Caveats of using acetaminophen hepatotoxicity models for natural product testing

Toxicology Letters

Volumn 215, Issue 1, 2012, Pages 40-41

  Jaeschke, Hartmut ^a   Williams, C David ^a   McGill, Mitchell R ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; HepG2 cells; Mitochondria; Protein adducts; Reactive metabolites

Indexed keywords

DIOSCIN; GLUTATHIONE; NATURAL PRODUCT; PARACETAMOL; PEROXYNITRITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DEATH; CELL STRAIN HEPG2; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMAN; LETTER; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MEMBRANE PERMEABILITY; METABOLIC ACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIOSGENIN; DRUG-INDUCED LIVER INJURY; HUMANS; MALE;

EID: 84867606870     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.09.023     Document Type: Letter

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