An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation

Free Radical Research

Volumn 42, Issue 7, 2008, Pages 618-624

  Batinic Haberle, Ines ^a   Benov, Ludmil T ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Diabetes; Isocitrate dehydrogenase inactivation; Manganese porphyrin; MnTM 2 PyP; SOD mimic

Indexed keywords

2 OXOGLUTARIC ACID; ACONITATE HYDRATASE; ANTIOXIDANT; FUMARATE HYDRATASE; FUMARIC ACID; HEMATOPORPHYRIN MANGANESE; ISOCITRATE DEHYDROGENASE; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STREPTOZOCIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; DECARBOXYLATION; DIABETES MELLITUS; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ESCHERICHIA COLI; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN SYNTHESIS; RAT; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES;

ACONITATE HYDRATASE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FREE RADICAL SCAVENGERS; ISOCITRATE DEHYDROGENASE; MALE; METALLOPORPHYRINS; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN BIOSYNTHESIS; RATS; RATS, WISTAR; REACTIVE NITROGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES; TIME FACTORS;

ESCHERICHIA COLI; RATTUS;

EID: 48449104019     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760802209639     Document Type: Article

References (66)

1. Xu, X., Zhao, J., Xu, Z., Peng, B., Huang, Q., Arnold, E. and Ding, J. (2004) Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. 279, pp. 33946-33957.
2. Haselbeck, RJ and McAlister-Henn, L. (1993) Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. 268, pp. 12116-12122.
3. Jennings, GT, Sechi, S., Stevenson, PM, Tuckey, RC, Parmelee, D. and McAlister-Henn, L. (1994) Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA. 269, pp. 23128-23134.
4. Jo, SH, Son, MK, Koh, HJ, Lee, SM, Song, IH, Kim, YO, Lee, YS, Jeong, KS, Kim, WB, Park, JW, Song, BJ and Huh, TL. (2001) Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. 276, pp. 16168-16176.
5. Lee, SM, Koh, HJ, Park, DC, Song, BJ, Huh, TL and Park, JW. (2002) Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. 32, pp. 1185-1196.
6. Kim, SY and Park, JW. (2003) Cellular defense against singlet oxygen-induced oxidative damage by cytosolic NADP+-dependent isocitrate dehydrogenase. 37, pp. 309-316.
7. Kim, SY, Lee, SM, Tak, JK, Choi, KS, Kwon, TK and Park, JW. (2007) Regulation of singlet oxygen-induced apoptosis by cytosolic NADP+ -dependent isocitrate dehydrogenase. 302, pp. 27-34.
8. Kim, HJ and Park, JW. (2005) Oxalomalate, a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase, regulates heat shock-induced apoptosis. 337, pp. 685-691.
9. Kim, HJ, Kang, BS and Park, JW. (2005) Cellular defense against heat shock-induced oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. 39, pp. 441-448.
10. Kil, IS, Shin, SW, Yeo, HS, Lee, YS and Park, JW. (2006) Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis. 70, pp. 1053-1061.
11. Lee, JH and Park, JW. (2007) Oxalomalate regulates ionizing radiation-induced apoptosis in mice. 42, pp. 44-51.
12. Lee, SH, Jo, SH, Lee, SM, Koh, HJ, Song, H., Park, JW, Lee, WH and Huh, TL. (2004) Role of NADP+-dependent isocitrate dehydrogenase (NADP+-ICDH) on cellular defence against oxidative injury by gamma-rays. 80, pp. 635-642.
13. Lee, JH, Kim, SY, Kil, IS and Park, JW. (2007) Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. 282, pp. 13385-13394.
14. Yang, ES, Richter, C., Chun, JS, Huh, TL, Kang, SS and Park, JW. (2002) Inactivation of NADP(+)-dependent isocitrate dehydrogenase by nitric oxide. 33, pp. 927-937.
15. Lee, JH, Yang, ES and Park, JW. (2003) Inactivation of NADP+-dependent isocitrate dehydrogenase by peroxynitrite. Implications for cytotoxicity and alcohol-induced liver injury. 278, pp. 51360-51371.
16. Lee, SM, Huh, TL and Park, JW. (2001) Inactivation of NADP(+)-dependent isocitrate dehydrogenase by reactive oxygen species. 83, pp. 1057-1065.
17. Benderdour, M., Charron, G., DeBlois, D., Comte, B. and Des Rosiers, C. (2003) Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: An event that precedes hypertrophy development. 278, pp. 45154-45159.
18. Yang, JH, Yang, ES and Park, JW. (2004) Inactivation of NADP+-dependent isocitrate dehydrogenase by lipid peroxidation products. 38, pp. 241-249.
19. Benov, L. and Fridovich, I. (1999) Why superoxide imposes an aromatic amino acid auxotrophy on Escherichia coli. The transketolase connection. 274, pp. 4202-4206.
20. Benov, L. and Al-Ibraheem, J. (2001) Glycerol metabolism in superoxide dismutase-deficient Escherichia coli. 35, pp. 867-872.
21. Benov, L., Kredich, NM and Fridovich, I. (1996) The mechanism of the auxotrophy for sulfur-containing amino acids imposed upon Escherichia coli by superoxide. 271, pp. 21037-21040.
22. Imlay, JA and Fridovich, I. (1991) Assay of metabolic superoxide production in Escherichia coli. 266, pp. 6957-6965.
23. Gort, AS and Imlay, JA. (1998) Balance between endogenous superoxide stress and antioxidant defenses. 180, pp. 1402-1410.
24. LaPorte, DC. (1993) The isocitrate dehydrogenase phosphorylation cycle: regulation and enzymology. 51, pp. 14-18.
25. Murakami, K., Tsubouchi, R., Fukayama, M., Ogawa, T. and Yoshino, M. (2006) Oxidative inactivation of reduced NADP-generating enzymes in E. coli: Iron-dependent inactivation with affinity cleavage of NADP-isocitrate dehydrogenase. 186, pp. 385-392.
26. Batinic-Haberle, I., Benov, L., Spasojevic, I. and Fridovich, I. (1998) The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic. 273, pp. 24521-24528.
27. Vance, CK and Miller, A. (1998) A simple proposal that can explain the inactivity of metal-substituted superoxide dismutases. 120, pp. 461-467.
28. Michel, E., Nauser, T., Sutter, B., Bounds, PL and Koppenol, WH. (2005) Kinetics properties of Cu,Zn-superoxide dismutase as a function of metal content. 439, pp. 234-240.
29. Goldstein, S., Fridovich, I. and Czapski, G. (2006) Kinetic properties of Cu,Zn-superoxide dismutase as a function of metal content-order restored. 41, pp. 937-941.
30. Benov, L. and Batinic-Haberle, I. (2005) A manganese porphyrin suppresses oxidative stress and extends the life span of streptozotocin-diabetic rats. 39, pp. 81-88.
31. Touati, D. (2002) Investigating phenotypes resulting from a lack of superoxide dismutase in bacterial null mutants. 349, pp. 145-154.
32. Touati, D. and Farr, SB. (1990) Elevated mutagenesis in bacterial mutants lacking superoxide dismutase. 186, pp. 646-651.
33. Imlay, JA and Fridovich, I. (1991) Isolation and genetic analysis of a mutation that suppresses the auxotrophies of superoxide dismutase-deficient Escherichia coli K12. 228, pp. 410-416.
34. Maniatis, T., Fritsch, EF and Sambrook, J. (1982) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
35. Hausladen, A. and Fridovich, I. (1996) Measuring nitric oxide and and superoxide: Rate constants for aconitase reactivity. 269, pp. 37-41.
36. Gardner, PR and Fridovich, I. (1991) Superoxide sensitivity of the Escherichia coli aconitase. 266, pp. 19328-19333.
37. Fatania, HR, al-Nassar, KE and Thomas, N. (1993) Chemical modification of rat liver cytosolic NADP(+)-linked isocitrate dehydrogenase by N-ethylmaleimide. Evidence for essential sulphydryl groups. 322, pp. 245-248.
38. Micheli, V., Simmonds, HA, Bari, M. and Pompucci, G. (1993) HPLC determination of oxidized and reduced pyridine coenzymes in human erythrocytes. 220, pp. 1-17.
39. Ross, AD, Sheng, H., Warner, DS, Piantadosi, CA, Batinic-Haberle, I., Day, BJ and Crapo, JD. (2002) Hemodynamic effects of metalloporphyrin catalytic antioxidants: Structure-activity relationships and species specificity. 33, pp. 1657-1669.
40. Fatania, H., al-Nassar, KE and Sidhan, V. (1993) Purification and partial characterisation of NADP(+)-linked isocitrate dehydrogenase from rat liver cytosol. 320, pp. 57-60.
41. Gardner, PR. (2002) Aconitase: Sensitive target and measure of superoxide. 349, pp. 9-23.
42. Liochev, SI and Fridovich, I. (1993) Modulation of the fumarases of Escherichia coli in response to oxidative stress. 301, pp. 379-384.
43. Liochev, SI and Fridovich, I. (1992) Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon. 89, pp. 5892-5896.
44. Colman, RF. (1969) The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. I. Reaction with 5,5′-dithiobis(2-nitrobenzoic acid). 8, pp. 888-898.
45. Colman, RF and Chu, R. (1970) The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. 3. Effect of N-ethylmaleimide on chemical and physical properties. 245, pp. 608-615.
46. Colman, RF and Chu, R. (1970) The role of sulfhydryl groups in the catalytic function of isocitrate dehydrogenase. II. Effect of N-ethylmaleimide on kinetic properties. 245, pp. 601-607.
47. Little, C. and Holland, P. (1972) Sulfhydril groups and the concerted inhibition of NADP+-linked isocitrate dehydrogenase. 50, pp. 1109-1113.
48. Panchenko, LF, Olfer'ev, AM, Loktaeva, TD, Ivkov, NN and Komissarova, T. (1976) Effect of thiol-oxidizing agents on several enzymes in rat liver mitochondria. 48, pp. 455-459.
49. Kil, IS and Park, JW. (2005) Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation. 280, pp. 10846-10854.
50. Winterbourn, CC and Metodiewa, D. (1999) Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide. 27, pp. 322-328.
51. Imlay, JA. (2006) Iron-sulphur clusters and the problem with oxygen. 59, pp. 1073-1082.
52. Keyer, K. and Imlay, JA. (1996) Superoxide accelerates DNA damage by elevating free-iron levels. 93, pp. 13635-13640.
53. Woodmansee, AN and Imlay, JA. (2002) Quantitation of intracellular free iron by electron paramagnetic resonance spectroscopy. 349, pp. 3-9.
54. Liochev, SI and Fridovich, I. (1999) Superoxide and iron: Partners in crime. 48, pp. 157-161.
55. Colman, RF. (1972) Role of metal ions in reactions catalyzed by pig heart triphosphopyridine nucleotide-dependent isocitrate dehydrogenase. II. Effect on catalytic properties and reactivity of amino acid residues. 247, pp. 215-223.
56. Chao, G., Shen, J., Tseng, CP, Park, SJ and Gunsalus, RP. (1997) Aerobic regulation of isocitrate dehydrogenase gene (icd) expression in Escherichia coli by the arcA and fnr gene products. 179, pp. 4299-4304.
57. Jung, IL, Kim, SK and Kim, IG. (2006) The RpoS-mediated regulation of isocitrate dehydrogenase gene expression in Escherichia coli. 52, pp. 21-26.
58. Djaman, O., Outten, FW and Imlay, JA. (2004) Repair of oxidized iron-sulfur clusters in Escherichia coli. 279, pp. 44590-44599.
59. Bautista, J., Satrustegui, J. and Machado, A. (1979) Evidence suggesting that the NADPH/NADP ratio modulates the splitting of the isocitrate flux between the glyoxylic and tricarboxylic acid cycles, in Escherichia coli. 105, pp. 333-336.
60. Davies, KJ and Lin, SW. (1988) Oxidatively denatured proteins are degraded by an ATP-independent proteolytic pathway in Escherichia coli. 5, pp. 225-236.
61. Ceriello, A. (2006) Oxidative stress and diabetes-associated complications. 1, pp. 60-62.
62. Rolo, AP and Palmeira, CM. (2006) Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. 212, pp. 167-178.
63. Brownlee, M. (2005) The pathobiology of diabetic complications: A unifying mechanism. 54, pp. 1615-1625.
64. Kil, IS, Lee, JH, Shin, AH and Park, JW. (2004) Glycation-induced inactivation of NADP(+)-dependent isocitrate dehydrogenase: Implications for diabetes and aging. 37, pp. 1765-1778.
65. Tse, HM, Milton, MJ and Piganelli, JD. (2004) Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity. 36, pp. 233-247.
66. Bottino, R., Balamurugan, AN, Tse, H., Thirunavukkarasu, C., Ge, X., Profozich, J., Milton, M., Ziegenfuss, A., Trucco, M. and Piganelli, JD. (2004) Response of human islets to isolation stress and the effect of antioxidant treatment. 53, pp. 2559-2568.