Nuclear factor-κB/signal Transducers and activators of transcription-1- mediated inflammatory responses in Lipopolysaccharide-activated macrophages are a major inhibitory target of kahweol, a coffee diterpene

Biological and Pharmaceutical Bulletin

Volumn 33, Issue 7, 2010, Pages 1159-1164

  Shen, Ting ^a   Park, Yung Chul ^a   Kim, Seong Hwan ^b   Lee, Jaehwi ^c   Cho, Jae Youl ^a  

^a Kangwon National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

Coffee diterpene; Kahweol; Nitric oxide; Nuclear factor kB; Prostaglandin E2; Signal transducer and activator of transcription 1

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOOXYGENASE 2; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JANUS KINASE 2; KAHWEOL; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NITRIC OXIDE; PICEATANNOL; PROSTAGLANDIN E2; PROTEIN KINASE B; STAT1 PROTEIN; TRANSCRIPTION FACTOR RELA; DITERPENE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PRIMER DNA; STAT1 PROTEIN, MOUSE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; IMMUNOMODULATION; INTRACELLULAR SIGNALING; MACROPHAGE; PHOTOTRANSDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; COFFEE; GENETICS; MACROPHAGE ACTIVATION; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; COFFEE; DINOPROSTONE; DITERPENES; DNA PRIMERS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STAT1 TRANSCRIPTION FACTOR;

EID: 77954504644     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.33.1159     Document Type: Article

References (30)

1. Qureshi N., Vogel S. N., Van Way C. 3rd, Papasian C. J., Qureshi A. A., Morrison D. C., Immunol. Res., 31, 243-260 (2005).
2. Malyshev I. Y., Shnyra A., Curr. Drug Targets Immune Endocr. Metabol. Disord., 3, 1-22 (2003).
3. Palaniyar N., Nadesalingam J., Reid K. B., Immunobiology, 205, 575-594 (2002).
4. Butchar J. P., Parsa K. V., Marsh C. B., Tridandapani S., Curr. Pharm. Des., 12, 4143-4153 (2006).
5. Yoshimura A., Cancer Sci., 97, 439-447 (2006).
6. Kobori M., Yoshida M., Ohnishi-Kameyama M., Shinmoto H., Br. J. Pharmacol., 150, 209-219 (2007).
7. Lee J. Y., Kim J. Y., Lee Y. G., Shin W. C., Chun T., Rhee M. H., Cho J. Y., Mol. Cells, 23, 198-206 (2007).
8. Cavin C., Holzhaeuser D., Scharf G., Constable A., Huber W. W., Schilter B., Food Chem. Toxicol., 40, 1155-1163 (2002).
9. Nkondjock A., Cancer Lett., 277, 121-125 (2009).
10. Cornelis M. C., El-Sohemy A., Curr. Opin. Clin. Nutr. Metab. Care, 10, 745-751 (2007).
11. de Roos B., Katan M. B., Curr. Opin. Lipidol., 10, 41-45 (1999).
12. Kim A. R., Cho J. Y., Lee J. Y., Choi J. S., Chung H. Y., J. Pharm. Pharmacol., 57, 475-481 (2005).
13. Cho J. Y., Mediators Inflamm., 2008, 298010 (2008).
14. Sudano I., Binggeli C., Spieker L., Luscher T. F., Ruschitzka F., Noll G., Corti R., Prog. Cardiovasc. Nurs., 20, 65-69 (2005).
15. Kim J. Y., Jung K. S., Jeong H. G., FEBS Lett., 569, 321-326 (2004).
16. Delgado M., Ganea D., J. Immunol., 165, 3051-3057 (2000).
17. Dell'Albani P., Santangelo R., Torrisi L., Nicoletti V. G., de Vellis J., Giuffrida Stella A. M., J. Neurosci. Res., 65, 417-424 (2001).
18. Lee Y. G., Chain B. M., Cho J. Y., Int. J. Biochem. Cell Biol., 41, 811-821 (2009).
19. Kim K. H., Jang S. A., Kim K. S., Park S., Park H. J., Lee S. J., Pyo S., Sohn E. H., J. Ginseng Res., 33, 177-182 (2009).
20. Lee Y. G., Lee W. M., Kim J. Y., Lee J. Y., Lee I. K., Yun B. S., Rhee M. H., Cho J. Y., Br. J. Pharmacol., 154, 852-863 (2008).
21. Yamaguchi K., Ishikawa T., Kondo Y., Fujisawa M., Mol. Cell. Endocrinol., 283, 68-75 (2008).
22. Gurung S. K., Lim H., Kim H. P., Park H., Biomol. Ther., 17, 418-421 (2009).
23. Binion D. G., Heidemann J., Li M. S., Nelson V. M., Otterson M. F., Rafiee P., Am. J. Physiol. Gastrointest. Liver Physiol., 297, G259-G268 (2009).
24. Hallmann D., Trumper K., Trusheim H., Ueki K., Kahn C. R., Cantley L. C., Fruman D. A., Horsch D., J. Biol. Chem., 278, 5099-5108 (2003).
25. Guha M., Mackman N., Cell Signal., 13, 85-94 (2001).
26. Lee J. Y., Lee Y. G., Lee J., Yang K. J., Kim A. R., Kim J. Y., Won M. H., Park J., Yoo B. C., Kim S., Cho W. J., Cho J. Y., J. Biol. Chem., 285, 9932-9948 (2010).
27. Kim O. S., Park E. J., Joe E. H., Jou I., J. Biol. Chem., 277, 40594-40601 (2002).
28. Dawn B., Xuan Y. T., Guo Y., Rezazadeh A., Stein A. B., Hunt G., Wu W. J., Tan W., Bolli R., Cardiovasc. Res., 64, 61-71 (2004).
29. Kim H. G., Kim J. Y., Hwang Y. P., Lee K. J., Lee K. Y., Kim D. H., Kim D. H., Jeong H. G., Toxicol. Appl. Pharmacol., 217, 332-341 (2006).
30. Kim H. Y., Park E. J., Joe E. H., Jou I., J. Immunol., 171, 6072-6079 (2003).