Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 295, Issue 2, 2008, Pages

  Campion, Sarah N ^a   Johnson, Rachel ^a   Aleksunes, Lauren M ^a   Goedken, Michael J ^b   Van Rooijen, Nico ^c   Scheffer, George L ^c   Cherrington, Nathan J ^d   Manautou, José E ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

Abcc4; Cytokine; Hepatotoxicity; Macrophage; Multidrug resistance protein; Transporter

Indexed keywords

ALANINE AMINOTRANSFERASE; CLODRONIC ACID; INTERLEUKIN 1BETA; MULTIDRUG RESISTANCE PROTEIN 4; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA; ABCC4 PROTEIN, MOUSE; CHEMOKINE; CYTOKINE; LIPOSOME; MULTIDRUG RESISTANCE PROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DEPLETION; DETOXIFICATION; KUPFFER CELL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN TRANSPORT; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ACETAMINOPHEN; ANIMALS; CHEMOKINES; CLODRONIC ACID; CYTOKINES; KUPFFER CELLS; LIPOSOMES; MALE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS;

EID: 52449129584     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00541.2007     Document Type: Article

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