Superoxide signaling in pain is independent of nitric oxide signaling

NeuroReport

Volumn 20, Issue 16, 2009, Pages 1424-1428

  Kim, Hee Young ^a   Wang, Jigong ^a   Lu, Ying ^a   Chung, Jin Mo ^a   Chung, Kyungsoon ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Hyperalgesia; Pain signaling pathway; Peroxynitrite; Reactive oxygen species

Indexed keywords

GUANYLATE CYCLASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PEROXYNITRITE; PROTEIN KINASE C; SUPEROXIDE; TEMPOL; 3 NITROTYROSINE; 3-NITROTYROSINE; 5,10,15,20 TETRAKIS(N METHYL 4' PYRIDYL)PORPHYRINATO IRON(III); 5,10,15,20-TETRAKIS(N-METHYL-4'-PYRIDYL)PORPHYRINATO-IRON(III); AMINE OXIDE; ANTIMYCIN A1; DRUG DERIVATIVE; ENZYME INHIBITOR; METALLOPORPHYRIN; NEUROPROTECTIVE AGENT; NITROSO DERIVATIVE; NOC 12; PEROXYNITROUS ACID; REACTIVE OXYGEN METABOLITE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HYPERALGESIA; MALE; MOUSE; NERVE LIGATION; NEUROCHEMISTRY; NEUROPATHIC PAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPINAL NERVE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; METABOLISM; METHODOLOGY; NEURALGIA; PAIN ASSESSMENT; PHYSIOLOGY; SPIN LABELING;

ANIMALS; ANTIMYCIN A; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HYPERALGESIA; MALE; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; NEURALGIA; NEUROPROTECTIVE AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROSO COMPOUNDS; PAIN MEASUREMENT; PEROXYNITROUS ACID; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SPIN LABELS; SUPEROXIDES; TYROSINE;

EID: 74049151604     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328330f68b     Document Type: Article

References (21)

1. Chung JM. The role of reactive oxygen species (ROS) in persistent pain. Mol Interv 2004; 4:248-250.
2. Lin Q, Palecek J, Paleckova V, Peng YB, Wu J, Cui M, et al. Nitric oxide mediates the central sensitization of primate spinothalamic tract neurons. J Neurophysiol 1999; 81:1075-1085.
3. Yoon YW, Sung B, Chung JM. Nitric oxide mediates behavioral signs of neuropathic pain in an experimental rat model. Neuroreport 1998; 9:367-372.
4. Schwartz ES, Kim HY, Wang J, Lee I, Klann E, Chung JM, et al. Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci 2009; 29:159-168.
5. Schwartz ES, Lee I, Chung K, Chung JM. Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain 2008; 138:514-524.
6. Hongpaisan J, Winters CA, Andrews SB. Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons. J Neurosci 2004; 24:10878-10887.
7. Park ES, Gao X, Chung JM, Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett 2006; 391:108-111.
8. Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H. Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology 2009; 56:702-708.
9. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50:355-363.
10. Tao YX, Johns RA. Activation of cGMP-dependent protein kinase Ialpha is required for N-methyl-D-aspartate- or nitric oxide-produced spinal thermal hyperalgesia. Eur J Pharmacol 2000; 392:141-145.
11. Kim HY, Chung JM, Chung K. Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci Lett 2008; 447:87-91.
12. Xu JY, Tseng LF. Nitric oxide/cyclic guanosine monophosphate system in the spinal cord differentially modulates intracerebroventricularly administered morphine- and beta-endorphin-induced antinociception in the mouse. J Pharmacol Exp Ther 1995; 274:8-16.
13. Lee I, Kim HK, Kim JH, Chung K, Chung JM. The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain 2007; 133:9-17.
14. Tal M. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport 1996; 7:1382-1384.
15. Szabo C, Ischiropoulos H, Radi R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov 2007; 6:662-680.
16. Lin Q, Wu J, Peng YB, Cui M, Willis WD. Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons. J Neurophysiol 1999; 81:1086-1094. (Pubitemid 29272426)
17. Hawkins RD, Zhuo M, Arancio O. Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation. J Neurobiol 1994; 25:652-665.
18. Crow JP. Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic Biol Med 2000; 28:1487-1494.
19. Salvemini D, Riley DP, Lennon PJ,Wang ZQ, Currie MG, Macarthur H, et al. Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br J Pharmacol 1999; 127:685-692.
20. Arora M, Kumar A, Kaundal RK, Sharma SS. Amelioration of neurological and biochemical deficits by peroxynitrite decomposition catalysts in experimental diabetic neuropathy. Eur J Pharmacol 2008; 596:77-83.
21. Nangle MR, Cotter MA, Cameron NE. Effects of the peroxynitrite decomposition catalyst, FeTMPyP, on function of corpus cavernosum from diabetic mice. Eur J Pharmacol 2004; 502:143-148.