Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

Free Radical Biology and Medicine

Volumn 47, Issue 7, 2009, Pages 992-1004

  Rabbani, Zahid N ^a   Spasojevic, Ivan ^a   Zhang, Xiuwu ^a   Moeller, Benjamin J ^a   Haberle, Sinisa ^a   Vasquez Vivar, Jeannette ^b   Dewhirst, Mark W ^a   Vujaskovic, Zeljko ^a   Batinic Haberle, Ines ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Angiogenesis; Anti cancer (anti tumor) therapy; Cancer biology; Free radicals; HIF1 ; Inflammation; Mn porphyrin; MnTE 2 PyP5+ (AEOL10113); Oxidative stress; Peroxynitrite scavenger; SOD mimic; VEGF

Indexed keywords

AEOL 10113; ANTINEOPLASTIC AGENT; CARBONATE DEHYDRATASE; CD31 ANTIGEN; CD68 ANTIGEN; DNA; ENDOGLIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MANGANESE MESO TETRAKIS(N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; PEROXYNITRITE; PIMONIDAZOLE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BREAST TUMOR; CANCER INHIBITION; CONTROLLED STUDY; DRUG MEGADOSE; DRUG STRUCTURE; DRUG TUMOR LEVEL; HYPOXIA; MACROPHAGE ACTIVATION; MICROVASCULATURE; MITOSIS INHIBITION; MOUSE; NITRATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TUMOR VOLUME;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL PROLIFERATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MAMMARY NEOPLASMS, EXPERIMENTAL; METALLOPORPHYRINS; MICE; MICE, INBRED BALB C; NEOVASCULARIZATION, PATHOLOGIC; OXIDATION-REDUCTION; OXIDATIVE STRESS;

MUS;

EID: 69249212132     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.07.001     Document Type: Article

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