol. Nutr. Metab. 2008, 33, 1290-1300.
109. Higgins, H. L., Means, J. H. The effect of certain drugs on the respiration and gaseous metabolism in normal human subjects. J. Pharmacol. Exp. Ther. 1915, 7, 1-30.
110. Acheson, K. J., Zahorska-Markiewicz, B., Pittet, P. H., Anantharaman, K., Jequier, E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am. J. Clin. Nutr. 1980, 33, 989.
111. Hollands, M. A., Arch, J. R., Cawthorne, M. A. A simple apparatus for comparative measurements of energy expenditure in human subjects: the thermic effect of caffeine. Am. J. Clin. Nutr. 1981, 34, 2291-2294.
112. Koot, P., Deurenberg, P. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Ann. Nutr. Metab. 1995, 39, 135-142.
113. Bracco, D., Ferrarra, J. M., Arnaud, M. J., Jéquier, E., Schutz, Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am. J. Physiol. 1995, 269, E671-E678.
114. Rudelle, S., Ferruzzi, M. G., Cristiani, I., Moulin, J., Macé, K., Acheson, K. J., Tappy, L. Effect of a thermogenic beverage on 24-hour energy metabolism in humans. Obesity. 2007, 15, 349-355.
115. Chiasson, J. L. Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the study to prevent non-insulin-dependent diabetes mellitus (STOP-NIDDM) trial. Endocr. Pract. 2006, 12 (Suppl 1), 25-30.
116. Kawamori, R., Tajima, N., Iwamoto, Y., Kashiwagi, A., Shimamoto, K., Kaku, K. Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet. 2009, 373, 1607-1614.
117. Rohn, S., Rawel, H. M., Kroll, J. Inhibitory effects of plant phenols on the activity of selected enzymes. J. Agric. Food Chem. 2002, 50, 3566-3571.
118. Narita, Y., Inouye, K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. J. Agric. Food Chem. 2009, 57, 9218-9225.
119. Hemmerle, H., Burger, H. J., Below, P., Schubert, G., Rippel, R., Schindler, P.W., Paulus, E., Herling, A.W. Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. J. Med. Chem. 1997, 40, 137-145.
120. Arion,W. J., Canfield,W. K., Ramos, F. C., Schindler, P.W., Burger, H. J., Hemmerle, H., Schubert, G., Below, P., Herling, A. W. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch. Biochem. Biophys. 1997, 339, 315-322.
121. Stümpel, F., Burcelin, R., Jungermann, K., Thorens, B. Normal kinetics of intestinal glucose absorption in the absence of GLUT2: evidence for a transport pathway requiring glucose phosphorylation and transfer into the endoplasmic reticulum. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 11330-11332.
122. Fujioka, K., Shibamoto, T. Chlorogenic acid and caffeine contents in various commercial brewed coffees. Food Chem. 2008, 106, 217-221.
123. Henry-Vitrac, C., Ibarra, A., Roller, M., Mérillon, J. M., Vitrac, X. Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J. Agric. Food Chem. 2010, 58, 4141-4144.
124. Bassoli, B. K., Cassolla, P., Borba-Murad, G. R., Constantin, J., Salgueiro-Pagadigorria, C. L., Bazotte, R. B., da Silva, R. S., de Souza, H. M. Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia. Cell Biochem. Funct. 2008, 26, 320-328.
125. Monteiro, M., Farah, A., Perrone, D., Trugo, L. C., Donangelo, C. Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans. J. Nutr. 2007, 137, 2196-2201.
126. Farah, A., Monteiro, M., Donangelo, C. M., Lafay, S. Chlorogenic acids from green coffee extract are highly bioavailable in humans. J. Nutr. 2008, 138, 2309-2315.
127. Renouf, M., et al. Nondairy creamer, but not milk, delays the appearance of coffee phenolic acid equivalents in human plasma. J. Nutr. 2010, 140, 259-263.
128. Knowler, W. C., Barrett-Connor, E., Fowler, S. E., Hamman, R. F., Lachin, J. M., Walker, E. A., Nathan, D. M. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 2002, 346, 393-403.
129. Klatsky, A. L., Morton, C., Udaltsova,N., Friedman, G. D. Coffee, cirrhosis, and transaminase enzymes. Arch. Intern. Med. 2006, 166, 1190-1195.
130. Hu, G., Tuomilehto, J., Pukkala, E., Hakulinen, T., Antikainen, R., Vartiainen, E., Jousilahti, P. Joint effects of coffee consumption and serum gamma-glutamyltransferase on the risk of liver cancer. Hepatology 2008, 48, 129-136.
131. Bravi, F., Bosetti, C., Tavani, A., Bagnardi, V., Gallus, S., Negri, E., Franceschi, S., La Vecchia, C. Coffee drinking and hepatocellular carcinoma risk: a meta-analysis. Hepatology 2007, 46, 430-435.
132. Goldfine, A. B., Fonseca, V., Shoelson, S. E. Therapeutic approaches to target inflammation in type 2 diabetes. Clinical Chem. 2010, 57, 162-167.
133. Goldfine, A. B., Fonseca, V., Jablonski, K. A., Pyle, L., Staten, M. A., Shoelson, S. E. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann. Intern. Med. 2010, 152, 346-357.
134. Zampelas, A., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Stefanadis, C. Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am. J. Clin. Nutr. 2004, 80, 862-867.
135. Lopez-Garcia, E., van Dam, R. M., Qi, L., Hu, F. B. Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am. J. Clin. Nutr. 2006, 84, 888-893.
136. Kotani, K., Tsuzaki, K., Sano, Y.,Maekawa, M., Fujiwara, S., Hamada, T., Sakane, N. The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population. Clin. Chem. Lab. Med. 2008, 46, 1434-1437.
137. Maki, T., Pham, N. M., Yoshida, D., Yin, G., Ohnaka, K., Takayanagi, R., Kono, S. The relationship of coffee and green tea consumption with high-sensitivity C-reactive protein in Japanese men and women. Clin. Chem. Lab. Med. 2010, 48, 849-854.
138. Williams, C. J., Fargnoli, J. L., Hwang, J. J., van Dam, R. M., Blackburn, G. L., Hu, F. B., Mantzoros, C. S. Coffee consumption is associated with higher plasma adiponectin concentrations in women with or without type 2 diabetes. Diabetes Care. 2008, 31, 504-507.
139. Imatoh, T., Tanihara, S., Miyazaki, M., Momose, Y., Uryu, Y., Une, H. Coffee consumption but not green tea consumption is associated with adiponectin levels in Japanese males. Eur. J. Nutr. 2011, 50, 279-284.
140. Chu, Y. F., Chen, Y., Black, R. M., Brown, P. H., Lyle, B. J., Liu, R. H., Ou, B. Type 2 diabetes-related bioactivities of coffee: assessment of antioxidant activity, NF-[kappa]B inhibition, and stimulation of glucose uptake. Food Chem. 2011, 124, 914-920.
141. Paur, I., Balstad, T. R., Blomhoff, R. Degree of roasting is the main determinant of the effects of coffee on NF-[kappa]B and EpRE. Free Radic. Biol. Med. 2010, 48, 1218-1227.
142. Feng, R., Lu, Y., Bowman, L. L., Qian, Y., Castranova, V., Ding, M. Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280, 27888-27895.
143. Shan, J., Fu, J., Zhao, Z., Kong, X., Huang, H., Luo, L., Yin, Z. Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-[kappa]B and JNK/AP-1 activation. Int. Immunopharmacol. 2009, 9, 1042-1048.
144. Cichocki, M., Blumczynska, J., Baer-Dubowska, W. Naturally occurring phenolic acids inhibit 12-Otetradecanoylphorbol-13-acetate induced NF-[kappa]B, iNOS and COX-2 activation in mouse epidermis. Toxicology. 2010, 268, 118-124.
145. Muscat, S., Pelka, J., Hegele, J., Weigle, B., Münch, G., Pischetsrieder, M. Coffee and Maillard products activate NF-kappaB in macrophages via H2O2 production. Mol. Nutr. Food Res. 2007, 51, 525-535.
146. Wühr, A., Deckert, M., Pischetsrieder, M. Identification of aminoreductones as active components in Maillard reaction mixtures inducing nuclear NF-kappaB translocation in macrophages. Mol. Nutr. Food Res. 2010, 54, 1021-1030.
147. Kim, H. G., Kim, J. Y., Hwang, Y. P., Lee, K. J., Lee, K. Y., Kim, D. H., Kim, D. H., Jeong, H. G. The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells. Toxicol. Appl. Pharmacol. 2006, 217, 332-341.
148. Shen, T., Park,Y. C., Kim, S. H., Lee, J., Cho, J.Y. Nuclear factor-kappaB/signal transducers and activators of transcription-1-mediated inflammatory responses in lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene. Biol. Pharm. Bull. 2010, 33, 1159-1164.
149. Flament, I., ed., Bessière-Thomas, Y. Coffee flavor chemistry; JohnWiley & Sons:West Sussex, 2002.
150. Chung, J. H., Choi, S. Y., Kim, J. Y., Kim, D. H., Lee, J. W., Choi, J. S., Chung, H. Y. 3-Methyl-1,2-cyclopentanedione Down-Regulates Age-Related NF-_B Signaling Cascade. J. Agric. Food Chem. 2007, 55, 6787-6792.
151. Choi, S. Y., Chung, J. H., Kim, D. H., Chung, S. W., Kim, J. Y., Yu, B. P., Chung, H. Y. Peroxisome proliferator-activated receptor gamma agonist action of 3-methyl-1,2-cyclopentanedione. Biochim. Biophys. Acta. 2007, 1770, 1612-1619.
152. Stumvoll, M., Häring, H. U. Glitazones: clinical effects and molecular mechanisms. Ann. Med. 2002, 34, 217-224.
153. Evans, J. L., Goldfine, I. D., Maddux, B. A., Grodsky, G. M. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes. 2003, 52, 1-8.
154. Fujioka, K., Shibamoto, T. Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: correlation with antioxidant activity. J. Agric. Food Chem. 2006, 54, 6054-6058.
155. Olthof, M. R., Hollman, P. C., Buijsman, M. N., van Amelsvoort, J. M., Katan, M. B. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J. Nutr. 2003, 133, 1806-1814.
156. Higgins, L. G., Cavin, C., Itoh, K., Yamamoto, M., Hayes, J. D. Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein. Toxicol. Appl. Pharmacol. 2008, 226, 328-337.
157. Cavin, C., Marin-Kuan, M., Langouët, S., Bezencon, C., Guignard, G., Verguet, C., Piguet, D., Holzhäuser, D., Cornaz, R., Schilter, B. Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. Food Chem. Toxicol. 2008, 46, 1239-1248.
158. Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., Strassburg, C. P. Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach. Gastroenterology. 2010, 139, 1699-1710, 1710.e1-2.
159. Boettler, U., Sommerfeld, K., Volz, N., Pahlke, G., Teller, N., Somoza, V., Lang, R., Hofmann, T., Marko, D. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. J. Nutr. Biochem. 2011, 22, 426-440.
160. Dinkova-Kostova, A. T., Talalay, P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol. Nutr. Food Res. 2008, 52 (Suppl 1), S128-S138.
161. Barros, R., Machado, U. F., Gustafsson, J. A. Estrogen receptors: new players in diabetes mellitus. Trends in Molecular Med. 2006, 12, 425-431.
162. Ropero, A. B., Alonso-Magdalena, P., Quesada, I., Nadal, A. The role of estrogen receptors in the control of energy and glucose homeostasis. Steroids. 2008, 73, 874-879.
163. Allred, K. F., Yackley, K. M., Vanamala, J., Allred, C. D. Trigonelline is a novel phytoestrogen in coffee beans. J. Nutr. 2009, 139, 1833-1838.
164. Mishinsky, J., Joseph, B., Sulman, F. G., Goldschmeid, A. L. Hypoglycemic effect of trigonelline. Lancet. 1967, 2, 1311-1312.
165. Shani (Mishinsky), J., Goldschmied, A., Joseph, B., Ahronson, Z., Sulman, F. G. Hypoglycemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats. Arch. Int. Pharmacodyn. Therap. 1974, 210, 27-37.
166. Yoshinari, O., Sato, H., Igarashi, K. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci. Biotechnol. Biochem. 2009, 73, 1033-1041.
167. Yoshinari, O., Igarashi, K. Anti-diabetic effect of trigonelline and nicotinic acid, on KK-A(y) mice. Curr. Med. Chem. 2010, 17, 2196-2202.
168. Atanasov, A. G., Dzyakanchuk, A. A., Schweizer, R. A. S., Nashev, L. G., Maurer, E. M., Odermatt, A. Coffee inhibits the reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1: a glucocorticoid connection in the anti-diabetic action of coffee? FEBS Lett. 2006, 580, 4081-4085.
169. Tomlinson, J. W., Stewart, P. M. Modulation of glucocorticoid action and the treatment of type-2 diabetes. Best Pract. Res. Clin. Endocrinol. Metab. 2007, 21, 607-619.
170. Fernández-Real, J. M., Ricart-Engel,W., Arroyo, E., Balancá, R., Casamitjana-Abella, R., Cabrero, D., Fernández-Castañer, M., Soler, J. Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care. 1998, 21, 62-68.
171. Haap, M., Fritsche, A., Mensing, H. J., Häring, H.-U., Stumvoll, M. Association of high serum ferritin concentration with glucose intolerance and insulin resistance in healthy people. Ann. Intern. Med. 2003, 139, 869-871.
172. Jiang, R., Ma, J., Ascherio, A., Stampfer, M. J.,Willett,W. C., Hu, F. B. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. Am. J. Clin. Nutr. 2004, 79, 70-75.
173. Rajpathak, S., Ma, J., Manson, J., Willett, W. C., Hu, F. B. Iron intake and the risk of type 2 diabetes in women: a prospective cohort study. Diabetes Care 2006, 29, 1370-1376.
174. Qi, L., van Dam, R. M., Rexrode, K., Hu, F. B. Heme iron from diet as a risk factor for coronary heart disease in women with type 2 diabetes. Diabetes Care 2007, 30, 101-106.
175. Abraham, D., Rogers, J., Gault, P., Kushner, J. P., McClain, D. A. Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis. Diabetologia. 2006, 49, 2546-2551.
176. Morck, T. A., Lynch, S. R., Cook, J. D. Inhibition of food iron absorption by coffee. Am. J. Clin. Nutr. 1983, 37, 416-420.
177. Mascitelli, L., Pezzetta, F., Sullivan, J. L. Inhibition of iron absorption by coffee and the reduced risk of type 2 diabetes mellitus. Arch. Intern. Med. 2007, 167, 204-205.
178. Tuomainen, T. P., Lagundoye, A., Voutilainen, S. Coffee intake and glucose homeostasis: is there a role for body iron? Arch. Intern. Med. 2010, 170, 1400-1401.
179. Guerrero-Romero, F., Rascón-Pacheco, R. A., Rodríguez-Morán, M., de la Peña, J. E., Wacher, N. Hypomagnesaemia and risk for metabolic glucose disorders: a 10-year follow-up study. Eur. J. Clin. Invest. 2008, 38, 389-396.
180. Rodríguez-Morán, M., Guerrero-Romero, F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003, 26, 1147-1152.
181. Mooren, F. C., Krüger, K., Völker, K., Golf, S. W., Wadepuhl, M., Kraus, A. Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial. Diabetes Obes. Metab. 2011, 13, 281-284.
182. U.S. Department of Agriculture, Agricultural Research Service. USDA National Nutrient Database for Standard Reference, Release 23. 2010. http://www.ars.usda.gov/ba/bhnrc/ndl (accessed June 13, 2011).
183. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorous, Magnesium, Vitamin D and Fluoride. National Academy Press: Washington, D.C. 1997.