PXR cross-talks with internal and external signals in physiological and pathophysiological responses

Drug Metabolism Reviews

Volumn 45, Issue 3, 2013, Pages 300-310

  Kodama, Susumu ^a   Negishi, Masahiko ^b  

^a TOHOKU UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cellular signal; Gene regulation; Nuclear receptor; Pregnane X receptor; Xenobiotics

Indexed keywords

BILE ACID; CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL; COLECALCIFEROL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN DEPENDENT KINASE 2; CYTOCHROME P450 3A4; GLUCAGON; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HEAT SHOCK PROTEIN 90; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HETERODIMER; HISTONE H3; INSULIN; LITHOCHOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOENOLPYRUVATE CARBOXYKINASE 1; PREGNANE X RECEPTOR; PROTEIN KINASE C; RETINOID X RECEPTOR; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STEROID HORMONE; STEROID RECEPTOR COACTIVATOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; XENOBIOTIC AGENT;

ADAPTIVE IMMUNITY; B LYMPHOCYTE; BACTERIAL FLORA; BILE FLOW; CANCER CELL CULTURE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL PROLIFERATION; CELL STRESS; CHOLESTASIS; CHOLESTEROL LIVER LEVEL; CHROMATIN STRUCTURE; CLINICAL FEATURE; COLON CANCER; CONCENTRATION (PARAMETERS); CROHN DISEASE; DEACETYLATION; DNA BINDING; DNA REPAIR; DNA RESPONSIVE ELEMENT; DNA SEQUENCE; DOWN REGULATION; EARLY RESPONSE GENE; ENERGY METABOLISM; ENERGY RESOURCE; EPITHELIAL MESENCHYMAL TRANSITION; FATTY ACID OXIDATION; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENOTYPE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HUMAN; HYPERTROPHY; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN RESPONSE; INTESTINE CANCER; LIGAND BINDING; LIPID LIVER LEVEL; LIPOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; LIVER INJURY; LIVER TOXICITY; LYMPHOCYTE PROLIFERATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REVIEW; SUMOYLATION; TRANSGENIC MOUSE; UBIQUITINATION; ULCERATIVE COLITIS; VITAMIN D RESPONSIVE ELEMENT; WILD TYPE; XENOBIOTIC METABOLISM;

ANIMALS; GENE EXPRESSION REGULATION; HUMANS; RECEPTOR CROSS-TALK; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS; XENOBIOTICS;

EID: 84880536932     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2013.795585     Document Type: Review

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