Induced CYP3A4 expression in confluent huh7 hepatoma cells as a result of decreased cell proliferation and subsequent pregnane x receptor activations

Molecular Pharmacology

Volumn 83, Issue 3, 2013, Pages 659-670

  Sivertsson, Louise ^a   Edebert, Irene ^a   Palmertz, Margareta Porsmyr ^b   Ingelman Sundberg, Magnus ^a   Neve, Etienne P A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN; ROSCOVITINE; SMALL INTERFERING RNA;

ARTICLE; CELL CONTACT; CELL CYCLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA FLANKING REGION; GENE SILENCING; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE 2; CYTOCHROME P-450 CYP3A; DOWN-REGULATION; HUMANS; LIVER; LIVER NEOPLASMS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RECEPTORS, STEROID; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; TRANSCRIPTOME; UP-REGULATION;

EID: 84874339252     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.082305     Document Type: Article

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