Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 598-605

  Bajt, Mary Lynn ^a   Ramachandran, Anup ^a   Yan, Hui Min ^a   Lebofsky, Margitta ^a   Farhood, Anwar ^b   Lemasters, John J ^c,d   Jaeschke, Hartmut ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b Brackenridge Hospital   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Acetaminophen; Cell death; DNA fragmentation; Drug hepatotoxicity; Mitochondria; Reactive oxygen species

Indexed keywords

ALANINE AMINOTRANSFERASE; APOPTOSIS INDUCING FACTOR; CYTOCHROME P450 2E1; DNA FRAGMENT; GLUTATHIONE; GLUTATHIONE DISULFIDE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; URIDINE TRIPHOSPHATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DNA STRAND BREAKAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; LIVER CELL; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; METABOLIC ACTIVATION; MITOCHONDRION; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; WILD TYPE;

ACETAMINOPHEN; ANIMALS; APOPTOSIS INDUCING FACTOR; BLOTTING, WESTERN; DNA FRAGMENTATION; DRUG-INDUCED LIVER INJURY; GLUTATHIONE DISULFIDE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER; MALE; MICE; MITOCHONDRIA, LIVER; NECROSIS; OVERDOSE; OXIDATIVE STRESS; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES;

ANIMALIA; MUS;

EID: 80051704387     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr116     Document Type: Article

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