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Volumn 17, Issue 2, 2009, Pages 213-219

Posttranslational modifications of PPAR-γ: Fine-tuning the metabolic master regulator

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 58849102970     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.473     Document Type: Article
Times cited : (128)

References (70)
  • 1
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • Lehrke M, Lazar MA. The many faces of PPARgamma. Cell 2005;123:993-999.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 2
    • 10644251916 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-gamma calls for activation in moderation: Lessons from genetics and pharmacology
    • Knouff C, Auwerx J. Peroxisome proliferatoractivated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology. Endocr Rev 2004;25: 899-918.
    • (2004) Endocr Rev , vol.25 , pp. 899-918
    • Knouff, C.1    Auwerx, J.2
  • 3
    • 0032505096 scopus 로고    scopus 로고
    • Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
    • Nolte RT, Wisely GB, Westin S et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 1998;395:137-143.
    • (1998) Nature , vol.395 , pp. 137-143
    • Nolte, R.T.1    Wisely, G.B.2    Westin, S.3
  • 4
    • 13844262924 scopus 로고    scopus 로고
    • Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes
    • Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev 2005;19: 453-461.
    • (2005) Genes Dev , vol.19 , pp. 453-461
    • Guan, H.P.1    Ishizuka, T.2    Chui, P.C.3    Lehrke, M.4    Lazar, M.A.5
  • 5
    • 21744435965 scopus 로고    scopus 로고
    • Controlling nuclear receptors: The circular logic of cofactor cycles
    • Perissi V, Rosenfeld MG. Controlling nuclear receptors: the circular logic of cofactor cycles. Nat Rev Mol Cell Biol 2005;6:542-554.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 542-554
    • Perissi, V.1    Rosenfeld, M.G.2
  • 6
    • 0037245786 scopus 로고    scopus 로고
    • Transactivation functions of the N-terminal domains of nuclear hormone receptors: Protein folding and coactivator interactions
    • Kumar R, Thompson EB. Transactivation functions of the N-terminal domains of nuclear hormone receptors: protein folding and coactivator interactions. Mol Endocrinol 2003;17:1-10.
    • (2003) Mol Endocrinol , vol.17 , pp. 1-10
    • Kumar, R.1    Thompson, E.B.2
  • 7
    • 29644433449 scopus 로고    scopus 로고
    • Fatty acid transduction of nitric oxide signaling: Multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferatoractivated receptor ligands
    • Baker PRS, Lin YM, Schopfer FJ et al. Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferatoractivated receptor ligands. J Biol Chem 2005;280:42464-42475.
    • (2005) J Biol Chem , vol.280 , pp. 42464-42475
    • Baker, P.R.S.1    Lin, Y.M.2    Schopfer, F.J.3
  • 8
    • 0028972025 scopus 로고
    • 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
    • Forman BM, Tontonoz P, Chen J et al. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 1995;83:803-812.
    • (1995) Cell , vol.83 , pp. 803-812
    • Forman, B.M.1    Tontonoz, P.2    Chen, J.3
  • 9
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Jarvinen H. Thiazolidinediones. N Engl J Med 2004;351:1106-1118.
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 10
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-595.
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3
  • 11
    • 0033212964 scopus 로고    scopus 로고
    • PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999;4:597-609.
    • (1999) Mol Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 12
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen ED, Sarraf P, Troy AE et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999;4:611-617.
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3
  • 13
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 14
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse
    • Imai T, Takakuwa R, Marchand S et al. Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci USA 2004;101:4543-4547.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4543-4547
    • Imai, T.1    Takakuwa, R.2    Marchand, S.3
  • 15
    • 14844295735 scopus 로고    scopus 로고
    • Lessons from human mutations in PPARgamma
    • Hegele RA. Lessons from human mutations in PPARgamma. Int J Obes (Lond) 2005;29(Suppl 1):S31-S35.
    • (2005) Int J Obes (Lond) , vol.29 , Issue.SUPPL. 1
    • Hegele, R.A.1
  • 16
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-gamma regulates osteoclastogenesis in mice
    • Wan Y, Chong LW, Evans RM. PPAR-gamma regulates osteoclastogenesis in mice. Nat Med 2007;13:1496-1503.
    • (2007) Nat Med , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.W.2    Evans, R.M.3
  • 17
    • 0033169058 scopus 로고    scopus 로고
    • An adipogenic cofactor bound by the differentiation domain of PPAR gamma
    • Castillo G, Brun RP, Rosenfield JK et al. An adipogenic cofactor bound by the differentiation domain of PPAR gamma. EMBO J 1999;18:3676-3687.
    • (1999) EMBO J , vol.18 , pp. 3676-3687
    • Castillo, G.1    Brun, R.P.2    Rosenfield, J.K.3
  • 18
    • 33744497272 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis
    • Hummasti S, Tontonoz P. The peroxisome proliferator-activated receptor N-terminal domain controls isotype-selective gene expression and adipogenesis. Mol Endocrinol 2006;20:1261-1275.
    • (2006) Mol Endocrinol , vol.20 , pp. 1261-1275
    • Hummasti, S.1    Tontonoz, P.2
  • 19
    • 41549153833 scopus 로고    scopus 로고
    • The adipogenic acetyltransferase Tip60 targets activation function 1 of PPARgamma
    • van Beekum O, Brenkman AB, Grøntved L et al. The adipogenic acetyltransferase Tip60 targets activation function 1 of PPARgamma. Endocrinology 2008;149:1840-1849.
    • (2008) Endocrinology , vol.149 , pp. 1840-1849
    • van Beekum, O.1    Brenkman, A.B.2    Grøntved, L.3
  • 20
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma
    • Hu ED, Kim JB, Sarraf P, Spiegelman BM. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPAR gamma. Science 1996;274:2100-2103.
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.D.1    Kim, J.B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 21
    • 33144463713 scopus 로고    scopus 로고
    • An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPAR gamma, adipogenesis, and insulin-responsive hexose transport
    • Tang XQ, Guilherme A, Chakladar A et al. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPAR gamma, adipogenesis, and insulin-responsive hexose transport. Proc Natl Acad Sci USA 2006;103:2087-2092.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 2087-2092
    • Tang, X.Q.1    Guilherme, A.2    Chakladar, A.3
  • 22
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
    • Camp HS, Tafuri SR. Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J Biol Chem 1997;272:10811-10816.
    • (1997) J Biol Chem , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 23
    • 0031939716 scopus 로고    scopus 로고
    • Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma
    • Reginato MJ, Krakow SL, Bailey ST, Lazar MA. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor gamma. J Biol Chem 1998;273:1855-1858.
    • (1998) J Biol Chem , vol.273 , pp. 1855-1858
    • Reginato, M.J.1    Krakow, S.L.2    Bailey, S.T.3    Lazar, M.A.4
  • 24
    • 0029775642 scopus 로고    scopus 로고
    • Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma
    • Zhang B, Berger J, Zhou GC et al. Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma. J Biol Chem 1996;271:31771-31774.
    • (1996) J Biol Chem , vol.271 , pp. 31771-31774
    • Zhang, B.1    Berger, J.2    Zhou, G.C.3
  • 25
    • 0031057517 scopus 로고    scopus 로고
    • Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site
    • Adams M, Reginato MJ, Shao D, Lazar MA, Chatterjee VK. Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem 1997;272: 5128-5132.
    • (1997) J Biol Chem , vol.272 , pp. 5128-5132
    • Adams, M.1    Reginato, M.J.2    Shao, D.3    Lazar, M.A.4    Chatterjee, V.K.5
  • 26
    • 0032894240 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma 1 and negatively regulates its transcriptional activity
    • Camp HS, Tafuri SR, Leff T. c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma 1 and negatively regulates its transcriptional activity. Endocrinology 1999;140:392-397.
    • (1999) Endocrinology , vol.140 , pp. 392-397
    • Camp, H.S.1    Tafuri, S.R.2    Leff, T.3
  • 27
    • 0030877565 scopus 로고    scopus 로고
    • Ligand-independent activation domain in the N terminus of peroxisome proliferatoractivated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin
    • Werman A, Hollenberg A, Solanes G et al. Ligand-independent activation domain in the N terminus of peroxisome proliferatoractivated receptor gamma (PPARgamma). Differential activity of PPARgamma1 and -2 isoforms and influence of insulin. J Biol Chem 1997;272:20230-20235.
    • (1997) J Biol Chem , vol.272 , pp. 20230-20235
    • Werman, A.1    Hollenberg, A.2    Solanes, G.3
  • 28
    • 0032569902 scopus 로고    scopus 로고
    • Interdomain communication regulating ligand binding by PPAR-gamma
    • Shao D, Rangwala SM, Bailey ST et al. Interdomain communication regulating ligand binding by PPAR-gamma. Nature 1998;396:377-380.
    • (1998) Nature , vol.396 , pp. 377-380
    • Shao, D.1    Rangwala, S.M.2    Bailey, S.T.3
  • 29
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl J Med 1998;339: 953-959.
    • (1998) N Engl J Med , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 30
    • 0035029255 scopus 로고    scopus 로고
    • Pioglitazone ameliorates tumor necrosis factoralpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma
    • Iwata M, Haruta T, Usui I et al. Pioglitazone ameliorates tumor necrosis factoralpha-induced insulin resistance by a mechanism independent of adipogenic activity of peroxisome proliferator-activated receptor-gamma. Diabetes 2001;50: 1083-1092.
    • (2001) Diabetes , vol.50 , pp. 1083-1092
    • Iwata, M.1    Haruta, T.2    Usui, I.3
  • 31
    • 38949216025 scopus 로고    scopus 로고
    • Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation
    • Hosooka T, Noguchi T, Kotani K et al. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nat Med 2008;14:188-193.
    • (2008) Nat Med , vol.14 , pp. 188-193
    • Hosooka, T.1    Noguchi, T.2    Kotani, K.3
  • 32
    • 21744438445 scopus 로고    scopus 로고
    • Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations
    • Compe E, Drane P, Laurent C et al. Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations. Mol Cell Biol 2005;25:6065-6076.
    • (2005) Mol Cell Biol , vol.25 , pp. 6065-6076
    • Compe, E.1    Drane, P.2    Laurent, C.3
  • 33
    • 33745670848 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis
    • Iankova I, Petersen RK, Annicotte JS et al. Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. Mol Endocrinol 2006;20:1494-1505.
    • (2006) Mol Endocrinol , vol.20 , pp. 1494-1505
    • Iankova, I.1    Petersen, R.K.2    Annicotte, J.S.3
  • 34
    • 0141561892 scopus 로고    scopus 로고
    • The transcriptional complexity of the TFIIH complex
    • Zurita M, Merino C. The transcriptional complexity of the TFIIH complex. Trends Genet 2003;19:578-584.
    • (2003) Trends Genet , vol.19 , pp. 578-584
    • Zurita, M.1    Merino, C.2
  • 35
    • 3242769187 scopus 로고    scopus 로고
    • Cellular control of gene expression by T-type cyclin/CDK9 complexes
    • Garriga J, Grana X. Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene 2004;337:15-23.
    • (2004) Gene , vol.337 , pp. 15-23
    • Garriga, J.1    Grana, X.2
  • 36
    • 7944236265 scopus 로고    scopus 로고
    • The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain
    • Yamashita D, Yamaguchi T, Shimizu M et al. The transactivating function of peroxisome proliferator-activated receptor gamma is negatively regulated by SUMO conjugation in the amino-terminal domain. Genes Cells 2004;9:1017-1029.
    • (2004) Genes Cells , vol.9 , pp. 1017-1029
    • Yamashita, D.1    Yamaguchi, T.2    Shimizu, M.3
  • 37
    • 4644257496 scopus 로고    scopus 로고
    • Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation
    • Floyd ZE, Stephens JM. Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation. Obes Res 2004;12:921-928.
    • (2004) Obes Res , vol.12 , pp. 921-928
    • Floyd, Z.E.1    Stephens, J.M.2
  • 38
    • 33646229801 scopus 로고    scopus 로고
    • Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation
    • Shimizu M, Yamashita D, Yamaguchi T, Hirose F, Osumi T. Aspects of the regulatory mechanisms of PPAR functions: analysis of a bidirectional response element and regulation by sumoylation. Mol Cell Biochem 2006;286:33-42.
    • (2006) Mol Cell Biochem , vol.286 , pp. 33-42
    • Shimizu, M.1    Yamashita, D.2    Yamaguchi, T.3    Hirose, F.4    Osumi, T.5
  • 39
    • 3142716146 scopus 로고    scopus 로고
    • Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    • Ohshima T, Koga H, Shimotohno K. Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification. J Biol Chem 2004;279:29551-29557.
    • (2004) J Biol Chem , vol.279 , pp. 29551-29557
    • Ohshima, T.1    Koga, H.2    Shimotohno, K.3
  • 41
    • 33748416853 scopus 로고    scopus 로고
    • A recurrent phosphosumoyl switch in transcriptional repression and beyond
    • Yang XJ, Gregoire S. A recurrent phosphosumoyl switch in transcriptional repression and beyond. Mol Cell 2006;23:779-786.
    • (2006) Mol Cell , vol.23 , pp. 779-786
    • Yang, X.J.1    Gregoire, S.2
  • 42
    • 30444440554 scopus 로고    scopus 로고
    • PDSM, a motif for phosphorylation-dependent SUMO modification
    • Hietakangas V, Anckar J, Blomster HA et al. PDSM, a motif for phosphorylation-dependent SUMO modification. Proc Natl Acad Sci USA 2006;103:45-50.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 45-50
    • Hietakangas, V.1    Anckar, J.2    Blomster, H.A.3
  • 43
    • 40849126935 scopus 로고    scopus 로고
    • Phosphorylation- Dependent sumoylation regulates ERR-alpha and -gamma transcriptional activity through a synergy control motif
    • Tremblay AM, Wilson BJ, Yang XJ, Giguère V. Phosphorylation- Dependent sumoylation regulates ERR-alpha and -gamma transcriptional activity through a synergy control motif. Mol Endocrinol 2007;22:570-584.
    • (2007) Mol Endocrinol , vol.22 , pp. 570-584
    • Tremblay, A.M.1    Wilson, B.J.2    Yang, X.J.3    Giguère, V.4
  • 44
    • 33750491062 scopus 로고    scopus 로고
    • Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
    • Lin DY, Huang YS, Jeng JC et al. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell 2006;24:341-354.
    • (2006) Mol Cell , vol.24 , pp. 341-354
    • Lin, D.Y.1    Huang, Y.S.2    Jeng, J.C.3
  • 45
    • 13544259457 scopus 로고    scopus 로고
    • The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification
    • Lee MB, Lebedeva LA, Suzawa M et al. The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol 2005;25:1879-1890.
    • (2005) Mol Cell Biol , vol.25 , pp. 1879-1890
    • Lee, M.B.1    Lebedeva, L.A.2    Suzawa, M.3
  • 46
    • 40849150778 scopus 로고    scopus 로고
    • Identification of SUMO-dependent chromatinassociated transcriptional repression components by a genome-wide RNAi screen
    • Stielow B, Sapetschnig A, Kruger I et al. Identification of SUMO-dependent chromatinassociated transcriptional repression components by a genome-wide RNAi screen. Mol Cell 2008;29:742-754.
    • (2008) Mol Cell , vol.29 , pp. 742-754
    • Stielow, B.1    Sapetschnig, A.2    Kruger, I.3
  • 47
    • 26444471700 scopus 로고    scopus 로고
    • A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma
    • Pascual G, Fong AL, Ogawa S et al. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 2005;437:759-763.
    • (2005) Nature , vol.437 , pp. 759-763
    • Pascual, G.1    Fong, A.L.2    Ogawa, S.3
  • 48
    • 33845970925 scopus 로고    scopus 로고
    • Parallel SUMOylation- dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPAR gamma
    • Ghisletti S, Huang W, Ogawa S et al. Parallel SUMOylation- dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPAR gamma. Mol Cell 2007; 25:57-70.
    • (2007) Mol Cell , vol.25 , pp. 57-70
    • Ghisletti, S.1    Huang, W.2    Ogawa, S.3
  • 49
    • 0034915764 scopus 로고    scopus 로고
    • Mechanisms underlying ubiquitination
    • Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem 2001;70:503-533.
    • (2001) Annu Rev Biochem , vol.70 , pp. 503-533
    • Pickart, C.M.1
  • 50
    • 0037335034 scopus 로고    scopus 로고
    • How the ubiquitin-proteasome system controls transcription
    • Muratani M, Tansey WP. How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol 2003;4:192-201.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 192-201
    • Muratani, M.1    Tansey, W.P.2
  • 51
    • 0033638393 scopus 로고    scopus 로고
    • The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation
    • Lonard DM, Nawaz Z, Smith CL, O'Malley BW. The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell 2000;5:939-948.
    • (2000) Mol Cell , vol.5 , pp. 939-948
    • Lonard, D.M.1    Nawaz, Z.2    Smith, C.L.3    O'Malley, B.W.4
  • 52
    • 0037351881 scopus 로고    scopus 로고
    • Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling
    • Reid G, Hubner MR, Metivier R et al. Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol Cell 2003;11:695-707.
    • (2003) Mol Cell , vol.11 , pp. 695-707
    • Reid, G.1    Hubner, M.R.2    Metivier, R.3
  • 53
    • 0035831494 scopus 로고    scopus 로고
    • Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes
    • Waite KJ, Floyd ZE, Arbour-Reily P, Stephens JM. Interferon-gamma-induced regulation of peroxisome proliferator-activated receptor gamma and STATs in adipocytes. J Biol Chem 2001;276:7062-7068.
    • (2001) J Biol Chem , vol.276 , pp. 7062-7068
    • Waite, K.J.1    Floyd, Z.E.2    Arbour-Reily, P.3    Stephens, J.M.4
  • 54
    • 41449112452 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells
    • Christianson JL, Nicoloro S, Straubhaar J, Czech MP. Stearoyl-CoA desaturase 2 is required for peroxisome proliferator-activated receptor gamma expression and adipogenesis in cultured 3T3-L1 cells. J Biol Chem 2008;283:2906-2916.
    • (2008) J Biol Chem , vol.283 , pp. 2906-2916
    • Christianson, J.L.1    Nicoloro, S.2    Straubhaar, J.3    Czech, M.P.4
  • 55
    • 0034674567 scopus 로고    scopus 로고
    • Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation
    • Hauser S, Adelmant G, Sarraf P et al. Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation. J Biol Chem 2000;275:18527-18533.
    • (2000) J Biol Chem , vol.275 , pp. 18527-18533
    • Hauser, S.1    Adelmant, G.2    Sarraf, P.3
  • 56
    • 0037040272 scopus 로고    scopus 로고
    • Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPAR gamma in adipocytes
    • Floyd ZE, Stephens JM. Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPAR gamma in adipocytes. J Biol Chem 2002;277:4062-4068.
    • (2002) J Biol Chem , vol.277 , pp. 4062-4068
    • Floyd, Z.E.1    Stephens, J.M.2
  • 57
    • 46249117032 scopus 로고    scopus 로고
    • T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    • Kintscher U, Hartge M, Hess K et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008;28: 1304-1310.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1304-1310
    • Kintscher, U.1    Hartge, M.2    Hess, K.3
  • 58
    • 35848970747 scopus 로고    scopus 로고
    • Mapping protein post-translational modifications with mass spectrometry
    • Witze ES, Old WM, Resing KA, Ahn NG. Mapping protein post-translational modifications with mass spectrometry. Nat Methods 2007;4:798-806.
    • (2007) Nat Methods , vol.4 , pp. 798-806
    • Witze, E.S.1    Old, W.M.2    Resing, K.A.3    Ahn, N.G.4
  • 59
    • 0141920726 scopus 로고    scopus 로고
    • Genetic modulation of PPAR gamma phosphorylation regulates insulin sensitivity
    • Rangwala SM, Rhoades B, Shapiro JS et al. Genetic modulation of PPAR gamma phosphorylation regulates insulin sensitivity. Dev Cell 2003;5:657-663.
    • (2003) Dev Cell , vol.5 , pp. 657-663
    • Rangwala, S.M.1    Rhoades, B.2    Shapiro, J.S.3
  • 60
    • 0037396071 scopus 로고    scopus 로고
    • Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance
    • Blüher M, Paschke R. Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance. Exp Clin Endocrinol Diabetes 2003;111:85-90.
    • (2003) Exp Clin Endocrinol Diabetes , vol.111 , pp. 85-90
    • Blüher, M.1    Paschke, R.2
  • 61
    • 0036024171 scopus 로고    scopus 로고
    • The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity
    • Hamer OW, Forstner D, Ottinger I et al. The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity. Exp Clin Endocrinol Diabetes 2002;110:230-234.
    • (2002) Exp Clin Endocrinol Diabetes , vol.110 , pp. 230-234
    • Hamer, O.W.1    Forstner, D.2    Ottinger, I.3
  • 62
    • 0034036693 scopus 로고    scopus 로고
    • Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesity
    • Evans D, Mann WA, de HJ et al. Variation in the gene for human peroxisome proliferator activated receptor gamma (PPARgamma) does not play a major role in the development of morbid obesity. Int J Obes Relat Metab Disord 2000;24:647-651.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 647-651
    • Evans, D.1    Mann2    WA, D.H.3
  • 63
    • 0004509649 scopus 로고    scopus 로고
    • The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
    • Clement K, Hercberg S, Passinge B et al. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord 2000;24: 391-393.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 391-393
    • Clement, K.1    Hercberg, S.2    Passinge, B.3
  • 64
    • 0043234630 scopus 로고    scopus 로고
    • Peroxisome proliferator- activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect
    • Armoni M, Kritz N, Harel C et al. Peroxisome proliferator- activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. J Biol Chem 2003;278: 30614-30623.
    • (2003) J Biol Chem , vol.278 , pp. 30614-30623
    • Armoni, M.1    Kritz, N.2    Harel, C.3
  • 65
    • 44849112707 scopus 로고    scopus 로고
    • Genome-wide approaches for identification of nuclear receptor target genes
    • Tavera-Mendoza LE, Mader S, White JH. Genome-wide approaches for identification of nuclear receptor target genes. Nucl Recept Signal 2006;4:e018.
    • (2006) Nucl Recept Signal , vol.4
    • Tavera-Mendoza, L.E.1    Mader, S.2    White, J.H.3
  • 66
    • 34547630151 scopus 로고    scopus 로고
    • ChIP-seq: Welcome to the new frontier
    • Mardis ER. ChIP-seq: welcome to the new frontier. Nat Methods 2007;4:613-614.
    • (2007) Nat Methods , vol.4 , pp. 613-614
    • Mardis, E.R.1
  • 67
    • 25844437172 scopus 로고    scopus 로고
    • Mutual interactions between the SUMO and ubiquitin systems: A plea of no contest
    • Ulrich HD. Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest. Trends Cell Biol 2005;15: 525-532.
    • (2005) Trends Cell Biol , vol.15 , pp. 525-532
    • Ulrich, H.D.1
  • 68
    • 36749010218 scopus 로고    scopus 로고
    • The age of crosstalk: Phosphorylation, ubiquitination, and beyond
    • Hunter T. The age of crosstalk: phosphorylation, ubiquitination, and beyond. Mol Cell 2007;28:730-738.
    • (2007) Mol Cell , vol.28 , pp. 730-738
    • Hunter, T.1
  • 69
    • 33846429592 scopus 로고    scopus 로고
    • Drug Insight: Mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors
    • Gervois P, Fruchart JC, Staels B. Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors. Nat Clin Pract Endocrinol Metab 2007;3: 145-156.
    • (2007) Nat Clin Pract Endocrinol Metab , vol.3 , pp. 145-156
    • Gervois, P.1    Fruchart, J.C.2    Staels, B.3
  • 70
    • 33646045898 scopus 로고    scopus 로고
    • Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases
    • Balint BL, Nagy L. Selective modulators of PPAR activity as new therapeutic tools in metabolic diseases. Endocr Metab Immune Disord Drug Targets 2006;6:33-43.
    • (2006) Endocr Metab Immune Disord Drug Targets , vol.6 , pp. 33-43
    • Balint, B.L.1    Nagy, L.2


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