Analysis of a metalloporphyrin antioxidant mimetic (MnTE-2-PyP) as a radiomitigator: Prostate tumor and immune status

Technology in Cancer Research and Treatment

Volumn 11, Issue 5, 2012, Pages 447-457

  Mehrotra, S ^a   Pecaut, M J ^a   Freeman, T L ^a   Crapo, J D ^b   Rizvi, A ^a   Luo Owen, X ^a   Slater, J M ^a   Gridley, D S ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Cancer; Ionizing radiation; Leukocytes; Lymphocytes; Oxidative stress

Indexed keywords

MANGANESE TETRAKIS (N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; METALLOPORPHYRIN; RADIOPROTECTIVE AGENT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BODY MASS; CONTROLLED STUDY; IMMUNE DEFICIENCY; IMMUNE STATUS; IMMUNOLOGICAL PARAMETERS; LEUKOCYTE; LYMPHOCYTE COUNT; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROSTATE TUMOR; RADIATION EXPOSURE; SPLEEN; SPLEEN SIZE; T LYMPHOCYTE; THROMBOCYTE; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR CELL; TUMOR GROWTH; WHOLE BODY RADIATION;

EID: 84865849471     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.7785/tcrt.2012.500260     Document Type: Article

References (34)

1. Simonsen, L. C., Cucinotta, F. A., Atwell, W., Nealy, J. E. Temporal analysis of the October 1989 proton flare using computerized anatomical models. Radiat Res 133, 1-11 (1993).
2. Dumont, F., Le Roux, A., Bischoff, P. Radiation countermeasure agents: an update. Expert Opin Ther Pat 20, 73-101 (2010).
3. Gauter-Fleckenstein, B., Fleckenstein, K., Owzar, K., Jiang, C., Reboucas, J. S., Batinic-Haberle, I., Vujaskovic, Z. Early and late administration of MnTE-2-PyP51 in mitigation and treatment of radiation-induced lung damage. Free Radic Biol Med 48, 1034-1043 (2010).
4. Gridley, D. S., Makinde, A. Y., Luo, X., Rizvi, A., Crapo, J. D., Dewhirst, M. W., Moeller, B. J., Pearlstein, R. D., Slater, J. M. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Res 27, 3101-3109 (2007).
5. Makinde, A. Y., Luo-Owen, X., Rizvi, A., Crapo, J. D., Pearlstein, R. D., Slater, J. M., Gridley, D. S. Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. Anticancer Res 29, 107-118 (2009).
6. Makinde, A. Y., Rizvi, A., Crapo, J. D., Pearlstein, R. D., Slater, J. M., Gridley, D. S. A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. Radiat Res 173, 441-452 (2010).
7. Pearlstein, R. D., Higuchi, Y., Moldovan, M., Johnson, K., Fukuda, S., Gridley, D. S., Crapo, J. D., Warner, D. S., Slater, J. M. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int J Radiat Biol 86, 145-163 (2010).
8. Mao, X. W., Crapo, J. D., Mekonnen, T., Lindsey, N., Martinez, P., Gridley, D. S., Slater, J. M. Radioprotective effect of a metalloporphyrin compound in rat eye model. Curr Eye Res 34, 62-72 (2009).
9. Vujaskovic, Z., Batinic-Haberle, I., Rabbani, Z. N., Feng, Q. F., Kang, S. K., Spasojevic, I., Samulski, T. V., Fridovich, I., Dewhirst, M. W., Anscher, M. S. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med 33, 857-863 (2002).
10. Gridley, D. S., Andres, M. L., Slater, J. M. Enhancement of prostate cancer xenograft growth with whole-body radiation and vascular endothelial growth factor. Anticancer Res 17, 923-928 (1997).
11. Duhrsen, U. Metcalf, D. Effects of irradiation of recipient mice on the behavior and leukemogenic potential of factor-dependent hematopoietic cell lines. Blood 75, 190-197 (1990).
12. Imaoka, T., Nishimura, M., Iizuka, D., Nishimura, Y., Ohmachi, Y., Shimada, Y. Pre-and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats. Mol Carcinog 50, 539-552 (2011). DOI: 10.1002/mc.20746
13. Milas, L., McBride, W. H., Hunter, N., Ito, H. Protection by S-2-13. (3-aminopropylamino)ethylphosphorothioic acid against radiation-and cyclophosphamide-induced attenuation in antitumor resistance. Cancer Res 44, 2382-2386 (1984).
14. Peterson, N. C., Servinsky, M. D., Christian, A., Peng, Z., Qiu, W., Mann, J., Dicello, J., Huso, D. L. Tamoxifen resistance and Her2/neu expression in an aged, irradiated rat breast carcinoma model. Carcinogenesis 26, 1542-1552 (2005).
15. Welsch, C. W., Goodrich-Smith, M., Brown, C. K., Miglorie, N., Clifton, K. H. Effect of an estrogen antagonist (tamoxifen) on the initiation and progression of gamma-irradiation-induced mammary tumors in female Sprague-Dawley rats. Eur J Cancer Clin Oncol 17, 1255-1258 (1981).
16. Zietman, A. L., Suit, H. D., Ramsay, J. R., Silobrcic, V., Sedlacek, R. S. Quantitative studies on the transplantability of murine and human tumors into the brain and subcutaneous tissues of NCr/Sed nude mice. Cancer Res 48, 6510-6516 (1988).
17. Li, N., Oberley, T. D., Oberley, L. W., Zhong, W. Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype. Prostate 35, 221-233 (1998).
18. Li, J. J., Oberley, L. W., St Clair, D. K., Ridnour, L. A., Oberley, T. D. Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene 10, 1989-2000 (1995).
19. Zhong, W., Oberley, L. W., Oberley, T. D., St Clair, D. K. Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene 14, 481-490 (1997).
20. Guo, H., Epperly, M. W., Bernarding, M., Nie, S., Gretton, J., Jefferson, M., Greenberger, J. S. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinomas. In vivo 17, 13-21 (2003).
21. Zhao, Y., Chaiswing, L., Oberley, T. D., Batinic-Haberle, I., St Clair, W., Epstein, C. J., St Clair, D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res 65, 1401-1405 (2005).
22. Thompson, T. C., Timme, T. L., Park, S. H., Yang, G., Ren, C. Mouse prostate reconstitution model system: A series of in vivo and in vitro models for benign and malignant prostatic disease. Prostate 43, 248-254 (2000).
23. Kajioka, E. H., Andres, M. L., Li, J., Mao, X. W., Moyers, M. F., Nelson, G. A., Slater, J. M., Gridley, D. S. Acute effects of whole-body proton irradiation on the immune system of the mouse. Radiat Res 153, 587-94 (2000).
24. Kajioka, E. H., Gheorghe, C., Andres, M. L., Abell, G. A., Folz-Holbeck, J., Slater, J. M., Nelson, G. A., Gridley, D. S. Effects of proton and gamma radiation on lymphocyte populations and acute response to antigen. In vivo 13, 525-33 (1999).
25. Pecaut, M. J., Dutta-Roy, R., Miller, G. M., Gridley, D. S. Radiation and primary immune response to lipopolysaccharide: lymphocyte distribution and function. In vivo 21, 463-70 (2007).
26. Liu, J., Yoshida, Y., Yamashita, U. Suppressive effect of reactive oxygen species on CD40-induced B cell activation. FEBS Lett 581, 5043-5049 (2007).
27. Tohyama, Y., Takano, T., Yamamura, H. B cell responses to oxidative stress. Curr Pharm Des 10, 835-839 (2004).
28. Park, H. R., Jung, U., Jo, S. K. Impairment of natural killer (NK) cells is an important factor in a weak Th1-like response in irradiated mice. Radiat Res 168, 446-452 (2007).
29. Li, Q., Lao, X., Pan, Q., Ning, N., Yet, J., Xu, Y., Li, S., Chang, A. E. Adoptive transfer of tumor reactive B cells confers host T-cell immunity and tumor regression. Clin Cancer Res 17, 4987-4995 (2011).
30. Lichtenstein, A., Seelig, M., Berek, J., Zighelboim, J. Human neutrophil-mediated lysis of ovarian cancer cells. Blood 74, 805-809 (1989).
31. Vaickus, L., Biddle, W., Cemerlic, D., Foon, K. A. Interferon gamma augments Lym-1-dependent, granulocyte-mediated tumor cell lysis. Blood 75, 2408-2416 (1990).
32. Wu, W. S. The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 25, 695-705 (2006).
33. Godbout, J. P. Glaser, R. Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol 1, 421-427 (2006).
34. Borrelli, A., Schiattarella, A., Mancini, R., Morrica, B., Cerciello, V., Mormile, M., d'Alesio, V., Bottalico, L., Morelli, F., D'Armiento, M., D'Armiento, F. P., Mancini, A. A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells. Free Radic Biol Med 46, 110-116 (2009).