Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression

Free Radical Biology and Medicine

Volumn 51, Issue 1, 2011, Pages 30-37

  Li, Hongliang ^a,b,c   Wang, Yong ^b   Pazhanisamy, Senthil K ^b,c   Shao, Lijian ^b,c   Batinic Haberle, Ines ^d   Meng, Aimin ^a   Zhou, Daohong ^b,c  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Free radicals; Hematopoietic stem progenitor cells; Ionizing radiation; Manganese(III) meso tetrakis (N ethylpyridinium 2 yl) porphyrin; Oxidative stress; Radioprotection; superoxide dismutase mimetic

Indexed keywords

ANTIOXIDANT; MANGANESE(III) MESO TETRAKIS (N ETHYLPYRIDINIUM 2 YL)PORPHYRIN; PROTEIN P16; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW SUPPRESSION; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; HEMATOPOIETIC STEM CELL; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RADIATION PROTECTION; WHOLE BODY RADIATION;

ANIMALS; ANTIOXIDANTS; BONE MARROW; BONE MARROW TRANSPLANTATION; CELL AGING; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELLS; MALE; METALLOPORPHYRINS; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; WHOLE-BODY IRRADIATION;

MUS;

EID: 79957968764     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.016     Document Type: Article

References (46)

1. P. Mauch, L. Constine, J. Greenberger, W. Knospe, J. Sullivan, and J.L. Liesveld Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy Int. J. Radiat. Oncol. Biol. Phys. 31 1995 1319 1339
2. N.G. Testa, J.H. Hendry, and G. Molineux Long-term bone marrow damage in experimental systems and in patients after radiation or chemotherapy Anticancer Res. 5 1985 101 110 (Pubitemid 15148825)
3. R.P. Gale Myelosuppressive effects of antineoplastic chemotherapy N.G. Testa, R.P. Gale, Hematopoiesis: Long-Term Effects of Chemotherapy and Radiation 1988 Dekker New York 63 73
4. H.P.E. Lohrmann, and W. Schreml Long-term hematopoietic damage after cytotoxic drug therapy for solid tumors N. Testa, R.P. Gale, Hematopoiesis: Long-Term Effects of Chemotherapy and Radiation 1988 Dekker New York 325 337
5. A. Meng, Y. Wang, S.A. Brown, Z.G. Van, and D. Zhou Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms Exp. Hematol. 31 2003 1348 1356 (Pubitemid 37510042)
6. S. Hellman, and L.E. Botnick Stem cell depletion: an explanation of the late effects of cytotoxins Int. J. Radiat. Oncol. Biol. Phys. 2 1977 181 184 (Pubitemid 8086051)
7. P. Mauch, M. Rosenblatt, and S. Hellman Permanent loss in stem cell self renewal capacity following stress to the marrow Blood 72 1988 1193 1196 (Pubitemid 18265879)
8. A. Meng, Y. Wang, Z.G. Van, and D. Zhou Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells Cancer Res. 63 2003 5414 5419 (Pubitemid 37139859)
9. Y. Wang, B.A. Schulte, A.C. LaRue, M. Ogawa, and D. Zhou Total body irradiation selectively induces murine hematopoietic stem cell senescence Blood 107 2006 358 366 (Pubitemid 43053564)
10. R.V. Gardner, R. Begue, and E. McKinnon The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on primitive hematopoietic stem cell (PHSC) function and numbers, after chemotherapy Exp. Hematol. 29 2001 1053 1059 (Pubitemid 32780996)
11. R. van Os, S. Robinson, T. Sheridan, J.M. Mislow, D. Dawes, and P.M. Mauch Granulocyte colony-stimulating factor enhances bone marrow stem cell damage caused by repeated administration of cytotoxic agents Blood 92 1998 1950 1956 (Pubitemid 28446684)
12. R. van Os, S. Robinson, T. Sheridan, and P.M. Mauch Granulocyte-colony stimulating factor impedes recovery from damage caused by cytotoxic agents through increased differentiation at the expense of self-renewal Stem Cells 18 2000 120 127 (Pubitemid 30176806)
13. Y. Wang, L. Liu, S.K. Pazhanisamy, H. Li, A. Meng, and D. Zhou Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells Free Radic. Biol. Med. 48 2010 348 356
14. W. Du, Z. Adam, R. Rani, X. Zhang, and Q. Pang Oxidative stress in Fanconi anemia hematopoiesis and disease progression Antioxid. Redox Signal. 10 2008 1909 1921
15. K. Ito, A. Hirao, F. Arai, K. Takubo, S. Matsuoka, and K. Miyamoto Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells Nat. Med. 12 2006 446 451
16. K. Miyamoto, K.Y. Araki, K. Naka, F. Arai, K. Takubo, and S. Yamazaki Foxo3a is essential for maintenance of the hematopoietic stem cell pool Cell Stem Cell 1 2007 101 112 (Pubitemid 46865800)
17. Z. Tothova, R. Kollipara, B.J. Huntly, B.H. Lee, D.H. Castrillon, and D.E. Cullen FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress Cell 128 2007 325 339 (Pubitemid 46137992)
18. S. Yalcin, X. Zhang, J.P. Luciano, S.K. Mungamuri, D. Marinkovic, and C. Vercherat Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells J. Biol. Chem. 283 2008 25692 25705
19. K. Ito, A. Hirao, F. Arai, S. Matsuoka, K. Takubo, and I. Hamaguchi Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Nature 431 2004 997 1002 (Pubitemid 39434422)
20. I. Batinic-Haberle, J.S. Reboucas, and I. Spasojevic Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential Antioxid. Redox Signal. 13 2010 877 918
21. I. Batinic-Haberle, I. Spasojevic, H.M. Tse, A. Tovmasyan, Z. Rajic, and D.K. St Clair Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities Amino Acids 2010 doi:10.1007/s00726-010-0603-6. [Epub ahead of print]
22. J.H. Lee, and J.W. Park A manganese porphyrin complex is a novel radiation protector Free Radic. Biol. Med. 37 2004 272 283 (Pubitemid 38760263)
23. + in mitigation and treatment of radiation-induced lung damage Free Radic. Biol. Med. 48 2010 1034 1043
24. X.W. Mao, J.D. Crapo, T. Mekonnen, N. Lindsey, P. Martinez, and D.S. Gridley Radioprotective effect of a metalloporphyrin compound in rat eye model Curr. Eye Res. 34 2009 62 72
25. B.J. Moeller, I. Batinic-Haberle, I. Spasojevic, Z.N. Rabbani, M.S. Anscher, and Z. Vujaskovic A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness Int. J. Radiat. Oncol. Biol. Phys. 63 2005 545 552 (Pubitemid 41317173)
26. M.C. Jaramillo, J.B. Frye, J.D. Crapo, M.M. Briehl, and M.E. Tome Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells Cancer Res. 69 2009 5450 5457
27. I. Batinic-Haberle Manganese porphyrins and related compounds as mimics of superoxide dismutase Methods Enzymol. 349 2002 223 233 (Pubitemid 34229509)
28. K. Rothkamm, and M. Lobrich Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses Proc. Natl. Acad. Sci. U. S. A. 100 2003 5057 5062 (Pubitemid 36542657)
29. S. Toyokuni, Y. Iwasa, S. Kondo, T. Tanaka, H. Ochi, and H. Hiai Intranuclear distribution of 8-hydroxy-2′-deoxyguanosine: an immunocytochemical study J. Histochem. Cytochem. 47 1999 833 836
30. J. Krishnamurthy, C. Torrice, M.R. Ramsey, G.I. Kovalev, K. Al-Regaiey, and L. Su Ink4a/Arf expression is a biomarker of aging J. Clin. Invest. 114 2004 1299 1307 (Pubitemid 40385301)
31. N.E. Sharpless Ink4a/Arf links senescence and aging Exp. Gerontol. 39 2004 1751 1759 (Pubitemid 39576145)
32. D. Gius, and D.R. Spitz Redox signaling in cancer biology Antioxid. Redox Signal. 8 2006 1249 1252 (Pubitemid 44182423)
33. W. Zhao, D.I. Diz, and M.E. Robbins Oxidative damage pathways in relation to normal tissue injury Br. J. Radiol. 80 Spec. No. 1 2007 S23 S31
34. W. Zhao, and M.E. Robbins Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications Curr. Med. Chem. 16 2009 130 143
35. I. Batinic-Haberle SOD enzymes and their mimics in cancer: Pro vs anti-oxidative mode of action. Part I Anticancer Agents Med. Chem. 11 2011 172 174
36. Z.N. Rabbani, I. Spasojevic, X. Zhang, B.J. Moeller, S. Haberle, J. Vasquez-Vivar, M.W. Dewhirst, Z. Vujaskovic, and I. Batinic-Haberle Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N- ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor Free Radic. Biol. Med. 47 2009 992 1004
37. D.J. Rossi, D. Bryder, J. Seita, A. Nussenzweig, J. Hoeijmakers, and I.L. Weissman Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age Nature 447 2007 725 729 (Pubitemid 46889729)
38. D.J. Rossi, C.H. Jamieson, and I.L. Weissman Stem cells and the pathways to aging and cancer Cell 132 2008 681 696 (Pubitemid 351253688)
39. A. Sancar, L.A. Lindsey-Boltz, K. Unsal-Kacmaz, and S. Linn Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints Annu. Rev. Biochem. 73 2004 39 85 (Pubitemid 39050363)
40. J. Campisi Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors Cell 120 2005 513 522 (Pubitemid 40269765)
41. C.M. Beausejour, A. Krtolica, F. Galimi, M. Narita, S.W. Lowe, and P. Yaswen Reversal of human cellular senescence: roles of the p53 and p16 pathways EMBO J. 22 2003 4212 4222 (Pubitemid 37021749)
42. H. Iwasa, J. Han, and F. Ishikawa Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway Genes Cells 8 2003 131 144 (Pubitemid 36511698)
43. K. Allampallam, V. Shetty, S. Mundle, D. Dutt, H. Kravitz, and P.L. Reddy Biological significance of proliferation, apoptosis, cytokines, and monocyte/macrophage cells in bone marrow biopsies of 145 patients with myelodysplastic syndrome Int. J. Hematol. 75 2002 289 297 (Pubitemid 43014062)
44. F. Zorat, V. Shetty, D. Dutt, L. Lisak, F. Nascimben, and K. Allampallam The clinical and biological effects of thalidomide in patients with myelodysplastic syndromes Br. J. Haematol. 115 2001 881 894 (Pubitemid 34042906)
45. L. Huang, A.R. Snyder, and W.F. Morgan Radiation-induced genomic instability and its implications for radiation carcinogenesis Oncogene 22 2003 5848 5854 (Pubitemid 37176705)
46. E.G. Wright Radiation-induced genomic instability in haemopoietic cells Int. J. Radiat. Biol. 74 1998 681 687 (Pubitemid 28566234)