Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase

Toxicology Letters

Volumn 177, Issue 3, 2008, Pages 188-197

  Andringa, Kelly K ^a   Bajt, Mary Lynn ^b   Jaeschke, Hartmut ^b   Bailey, Shannon M ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; Hepatotoxicity; HMG CoA synthase; Mitochondria; Proteomics; Thiols

Indexed keywords

ALANINE AMINOTRANSFERASE; CELL PROTEIN; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; MITOCHONDRIAL PROTEIN; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; THIOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DOWN REGULATION; DRUG METABOLISM; DRUG OVERDOSE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME METABOLISM; KETOGENESIS; LIVER FAILURE; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PROCESSING; PROTEOMICS; TOXICOKINETICS;

ACETAMINOPHEN; ALANINE TRANSAMINASE; ANIMALS; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; LIVER; MALE; MICE; MICE, INBRED C3H; MITOCHONDRIAL PROTEINS; PROTEOMICS; SULFHYDRYL COMPOUNDS;

EID: 40849137599     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.01.010     Document Type: Article

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