Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 85, Issue 1, 2003, Pages 142-150

  Wu, Annie S ^a   Kiaei, Mahmoud ^a   Aguirre, Norberto ^a   Crow, John P ^b   Calingasan, Noel Y ^a   Browne, Susan E ^a   Beal, M Flint ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Amyotrophic lateral sclerosis; Antioxidant; Cu Zn superoxide dismutase; Iron porphyrin; Metalloporphyrin; Protein carbonyls

Indexed keywords

CARBONYL DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; IRON DERIVATIVE; METALLOPORPHYRIN; PORPHYRIN IRON; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; GENE MUTATION; HINDLIMB; IRON THERAPY; LIPID PEROXIDATION; MALE; MOTOR NEURON DISEASE; MOUSE; MUSCLE WEAKNESS; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PORPHYRIN METABOLISM; PRIORITY JOURNAL; PROTEIN CONTENT; SPINAL CORD; STATISTICAL SIGNIFICANCE; SURVIVAL; TRANSGENIC ANIMAL;

ANIMALIA; MUS MUSCULUS;

EID: 0037380924     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01639.x     Document Type: Article

References (45)

1. Andrus P. K., Fleck T. J., Gurney M. E. and Hall E. D. (1998) Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 71, 2041-2048.
2. Batinic-Haberle I., Benov L., Spasojevic I. and Fridovich I. (1998) The ortho effect makes manganese (III) meso-tetrakis (N-methylpyridinium-2-yl) porphyrin a powerful and potentially useful superoxide dismutase mimic. J. Biol. Chem. 273, 24521-24528.
3. Beal M. F., Ferrante R. J., Browne S. E., Matthews R. T., Kowall N. W. and Brown R. H. Jr (1997) Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann. Neurol. 42, 644-654.
4. Beauchamp C. and Fridovich I. (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44, 276-287.
5. Beckman J. S., Carson M., Smith C. D. and Koppenol W. H. (1993) ALS, SOD and peroxynitrite. Nature 364, 584.
6. Benov L. and Fridovich I. (1995) A superoxide dismutase mimic protects soda sodB Escherichia coli against aerobic heating and stationary-phase death. Arch. Biochem. Biophys. 322, 291-294.
7. Bogdanov M. B., Ramos L. E., Xu Z. and Beal M. F. (1998) Elevated 'hydroxyl radical' generation in vivo in an animal model of amyotrophic lateral sclerosis. J. Neurochem. 71, 1321-1324.
8. Cleveland D. W. and Liu J. (2000) Oxidation versus aggregation - how do SOD1 mutants cause ALS? Nat. Med. 6, 1320-1321.
9. Cookson M. R. and Shaw P. J. (1999) Oxidative stress and motor neurone disease. Brain Pathol. 9, 165-186.
10. Crow J. P. (1999) Manganese and iron porphyrins catalyze peroxynitrite decomposition and simultaneously increase nitration and oxidant yield: implications for their use as peroxynitrite scavengers in vivo. Arch. Biochem. Biophys. 371, 41-52.
11. Crow J. P. (2000) Peroxynitrite scavenging by metalloporphyrins and thiolates. Free Radic. Biol. Med. 28, 1487-1494.
12. Crow J. P., Sampson J. B., Zhuang Y., Thompson J. A. and Beckman J. S. (1997) Decreased zinc affinity of amyotrophic lateral sclerosis-associated superoxide dismutase mutants leads to enhanced catalysis of tyrosine nitration by peroxynitrite. J. Neurochem. 69, 1936-1944.
13. Cuzzocrea S., Zingarelli B., Costantino G. and Caputi A. P. (1999) Beneficial effects of Mn (III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-]induced pleurisy. Free Radic. Biol. Med. 26, 25-33.
14. Day B. J. and Crapo J. D. (1996) A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced lung injury in vivo. Toxicol. Appl. Pharmacol. 140, 94-100.
15. Deng H. X., Hentati A., Tainer J. A., Iqbal Z., Cayabyab A., Hung W. Y., Getzoff E. D., Hu P., Herzfeldt B., Roos R. P. et al. (1993) Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261, 1047-1051.
16. Dugan L. L., Du Turetsky D. M. C., Lobner D., Wheeler M., Almli C. R., Shen C. K., Luh T. Y., Choi D. W. and Lin T. S. (1997) Carboxyfullerenes as neuroprotective agents. Proc. Natl Acad. Sci. USA 94, 9434-9439.
17. Estevez A. G., Crow J. P., Sampson J. B., Reiter C., Zhuang Y., Richardson G. J., Tarpey M. M., Barbeito L. and Beckman J. S. (1999) Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 286, 2498-2500.
18. Faulkner K. M., Liochev S. I. and Fridovich I. (1994) Stable Mn (III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo. J. Biol. Chem. 269, 23471-23476.
19. Ferrante R. J., Browne S. E., Shinobu L. A., Bowling A. C., Baik M. J., MacGarvey U., Kowall N. W., Brown R. H. Jr and Beal M. F. (1997a) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J. Neurochem. 69, 2064-2074.
20. Ferrante R. J., Shinobu L. A., Schulz J. B., Matthews R. T., Thomas C. E., Kowall N. W., Gurney M. E. and Beal M. F. (1997b) Increased 3-nitrotyrosine and oxidative damage in mice with a human copper/zinc superoxide dismutase mutation. Ann. Neurol. 42, 326-334.
21. Ferrer-Sueta G., Batinic-Haberle I., Spasojevic I., Fridovich I. and Radi R. (1999) Catalytic scavenging of peroxynitrite by isomeric Mn (III) N-methylpyridylporphyrins in the presence of reductants. Chem. Res. Toxicol. 12, 442-449.
22. Goto J. J., Zhu H., Sanchez R. J., Nersissian A., Gralla E. B., Valentine J. S. and Cabelli D. E. (2000) Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis. J. Biol. Chem. 275, 1007-1014.
23. Gurney M. E., Pu H., Chiu A. Y., Dal Canto M. C., Polchow C. Y., Alexander D. D., Caliendo J., Hentati A., Kwon Y. W., Deng H. X. et al. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775.
24. Gurney M. E., Cutting F. B., Zhai P., Doble A., Taylor C. P., Andrus P. K. and Hall E. D. (1996) Benefit of vitamin E, rilazole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann. Neurol. 39, 147-157.
25. Hall E. D., Andrus P. K., Oostveen J. A., Fleck T. J. and Gurney M. E. (1998) Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS. J. Neurosci. Res. 53, 66-77.
26. Higgins C. M., Jung C., Ding H. and Xu Z. (2002) Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS. J. Neurosci. 22, RC215.
27. Hsu S. M., Raine L. and Fanger H. (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29, 577-580.
28. Jung C., Rong Y., Doctrow S., Baudry M., Malfroy B. and Xu Z. (2001) Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model. Neurosci. Lett. 304, 157-160.
29. Klivenyi P., Ferrante R. J., Matthews R. T., Bogdanov M. B., Klein A. M., Andreassen O. A., Mueller G., Wermer M., Kaddurah-Daouk R. and Beal M. F. (1999) Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 5, 347-350.
30. Lee J. B., Hunt J. A. and Groves J. T. (1997) Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples. Bioorg. Med. Chem. Lett. 7, 2913-2918.
31. Lee J. B., Hunt J. A. and Groves J. T. (1998) Manganese porphyrins as redox-coupled peroxynitrite reductases. J. Am. Chem. Soc. 120, 6053-6061.
32. Liochev S. I. and Fridovich I. (1995) A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli. Arch. Biochem. Biophys. 321, 271-275.
33. Liu R., Althaus J. S., Ellerbrock B. R., Becker D. A. and Gurney M. E. (1998) Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann. Neurol. 44, 763-770.
34. Mackensen G. B., Patel M., Sheng H., Calvi C. L., Batinic-Haberle I., Day B. J., Liang L. P., Fridovich I., Crapo J. D., Pearlstein R. D. et al. (2001) Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J. Neurosci. 21, 4582-4592.
35. Mattiazzi M., D'Aurelio M., Gajewski C. D., Martushova K., Kiaei M., Beal M. F. and Manfredi G. (2002) Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J. Biol. Chem. 5, 5.
36. Menzies F. M., Ince P. G. and Shaw P. J. (2002) Mitochondrial involvement in amyotrophic lateral sclerosis. Neurochem. Int. 40, 543-551.
37. Okado-Matsumoto A. and Fridovich I. (2002) Amyotrophic lateral sclerosis: a proposed mechanism. Proc. Natl Acad. Sci. USA 11, 11.
38. Patel M. and Day B. J. (1999) Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol. Sci. 20, 359-364.
39. Poduslo J. F., Whelan S. L., Curran G. L. and Wengenack T. M. (2000) Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. Ann. Neurol. 48, 943-947.
40. Rosen D. R., Siddique T., Patterson D., Figlewicz D. A., Sapp P., Hentati A., Donaldson D., Goto J., O'Regan J. P., Deng H. X. et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362, 59-62.
41. Subramaniam J. R., Lyons W. E., Liu J., Bartnikas T. B., Rothstein J., Price D. L., Cleveland D. W., Gitlin J. D. and Wong P. C. (2002) Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5, 301-307.
42. Szabo C. (1998) Potential role of the peroxynitrate-poly (ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock. Shock 9, 341-344.
43. Wiedau-Pazos M., Goto J. J., Rabizadeh S., Gralla E. B., Roe J. A., Lee M. K., Valentine J. S. and Bredesen D. E. (1996) Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis. Science 271, 515-518.
44. Zhu S., Stavrovskaya I. G., Drozda M., Kim B. Y., Ona V., Li M., Sarang S., Liu A. S., Hartley D. M., Wu du C. et al. (2002) Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417, 74-78.
45. Zingarelli B., Day B. J., Crapo J. D., Salzman A. L. and Szabo C. (1997) The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br. J. Pharmacol. 120, 259-267.