Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity

Molecular Pharmacology

Volumn 82, Issue 5, 2012, Pages 1001-1007

  Sharma, Manju ^a   Gadang, Vidya ^a   Jaeschke, Anja ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLYCOGEN SYNTHASE KINASE 3BETA; MIXED LINEAGE KINASE 3; PARACETAMOL; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 140; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME INDUCTION; IN VITRO STUDY; KNOCKOUT MOUSE; LIVER CELL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOXIC HEPATITIS; WILD TYPE;

ACETAMINOPHEN; ANIMALS; CELL LINE, TUMOR; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; GLUTATHIONE; GTPASE-ACTIVATING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84867808435     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.079863     Document Type: Article

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