Temporal and spatial profiles of cell loss after spinal cord injury: Reduction by a metalloporphyrin

Journal of Neuroscience Research

Volumn 85, Issue 10, 2007, Pages 2175-2185

  Ling, Xiang ^a   Liu, Danxia ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Antioxidant therapy; Apoptosis; Mn(III) tetrakis (4 benzoic acid) porphyrin; Scavenger of reactive species; Secondary cell death

Indexed keywords

MANGANESE TETRAKIS (4 BENZOIC ACID) PORPHYRIN; METALLOPORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CONTROLLED STUDY; GRAY MATTER; MALE; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; WHITE MATTER;

ANIMALS; APOPTOSIS; CELL COUNT; CELL SURVIVAL; FREE RADICAL SCAVENGERS; IN SITU NICK-END LABELING; INJECTIONS, INTRAPERITONEAL; MALE; METALLOPORPHYRINS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS;

EID: 34547490741     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21362     Document Type: Article

References (61)

1. Abe YT, Yamamoto T, Sugiyama Y, Watanabe T, Saito N, Kayama H, Kumagai T. 1999. Apoptotic cells associated with Wallerian degeneration after experimental spinal cord injury: a possible mechanism of oligodendroglial death. J Neurotrauma 16:945-952.
2. Allen AR. 1911. Surgery of experimental spinal cord injury equivalent to crush injury of fracture dislocation of spinal column. JAMA 57:878-880.
3. Anderson DK, Hall ED. 1993. Pathophysiology of spinal cord trauma. Ann Emerg Med 22:987-992.
4. Anderson DK, Saunders RD, Demediuk P, Dugan LL, Braughler JM, Hall ED, Means ED, Horrocks LA. 1985. Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E and selenium. Cent Nerv Syst Trauma 2:257-267.
5. Balentine JD. 1985. Hypothesis in spinal cord trauma research. In: Becker DP, Povlishcock JT editors. Central Nervous System Trauma Status Report. Bethesda, MD: National Institutes of Health. p 455-461.
6. Bao F, DeWitt DS, Prough DS, Liu D. 2003. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 71:220-227.
7. Bao F, Liu D. 2002. Peroxynitrite generated in the rat spinal cord induces neuron death and neurological deficits. Neuroscience 115:839-849.
8. Bao F, Liu D. 2003. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience 116:59-70.
9. Bao F, Liu D. 2004. Hydroxyl radicals generated in the rat spinal cord at the level produced by impact injury induce cell death by necrosis and apoptosis: protection by a metalloporphyrin. Neuroscience 126:285-295.
10. Basso DM, Beattie MS, Bresnahan JC. 1996. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256.
11. Bracken MB, Shepard MJ, Coffins WF, Holford TR, Young W, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon J, Marshall LF, Perot PL, Piepmeier J, Sonntag VKH, Wagner FC, Wilberger JE, Winn HR. 1990. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med 322:1405-1411.
12. Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL Jr, Piepmeier J, Sonntag VK, Wagner F, Wilberger JE, Winn HR, Young W. 1997. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277:1597-1604.
13. Bresnahan JC, Beattie MS, Stokes BT, Conway KM. 1991. Three-dimensional computer-assisted analysis of graded contusion lesions in the spinal cord of the rat. J Neurotrauma 8:91-101.
14. Bresnahan JC, Beattie MS, Todd FD 3rd, Noyes DH. 1987. A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device. Exp Neurol 95:548-570.
15. Crow JP. 2000. Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic Biol Med 28:1487-1494.
16. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. 1997. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 3:73-76.
17. Day BJ, Batinic-Haberle I, Crapo JD. 1999. Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med 26: 730-736.
18. Day BJ, Fridovich I, Crapo JD. 1997. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys 347:256-262.
19. Demopoulos HB, Flamm ES, Pietronigro DD, Seligman ML. 1980. The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl 492:91-119.
20. Ducker TB, Kindt GW, Kempf LG. 1971. Pathological findings in acute experimental spinal cord trauma. J Neurosurg 35:700-708.
21. Faden AI, Simon RP. 1988. A potential role for excitotoxins in the pathophysiology of spinal cord injury. Ann Neurol 23:623-626.
22. Goodkin R, Campbell JB. 1969. Sequential pathologic changes in spinal cord injury: a preliminary report. Surg Forum 20:430-432.
23. Grossman SD, Rosenberg LJ, Wrathall JR. 2001. Temporal-spatial pattern of acute neuronal and glial loss after spinal cord contusion. Exp Neurol 168:273-282.
24. Hachmeister JE, Valluru L, Bao F, Liu D. 2006. Mn (III) Tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone. J Neurotrauma 23:1766-1778.
25. Hall ED, Andrus PK, Yonkers PA. 1993. Brain hydroxyl radical generation in acute experimental head injury. J Neurochem 60:588-594.
26. Hall ED, Yonkers PA, Andrus PK, Cox JW, Anderson DK. 1992. Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury. J Neurotrauma 9 Suppl 2:S425-S442.
27. Katoh K, Ikata T, Katoh S, Hamada Y, Nakauchi K, Sano T, Niwa M. 1996. Induction and its spread of apoptosis in rat spinal cord after mechanical trauma. Neurosci Lett 216:9-12.
28. Kline AE, Massucci JL, Ma X, Zafonte RD, Dixon CE. 2004. Bromocriptine reduces lipid peroxidation and enhances spatial learning and hippocampal neuron survival in a rodent model of focal brain trauma. J Neurotrauma 21:1712-1722.
29. Leski ML, Bao F, Wu L, Qian H, Sun D, Liu D. 2001. Protein and DNA oxidation in spinal injury: neurofilaments - an oxidation target. Free Radic Biol Med 30:613-624.
30. Li GL, Brodin G, Farooque M, Funa K, Holtz A, Wang WL, Olsson Y. 1996. Apoptosis and expression of Bcl-2 after compression trauma to rat spinal cord. J Neuropathol Exp Neurol. 55:280-289.
31. Li GL, Farooque M, Holtz A, Olsson Y. 1999. Apoptosis of oligodendrocytes occurs for long distances away from the primary injury after compression trauma to rat spinal cord. Acta Neuropathol (Berl) 98: 473-480.
32. Liang LP, Ho YS, Patel M. 2000. Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience 101: 563-570.
33. Liu D, Bao F, Prough DS, Dewitt DS. 2005. Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin. J Neurotrauma 22:1123-1133.
34. Liu D, Li L, Augustus L. 2001. Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone. J Neurochem 77:1036-1047.
35. Liu D, Ling X, Wen J, Liu J. 2000. The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein. J Neurochem 75:2144-2154.
36. Liu D, Liu J, Sun D, Alcock NW, Wen J. 2003. Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals. Free Radic Biol Med 34:64-71.
37. Liu D, Liu J, Sun D, Wen J. 2004. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma 21:805-816.
38. Liu D, Liu J, Wen J. 1999. Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction. Free Radic Biol Med 27:478-482.
39. Liu D, Sybert TE, Qian H, Liu J. 1998. Superoxide production after spinal injury detected by microperfusion of cytochrome c. Free Radic Biol Med 25:298-304.
40. Liu XZ, Xu XM, Hu R, Du C, Zhang S X, McDonald JW, Dong HX, Wu YJ, Fan GS, Jacquin MF, Hsu CY, Choi DW. 1997. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci. 17:5395-5406.
41. Lou J, Lenke LG, Ludwig FJ, O'Brien MF. 1998. Apoptosis as a mechanism of neuronal cell death following acute experimental spinal cord injury. Spinal Cord 36:683-690.
42. Lucas JH, Wheeler DG, Guan Z, Suntres Z, Stokes BT. 2002. Effect of glutathione augmentation on lipid peroxidation after spinal cord injury. J Neurotrauma 19:763-775.
43. Luo J, Shi R. 2004. Diffusive oxidative stress following acute spinal cord injury in guinea pigs and its inhibition by polyethylene glycol. Neurosci Lett 359:167-170.
44. Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD, Wallace DC. 1998. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet 18:159-163.
45. Noble LJ, Wrathall JR. 1985. Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol 88:135-149.
46. Noble LJ, Wrathall JR. 1989. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat. Exp Neurol 103:34-40.
47. Patel M, Day BJ. 1999. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol Sci 20:359-364.
48. Pratico D, Reiss P, Tang LX, Sung S, Rokach J, McIntosh TK. 2002. Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury. J Neurochem 80:894-898.
49. Qian H, Liu D. 1997. The time course of malondialdehyde production following impact injury to rat spinal cord as measured by microdialysis and high pressure liquid chromatography. Neurochem Res 22:1231-1236.
50. Sheng H, Spasojevic I, Warner DS, Batinic-Haberle I. 2004. Mouse spinal cord compression injury is ameliorated by intrathecal canonic manganese(III) porphyrin catalytic antioxidant therapy. Neurosci Lett 366:220-225.
51. Shuman SL, Bresnahan JC, Beattie MS. 1997. Apoptosis of microglia and oligodendrocytes after spinal cord contusion in rats. J Neurosci Res 50:798-808.
52. Springer JE, Azbill RD, Mark RJ, Begley JG, Waeg G, Mattson MP. 1997. 4-Hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake. J Neurochem 68:2469-2476.
53. Tatton WG, Chalmers-Redman RM, Ju WY, Wadia J, Tatton NA. 1997. Apoptosis in neurodegenerative disorders: potential for therapy by modifying gene transcription. J Neural Transm Suppl 49:245-268.
54. Tyurin VA, Tyurina YY, Borisenko GG, Sokolova TV, Ritov VB, Quinn PJ, Rose M, Kochanek P, Graham SH, Kagan VE. 2000. Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates. J Neurochem 75:2178-2189.
55. Vaziri ND, Lee YS, Lin CY, Lin VW, Sindhu RK. 2004. NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury. Brain Res 995:76-83.
56. White RJ. 1975. Pathology of spinal cord injury in experimental lesions. Clin Orthop Relat Res 112:16-26.
57. Wu L, Xu H, DeWett DS, Liu D. 2004. The time courses of concentration changes of a metalloporphyrin in CSF and in blood following spinal cord injury. 34th Annual Meeting of the. Society for Neuroscience, San Diego, CA, October 23-27, 2004.
58. Xu W, Chi L, Xu R, Ke Y, Luo C, Cai J, Qiu M, Gozal D, Liu R. 2005. Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord 43:204-213.
59. Yong C, Arnold PM, Zoubine MN, Citron BA, Watanabe I, Berman NE, Festoff BW. 1998. Apoptosis in cellular compartments of rat spinal cord after severe contusion injury. J Neurotrauma 15:459-472.
60. Young W. 1987. The post-injury responses in trauma and ischemia: secondary injury or protective mechanisms? Cent Nerv Syst Trauma 4:27-51.
61. Zingarelli B, Day BJ, Crapo JD, Salzman AL, Szabo C. 1997. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 120:259-267.