Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure

Drug Metabolism and Disposition

Volumn 37, Issue 8, 2009, Pages 1779-1784

  James, Laura P ^a,b,g   Letzig, Lynda ^b   Simpson, Pippa M ^c   Capparelli, Edmund ^d   Roberts, Dean W ^a,b   Hinson, Jack A ^b   Davern, Timothy J ^e   Lee, William M ^f  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF TEXAS AT DALLAS   (United States)

^g ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (CYSTEINYL) N(4 HYDROXYPHENYL)ACETAMIDE; ACETYLCYSTEINE; AMINOTRANSFERASE; BILIRUBIN; BINDING PROTEIN; CREATININE; PARACETAMOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CYTOLYSIS; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG OVERDOSE; ELECTROCHEMICAL DETECTION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTOXICATION; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; TOXICOKINETICS;

ACETAMINOPHEN; ACETYLCYSTEINE; ADULT; ANALGESICS, NON-NARCOTIC; ANTIDOTES; BAYES THEOREM; BENZOQUINONES; BIOLOGICAL MARKERS; BIOTRANSFORMATION; DATABASES AS TOPIC; FEMALE; HALF-LIFE; HUMANS; IMINES; LIVER FAILURE, ACUTE; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NONLINEAR DYNAMICS; OVERDOSE; YOUNG ADULT;

EID: 67650802351     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.026195     Document Type: Article

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