Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial

Diabetes, Obesity and Metabolism

Volumn 13, Issue 3, 2011, Pages 281-284

  Mooren, F C ^a   Kruger K ^a   Volker K ^b   Golf, S W ^a   Wadepuhl, M ^c   Kraus, A ^d  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c VSA Versuchsplanung und Statistische Auswertung   (Germany)

^d Verla Pharm Arzneimittel   (Germany)

Author keywords

Diabetes mellitus; Glycaemic control; Insulin resistance; Insulin sensitivity index; Magnesium; Metabolic syndrome; Randomized trial

Indexed keywords

GLUCOSE; INSULIN; LIPID; MAGNESIUM ASPARTATE;

ADULT; AGED; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; GLUCOSE BLOOD LEVEL; HUMAN; INCIDENCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; LIPID ANALYSIS; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RANDOMIZED CONTROLLED TRIAL;

EID: 78851470366     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2010.01332.x     Document Type: Letter

References (12)

1. Volpe SL. Magnesium, the metabolic syndrome, insulin resistance, and type 2 diabetes mellitus. Crit Rev Food Sci Nutr 2008; 48: 293-300.
2. Song Y, He K, Levitan EB, Manson JE, Liu S. Effects of oral magnesium supplementation on glycaemic control in type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Diabet Med 2006; 23: 1050-1056.
3. Gutt M, Davis CL, Spitzer SB et al. Validation of the insulin sensitivity index (ISI0, 120): comparison with other measures. Diabet Res Clin Pract 2000; 47: 177-184.
4. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. Diabet Care 1999; 22: 1462-1470.
5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and h-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
6. Hays NP, Starling RD, Liu X et al. Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial. Arch Intern Med 2004; 164: 210-217.
7. Paolisso G, Scheen A, Cozzolino D et al. Changes in glucose turnover parameters and improvement of glucose oxidation after 4-week magnesium administration in elderly noninsulin-dependent (type II) diabetic patients. J Clin Endocrinol Metab 1994; 78: 1510-1514.
8. Hadjistavri LS, Sarafidis PA, Georgianos PI et al. Beneficial effect of oral magnesium supplementation on insulin sensitivity and serum lipid profile. Med Sci Monit 2010; 16: 13-18.
9. Basso LE, Ubbink JB, Delport R. Erythrocyte magnesium concentration as an index of magnesium status: a perspective from a magnesium supplementation study. Clin Chim Acta 2000; 291: 1-8.
10. Hays NP, Starlinge RD, Sullivana DH, Fluckeya JD, Cokera RH, Evansa WJ. Comparison of insulin sensitivity assessment indices with euglycemic-hyperinsulinemic clamp data after a dietary and exercise intervention in older adults. Metab Clin Exp 2006; 55: 525-532.
11. Chazova I, Almazov VA, Shlyakhto E. Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin. Diabet Obes Metab 2006; 8: 456-465.
12. Schneider F, Vossler S, Franke S, Bär F, Konrad T. Impact of insulin sensitivity treatment with pioglitazone on endothelial function in non-diabetic patients with arterial hypertension. Int J Clin Pharmacol Ther 2009; 47: 311-320.