Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen

Toxicology in Vitro

Volumn 25, Issue 2, 2011, Pages 475-484

  Knockaert, Laetitia ^a,b   Descatoire, Véronique ^c   Vadrot, Nathalie ^d   Fromenty, Bernard ^a,b   Robin, Marie Anne ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c BICHAT HOSPITAL   (France)

^d CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Acetaminophen; Cytochrome P450 2E1; Ethanol; Mitochondria; Reactive oxygen species

Indexed keywords

ALCOHOL; CYTOCHROME P450 2E1; GLUTATHIONE; HEAT SHOCK PROTEIN 70; MANGANESE SUPEROXIDE DISMUTASE; PARACETAMOL; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL DEATH; CELL STRAIN COS7; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOPLASMIC RETICULUM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEIN EXPRESSION;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOCHROME P-450 CYP2E1; ETHANOL; GLUTATHIONE; HSP70 HEAT-SHOCK PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 79151471077     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.11.019     Document Type: Article

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