Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 342, Issue 3, 2012, Pages 676-687

  Aubert, Jacinthe ^a   Begriche, Karima ^a   Delannoy, Matthieu ^a   Morel, Isabelle ^a,b   Pajaud, Julie ^a   Ribault, Catherine ^a   Lepage, Sylvie ^b   McGill, Mitchell R ^c   Lucas Clerc, Catherine ^b   Turlin, Bruno ^a,b   Robin, Marie Anne ^a   Jaeschke, Hartmut ^c   Fromenty, Bernard ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CYTOCHROME P450 2E1; GLUTATHIONE; LACTIC ACID; MITOCHONDRIAL DNA; PARACETAMOL; PARACETAMOL GLUCURONIDE; STRESS ACTIVATED PROTEIN KINASE; TRIACYLGLYCEROL;

AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DRUG BLOOD LEVEL; DRUG OVERDOSE; FEMALE; GENE EXPRESSION; GENOTYPE; GLUCURONIDATION; HISTOPATHOLOGY; LACTATE BLOOD LEVEL; MALE; MOUSE; NICK END LABELING; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; STRAIN DIFFERENCE; TOXIC HEPATITIS; WILD TYPE;

3-HYDROXYBUTYRIC ACID; ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 CYP2E1; DNA, MITOCHONDRIAL; DRUG-INDUCED LIVER INJURY; FATTY LIVER; FEMALE; GLUCURONIDES; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LACTIC ACID; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; OBESITY; SULFATES; TRIGLYCERIDES;

EID: 84865159199     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.112.193813     Document Type: Article

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