Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways

Free Radical Biology and Medicine

Volumn 46, Issue 2, 2009, Pages 212-219

  Batinić Haberle, Ines ^a   Ndengele, Michael M ^b   Cuzzocrea, Salvatore ^c,d   Rebouças, Júlio S ^a   Spasojević, Ivan ^a   Salvemini, Daniela ^b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MESSINA   (Italy)

^d IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

Author keywords

Cytokines; Free radicals; Mn porphyrins; MnTBAP; MnTE 2 PyP; MnTnHex 2 PyP; Morphine tolerance; Nitrotyrosine; Pain management; Peroxynitrite; Peroxynitrite scavengers; SOD mimics

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; IRON MESO TETRAKIS (N METHYLPYRIDINIUM 4 YL)PORPHYRIN; MANGANESE 2 N ALKYLPYRIDYLPORPHYRIN DERIVATIVE; MANGANESE MESO TETRAKIS(N N HEXYLPYRIDINIUM 2 YL)PORPHYRIN; MANGANESE TETRAKIS(4 CARBOXYLATOPHENYL)PORPHYRIN; METALLOPORPHYRIN; MORPHINE; OXYGEN; PEROXYNITRITE; PORPHYRIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DOSE REDUCTION; DRUG MECHANISM; HYDROPHILICITY; LIPOPHILICITY; MALE; MORPHINE TOLERANCE; MOUSE; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; ROTAROD TEST;

ANALGESICS; ANIMALS; DRUG TOLERANCE; HUMANS; HYDROPHOBICITY; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; METALLOPORPHYRINS; MICE; MORPHINE; MOTOR ACTIVITY; OXIDATIVE STRESS; PAIN; PEROXYNITROUS ACID; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 58049121543     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.09.037     Document Type: Article

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