Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species: Implications for the use of exogenous ubiquinones as therapies and experimental tools

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21295-21312

  James, Andrew M ^a   Cochemé, Helena M ^a   Smith, Robin A J ^b   Murphy, Michael P ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BIOCHEMISTRY; ENZYME KINETICS; HYDROPHILICITY; OXIDATION; REACTION KINETICS; REDUCTION; RESPIRATORY MECHANICS;

ELECTRON CARRIERS; MITOCHONDRIA; POTENTIAL THERAPIES; RESPIRATORY CHAIN;

CELLS;

CYCLOSPORIN A; CYTOCHROME C; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; IDEBENONE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINATE DEHYDROGENASE (UBIQUINONE); THIOL; UBIDECARENONE; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINONE;

ANIMAL TISSUE; ARTICLE; AUTOOXIDATION; BINDING SITE; CATTLE; CONTROLLED STUDY; HEART MITOCHONDRION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MITOCHONDRION; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOLECULAR MODEL; NONHUMAN; OXIDATION REDUCTION REACTION; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; RESPIRATORY CHAIN; SACCHAROMYCES CEREVISIAE; YEAST;

ACONITATE HYDRATASE; ANIMALS; ANTIOXIDANTS; BINDING SITES; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; FATTY ACIDS; GLYCEROLPHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIA; MITOCHONDRIA, LIVER; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MYOCARDIUM; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PHOSPHORYLATION; PROTEIN BINDING; RATS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS; SUPEROXIDES; TIME FACTORS; UBIQUINONE;

EID: 20444392739     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501527200     Document Type: Article

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