Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

Journal of Experimental Medicine

Volumn 203, Issue 1, 2006, Pages 7-13

  Ito, Kazuhiro ^a   Yamamura, Satoshi ^a   Essilfie Quaye, Sarah ^a   Cosio, Borja ^a   Ito, Misako ^a   Barnes, Peter J ^a   Adcock, Ian M ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DEACETYLATION; DRUG SENSITIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; LIGAND BINDING; MACROPHAGE; PRIORITY JOURNAL; RECEPTOR BINDING; RNA INTERFERENCE; SITE DIRECTED MUTAGENESIS;

CELL LINE, TUMOR; CELLS, CULTURED; DEXAMETHASONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTONE DEACETYLASES; HUMANS; INTERLEUKIN-1; MACROPHAGES, ALVEOLAR; NF-KAPPA B; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 31344446119     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20050466     Document Type: Article

References (27)

1. Beato, M. 1996. Chromatin structure and the regulation of gene expression: remodeling at the MMTV promoter. J. Mol. Med. 74:711-724.
2. Wolffe, A.P. 1997. Transcriptional control. Sinful repression. Nature. 387:16-17.
3. Ura, K., H. Kurumizaka, S. Dimitrov, G. Almouzni, and A.P. Wolffe. 1997. Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression. EMBO J. 16:2096-2107.
4. de Ruijter, A.J., A.H. van Gennip, H.N. Caron, S. Kemp, and A.B. van Kuilenburg. 2003. Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem. J. 370:737-749.
5. Thiagalingam, S., K.H. Cheng, H.J. Lee, N. Mineva, A. Thiagalingam, and J.F. Ponte. 2003. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann. NY Acad. Sci. 983:84-100.
6. Ito, K., M. Ito, W.M. Elliott, B. Cosio, G. Caramori, O.M. Kon, A. Barczyk, S. Hayashi, I.M. Adcock, J.C. Hogg, and P.J. Barnes. 2005. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N. Engl. J. Med. 352:1967-1976.
7. Cosio, B.G., L. Tsaprouni, K. Ito, E. Jazrawi, I.M. Adcock, and P.J. Barnes. 2004. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J. Exp. Med. 200:689-695.
8. Abbinante-Nissen, J.M., L.G. Simpson, and G.D. Leikauf. 1995. Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells. Am. J. Physiol. 268:L601-L606.
9. Lasa, M., S.M. Abraham, C. Boucheron, J. Saklatvala, and A.R. Clark. 2002. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol. Cell. Biol. 22:7802-7811.
10. Ray, A., K.E. Prefontaine, and P. Ray. 1994. Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269:12940-12946.
11. Adcock, I.M., and K. Ito. 2000. Molecular mechanisms of corticosteroid actions. Monaldi Arch. Chest Dis. 55:256-266.
12. Ogawa, S., J. Lozach, C. Benner, G. Pascual, R.K. Tangirala, S. Westin, A. Hoff mann, S. Subramaniam, M. David, M.G. Rosenfeld, and C.K. Glass. 2005. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 122:707-721.
13. Barnes, P.J. 2000. Mechanisms in COPD: differences from asthma. Chest. 117:10S-14S.
14. Barnes, P.J. 2000. Inhaled corticosteroids are not beneficial in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 161:342-344.
15. Culpitt, S.V., D.F. Rogers, P. Shah, C. De Matos, R.E. Russell, L.E. Donnelly, and P.J. Barnes. 2003. Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 167:24-31.
16. Ito, K., S. Lim, G. Caramori, K.F. Chung, P.J. Barnes, and I.M. Adcock. 2001. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15:1110-1112.
17. Kagoshima, M., T. Wilcke, K. Ito, L. Tsaprouni, P.J. Barnes, N. Punchard, and I.M. Adcock. 2001. Glucocorticoid-mediated transrepression is regulated by histone acetylation and DNA methylation. Eur. J. Pharmacol. 429:327-334.
18. Kochetkova, M., and M.F. Shannon. 1996. DNA triplex formation selectively inhibits granulocyte-macrophage colony-stimulating factor gene expression in human T cells. J. Biol. Chem. 271:14438-14444.
19. Ito, K., P.J. Barnes, and I.M. Adcock. 2000. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 20:6891-6903.
20. Nissen, R.M., and K.R. Yamamoto. 2000. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 14:2314-2329.
21. Wang, C., M. Fu, R.H. Angeletti, L. Siconolfi-Baez, A.T. Reutens, C. Albanese, M.P. Lisanti, B.S. Katzenellenbogen, S. Kato, T. Hopp, et al. 2001. Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity. J. Biol. Chem. 276:18375-18383.
22. Fu, M., C. Wang, X. Zhang, and R. Pestell. 2003. Nuclear receptor modifications and endocrine cell proliferation. J. Steroid Biochem. Mol. Biol. 85:133-138.
23. Rogatsky, I., H.F. Luecke, D.C. Leitman, and K.R. Yamamoto. 2002. Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts. Proc. Natl. Acad. Sci. USA. 99:16701-16706.
24. Cosio, B.G., B. Mann, K. Ito, E. Jazrawi, P.J. Barnes, K.F. Chung, and I.M. Adcock. 2004. Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am. J. Respir. Crit. Care Med. 170:141-147.
25. Lim, S., N. Roche, B.G. Oliver, W. Mattos, P.J. Barnes, and K.F. Chung. 2000. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am. J. Respir. Crit. Care Med. 162:1355-1360.
26. Eickelberg, O., A. Pansky, R. Mussmann, M. Bihl, M. Tamm, P. Hildebrand, A.P. Perruchoud, and M. Roth. 1999. Transforming growth factor-beta1 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts. J. Biol. Chem. 274:12933-12938.
27. Usmani, O.S., K. Ito, K. Maneechotesuwan, M. Ito, M. Johnson, P.J. Barnes, and I.M. Adcock. 2005. Glucocorticoid Receptor Nuclear Translocation in Airway Cells Following Inhaled Combination Therapy. Am. J. Respir. Crit. Care Med. 172:704-712.