Rabbit pregnane X receptor is activated by rifampicin

Drug Metabolism and Disposition

Volumn 28, Issue 5, 2000, Pages 529-537

  Savas, Üzen ^a   Wester, Michael R ^a   Griffin, Keith J ^a   Johnson, Eric F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; GLUCOCORTICOID RECEPTOR; PREGNANE DERIVATIVE; RIFAMPICIN;

AMINO ACID SEQUENCE; ARTICLE; DNA FLANKING REGION; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RABBIT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBIOTICS, ANTITUBERCULAR; ARYL HYDROCARBON HYDROXYLASES; CELL NUCLEUS; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DNA; ENZYME INDUCTION; HUMANS; KIDNEY; LIVER; MICE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; POLY A; RABBITS; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIFAMPIN; RNA; TRANSFECTION;

ORYCTOLAGUS CUNICULUS; STAPHYLOCOCCUS PHAGE 3A;

EID: 0034088790     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bacs M, Gulick T, Hueng-Sik C, Martinoli MG, Simha D and Moore DD (1994) A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements. Mol Cell Biol 14:1544-1552.
2. Barwick JL, Quattrochi LC, Mills AS, Potenza C, Tukey RH and Guzelian PS (1996) Transspecies gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes. Mol Pharmacol 50:10-16.
3. Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Backman M, Ohlsson R, Postlind H, Blomquist P and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:12208-12213.
4. Blumberg B, Sabbagh WJ, Juguilon H, Bolado JJ, van Meter CM, Ong ES and Evans RM (1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205.
5. Burger H-J, Schuetz JD, Schuetz EG and Guzelian PS (1992) Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16α-carbonitrile: Analysis by transient transfection into primary monolayer cultures of adult rat hepatocyles. Proc Natl Acad Sci USA 89:2145-2149.
6. Choi HS, Chung M, Tzameli I, Simha D, Lee YK, Seol W and Moore DD (1997) Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. J Biol Chem 272:23565-23571.
7. Dalet C, Blanchard JM, Guzelian P, Barwick J, Hartle H and Maurel P (1986) Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression. Nucleic Acids Res 14:5999-6015.
8. Daujat M, Pichard L, Dalet C, Larroque C, Bonfils C, Pompon D, Li D, Guzelian PS and Maurel P (1987) Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers. Biochem Pharmacol 36:3597-3606.
9. Gronemeyer H and Moras D (1995) How to finger DNA. Nature (Lond) 375:190-191.
10. Guengerich FP (1999) Cytochrome P-450 3A4: Regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 39:1-17.
11. Honkakoski P, Zelko I, Sueyoshi T and Negishi M (1998) The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene. Mol Cell Biol 18:5652-5658.
12. Hsu MH, Palmer CNA, Song W, Griffin KJ and Johnson EF (1998) A carboxyl-terminal extension of the zinc finger domain contributes to the specificity and polarity of peroxisome proliferator-activated receptor DNA binding. J Biol Chem 273:27988-27997.
13. Huss JM and Kasper CB (1998) Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression. J Biol Chem 273:16155-16162.
14. Huss JM, Wang SI, Astrom A, McQuiddy P and Kasper CB (1996) Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3 A gene is mediated by elements unrelated to a glucocorticoid receptor binding. Prof Natl Acad Sci USA 93:4666-4670.
15. Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T and Lehmann JM (1998) An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82.
16. Kocarek TA, Schuetz EG, Strom SC, Fisher RA and Guzelian PS (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 23:415-421.
17. Kozak M (1991) Structural features in eukaryotic mRNAs that modulate the initiation of translation. J Boil Chem 266:19867-19870.
18. Lee SST, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H and Gonzalez FJ (1995) Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15:3012-3022.
19. Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT and Kliewer SA (1998) The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023.
20. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Urnesono K, Blumberg B, Kastner P, Mark M, Chambon P and Evans RM (1995) The nuclear receptor superfamily: The second decade. Cell 83:835-839.
21. Matsubara S, Yamamoto S, Sogawa K, Yokotani N, Fujii-Kuriyama Y, Haniu M, Shively JE, Gotoh O, Kusunose E and Kusunose M (1987) cDNA cloning and inducible expression during pregnancy of the mRN A for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome P-450p-2). J Biol Chem 262:13366-13371.
22. Maurel P (1996) The CYP3 family, in Cytochromes P450: Metabolic and Toxicological Aspects (Ionnides C ed) pp 241-270, CRC Press, Inc., Boca Raton, FL.
23. Nuclear Receptors Nomenclature Committee (1999) A unified nomenclature system for the nuclear receptor superfamily (letter). Cell 97:161-163.
24. Palmer CNA, Griffin KJ and Johnson EF (1993) Rabbit prostaglandin omega-hydroxylase (CYP4A4): Gene structure and expression. Arch Biochem Biophys 300:670-676.
25. Palmer CNA, Hsu M-H, Griffin KJ and Johnson EF (1995) Novel sequence determinants in peroxisome proliferator signaling. J Biol Chem 270:16114-16121.
26. Palmer CNA, Hsu MH, Griffin KJ, Raucy JL and Johnson EF (1998) Peroxisome proliferator activated receptor-α expression in human liver. Mol Pharmacol 53:14-22.
27. Pascussi JM, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P and Vilarem MJ (1999) Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene. Biochem Biophys Res Commun 260:377-381.
28. Pereira TM, Carlstedt-Duke J, Leckner MC and Gustafsson JÅ (1998) Identification of a functional glucocorticoid response clement in the CYP3A/1GC2 gene. DNA Cell Biol 17:39-49.
29. Peters JM, Cattley RC and Gonzalez FJ (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis 18:2029-2033.
30. Potenza CL, Pendurthi UR, Strom DK, Tukey RH, Griffin KJ, Schwab GE and Johnson EF (1989) Regulation of the rabbit cylochrome P-450 3c gene: Age dependent expression and transcriptional activation by rifampicin. J Biol Chem 264:16222-16228.
31. Quattrochi LC, Mills AS, Barwick JL, Yockey CB and Guzelian PS (1995) A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids. J Biol Chem 270:28917-28923.
32. Sambrook J, Fritsch EF and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
33. Schuetz EG, Wrighton SA, Barwick JL and Guzelian PS (1984) Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16α-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo. J Biol Chem 259:1999-2006.
34. Schuetz JD, Schuetz EG, Thottassery JV, Guzelian PS, Strom S and Sun D (1996) Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol 49:63-72.
35. Smith DP, Mason CS, Jones EA and Old RW (1994) A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor. Nucleic Acids Res 22:66-71.
36. Sueyoshi T, Kawamoto T, Zelko I, Honkakoski P and Negishi M (1999) The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene. J Biol Chem 274:6043-6046.
37. Tanaka E (1998) Clinically important phannacokinetic drug-drug interactions: Role of cytochrome P450 enzymes. J Clin Pharm Ther 23:403-416.
38. Wrighton SA, Schuetz EG, Watkins PB, Maurel P, Barwick J, Bailey BS, Hartle HT, Young B and Guzelian P (1985) Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat. Mol Pharmacol 28:312-321.
39. Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W and Yan B (1999) Rat Pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys 368:14-22.