Chlorogenic acid and synthetic chlorogenic acid derivatives: Novel inhibitors of hepatic glucose-6-phosphate translocase

Journal of Medicinal Chemistry

Volumn 40, Issue 2, 1997, Pages 137-145

  Hemmerle, Horst ^a   Burger, Hans Joerg ^a   Below, Peter ^a   Schubert, Gerrit ^a   Rippel, Robert ^a   Schindler, Peter W ^a   Paulus, Erich ^a   Herling, Andreas W ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROGENIC ACID; CHLOROGENIC ACID DERIVATIVE; GLUCOSE 6 PHOSPHATE TRANSLOCASE; GLUCOSE 6 PHOSPHATE TRANSLOCASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENZYME INHIBITION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; INHIBITION KINETICS; LIVER MICROSOME; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT;

ANIMALS; ANTIPORTERS; CHLOROGENIC ACID; ENZYME INHIBITORS; GLUCOSE; LIVER; MALE; MICROSOMES, LIVER; MONOSACCHARIDE TRANSPORT PROTEINS; PERFUSION; PHOSPHOTRANSFERASES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031022886     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9607360     Document Type: Article

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46. For the Xray analysis we deprotected 24 with p-toluolsulfonic acid in methanol to the tetrol which was subsequently transformed to the well crystallizing tetraacetate 24a. (Matrix Presented)