Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

Hepatology

Volumn 54, Issue 6, 2011, Pages 2208-2217

  Saini, Simrat P S ^a   Zhang, Bin ^a   Niu, Yongdong ^a,b   Jiang, Mengxi ^a   Gao, Jie ^a   Zhai, Yonggong ^c   Hoon Lee, Jung ^a   Uppal, Hirdesh ^a   Tian, Hui ^a   Tortorici, Michael A ^a   Poloyac, Samuel M ^a   Qin, Wenxin ^b   Venkataramanan, Raman ^a   Xie, Wen ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2E1; CYTOCHROME P450 3A11; DRUG METABOLITE; GLUTATHIONE TRANSFERASE; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; PARACETAMOL; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; TO 1317; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SULFATION; ENZYME REPRESSION; GENE CONTROL; LIVER PROTECTION; LIVER TOXICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE S-TRANSFERASE PI; LIVER; LIVER FAILURE, ACUTE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; ORPHAN NUCLEAR RECEPTORS; PROMOTER REGIONS, GENETIC; RECEPTORS, STEROID; SULFOTRANSFERASES;

EID: 82455171620     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24646     Document Type: Article

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